LOCUS       NM_001134765            1799 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus otoconin 90 (Oc90), mRNA.
ACCESSION   NM_001134765 XM_001071534 XM_001075003
VERSION     NM_001134765.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1799)
  AUTHORS   Feng,M.Y., Gu,H.H., Tian,Q., Yang,H.L. and Zhuang,J.H.
  TITLE     Molecular Mediators of Estrogen Reduction-induced Otolith Shedding
  JOURNAL   Curr Med Sci 41 (4), 667-672 (2021)
   PUBMED   34403090
  REMARK    GeneRIF: Molecular Mediators of Estrogen Reduction-induced Otolith
            Shedding.
REFERENCE   2  (bases 1 to 1799)
  AUTHORS   Moreland,K.T., Hong,M., Lu,W., Rowley,C.W., Ornitz,D.M., De
            Yoreo,J.J. and Thalmann,R.
  TITLE     In vitro calcite crystal morphology is modulated by otoconial
            proteins otolin-1 and otoconin-90
  JOURNAL   PLoS One 9 (4), e95333 (2014)
   PUBMED   24748133
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1799)
  AUTHORS   Yang,H., Zhao,X., Xu,Y., Wang,L., He,Q. and Lundberg,Y.W.
  TITLE     Matrix recruitment and calcium sequestration for spatial specific
            otoconia development
  JOURNAL   PLoS One 6 (5), e20498 (2011)
   PUBMED   21655225
REFERENCE   4  (bases 1 to 1799)
  AUTHORS   Florea,L., Di Francesco,V., Miller,J., Turner,R., Yao,A.,
            Harris,M., Walenz,B., Mobarry,C., Merkulov,G.V., Charlab,R.,
            Dew,I., Deng,Z., Istrail,S., Li,P. and Sutton,G.
  TITLE     Gene and alternative splicing annotation with AIR
  JOURNAL   Genome Res 15 (1), 54-66 (2005)
   PUBMED   15632090
REFERENCE   5  (bases 1 to 1799)
  AUTHORS   Hurle,B., Ignatova,E., Massironi,S.M., Mashimo,T., Rios,X.,
            Thalmann,I., Thalmann,R. and Ornitz,D.M.
  TITLE     Non-syndromic vestibular disorder with otoconial agenesis in
            tilted/mergulhador mice caused by mutations in otopetrin 1
  JOURNAL   Hum Mol Genet 12 (7), 777-789 (2003)
   PUBMED   12651873
REFERENCE   6  (bases 1 to 1799)
  AUTHORS   Verpy,E., Leibovici,M. and Petit,C.
  TITLE     Characterization of otoconin-95, the major protein of murine
            otoconia, provides insights into the formation of these inner ear
            biominerals
  JOURNAL   Proc Natl Acad Sci U S A 96 (2), 529-534 (1999)
   PUBMED   9892667
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Aug 25, 2022 this sequence version replaced NM_001134765.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA5760389, SAMEA5760393
                              [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-49                JAXUCZ010000007.1  99558338-99558386   c
            50-142              JAXUCZ010000007.1  99555051-99555143   c
            143-205             JAXUCZ010000007.1  99547483-99547545   c
            206-262             JAXUCZ010000007.1  99546555-99546611   c
            263-437             JAXUCZ010000007.1  99543820-99543994   c
            438-550             JAXUCZ010000007.1  99539459-99539571   c
            551-679             JAXUCZ010000007.1  99536681-99536809   c
            680-718             JAXUCZ010000007.1  99536504-99536542   c
            719-769             JAXUCZ010000007.1  99535152-99535202   c
            770-817             JAXUCZ010000007.1  99534621-99534668   c
            818-871             JAXUCZ010000007.1  99532861-99532914   c
            872-988             JAXUCZ010000007.1  99531570-99531686   c
            989-1160            JAXUCZ010000007.1  99530526-99530697   c
            1161-1267           JAXUCZ010000007.1  99527655-99527761   c
            1268-1799           JAXUCZ010000007.1  99524975-99525506   c
FEATURES             Location/Qualifiers
     source          1..1799
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q33"
     gene            1..1799
                     /gene="Oc90"
                     /note="otoconin 90"
                     /db_xref="GeneID:690625"
                     /db_xref="RGD:1593441"
     exon            1..49
                     /gene="Oc90"
                     /inference="alignment:Splign:2.1.0"
     exon            50..142
                     /gene="Oc90"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..1560
                     /gene="Oc90"
                     /note="otoconin-90-like"
                     /codon_start=1
                     /product="otoconin-90 precursor"
                     /protein_id="NP_001128237.2"
                     /db_xref="GeneID:690625"
                     /db_xref="RGD:1593441"
