LOCUS       NM_031329               4153 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Rattus norvegicus occludin (Ocln), mRNA.
ACCESSION   NM_031329
VERSION     NM_031329.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4153)
  AUTHORS   Xu,K., Liu,X.N., Zhang,H.B., Zhu,X.P. and Zhang,X.J.
  TITLE     Tear film instability is associated with weakened colocalization
            between occludin and MUC5AC in scopolamine-induced dry eye disease
            (DED) rats
  JOURNAL   Int Ophthalmol 43 (2), 463-473 (2023)
   PUBMED   35908134
  REMARK    GeneRIF: Tear film instability is associated with weakened
            colocalization between occludin and MUC5AC in scopolamine-induced
            dry eye disease (DED) rats.
REFERENCE   2  (bases 1 to 4153)
  AUTHORS   Andersson,E.A., Rocha-Ferreira,E., Hagberg,H., Mallard,C. and
            Ek,C.J.
  TITLE     Function and Biomarkers of the Blood-Brain Barrier in a Neonatal
            Germinal Matrix Haemorrhage Model
  JOURNAL   Cells 10 (7), 1677 (2021)
   PUBMED   34359845
  REMARK    GeneRIF: Function and Biomarkers of the Blood-Brain Barrier in a
            Neonatal Germinal Matrix Haemorrhage Model.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4153)
  AUTHORS   Xu,X., Zhang,X., Gao,L., Liu,C. and You,K.
  TITLE     Neonatal Hyperoxia Downregulates Claudin-4, Occludin, and ZO-1
            Expression in Rat Kidney Accompanied by Impaired Proximal Tubular
            Development
  JOURNAL   Oxid Med Cell Longev 2020, 2641461 (2020)
   PUBMED   33343804
  REMARK    GeneRIF: Neonatal Hyperoxia Downregulates Claudin-4, Occludin, and
            ZO-1 Expression in Rat Kidney Accompanied by Impaired Proximal
            Tubular Development.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4153)
  AUTHORS   Hou,Q., Huang,Y., Wang,Y., Liao,L., Zhu,Z., Zhang,W., Liu,Y.,
            Li,P., Chen,X. and Liu,F.
  TITLE     Lactobacillus casei LC01 Regulates Intestinal Epithelial
            Permeability through miR-144 Targeting of OCLN and ZO1
  JOURNAL   J Microbiol Biotechnol 30 (10), 1480-1487 (2020)
   PUBMED   32807750
  REMARK    GeneRIF: Lactobacillus casei LC01 Regulates Intestinal Epithelial
            Permeability through miR-144 Targeting of OCLN and ZO1.
REFERENCE   5  (bases 1 to 4153)
  AUTHORS   Ribeiro Hudson,A.S., Nascimento Soares,A.D., Coelho Horta,N.A.,
            Fuscaldi,L.L., Machado-Moreira,C.A., Soares,D.D., Coimbra,C.C., de
            Oliveira Poletini,M., Cardoso,V.N. and Wanner,S.P.
  TITLE     The magnitude of physical exercise-induced hyperthermia is
            associated with changes in the intestinal permeability and
            expression of tight junction genes in rats
  JOURNAL   J Therm Biol 91, 102610 (2020)
   PUBMED   32716860
  REMARK    GeneRIF: The magnitude of physical exercise-induced hyperthermia is
            associated with changes in the intestinal permeability and
            expression of tight junction genes in rats.
REFERENCE   6  (bases 1 to 4153)
  AUTHORS   Hussar,P., Tserentsoodol,N., Koyama,H., Yokoo-Sugawara,M.,
            Matsuzaki,T., Takami,S. and Takata,K.
  TITLE     The glucose transporter GLUT1 and the tight junction protein
            occludin in nasal olfactory mucosa
  JOURNAL   Chem Senses 27 (1), 7-11 (2002)
   PUBMED   11751462
  REMARK    GeneRIF: present in the junctions of the olfactory epithelium, and
            in the endothelial cells in the blood vessels in the lamina propria
            of the olfactory mucosa
REFERENCE   7  (bases 1 to 4153)
  AUTHORS   Duffy,H.S., John,G.R., Lee,S.C., Brosnan,C.F. and Spray,D.C.
