LOCUS       NM_001409045            5769 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus obscurin like cytoskeletal adaptor 1 (Obsl1),
            transcript variant 2, mRNA.
ACCESSION   NM_001409045 XM_006245305
VERSION     NM_001409045.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5769)
  AUTHORS   Yan,J., Yan,F., Li,Z., Sinnott,B., Cappell,K.M., Yu,Y., Mo,J.,
            Duncan,J.A., Chen,X., Cormier-Daire,V., Whitehurst,A.W. and
            Xiong,Y.
  TITLE     The 3M complex maintains microtubule and genome integrity
  JOURNAL   Mol Cell 54 (5), 791-804 (2014)
   PUBMED   24793695
REFERENCE   2  (bases 1 to 5769)
  AUTHORS   Litterman,N., Ikeuchi,Y., Gallardo,G., O'Connell,B.C., Sowa,M.E.,
            Gygi,S.P., Harper,J.W. and Bonni,A.
  TITLE     An OBSL1-Cul7Fbxw8 ubiquitin ligase signaling mechanism regulates
            Golgi morphology and dendrite patterning
  JOURNAL   PLoS Biol 9 (5), e1001060 (2011)
   PUBMED   21572988
  REMARK    GeneRIF: OBSL1 is a critical regulator of Cul7 (cullin 7) in Golgi
            morphogenesis and dendrite elaboration.
REFERENCE   3  (bases 1 to 5769)
  AUTHORS   Fukuzawa,A., Lange,S., Holt,M., Vihola,A., Carmignac,V.,
            Ferreiro,A., Udd,B. and Gautel,M.
  TITLE     Interactions with titin and myomesin target obscurin and
            obscurin-like 1 to the M-band: implications for hereditary
            myopathies
  JOURNAL   J Cell Sci 121 (11), 1841-1851 (2008)
   PUBMED   18477606
  REMARK    GeneRIF: Titin mutations that have been linked to limb-girdle
            muscular dystrophy 2J (LGMD2J) or Salih myopathy weaken or abrogate
            titin-obscurin and titin-Obsl1 binding, and lead to obscurin
            mislocalization.
REFERENCE   4  (bases 1 to 5769)
  AUTHORS   Geisler,S.B., Robinson,D., Hauringa,M., Raeker,M.O., Borisov,A.B.,
            Westfall,M.V. and Russell,M.W.
  TITLE     Obscurin-like 1, OBSL1, is a novel cytoskeletal protein related to
            obscurin
  JOURNAL   Genomics 89 (4), 521-531 (2007)
   PUBMED   17289344
  REMARK    GeneRIF: OBSL1 is expressed in a broad range of tissues and
            localizes to the intercalated discs, to the perinuclear region, and
            overlying the Z lines and M bands of adult rat cardiac myocytes
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Jul 7, 2022 this sequence version replaced XM_006245305.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643296.24665.1,
                                           SRR26643291.26040.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1249              JAXUCZ010000009.1  84441167-84442415   c
            1250-1519           JAXUCZ010000009.1  84439476-84439745   c
            1520-1771           JAXUCZ010000009.1  84439147-84439398   c
            1772-2074           JAXUCZ010000009.1  84438699-84439001   c
            2075-2371           JAXUCZ010000009.1  84438253-84438549   c
            2372-2644           JAXUCZ010000009.1  84436271-84436543   c
            2645-2917           JAXUCZ010000009.1  84434612-84434884   c
