LOCUS       NM_001108256            5157 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus OCRL, inositol polyphosphate-5-phosphatase
            (Ocrl), mRNA.
ACCESSION   NM_001108256 XM_001068583 XM_229106
VERSION     NM_001108256.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5157)
  AUTHORS   Nakatsu,F., Messa,M., Nandez,R., Czapla,H., Zou,Y.,
            Strittmatter,S.M. and De Camilli,P.
  TITLE     Sac2/INPP5F is an inositol 4-phosphatase that functions in the
            endocytic pathway
  JOURNAL   J Cell Biol 209 (1), 85-95 (2015)
   PUBMED   25869668
REFERENCE   2  (bases 1 to 5157)
  AUTHORS   Luo,N., West,C.C., Murga-Zamalloa,C.A., Sun,L., Anderson,R.M.,
            Wells,C.D., Weinreb,R.N., Travers,J.B., Khanna,H. and Sun,Y.
  TITLE     OCRL localizes to the primary cilium: a new role for cilia in Lowe
            syndrome
  JOURNAL   Hum Mol Genet 21 (15), 3333-3344 (2012)
   PUBMED   22543976
REFERENCE   3  (bases 1 to 5157)
  AUTHORS   Coon,B.G., Hernandez,V., Madhivanan,K., Mukherjee,D., Hanna,C.B.,
            Barinaga-Rementeria Ramirez,I., Lowe,M., Beales,P.L. and
            Aguilar,R.C.
  TITLE     The Lowe syndrome protein OCRL1 is involved in primary cilia
            assembly
  JOURNAL   Hum Mol Genet 21 (8), 1835-1847 (2012)
   PUBMED   22228094
REFERENCE   4  (bases 1 to 5157)
  AUTHORS   Noakes,C.J., Lee,G. and Lowe,M.
  TITLE     The PH domain proteins IPIP27A and B link OCRL1 to receptor
            recycling in the endocytic pathway
  JOURNAL   Mol Biol Cell 22 (5), 606-623 (2011)
   PUBMED   21233288
REFERENCE   5  (bases 1 to 5157)
  AUTHORS   Bernard,D.J. and Nussbaum,R.L.
  TITLE     X-inactivation analysis of embryonic lethality in Ocrl wt/-;
            Inpp5b-/- mice
  JOURNAL   Mamm Genome 21 (3-4), 186-194 (2010)
   PUBMED   20195868
REFERENCE   6  (bases 1 to 5157)
  AUTHORS   Rodriguez-Gabin,A.G., Ortiz,E., Demoliner,K., Si,Q., Almazan,G. and
            Larocca,J.N.
  TITLE     Interaction of Rab31 and OCRL-1 in oligodendrocytes: its role in
            transport of mannose 6-phosphate receptors
  JOURNAL   J Neurosci Res 88 (3), 589-604 (2010)
   PUBMED   19795375
REFERENCE   7  (bases 1 to 5157)
  AUTHORS   Choudhury,R., Noakes,C.J., McKenzie,E., Kox,C. and Lowe,M.
  TITLE     Differential clathrin binding and subcellular localization of OCRL1
            splice isoforms
  JOURNAL   J Biol Chem 284 (15), 9965-9973 (2009)
   PUBMED   19211563
  REMARK    GeneRIF: OCRL1 exists as two functional pools, one participating in
            clathrin-mediated trafficking events such as endocytosis and
            another that is much less or not involved in this process
REFERENCE   8  (bases 1 to 5157)
  AUTHORS   Faucherre,A., Desbois,P., Satre,V., Lunardi,J., Dorseuil,O. and
            Gacon,G.
  TITLE     Lowe syndrome protein OCRL1 interacts with Rac GTPase in the
            trans-Golgi network
  JOURNAL   Hum Mol Genet 12 (19), 2449-2456 (2003)
   PUBMED   12915445
REFERENCE   9  (bases 1 to 5157)
  AUTHORS   Janne,P.A., Suchy,S.F., Bernard,D., MacDonald,M., Crawley,J.,
            Grinberg,A., Wynshaw-Boris,A., Westphal,H. and Nussbaum,R.L.
