LOCUS       NP_001119749             694 aa            linear   ROD 30-JUL-2024
DEFINITION  outer dynein arm-docking complex subunit 1 [Rattus norvegicus].
ACCESSION   NP_001119749 XP_001080782 XP_218574
VERSION     NP_001119749.1
DBSOURCE    REFSEQ: accession NM_001126277.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 694)
  AUTHORS   Hjeij,R., Onoufriadis,A., Watson,C.M., Slagle,C.E., Klena,N.T.,
            Dougherty,G.W., Kurkowiak,M., Loges,N.T., Diggle,C.P.,
            Morante,N.F., Gabriel,G.C., Lemke,K.L., Li,Y., Pennekamp,P.,
            Menchen,T., Konert,F., Marthin,J.K., Mans,D.A., Letteboer,S.J.,
            Werner,C., Burgoyne,T., Westermann,C., Rutman,A., Carr,I.M.,
            O'Callaghan,C., Moya,E., Chung,E.M., Sheridan,E., Nielsen,K.G.,
            Roepman,R., Bartscherer,K., Burdine,R.D., Lo,C.W., Omran,H. and
            Mitchison,H.M.
  CONSRTM   UK10K Consortium
  TITLE     CCDC151 mutations cause primary ciliary dyskinesia by disruption of
            the outer dynein arm docking complex formation
  JOURNAL   Am J Hum Genet 95 (3), 257-274 (2014)
   PUBMED   25192045
REFERENCE   2  (residues 1 to 694)
  AUTHORS   Onoufriadis,A., Paff,T., Antony,D., Shoemark,A., Micha,D., Kuyt,B.,
            Schmidts,M., Petridi,S., Dankert-Roelse,J.E., Haarman,E.G.,
            Daniels,J.M., Emes,R.D., Wilson,R., Hogg,C., Scambler,P.J.,
            Chung,E.M., Pals,G. and Mitchison,H.M.
  CONSRTM   UK10K
  TITLE     Splice-site mutations in the axonemal outer dynein arm docking
            complex gene CCDC114 cause primary ciliary dyskinesia
  JOURNAL   Am J Hum Genet 92 (1), 88-98 (2013)
   PUBMED   23261303
REFERENCE   3  (residues 1 to 694)
  AUTHORS   Knowles,M.R., Leigh,M.W., Ostrowski,L.E., Huang,L., Carson,J.L.,
            Hazucha,M.J., Yin,W., Berg,J.S., Davis,S.D., Dell,S.D.,
            Ferkol,T.W., Rosenfeld,M., Sagel,S.D., Milla,C.E., Olivier,K.N.,
            Turner,E.H., Lewis,A.P., Bamshad,M.J., Nickerson,D.A., Shendure,J.
            and Zariwala,M.A.
  CONSRTM   Genetic Disorders of Mucociliary Clearance Consortium
  TITLE     Exome sequencing identifies mutations in CCDC114 as a cause of
            primary ciliary dyskinesia
  JOURNAL   Am J Hum Genet 92 (1), 99-106 (2013)
   PUBMED   23261302
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC160835.1.
            
            On or before May 7, 2008 this sequence version replaced
            XP_218574.4, XP_001080782.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC160835.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..694
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     Protein         1..694
                     /product="outer dynein arm-docking complex subunit 1"
                     /note="coiled-coil domain-containing protein 114;
                     coiled-coil domain containing 114"
                     /calculated_mol_wt=78040
     Region          24..>319
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          271..290
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (B1H228.1)"
     Region          531..550
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (B1H228.1)"
     Site            536
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (B1H228.1)"
     Site            542
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (B1H228.1)"
     Site            543
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (B1H228.1)"
     Site            545
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (B1H228.1)"
     Region          571..694
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (B1H228.1)"
     CDS             1..694
                     /gene="Odad1"
                     /gene_synonym="Ccdc114; RGD1308141"
                     /coded_by="NM_001126277.2:170..2254"
                     /db_xref="GeneID:308594"
                     /db_xref="RGD:1308141"
ORIGIN      
        1 mrlglssrsa rseegseifl egpvdgelsr lhrqrkvmel erraysrevh qrirkqveei
       61 rqlemlrakl qmqinvaqtq vkrlgdkkrl admdhllkcr aqvqieieal qeqnralekq
      121 iqdwethilt qskdistpdv ildqkmkiqr ririledqld rvtchfdihl vrnaalreel
      181 ellriergry lnmdrklkke ihllqemvga lstsstsayt areeaktkmg mlqeraekel
      241 aqsdteaqil lrqishleql hrflklknhd rqpdpgvvqk eeqrawetse glrktsqekl
      301 vlryedtlnk laqltgesdp dllvekylel eernfaefnf ineqnselyh lqeeikemqe
      361 alvsehasqd kqslereqqc kvlqqdvekv cseserlear fqvlrvqlek iktdiqvlfd
      421 kaqcdnsvik dllgvktymr drdiglflst iekrlvqllt vqaflevqnn vpladaalla
      481 lgqsiqeppk kttplkppdt medssgvvik ddypmskeel lsqvmklvql qdeegspkkr
      541 dsspsltlss prislaaasv harkasvvpe silshktgrg rgtgsishvt fgdsasapgp
      601 vtlastsasg lpvsgrgsqg grgafkhtss ssylgstgyl etsrgresgt ggghsqsmgs
      661 emsrgfssgs gqtssaapas rpssatskds rgyn
//