            2918-3190           JAXUCZ010000009.1  84433580-84433852   c
            3191-3463           JAXUCZ010000009.1  84430557-84430829   c
            3464-3739           JAXUCZ010000009.1  84429544-84429819   c
            3740-4027           JAXUCZ010000009.1  84429182-84429469   c
            4028-4297           JAXUCZ010000009.1  84427890-84428159   c
            4298-4570           JAXUCZ010000009.1  84427502-84427774   c
            4571-4837           JAXUCZ010000009.1  84426562-84426828   c
            4838-4950           JAXUCZ010000009.1  84425671-84425783   c
            4951-5107           JAXUCZ010000009.1  84425001-84425157   c
            5108-5269           JAXUCZ010000009.1  84424701-84424862   c
            5270-5374           JAXUCZ010000009.1  84424284-84424388   c
            5375-5644           JAXUCZ010000009.1  84423707-84423976   c
            5645-5769           JAXUCZ010000009.1  84422895-84423019   c
FEATURES             Location/Qualifiers
     source          1..5769
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q33"
     gene            1..5769
                     /gene="Obsl1"
                     /gene_synonym="RGD1306073"
                     /note="obscurin like cytoskeletal adaptor 1"
                     /db_xref="GeneID:363259"
                     /db_xref="RGD:1306073"
     exon            1..1249
                     /gene="Obsl1"
                     /gene_synonym="RGD1306073"
                     /inference="alignment:Splign:2.1.0"
     CDS             238..5655
                     /gene="Obsl1"
                     /gene_synonym="RGD1306073"
                     /EC_number="2.7.11.18"
                     /note="isoform 2 is encoded by transcript variant 2;
                     Obscurin-like protein 1; obscurin-like 1"
                     /codon_start=1
                     /product="obscurin-like protein 1 isoform 2"
                     /protein_id="NP_001395974.1"
                     /db_xref="GeneID:363259"
                     /db_xref="RGD:1306073"
                     /translation="MKASSGDQGSPPCFLRFPRPVRVVSGAEAELKCVVLGEPPPTVL
                     WEKGGQQLVASERLSFPEDGAEHGLLLSGALPTDAGVYVCRARNAAGEAYAAAAVTVL
                     EPPAPEPEPQSSECPPPPPGTGEGAPVFLTGPQSQWVLRGAEVVLTCQVGGLPEPKLY
                     WEKDGMALDEVWDSSHYTLEPDRGASDGGASLTLRILAARLPDSGVYVCHARNAHGHA
                     QAGALLQVHQPHENPPQDPDEPPVRVIEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPE
                     IEWHLEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQL
                     HVKEPRLRFTRPLQDVEGREHGIVVLECKVPNSRIPTAWFREDQRLLPCRKYEQIEEG
                     TVRRLVIHRLKADDDGVYLCEMRGRVRTVANVTVKGPILKRLPRKLDVLEGENAVLLV
                     ETQEAGVQGCWSRDGEELPATCQSSCGHMHALVLPGVTREDAGEVTFSLGNSRTTTLL
                     RVKCVKHSPPGPPVLVEMFKGQKNTVLLTWKPPEPPPETSFIYRLERQEVGSEDWIQC
                     FSIEKAGAVEVPGDCVPTEGDYRFRICTVSEHGRSPHVVFNGSAHLVPTARLVSGLED
                     VQVYDGEDAVFSLDLSTIIQGSWFLNGELLKNDEAEGQVEPGALRYRIEQKGLQHRLI