  TITLE     Functional overlap between murine Inpp5b and Ocrl1 may explain why
            deficiency of the murine ortholog for OCRL1 does not cause Lowe
            syndrome in mice
  JOURNAL   J Clin Invest 101 (10), 2042-2053 (1998)
   PUBMED   9593760
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            On Apr 19, 2010 this sequence version replaced NM_001108256.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760386,
                              SAMEA5760389 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-242               JAXUCZ010000021.1  131967471-131967712
            243-322             JAXUCZ010000021.1  131967950-131968029
            323-402             JAXUCZ010000021.1  131971386-131971465
            403-441             JAXUCZ010000021.1  131974382-131974420
            442-552             JAXUCZ010000021.1  131985288-131985398
            553-639             JAXUCZ010000021.1  131985811-131985897
            640-757             JAXUCZ010000021.1  131986472-131986589
            758-919             JAXUCZ010000021.1  131986676-131986837
            920-1021            JAXUCZ010000021.1  131988256-131988357
            1022-1136           JAXUCZ010000021.1  131989702-131989816
            1137-1253           JAXUCZ010000021.1  131991493-131991609
            1254-1441           JAXUCZ010000021.1  131991714-131991901
            1442-1553           JAXUCZ010000021.1  131993768-131993879
            1554-1663           JAXUCZ010000021.1  131996999-131997108
            1664-1799           JAXUCZ010000021.1  131998230-131998365
            1800-1910           JAXUCZ010000021.1  132001249-132001359
            1911-2076           JAXUCZ010000021.1  132001947-132002112
            2077-2312           JAXUCZ010000021.1  132002355-132002590
            2313-2336           JAXUCZ010000021.1  132010293-132010316
            2337-2453           JAXUCZ010000021.1  132012990-132013106
            2454-2538           JAXUCZ010000021.1  132013867-132013951
            2539-2666           JAXUCZ010000021.1  132014552-132014679
            2667-2778           JAXUCZ010000021.1  132015598-132015709
            2779-5157           JAXUCZ010000021.1  132015920-132018298
FEATURES             Location/Qualifiers
     source          1..5157
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq35"
     gene            1..5157
                     /gene="Ocrl"
                     /gene_synonym="OCRL-1"
                     /note="OCRL, inositol polyphosphate-5-phosphatase"
                     /db_xref="GeneID:317576"
                     /db_xref="RGD:1594526"
     exon            1..242
                     /gene="Ocrl"
                     /gene_synonym="OCRL-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             204..2903
                     /gene="Ocrl"
                     /gene_synonym="OCRL-1"
                     /EC_number="3.1.3.56"
                     /EC_number="3.1.3.36"
                     /EC_number="3.1.3.86"
                     /note="inositol polyphosphate 5-phosphatase OCRL-1;
                     oculocerebrorenal syndrome of Lowe; phosphatidylinositol
                     3,4,5-triphosphate 5-phosphatase"
                     /codon_start=1
                     /product="inositol polyphosphate 5-phosphatase OCRL"
                     /protein_id="NP_001101726.2"
                     /db_xref="GeneID:317576"
                     /db_xref="RGD:1594526"
                     /translation="MEPRLPIGAQPLAMVAGLEMKGPLREPCVLTLARRNGQYELIIQ
                     LHGKEQHVQDIIPINSHFRCVQEAEETLLIDIASNSGCKIRVQGDWTRERHFEIPDEE
