LOCUS       NM_012995                658 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus oncomodulin (Ocm), mRNA.
ACCESSION   NM_012995 XM_341036
VERSION     NM_012995.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 658)
  AUTHORS   Vologzhannikova,A.A., Khorn,P.A., Shevelyova,M.P., Kazakov,A.S.,
            Emelyanenko,V.I., Permyakov,E.A. and Permyakov,S.E.
  TITLE     The Highly Conservative Cysteine of Oncomodulin as a Feasible Redox
            Sensor
  JOURNAL   Biomolecules 11 (1), 66 (2021)
   PUBMED   33419032
  REMARK    GeneRIF: The Highly Conservative Cysteine of Oncomodulin as a
            Feasible Redox Sensor.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 658)
  AUTHORS   Schwaller,B.
  TITLE     Cytosolic Ca2+ buffers
  JOURNAL   Cold Spring Harb Perspect Biol 2 (11), a004051 (2010)
   PUBMED   20943758
  REMARK    Review article
REFERENCE   3  (bases 1 to 658)
  AUTHORS   Permyakov,S.E., Bakunts,A.G., Permyakova,M.E., Denesyuk,A.I.,
            Uversky,V.N. and Permyakov,E.A.
  TITLE     Metal-controlled interdomain cooperativity in parvalbumins
  JOURNAL   Cell Calcium 46 (3), 163-175 (2009)
   PUBMED   19651438
REFERENCE   4  (bases 1 to 658)
  AUTHORS   Henzl,M.T., Davis,M.E. and Tan,A.
  TITLE     Leucine 85 is an important determinant of divalent ion affinity in
            rat beta-parvalbumin (Oncomodulin)
  JOURNAL   Biochemistry 47 (51), 13635-13646 (2008)
   PUBMED   19075559
  REMARK    GeneRIF: Leucine 85 is an important determinant of divalent ion
            affinity in rat beta-parvalbumin
REFERENCE   5  (bases 1 to 658)
  AUTHORS   Henzl,M.T. and Tanner,J.J.
  TITLE     Solution structure of Ca2+-free rat beta-parvalbumin (oncomodulin)
  JOURNAL   Protein Sci 16 (9), 1914-1926 (2007)
   PUBMED   17766386
  REMARK    GeneRIF: Solution structure of Ca2+-free oncomodulin is reported.
REFERENCE   6  (bases 1 to 658)
  AUTHORS   Ahmed,F.R., Przybylska,M., Rose,D.R., Birnbaum,G.I., Pippy,M.E. and
            MacManus,J.P.
  TITLE     Structure of oncomodulin refined at 1.85 A resolution. An example
            of extensive molecular aggregation via Ca2+
  JOURNAL   J Mol Biol 216 (1), 127-140 (1990)
   PUBMED   2231727
REFERENCE   7  (bases 1 to 658)
  AUTHORS   Banville,D. and Boie,Y.
  TITLE     Retroviral long terminal repeat is the promoter of the gene
            encoding the tumor-associated calcium-binding protein oncomodulin
            in the rat
  JOURNAL   J Mol Biol 207 (3), 481-490 (1989)
   PUBMED   2474657
REFERENCE   8  (bases 1 to 658)
  AUTHORS   Williams,T.C., Corson,D.C., Sykes,B.D. and MacManus,J.P.
  TITLE     Oncomodulin. 1H NMR and optical stopped-flow spectroscopic studies
            of its solution conformation and metal-binding properties
  JOURNAL   J Biol Chem 262 (13), 6248-6256 (1987)
   PUBMED   3571255
REFERENCE   9  (bases 1 to 658)
  AUTHORS   Gillen,M.F., Banville,D., Rutledge,R.G., Narang,S., Seligy,V.L.,
            Whitfield,J.F. and MacManus,J.P.