                     LQTVKHQDNGALVGFICPGVQDSAALSIQESPVHILSPQDKVLLTFTTSERVVLTCEL
                     SRVDFPATWYKDGQKVEESESLVVKMDGRKHRLILPEAQVRDSGEFECRTEGISAFFS
                     VTVQDPPVHIVDPQEHVFVHAITSESVMLTCEVDREDAAVHWYKDGQEVEESAVIVLE
                     KEGPRHRLVLPAAQPSDGGEFQCVVGDERAYFTVTITDVSSWIVYPNGKVYVAAVRLE
                     RVVLTCELCRPWAEVRWTKDGEEVLESPALLLEKEDTIRRLVLPSVQLEDSGEYLCEI
                     HDESASFTITVTEPPVRIIYPQDEVTLHAVSLECVVLTCELSRVDAPVRWYKDGLEVE
                     ETEALVLQSDGPRRRLVLPAAQPEDGGEFVCDAGDDSAFFTVTVTAPPERIVHPVARS
                     LDLQFGAPGHVELRCEVAPAGSQVRWYKDGLEVEVSDALQLGAEGPARTLTLPHAQPE
                     DAGEYVCETRDEAVTFNVSLAELPVQFLAPEAVPNPLCVVPGEPVMLSCELSRASAHV
                     SWSHNGNPVKQGEGLELRAEGPRRILCIQAADLAHTGVYTCQSGTAPGAPSLSFNVQV
                     AEPPPVKLVSELTPLTVHEGDDATFQCEVSPPDAEVTWLRNGAIVTPGPQLEMVHSGS
                     SRTLIIRGCQLKDAGTVTARAGATDTSARLHVRETELLFLRRLQDVRAEEGQDVYLEV
                     ETGRVGAPGAVRWLRGGEPLPLDSRLTTAQDGHVHRLSIHGVLLTDQGTYGCESHHDR
                     TLARLSVRPRQLRELRPLEDVTVHEGGSATFQLELSQEGVTGEWAQGGVRLHPGPKCH
                     IHSEGRTHCLVLSGLGLADSGCISFTADTLRCAARLTVREVPVTIVQGPQDLEVTEGD
                     TATFECELSQTLADVIWEKDGQALSLSPRLRLQSLGTRRLLLLRRCSSSDAGTYCCAV
                     GTARSGPARLTVREREVSVLGELRSLSAREGDSATFECTVSESETTGRWELGGRALRP
                     GGRVRIRQEGKKHILVLSELRTEDTGEVCFQAGPAQSLARLEVEALPLQMCRRPPREK
                     TVLVDRRAVLEVTVSRPGGHVCWMREGVELCPGSKYEMRSHGTTHSLVIHDVRPEDQG
                     TYSCQAGQDSADTQLLVEGDD"
     exon            1250..1519
                     /gene="Obsl1"
                     /gene_synonym="RGD1306073"
                     /inference="alignment:Splign:2.1.0"
     exon            1520..1771
                     /gene="Obsl1"
                     /gene_synonym="RGD1306073"
                     /inference="alignment:Splign:2.1.0"
     exon            1772..2074
                     /gene="Obsl1"
                     /gene_synonym="RGD1306073"
                     /inference="alignment:Splign:2.1.0"
     exon            2075..2371
                     /gene="Obsl1"
                     /gene_synonym="RGD1306073"
                     /inference="alignment:Splign:2.1.0"
     exon            2372..2644
                     /gene="Obsl1"
                     /gene_synonym="RGD1306073"
                     /inference="alignment:Splign:2.1.0"
     exon            2645..2917
                     /gene="Obsl1"
                     /gene_synonym="RGD1306073"
                     /inference="alignment:Splign:2.1.0"
     exon            2918..3190
                     /gene="Obsl1"
                     /gene_synonym="RGD1306073"
                     /inference="alignment:Splign:2.1.0"
     exon            3191..3463
                     /gene="Obsl1"
                     /gene_synonym="RGD1306073"
                     /inference="alignment:Splign:2.1.0"
     exon            3464..3739
                     /gene="Obsl1"