  TITLE     Reciprocal regulation of the junctional proteins claudin-1 and
            connexin43 by interleukin-1beta in primary human fetal astrocytes
  JOURNAL   J Neurosci 20 (23), RC114 (2000)
   PUBMED   11090614
REFERENCE   8  (bases 1 to 4153)
  AUTHORS   Sheth,B., Fontaine,J.J., Ponza,E., McCallum,A., Page,A., Citi,S.,
            Louvard,D., Zahraoui,A. and Fleming,T.P.
  TITLE     Differentiation of the epithelial apical junctional complex during
            mouse preimplantation development: a role for rab13 in the early
            maturation of the tight junction
  JOURNAL   Mech Dev 97 (1-2), 93-104 (2000)
   PUBMED   11025210
REFERENCE   9  (bases 1 to 4153)
  AUTHORS   Lee,D.H. and Kim,D.H.
  TITLE     S-methylation of 2-mercaptopyrazine in rat liver microsomes and
            cytosol
  JOURNAL   Xenobiotica 29 (9), 909-916 (1999)
   PUBMED   10548451
REFERENCE   10 (bases 1 to 4153)
  AUTHORS   Furuse,M., Fujita,K., Hiiragi,T., Fujimoto,K. and Tsukita,S.
  TITLE     Claudin-1 and -2: novel integral membrane proteins localizing at
            tight junctions with no sequence similarity to occludin
  JOURNAL   J Cell Biol 141 (7), 1539-1550 (1998)
   PUBMED   9647647
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Nov 27, 2020 this sequence version replaced NM_031329.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC062037.1, SRR26360176.2469786.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-81                JAXUCZ010000002.1  33441118-33441198   c
            82-198              JAXUCZ010000002.1  33430295-33430411   c
            199-877             JAXUCZ010000002.1  33428510-33429188   c
            878-1039            JAXUCZ010000002.1  33423660-33423821   c
            1040-1188           JAXUCZ010000002.1  33404592-33404740   c
            1189-1404           JAXUCZ010000002.1  33400798-33401013   c
            1405-1576           JAXUCZ010000002.1  33398219-33398390   c
            1577-1618           JAXUCZ010000002.1  33395536-33395577   c
            1619-4153           JAXUCZ010000002.1  33391303-33393837   c
FEATURES             Location/Qualifiers
     source          1..4153
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q12"
     gene            1..4153
                     /gene="Ocln"
                     /note="occludin"
                     /db_xref="GeneID:83497"
                     /db_xref="RGD:620089"
     exon            1..81
                     /gene="Ocln"
                     /inference="alignment:Splign:2.1.0"
     exon            82..198
                     /gene="Ocln"
                     /inference="alignment:Splign:2.1.0"
     CDS             149..1720
                     /gene="Ocln"
                     /EC_number="2.1.1.67"
                     /codon_start=1
                     /product="occludin"
                     /protein_id="NP_112619.2"
                     /db_xref="GeneID:83497"
                     /db_xref="RGD:620089"
                     /translation="MSVRPFESPPPYRPDEFKPNHYAPSNDMYGGEMHVRPMLSQPAY
                     SFYPEDEILHFYKWTSPPGVIRILSMLVIVMCIAVFACVASTLAWDRAYGTGIFGGSM
                     NYPYGSGFGSYGGGFGGYGYGYGYGYGGYTDPRAAKGFLLAMAAFCFIASLVIFVTSV
                     IRSGMSRTRRYYLIVIIVSAILGIMVFIATIVYIMGVNPTAQASGSMYGSQIYTICSQ