  TITLE     A complete complementary DNA for the oncodevelopmental
            calcium-binding protein, oncomodulin
  JOURNAL   J Biol Chem 262 (11), 5308-5312 (1987)
   PUBMED   3558395
REFERENCE   10 (bases 1 to 658)
  AUTHORS   MacManus,J.P., Watson,D.C. and Yaguchi,M.
  TITLE     The complete amino acid sequence of oncomodulin--a parvalbumin-like
            calcium-binding protein from Morris hepatoma 5123tc
  JOURNAL   Eur J Biochem 136 (1), 9-17 (1983)
   PUBMED   6617664
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Nov 27, 2020 this sequence version replaced NM_012995.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: J02705.1, SRR22582419.1207483.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680442, SAMN11044071
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-70                JAXUCZ010000012.1  15700626-15700695
            71-134              JAXUCZ010000012.1  15704575-15704638
            135-267             JAXUCZ010000012.1  15705887-15706019
            268-377             JAXUCZ010000012.1  15706465-15706574
            378-658             JAXUCZ010000012.1  15710095-15710375
FEATURES             Location/Qualifiers
     source          1..658
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12p11"
     gene            1..658
                     /gene="Ocm"
                     /gene_synonym="Ocm2; OM"
                     /note="oncomodulin"
                     /db_xref="GeneID:25503"
                     /db_xref="RGD:3222"
     exon            1..70
                     /gene="Ocm"
                     /gene_synonym="Ocm2; OM"
                     /inference="alignment:Splign:2.1.0"
     exon            71..134
                     /gene="Ocm"
                     /gene_synonym="Ocm2; OM"
                     /inference="alignment:Splign:2.1.0"
     CDS             74..403
                     /gene="Ocm"
                     /gene_synonym="Ocm2; OM"
                     /note="parvalbumin beta; oncmodulin; oncomodulin 2"
                     /codon_start=1
                     /product="oncomodulin"
                     /protein_id="NP_037127.1"
                     /db_xref="GeneID:25503"
                     /db_xref="RGD:3222"
                     /translation="MSITDILSAEDIAAALQECQDPDTFEPQKFFQTSGLSKMSASQV
                     KDIFRFIDNDQSGYLDGDELKYFLQKFQSDARELTESETKSLMDAADNDGDGKIGADE
                     FQEMVHS"
     exon            135..267
                     /gene="Ocm"
                     /gene_synonym="Ocm2; OM"
                     /inference="alignment:Splign:2.1.0"
     exon            268..377
                     /gene="Ocm"
                     /gene_synonym="Ocm2; OM"
                     /inference="alignment:Splign:2.1.0"
     exon            378..658
                     /gene="Ocm"
                     /gene_synonym="Ocm2; OM"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaaggcgtga ctgcagaaga atcctggtgt tccaagtcgt tcttgccggc gagaccaccg
       61 tgcgggacag aaaatgagca tcacggacat cctgagcgct gaggacattg cggcagccct
      121 gcaggaatgc caagacccag acacctttga accacaaaag ttcttccaga catcgggcct
      181 ctccaagatg tctgccagcc aagtgaagga tatcttccgg ttcatagaca acgaccagag
      241 tggatacctg gatggagatg agctcaagta tttcctacag aagttccaga gtgacgccag
      301 agaactgact gagtcagaga ccaagtcctt gatggacgcg gcggacaacg acggagacgg
      361 gaagattggg gcggatgaat tccaggaaat ggtgcactct taaggcccaa gtctacggaa
      421 gagagagagg ggaaggggca aatctgcctg aaggtttcaa aagccctggg actgggaagc
      481 tccccaacct ctcccgaact actttaccga gtcccccgaa gcccttctgc accatgttcc
      541 ttgttgaggg aatgcaatgg tttgtgatgg tgggtaggtc ctgataacct ctgtaagcac
      601 cccccccccg gcagacaatg cctttaaaaa ccacccaata aaatcatttc tcatcatt
//