                     /gene_synonym="RGD1306073"
                     /inference="alignment:Splign:2.1.0"
     exon            3740..4027
                     /gene="Obsl1"
                     /gene_synonym="RGD1306073"
                     /inference="alignment:Splign:2.1.0"
     exon            4028..4297
                     /gene="Obsl1"
                     /gene_synonym="RGD1306073"
                     /inference="alignment:Splign:2.1.0"
     exon            4298..4570
                     /gene="Obsl1"
                     /gene_synonym="RGD1306073"
                     /inference="alignment:Splign:2.1.0"
     exon            4571..4837
                     /gene="Obsl1"
                     /gene_synonym="RGD1306073"
                     /inference="alignment:Splign:2.1.0"
     exon            4838..4950
                     /gene="Obsl1"
                     /gene_synonym="RGD1306073"
                     /inference="alignment:Splign:2.1.0"
     exon            4951..5107
                     /gene="Obsl1"
                     /gene_synonym="RGD1306073"
                     /inference="alignment:Splign:2.1.0"
     exon            5108..5269
                     /gene="Obsl1"
                     /gene_synonym="RGD1306073"
                     /inference="alignment:Splign:2.1.0"
     exon            5270..5374
                     /gene="Obsl1"
                     /gene_synonym="RGD1306073"
                     /inference="alignment:Splign:2.1.0"
     exon            5375..5644
                     /gene="Obsl1"
                     /gene_synonym="RGD1306073"
                     /inference="alignment:Splign:2.1.0"
     exon            5645..5769
                     /gene="Obsl1"
                     /gene_synonym="RGD1306073"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtctaggctg tagggcccct cgctgcgcag gcaaacagga aggactgccc cctgagttct
       61 gggctcgggg cccgggaatt gccgcgcagc agggctgcag cctgggtcca ggataaggag
      121 acgagcaggc accagcggtc acaggagtcc caccggtccc tgatccccct ccgccacgcc
      181 ctggtctctg ctcccggcct tcccgcgctc ccaggcaggc catctgcagc ggccgcaatg
      241 aaggccagtt caggggatca ggggagtccc ccgtgtttcc tacgcttccc gcggcccgtg
      301 cgggtggtaa gtggcgcgga ggccgagctc aaatgcgtgg tcctgggaga gccgccgccc
      361 accgtcttgt gggagaaagg cgggcagcag ctggtggcct cggagcgcct gagctttcca
      421 gaggacggcg ccgagcacgg cctgctgttg agcggcgcgc tgcccaccga cgccggggtc
      481 tacgtgtgcc gcgcccgcaa cgcggccgga gaggcctacg cggcggccgc cgtcaccgtg
      541 ctggaacccc cggccccaga gcccgagccc cagtcttccg agtgtccgcc gccgcctccg
      601 ggcaccgggg agggcgcccc ggtgtttctg acgggacccc agtcccagtg ggtgctgcga
      661 ggggcggagg tggtgctgac gtgccaggtg ggaggcctcc cggagcccaa gctgtactgg
      721 gagaaggatg ggatggcctt ggacgaagtg tgggacagca gccactacac gctggagccg
      781 gaccgcggcg cgagtgacgg gggcgcaagc ctgacgttac gcatcctggc agcgcggctg
      841 cccgattccg gggtgtacgt gtgccacgcc cgcaacgcgc acggccacgc gcaggcgggc
      901 gcgctgctcc aggtgcacca gccccacgag aacccgcccc aggatcccga tgagcccccc