                     /translation="MATMIVLLMVSMLTIPCVGGHALDTPNPQELPPGLSKNINITFF
                     NGVFKNVESVTEIFDCLGSHFTWLQAVFTNFPLLLQFVNSMRCVAGLCPRDFEDYGCA
                     CRFEMEGLPLDESDSCCFQHRRCYEEAVEMDCLQDPAKLSADVDCISKQITCESEDPC
                     ERLLCTCDKAAVECLAQSGINSSLNFLDASFCLVQTPETTSGKAVTPPPRGVPEKPTD
                     TSQIAQSGEVAGERRADTLTTLSRTKSVQDLQDIQASRTTSSPGSAEIIAIAKGTTHG
                     SAGIKSVRLEVSSVDNSSRETTGKACGRLAFLHLGDGGSMKAMLHLGEMLFCLTSHCP
                     EEFESYGCYCGREGRGVPRDTLDRCCLSHHCCLEQMRQLGCLHGRHSRSSVVCEHHTP
                     KCVGQSLCEKLLCACDQMAAECMASAFFNQSLKSPDQPECQGEPVSCEDGMLGGTLAS
                     SVDSSSEENSEEAAPQMEPLRSRLQEKPSGPLGIRTLGGR"
     exon            143..205
                     /gene="Oc90"
                     /inference="alignment:Splign:2.1.0"
     exon            206..262
                     /gene="Oc90"
                     /inference="alignment:Splign:2.1.0"
     exon            263..437
                     /gene="Oc90"
                     /inference="alignment:Splign:2.1.0"
     exon            438..550
                     /gene="Oc90"
                     /inference="alignment:Splign:2.1.0"
     exon            551..679
                     /gene="Oc90"
                     /inference="alignment:Splign:2.1.0"
     exon            680..718
                     /gene="Oc90"
                     /inference="alignment:Splign:2.1.0"
     exon            719..769
                     /gene="Oc90"
                     /inference="alignment:Splign:2.1.0"
     exon            770..817
                     /gene="Oc90"
                     /inference="alignment:Splign:2.1.0"
     exon            818..871
                     /gene="Oc90"
                     /inference="alignment:Splign:2.1.0"
     exon            872..988
                     /gene="Oc90"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1160
                     /gene="Oc90"
                     /inference="alignment:Splign:2.1.0"
     exon            1161..1267
                     /gene="Oc90"
                     /inference="alignment:Splign:2.1.0"
     exon            1268..1799
                     /gene="Oc90"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagcaacact ggatcatcca acagcctttg agtggagctt cacttcacag aagctgctct
       61 agcctacgcc tacaccttgt cctctgcatg gcaacaatga ttgtgctgct catggtcagt
      121 atgctgacga tcccctgtgt tgggggccat gctctggaca caccaaatcc ccaggaactg
      181 cctccaggat tgtcaaaaaa tatcaatatc actttcttca acggagtgtt taaaaacgtg
      241 gaaagtgtga ccgaaatttt tgactgtcta ggctctcact tcacctggct gcaggctgtc
      301 ttcaccaact tccctctgct gctccagttt gtaaacagta tgaggtgtgt ggctggcctc
      361 tgtccccggg actttgaaga ctatggttgt gcctgcaggt ttgagatgga agggctgcct
      421 ctggatgagt ctgatagctg ctgcttccag catcgcaggt gctatgagga agctgttgag
      481 atggactgtc tccaggaccc tgccaagctc agtgcagatg tggattgcat cagcaaacag
      541 atcacatgtg agtccgagga tccctgtgag cgccttctgt gtacctgtga caaggctgcc
      601 gtggaatgcc tggctcagtc tggcatcaac tcttccctga atttcctgga tgcttccttc
      661 tgcctggttc agactccaga gacaactagt gggaaggctg tgacaccgcc gcctagaggg
      721 gttcctgaaa agcccacaga caccagtcag atagcccagt caggagaagt ggcgggtgag
      781 agaagagcag acacactaac aacactctcc aggacaaaat ctgtccaaga tcttcaagat
      841 atacaagctt ctaggaccac atcaagtccc ggatctgcag agattattgc catagctaaa
      901 ggtacaaccc atggttctgc tggcattaag tcagtgaggt tggaagtatc gtctgttgac
      961 aatagttctc gggaaacaac tggaaaagcc tgtggcagat tggccttcct gcatctgggt
     1021 gatgggggca gcatgaaggc catgctgcac cttggagaga tgctcttctg tctaacatcc
     1081 cactgcccag aggaatttga atcttatggc tgctactgtg gaagagaagg aagaggagtg
     1141 ccaagggaca cccttgatag gtgctgtttg tcccatcact gctgtttgga gcagatgaga
     1201 cagctgggct gtctccatgg aaggcattct cggtcatctg tggtatgtga acaccacaca
     1261 cccaaatgtg tggggcagag cctgtgtgag aagctactat gcgcctgtga ccagatggcg
     1321 gctgagtgca tggcctctgc cttctttaat caaagcctca agtcacctga ccaacctgag
     1381 tgccaaggcg agcctgtgtc ctgtgaggat ggcatgctcg ggggaacctt ggcctcttct
     1441 gtggattcca gttctgagga gaatagtgag gaagctgcac ctcagatgga acccctaaga
     1501 agcagattgc aggagaagcc ttctggtccc ttggggatca ggacccttgg tggaagataa
     1561 gatgctacat gctgtgccag tagttctgag ctgcctgagc tttttggccc tcagtcctct
     1621 gtccataaga gccttagcag gatatccaag ggagcaggga cagccacctc tttacccata
     1681 agcctcctga aacttgtcag cctacagaca cgtgtgtctg gagactgaat gcagatgaca
     1741 gcacttccct ttttcctgta gttcgttatg gaagctcaat aaattctcca tgccatatg
//