                     RCLKFLSEVLAAQEAQSQLLVPEQKDSSNWYQKLDTKDKPAYSGLLGFEDNFSSMNLD
                     KKMNTQNPPTGIHREPPPPPSSNRMLPREKEALNKEQPKVTNTMRKLFAPNSQSGQRE
                     GLIKHILAKREKEYVNIQSFRFFVGTWNVNGQSPDSSLEPWLNCDPNPPDIYCIGFQE
                     LDLSTEAFFYFESVKEQEWAMAVERGLPSKAKYKKVQLVRLVGMMLLVFAKKDQCQYI
                     RDIATETVGTGIMGKMGNKGGVAMRFVFHNTTFCIVNSHLAAHVEEFERRNQDYKDIC
                     ARMSFSVPNQTLPQVNIMKHDVVIWLGDLNYRLCMPDANEVKSLINKNELQKLLKFDQ
                     LNIQRTQKKAFVDFNEGEIKFIPTYKYDSKTDRWDSSGKCRVPAWCDRILWRGINVNQ
                     LHYRSHMELKTSDHKPVSALFHIGVKVVDERRYRKVFEDIVRIMDRMENDFLPSLDLS
                     RREFMFENVKFRQLQKEKFQISNNGQVPCHFSFIPKLNDTQYCKPWLRAEPFEGYLEP
                     NETIDISLDVYVSKDSVTILNSGEDKIEDILVLHLDRGKDYFLTISGNYLPSCFGTSL
                     EALCRMKRPIREVPVTKLIDLEEDSFLEKEKSLLQMVPLDEGTSERPLQVPKEIWLLV
                     DHLFKYACHQEDLFQTPGMQEELQQIIDCLDTSIPETIPGSNHSVAEALLIFLEALPE
                     PVICYELYQRCLDSAHDPRICKQVISQLPRCHRNVFRYLMAFLRELLKFSDYNNVSTN
                     MIATLFTSLLLRPPPNLMARQTPSDRQRAIQFLLVFLLGSEED"
     exon            243..322
                     /gene="Ocrl"
                     /gene_synonym="OCRL-1"
                     /inference="alignment:Splign:2.1.0"
     exon            323..402
                     /gene="Ocrl"
                     /gene_synonym="OCRL-1"
                     /inference="alignment:Splign:2.1.0"
     exon            403..441
                     /gene="Ocrl"
                     /gene_synonym="OCRL-1"
                     /inference="alignment:Splign:2.1.0"
     exon            442..552
                     /gene="Ocrl"
                     /gene_synonym="OCRL-1"
                     /inference="alignment:Splign:2.1.0"
     exon            553..639
                     /gene="Ocrl"
                     /gene_synonym="OCRL-1"
                     /inference="alignment:Splign:2.1.0"
     exon            640..757
                     /gene="Ocrl"
                     /gene_synonym="OCRL-1"
                     /inference="alignment:Splign:2.1.0"
     exon            758..919
                     /gene="Ocrl"
                     /gene_synonym="OCRL-1"
                     /inference="alignment:Splign:2.1.0"
     exon            920..1021
                     /gene="Ocrl"
                     /gene_synonym="OCRL-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1136
                     /gene="Ocrl"
                     /gene_synonym="OCRL-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1137..1253
                     /gene="Ocrl"
                     /gene_synonym="OCRL-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1254..1441
                     /gene="Ocrl"
                     /gene_synonym="OCRL-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1442..1553
                     /gene="Ocrl"
                     /gene_synonym="OCRL-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1554..1663
                     /gene="Ocrl"
                     /gene_synonym="OCRL-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1664..1799
                     /gene="Ocrl"
                     /gene_synonym="OCRL-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1800..1910
                     /gene="Ocrl"
                     /gene_synonym="OCRL-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1911..2076
                     /gene="Ocrl"
                     /gene_synonym="OCRL-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2077..2312
                     /gene="Ocrl"
                     /gene_synonym="OCRL-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2313..2336
                     /gene="Ocrl"