      961 gtacgcgtga tagagccgct caaatgcgcg cccaagacct tctgggtgaa cgagggcaag
     1021 cacgccaagt tccgctgcta cgtgatgggc aagcctgagc ccgagatcga atggcacttg
     1081 gagggccgcc ctctgctccc cgaccgccgc cgcctcatgt accgcgaccg tgacggtggc
     1141 tttgtactta aggtgctcta ctgccaggcc aaggaccgtg gcctctacgt gtgcgcggcg
     1201 cgcaactccg cgggccagac cctaagcgcg gttcagctgc acgtgaaaga accgcgcctc
     1261 cggttcacaa ggcctctgca ggatgtggag ggtcgagagc atgggatcgt agtcctagag
     1321 tgtaaagtac ccaactctcg gattcccacc gcctggttcc gagaggacca gcgactgtta
     1381 ccctgccgca agtacgagca gattgaagaa ggcactgtga gacgcctcgt catccacagg
     1441 ctgaaggcag atgacgatgg tgtctatctg tgcgagatgc ggggtcgagt gcgcacggta
     1501 gccaacgtga ctgtcaaagg acccatcctg aagcgcttac cccggaagct ggatgtcctg
     1561 gagggagaga acgcggtgct gctggtggag actcaagaag ctggggtcca ggggtgctgg
     1621 agccgtgatg gggaggagct gccagccacc tgccagagta gttgtggtca catgcatgcc
     1681 ctggtccttc ctggggtgac ccgagaagat gctggcgagg tcacctttag cctgggcaac
     1741 tcccgtacca ccaccctgct cagagtcaaa tgtgtcaagc acagtcctcc tgggccccct
     1801 gtactggttg agatgttcaa aggccaaaag aacacagtcc tgctgacctg gaagccccca
     1861 gagccacctc cagaaacctc cttcatctac cgcctggagc ggcaggaagt cgggtctgag
     1921 gattggatcc agtgcttcag cattgagaaa gctggagccg tagaggtgcc aggggactgt
     1981 gtacccaccg agggtgacta ccgcttccgc atctgcacag tcagtgaaca tggccgcagt
     2041 ccccatgtcg tgttcaatgg ctctgctcac cttgtgccca cagctcgcct ggtgtcaggc
     2101 ctggaagatg tgcaggtgta tgacggggaa gatgccgtct tctcccttga tctgtccacc
     2161 atcatccagg gctcttggtt ccttaatgga gagctgctca agaatgatga ggcagagggc
     2221 caggtggagc ctggagccct ccggtaccga atagagcaga agggcctgca gcacagactc
     2281 atcctgcaaa cggtcaagca ccaggacaat ggggccctgg taggcttcat ctgccctggt
     2341 gtgcaagatt ctgctgccct cagtatccaa gaaagcccag tgcacatcct gagtccccag
     2401 gataaggtgt tgctgacctt cacgacctct gaacgggtag tgttgacctg tgagctctca
     2461 agagtggatt ttccagcaac ctggtacaag gatgggcaga aggtggagga gagcgagtcg
     2521 ctcgtagtga agatggatgg gcgcaaacac cgactgatcc tgcctgaggc tcaagtccga
     2581 gacagtggtg aatttgaatg cagaacggaa gggatctcag ccttcttcag tgtcactgtt
     2641 caagatcccc cagtgcacat cgtggacccc caagaacatg tgtttgtcca tgccatcact
     2701 tccgagagtg tcatgctgac ctgtgaggtg gaccgagagg acgcagctgt gcactggtac
     2761 aaggatgggc aggaggtgga ggagagtgcc gtcatcgtat tagaaaagga agggccccgt
     2821 caccgcctgg tgcttcctgc agctcagccc tctgacgggg gcgagtttca gtgtgtggtg
     2881 ggagacgaac gggcctactt cacagttacc atcacagatg tctcttcatg gatcgtgtac
     2941 cccaatggca aagtgtatgt ggcagctgta cgcctagaac gtgtggtgct gacctgtgag
     3001 ctgtgccggc cctgggctga ggtgcgctgg accaaagatg gggaggaggt attggagagc
     3061 ccagcactgc tcctggagaa ggaggatacc atccggcgcc tggtgctgcc ctctgtccag
     3121 cttgaggact ctggcgagta cctgtgtgaa atccatgatg agtcagcttc cttcaccatc
     3181 accgtcacag agccccctgt gcggatcata tacccccagg atgaggtgac cttacatgct
     3241 gtgagtctgg aatgtgtggt gctcacatgt gagctgtccc gagtggacgc tcctgtacga
     3301 tggtacaagg acgggctaga ggtggaggag acggaggccc tggtgctcca gagtgatggg