                     FYTPGGTGLYVDQYLYHYCVVDPQEAIAIVLGFMIIVAFALIIVFAVKTRRKMDRYDK
                     SNILWDKEHIYDEQPPNVEEWVKNVSAGTQDMPPPPSDYAERVDSPMAYSSNGKVNGK
                     RSYPDSLYKSPPLVPEVAQEIPLTLSVDDFRQPRYSSNDNLETPSKRTPTKGKAGKAK
                     RTDPDHYETDYTTGGESCDELEEDWLREYPPITSDQQRQLYKRNFDAGLQEYKSLLAE
                     LDEVNKELSRLDRELDDYREESEEYMAAADEYNRLKQVKGSADYKSKKNYCKQLKSKL
                     SHIKRMVGDYDRRKT"
     exon            199..877
                     /gene="Ocln"
                     /inference="alignment:Splign:2.1.0"
     exon            878..1039
                     /gene="Ocln"
                     /inference="alignment:Splign:2.1.0"
     exon            1040..1188
                     /gene="Ocln"
                     /inference="alignment:Splign:2.1.0"
     exon            1189..1404
                     /gene="Ocln"
                     /inference="alignment:Splign:2.1.0"
     exon            1405..1576
                     /gene="Ocln"
                     /inference="alignment:Splign:2.1.0"
     exon            1577..1618
                     /gene="Ocln"
                     /inference="alignment:Splign:2.1.0"
     exon            1619..4153
                     /gene="Ocln"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccttctttc cttaggcgac cgcggtggag ttgcgggaga gcgatctaga gcctggagca
       61 acgcggctag gggcgcagca ggtctgcttg tcttgggagc cttgacatct tgttcatcat
      121 aaagatcagg tgaccagtga catcagccat gtctgtgagg ccttttgaga gtccacctcc
      181 ttacaggccg gatgaattca aacccaatca ttatgcacca agcaatgaca tgtatggcgg
      241 agagatgcac gttcgaccaa tgctctctca gccggcatac tctttttacc cggaagacga
      301 aattcttcac ttctacaagt ggacgtcgcc tccaggggtg attcggatcc tgtctatgct
      361 cgtcatcgtg atgtgcatcg ctgtattcgc ctgcgtggct tccacacttg cttgggacag
      421 agcctatgga acgggcatct ttggaggaag tatgaactac ccttacggca gcggcttcgg
      481 tagctatgga ggtggcttcg gaggttacgg ttacggctac ggttacggct acggagggta
      541 cacagacccc agagcggcaa agggtttcct gctggccatg gcggcctttt gcttcatcgc
      601 ttccttggtg atctttgtta ccagcgtcat tagatcggga atgtccagaa cgagaagata
      661 ctacttgatc gtgatcatag tcagcgcaat cctgggcatc atggtgttca ttgccacgat
      721 cgtgtacata atgggagtca acccgactgc ccaggcttct ggatctatgt acggttcaca
      781 gatctatacc atctgcagcc agttttatac tcctggaggc actggtctct acgtggacca
      841 atatttgtat cactactgtg tggtggatcc ccaggaggct atagccattg tcctggggtt
      901 catgattatt gtggcttttg ctttaatcat tgtttttgct gtgaaaaccc gaagaaagat
      961 ggaccggtat gataagtcta atattttgtg ggataaggaa cacatttatg atgaacagcc
     1021 ccctaatgtg gaagagtggg ttaaaaatgt gtctgcaggc acacaagaca tgcctccacc
     1081 cccatctgac tatgcggaaa gagtcgacag tccgatggcc tactcctcca acggcaaagt
     1141 gaatggcaag agatcctacc cagactcttt gtataagtca ccgcctctgg tacctgaagt
     1201 agcccaggag attcctctga ccttgtccgt ggatgacttc aggcagcctc ggtacagcag
     1261 caacgataac ctagagacac cttctaaaag gactcccacg aaggggaaag cagggaaggc
     1321 gaagaggaca gacccagacc actatgaaac cgactacacg acaggtggcg agtcctgcga
     1381 tgagctggag gaggactggc tcagggaata tccacctatc acttcagatc aacagagaca
     1441 actgtacaag agaaattttg atgcaggttt acaggagtat aagagtttac tggcagaact
     1501 cgacgaggtc aacaaagagc tctctcgtct cgacagagaa ctggatgact acagagagga