                     /gene_synonym="OCRL-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2337..2453
                     /gene="Ocrl"
                     /gene_synonym="OCRL-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2454..2538
                     /gene="Ocrl"
                     /gene_synonym="OCRL-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2539..2666
                     /gene="Ocrl"
                     /gene_synonym="OCRL-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2667..2778
                     /gene="Ocrl"
                     /gene_synonym="OCRL-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2779..5157
                     /gene="Ocrl"
                     /gene_synonym="OCRL-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gactctctcc tcccggctcc ccagctcccc ggctggctcc caggctcccg ggctcccggg
       61 ctcccaggct ccccgcgccc agcggcgccg gagctcttcc tctccgccta ggcaaggcgg
      121 gcgggcgggc ggcaggccgc aggaggcggt gtcgtggaat ccgctggcag tccgcagccc
      181 cgcagagcct ggaggccgcc ctgatggagc cgcggctccc gatcggagct cagcccctgg
      241 caatggtggc gggtttggag atgaagggtc ctctccggga gccctgcgtc ctgaccctag
      301 cccggaggaa cgggcaatat gagttaataa tccagttgca tgggaaggaa cagcatgttc
      361 aagatatcat tcctataaat agccacttca gatgtgttca agaagcagaa gaaactcttt
      421 tgattgatat tgcttcaaac agtggctgca aaattcgggt acagggagac tggaccagag
      481 agcgccactt tgaaattcct gatgaagaac gctgtttgaa gttcctctca gaggtccttg
      541 ctgctcagga agctcagtca cagcttcttg ttccagaaca aaaagactca tctaactggt
      601 accagaaatt agacactaag gataaacctg cttattcagg actgcttgga tttgaagata
      661 atttttcatc tatgaattta gataaaaaaa tgaatacaca aaatcccccc acagggattc
      721 atcgggaacc accccctcca ccttcttcaa atagaatgct tccacgtgaa aaggaagctt
      781 taaacaaaga acagcccaaa gtgaccaata ccatgcggaa gctgttcgca ccaaacagcc
      841 aatctggcca gcgagagggt ctcatcaaac acatccttgc aaagcgagag aaagagtatg
      901 tcaacatcca gtctttcaga ttttttgttg gaacttggaa tgtgaatggc cagtctccag
      961 acagcagctt agaaccttgg ctgaactgtg atccaaatcc tcctgatatt tactgcattg
     1021 gattccaaga gctggacttg agcacagaag cctttttcta ctttgagtct gtaaaagagc
     1081 aagaatgggc catggctgtg gaaaggggtc tgccttcgaa ggccaagtat aaaaaggttc
     1141 aactggtccg ccttgtgggg atgatgcttc tcgtatttgc caaaaaagat cagtgtcaat
     1201 atatccgaga tattgctaca gaaacagtcg gaacaggaat catggggaaa atgggaaaca
     1261 aaggtggagt agctatgaga tttgtgttcc acaacaccac tttctgcatt gtcaattccc
     1321 acctggctgc ccacgtggaa gagtttgaac gaaggaacca ggattataaa gacatctgtg
     1381 cgagaatgag cttttcagtc cccaatcaga ctctcccaca agtgaacatc atgaagcatg
     1441 atgttgtcat ttggttggga gacttgaact acagactttg catgcctgat gccaatgagg
     1501 tgaaaagtct tattaataaa aatgagcttc agaagctgtt gaaattcgac cagttaaaca
     1561 ttcagcgcac acagaaaaaa gcttttgtgg atttcaatga aggggaaatc aagtttattc
     1621 ccacttacaa gtatgattct aaaactgaca gatgggattc cagtgggaaa tgccgagtcc
     1681 cagcctggtg tgaccgaatt ctttggagag gaataaatgt taatcaactt cattaccgga
     1741 gtcacatgga actcaaaact agtgaccaca aacctgttag cgccctgttc catattgggg
     1801 tgaaggttgt agatgaacgg cggtatcgga aggtctttga agatattgta cgcattatgg
     1861 acagaatgga aaatgacttc cttccttcat tagaccttag caggagagag tttatgtttg
     1921 agaatgtgaa gtttcggcag ctgcaaaagg agaagttcca gatcagcaac aatggacagg
     1981 ttccctgcca tttttctttc atccctaagc ttaatgacac ccaatactgc aagccatggc
     2041 ttcgagctga accttttgag ggctacttgg agccaaacga gacaatagac atttcccttg
     2101 atgtatacgt cagcaaagac tctgtaacca tcctgaactc tggtgaagat aagattgaag
     2161 atattcttgt cctccatttg gatcgaggaa aagattactt cttgaccatc agtgggaatt
     2221 accttccaag ttgctttgga acctcattgg aggctttgtg ccgaatgaaa agaccaatcc