     3361 cctcgtcgcc gcctggtgtt gcctgcggcc cagccggagg acgggggcga gtttgtgtgt
     3421 gatgctgggg atgattcagc cttcttcact gtcactgtca cagctccacc agagagaatt
     3481 gtgcacccag tggcccgatc cctggatttg cagtttgggg ctccaggaca cgtggagcta
     3541 cgctgtgaag tggccccggc tgggtctcag gtgcgctggt acaaggatgg gctagaggta
     3601 gaagtgtcag atgcactgca gctgggtgcg gaggggcccg cccgcactct caccctgccc
     3661 cacgcccagc ctgaggatgc cggggagtat gtatgtgaga cccgagatga ggctgtcacc
     3721 ttcaacgtca gcctggctga gcttccagtg cagtttctgg ctccagaggc agtcccaaac
     3781 ccgctctgcg tggttcctgg ggagccagtg atgctgagct gtgagctgtc ccgagcaagc
     3841 gcacacgtgt cctggagcca taatgggaac cctgtgaagc agggtgaagg actagagctt
     3901 cgagctgagg gtcctcgccg aatcctctgc atccaggctg cagacctagc tcacacaggt
     3961 gtctacacct gccagtctgg gacagcccct ggggccccaa gcctcagctt caatgtccag
     4021 gtggctgagc cccctccagt gaagctggtc tcggaactga cgcccctgac agtccacgag
     4081 ggtgatgacg ccacattcca gtgtgaagtt tcgccaccag atgccgaggt cacctggcta
     4141 cgcaatggag ccattgtcac tccagggcca cagctggaaa tggtccacag tggttcaagc
     4201 cgcactttga tcatccgagg ctgccaactc aaagacgcag ggaccgtgac ggcacgagct
     4261 ggagccactg acacaagtgc caggctccat gttcgagaga cagagctgct cttcctgcgg
     4321 cggctgcagg atgtgcgggc ggaggaaggc caggatgtgt accttgaggt ggagacaggc
     4381 cgagtaggtg cacctggagc tgtccgctgg ctacgaggtg gggaacctct tcccctggac
     4441 tctcgcctga ccacggccca ggatggccat gtccaccgtc tctctatcca tggcgtcctg
     4501 cttaccgacc agggtaccta cggctgcgag agccaccacg atcgcactct ggccaggctc
     4561 agtgtgaggc ctcggcagct gagggaactt cggcctctgg aggatgtgac cgtccatgag
     4621 gggggcagtg ccaccttcca gctggagctg tcccaggagg gtgtgaccgg agaatgggcc
     4681 cagggtggag tgcggctaca cccagggccc aagtgccaca ttcattcaga aggccgcact
     4741 cactgcttgg tgctaagcgg cctgggtctg gctgactcgg gctgtatctc cttcactgcg
     4801 gatacccttc gatgtgccgc tcggctcaca gtgagagagg tcccagtgac tattgtgcag
     4861 gggccacagg acctagaagt gactgaaggt gacacagcca cgttcgagtg cgagctttcc
     4921 cagactttgg ctgacgtaat atgggagaag gatgggcagg cgctctctct cagcccgcgc
     4981 ctccggctcc agtctctcgg cacgcgccgc cttctgcttc tgcggcgttg cagctcctca
     5041 gacgccggga cctactgctg cgctgtgggg acagctcgct cggggcctgc gcgcttgacc
     5101 gtgcgcgaac gagaggtgtc tgtgctcggt gagctcaggt cgcttagcgc ccgcgaagga
     5161 gacagcgcta cattcgagtg caccgtgtcg gagtccgaga caaccggacg ctgggagctc
     5221 ggaggccgcg cgctgagacc cggaggccgc gttcgcatcc gacaggaagg gaagaaacac
     5281 attctggtgc tgagcgaact gcgaaccgag gacaccggag aagtctgctt ccaggcggga
     5341 cccgcccagt ccttggctcg gctggaggtg gaggcgttgc ctctccagat gtgccgccgc
     5401 ccacctcgcg agaagacggt tctggtcgac cgcagggcgg tgttggaggt gactgtgtcc
     5461 cgccctgggg gccacgtgtg ttggatgcgg gagggggtcg aattatgccc gggaagcaag
     5521 tatgagatgc gtagccacgg caccacccac agcctagtca tccatgacgt ccgacctgag
     5581 gaccagggca catacagctg ccaagcaggc caggacagtg ctgacacaca gctgctggta
     5641 gagggtgacg actgatacac accaagcagg tgccctcgga ccatttggaa ggatcgtacc
     5701 cttatactgg gcagggtggg gagggaggag ccagaggtat cgggtaacaa taaagactgt
     5761 tcacgccca
//