     1561 gagcgaagag tacatggctg ctgctgatga atataacaga ctaaagcaag ttaagggatc
     1621 tgcagattat aaaagcaaga agaattactg caagcagtta aagagcaaat tatcacacat
     1681 caagaggatg gtgggagact atgacagacg gaaaacctag acagatgctg gttgctggag
     1741 aagtgagaga gaggtgcatc tatctacctg cccagtgtct gcagttctcc ccagaggcaa
     1801 actgactttg gactctcgtc tgggaagtta aaactttgtg atcattacaa agtttccata
     1861 gctttaatac catccgtttc ctgtctccag tattgaagca ttttataaat ggcttttgat
     1921 aattgactgg gctgaacact ccaattaaga attttacatt ttcaacattg attcttgtat
     1981 taagaatgaa atgttgtttg aggttttaaa tgtagagaaa ggtcctggtg tgagctgtga
     2041 tgtgaacact cacactagac agtgtcttgt atgacagata tgaggtatgt cttgataccc
     2101 aagtgtgttc ccccaggtag actgtctaat gaatcttcac agcagccctc aggtgactgt
     2161 ttttataatc aggttgtttt ggttttctag acagggtttc tctgtgtacc cctggttgac
     2221 ctagaactta gtctgtagac caggttgtcc ttgaactcac agacttcctc tgagtgctgg
     2281 gtgcaggaat taaaggcgtg tactgttata atcacttttc ctgtaaggaa actgggtcct
     2341 tggggtgaca tctccaaact gagactgcct gtttcacaaa ggcagttttg gctaagtctg
     2401 ttttatgact ctgcaaatta cagcatgcct gcctttcgag tttccactcc tgcgtaggat
     2461 acattctatc ggccaccttc cctaccactc ttcttcctat attgacttta acaaatgaat
     2521 aggattattt tacatttttt cctaacactt aagatcatat aaaattaacg agtatgtgga
     2581 atttaagaat tgcaaatata tatttacact tgagagatga ttttaaatct ggggttaaag
     2641 tgccttttta tctttcgtag tttacatgct tttttgataa cccactagac ctttccattg
     2701 tatcagagga tccaattaca tttacaatta tgacttgaat tgtatttcac aggaatgctc
     2761 aagttttgta catattttat aaggtattaa acctgatgtt ctctttctat aatgtgctta
     2821 tttgatatca ttagtactct tgaattcagt tgtgtaaaac tacactggag tgtcactgtg
     2881 tgacctgtct tgggttctgt gctcacaggt ggttgcccag cccttgggca gtgaacaagc
     2941 tgtgtctaaa atgggatagt gttcatacac agcacaacac ttagacagtg cctataaatc
     3001 ccataatggc ctttagaagt taaaattctt atcagtagca taaaattagt tgatagtact
     3061 ttataaacta aattggcatc cagcccagtt tggtctgttt tagccgaaaa tgttttatat
     3121 atacctttca gacatcgaag tacatgtttt tgtttataca attttgagtt attctccaat
     3181 gataaaaatt taaatagtga ctttgtgtaa cactggttct cttttttttt ttcaagttga
     3241 aaaaattcat tttctatatg ctgaccgtag tacagaaagt atttttcatg ccttggggat
     3301 tgagcccgag tggaaaggac tgttcagagc tccgtcactg acctttatgt taatcagctc
     3361 tccactctgc actctgggaa gtccttcatg ctgttctgtt ttgaattaga cagggtttca
     3421 catggtagct caggctggcc ttgaactaat gattactaga gactggcttc aaatttgcag
     3481 tcctcctgcc tccactcccc aggtggcagg tagattagag gctctcctcc atgcctggct
     3541 catacttagt ttatgaagcc aacttgctag tgctcacaaa acaggcctgt ttagttaggt
     3601 gaagaaaatg aagtggcagg agtcataaaa cggtgccata gaatgagatg ttggaagaat
     3661 aaaagaaatg attcttttcc aacgtggtgc tacctctgtg ggcctgaagc cagtatcagg
     3721 gtgtgcccat tggtgcagaa atgaacaact agctgatgta atctagagag tctgctatgg
     3781 cagttcctta atataaaata ggggctagat taaacgttag aggcgtttta cattctgacc
     3841 tgtggttttc atacctgctt tctgctagta aaactattct gggcagtagt tatgtgaaaa
     3901 cataaccctt ctcaggaaag ttccctgcat tagaggatgc cgtgtgtgtg tgtgtgtgtg
     3961 tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgttataagt aggtaagatc
     4021 aatgttttcc attttgaaag gctgaaaaca ttagaataaa catacatgaa ctaacccctc
     4081 ccccaagaaa gacaatgaca ttttgttgta tgtgctttat atttttgaaa taaagtctag
     4141 tatttacagt aaa
//