     2281 gagaagttcc tgtcaccaaa ctcatagact tggaagaaga cagcttccta gaaaaggaga
     2341 aatcccttct gcagatggtc cccttggatg aaggtaccag tgagcgaccc cttcaagtcc
     2401 ccaaagagat ctggcttcta gtagatcact tgttcaaata tgcatgtcac caggaggact
     2461 tgttccaaac ccctggaatg caggaggagt tacagcagat cattgattgt ctggatacca
     2521 gcattcctga gacaatccct ggtagtaacc attctgtggc tgaagcactg ctcattttcc
     2581 tggaagccct gccagagcca gtcatctgtt atgagctgta tcagcgatgt ctcgactctg
     2641 ctcatgatcc tcggatctgc aaacaggtca tttcccagct tccaaggtgc catagaaatg
     2701 ttttccgcta cttgatggca ttccttcgag aactcttaaa attctctgat tacaacaatg
     2761 tcagcaccaa catgatcgct actctgttca ctagccttct cctaaggcct ccaccaaacc
     2821 tcatggcaag acagactcca agtgaccgcc agcgcgccat ccagtttctt ctagtcttcc
     2881 tgcttgggag cgaggaagac taaatctttt cctatctgag attctagagg aggaagatct
     2941 tgggctccga gtagttcaga atgatttgaa aagtcatgac acaaaaaggg tctattgtag
     3001 gatcttacat tctgttaata atacaaaggg aagagtttcc taatccttcc ataccatatc
     3061 ctacacagca aaatcctttt agacatatat tgccaagcca aagttaccat atttcggtgt
     3121 ttttgtgttt actctttgta aagcaaagag gtctgtattt acacaccttt tctggaggtt
     3181 ttctgccctg cttcctagtc ctcatgattt aataccctag gcctggattg agaggcattc
     3241 ccattctaag cctacaagca ctacttgcta tatagcccag acttgtctgc agtcctttgt
     3301 acacaatgca ctttggatcc accctctcct catgtcacta ctttgcacac ttcctccgtt
     3361 aatgctatcg ctttgaagga agcctggatg aggttagtga ctccgtgggt atcctgaaca
     3421 gtgaagttca ctgtctacat gtgattgtta catgcgttcg tgcatttcta ctacaataat
     3481 gtctatgtgt cactgtaata ttggccttct tgtggagcca cacttggtgg aaccatattc
     3541 ccttgtctca gaccatgttt agttatgtaa ttttatggac tattagagat ggcatcccac
     3601 tgatgtgaaa aacatcacaa cagcgaggaa agcactgtga ctatgtcaga gtgaaaatgt
     3661 ccctgcttcc catcctcttt ccctggtaat atccacacta gacatgagga gcaatcctgc
     3721 atgtcatggt acccatcttc cccactagaa acccacttcc agaataatgt ttgcatcaca
     3781 ctcaaaagag gagtttgtgc acctcaagta aggcccaatg gagctttcct cactctccaa
     3841 aacaagtatt gagggtaacc ctcagaagcc agtctcctat cttcagaagt attgagggaa
     3901 cacattgacc tcctcaacag ggctgactct aagctccaca tctgcctcct tcaagcaaag
     3961 acttcaaaga ctgcccttgg cttgagacac tatatccagt gctgtgtatg agagactggt
     4021 ccatgggacc agccacacac attacctctt ccacttgaaa cgactctaag gttttcattt
     4081 tattcaagcg gtatgggaca gacaaacttt ttaaaaatca acttgttgac tgacaaacca
     4141 gctgccagct tctggctgca aaaactgcct ggtgaaattg acttgctcgg tttcattcac
     4201 caaaccaacc caagtcgtct cgttcttgcc tatgtacaat cttgggtact gattccatca
     4261 gtagcatctt ataccatcca aggagagggc cagggaaaca gccaccatca aatggttttc
     4321 cagcttcccc gtctcttcaa aaattgagtt cttgggagaa caaaaggtat gtatcctgca
     4381 atagacctga taagccctca aataagtggg agttgggaaa tcagagtcaa agtattggtg
     4441 ccagctcact gaggatctga ttgggtcaac agttgattaa cggaagactg agaggaaaag
     4501 aaagttgtca tatctattag gccagaaagt aatcactgaa gaagcagatg atgtggaaca
     4561 aggtggtcca cagggaaatg cctctcctgg gcccacttta caataccttg ccaagcttgg
     4621 gtcttcagat gagcaaggat atggtgagtg gggcctctgt ggagcatgca cgtagtgccc
     4681 tgtcttcatc aggccaaagc accaagttgc ttcactgcct cagccttttg tccagcttgg
     4741 cctgggattt atatagagct gagggtttta gacaatctcc aggtagggga tacaaaacag
     4801 atcagatgga agaaacctgc ttccctatcc tgcctatcct gcacctcagc ctcttaattc
     4861 ctaattcctc caaggtacta tttcatagtt gctctgaatt aaggatttca catccaactg
     4921 gtacggaaag actccgcacc tagcatcttt gggaagaaat gattccaatc taatgggtga
     4981 tactgcatta gtttcccttt ctgattctta atctgtaggt ctttgttata cttcacaaaa
     5041 aggaaaaatg tctcggtcac tacgcaaagc tgctagtgga attctgtatt ttgtgtcatc
     5101 ttttttatta taatttattg caattttatg aataaatata tgttgtgtga aaactca
//
