LOCUS       NM_001033958             960 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus alpha-2u globulin PGCL4 (Obp3), transcript
            variant 2, mRNA.
ACCESSION   NM_001033958 XM_575835
VERSION     NM_001033958.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 960)
  AUTHORS   Vasudevan,A., Kumar,V., Chiang,Y.N., Yew,J.Y., Cheemadan,S. and
            Vyas,A.
  TITLE     alpha2u-globulins mediate manipulation of host attractiveness in
            Toxoplasma gondii-Rattus novergicus association
  JOURNAL   ISME J 9 (9), 2112-2115 (2015)
   PUBMED   25853804
  REMARK    GeneRIF: T. gondii infection enhances hepatic production and
            urinary excretion of alpha2u-globulins in rats; alpha2u-globulins
            are sufficient to recapitulate male sexual attractiveness akin to
            effects of the infection
REFERENCE   2  (bases 1 to 960)
  AUTHORS   Gomez-Baena,G., Armstrong,S.D., Phelan,M.M., Hurst,J.L. and
            Beynon,R.J.
  TITLE     The major urinary protein system in the rat
  JOURNAL   Biochem Soc Trans 42 (4), 886-892 (2014)
   PUBMED   25109974
  REMARK    Review article
REFERENCE   3  (bases 1 to 960)
  AUTHORS   Portman,K.L., Long,J., Carr,S., Briand,L., Winzor,D.J., Searle,M.S.
            and Scott,D.J.
  TITLE     Enthalpy/entropy compensation effects from cavity desolvation
            underpin broad ligand binding selectivity for rat odorant binding
            protein 3
  JOURNAL   Biochemistry 53 (14), 2371-2379 (2014)
   PUBMED   24665925
  REMARK    GeneRIF: Obp3 binding energetics are modulated by two desolvation
            processes with quite different thermodynamic signatures
REFERENCE   4  (bases 1 to 960)
  AUTHORS   Sun,S.H., Liu,S.Q., Cai,C.P., Cai,R., Chen,L. and Zhang,Q.B.
  TITLE     Down-regulation of alpha-2u globulin in renal mitochondria of
            STZ-induced diabetic rats observed by a proteomic method
  JOURNAL   Ann Endocrinol (Paris) 73 (6), 530-541 (2012)
   PUBMED   23131471
  REMARK    GeneRIF: Down-regulation of alpha-2u globulin in renal mitochondria
            of STZ-induced diabetic rats.
REFERENCE   5  (bases 1 to 960)
  AUTHORS   Yabuki,M., Scott,D.J., Briand,L. and Taylor,A.J.
  TITLE     Dynamics of odorant binding to thin aqueous films of rat-OBP3
  JOURNAL   Chem Senses 36 (7), 659-671 (2011)
   PUBMED   21536621
  REMARK    GeneRIF: Because rat-OBP3 exhibits typical odorant-binding
            characteristics, the results not only provide fundamental
            information on the kinetics of odorant mass transfer induced by the
            presence of OBPs in the olfactory mucus layer but also support the
            possibility that vertebrate OBPs may facilitate the accumulation of
            odorants in the olfactory epithelium
REFERENCE   6  (bases 1 to 960)
  AUTHORS   Saito,K., Nishikawa,J., Imagawa,M., Nishihara,T. and Matsuo,M.
  TITLE     Molecular evidence of complex tissue- and sex-specific mRNA
            expression of the rat alpha(2u)-globulin multigene family
  JOURNAL   Biochem Biophys Res Commun 272 (2), 337-344 (2000)
   PUBMED   10833415
REFERENCE   7  (bases 1 to 960)
  AUTHORS   Shaw,P.H., Walter-Sierra,R., Tamone,F. and Schibler,U.
  TITLE     Rapid identification of DNA fragments containing promoters for RNA
            polymerase II
  JOURNAL   Gene 84 (2), 371-381 (1989)
   PUBMED   2558970
REFERENCE   8  (bases 1 to 960)
  AUTHORS   Gao,F., Endo,H. and Yamamoto,M.
  TITLE     Length heterogeneity in rat salivary gland alpha 2 mu globulin
            mRNAs: multiple splice-acceptors and polyadenylation sites
  JOURNAL   Nucleic Acids Res 17 (12), 4629-4636 (1989)
   PUBMED   2473438
REFERENCE   9  (bases 1 to 960)
  AUTHORS   Winderickx,J., van Dijck,P., Dirckx,L., Volckaert,G., Rombauts,W.,
            Heyns,W. and Verhoeven,G.
  TITLE     Comparison of the 5' upstream putative regulatory sequences of
            three members of the alpha 2u-globulin gene family
  JOURNAL   Eur J Biochem 165 (3), 521-529 (1987)
   PUBMED   2439333
REFERENCE   10 (bases 1 to 960)
  AUTHORS   Laperche,Y., Lynch,K.R., Dolan,K.P. and Feigelson,P.
  TITLE     Tissue-specific control of alpha 2u globulin gene expression:
            constitutive synthesis in the submaxillary gland
  JOURNAL   Cell 32 (2), 453-460 (1983)
   PUBMED   6186396
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Oct 14, 2005 this sequence version replaced NM_001033958.1.
            
            Transcript Variant: This variant (2) differs in the 3' UTR compared
            to variant 1. Variant 1, 2, and 3 encode the same protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB039825.1, SRR22582416.657644.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on computational evidence
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-157               JAXUCZ010000005.1  79640519-79640675   c
            158-291             JAXUCZ010000005.1  79640078-79640211   c
            292-365             JAXUCZ010000005.1  79639776-79639849   c
            366-476             JAXUCZ010000005.1  79638991-79639101   c
            477-578             JAXUCZ010000005.1  79638544-79638645   c
            579-624             JAXUCZ010000005.1  79638328-79638373   c
            625-960             JAXUCZ010000005.1  79637234-79637569   c
FEATURES             Location/Qualifiers
     source          1..960
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q24"
     gene            1..960
                     /gene="Obp3"
                     /note="alpha-2u globulin PGCL4"
                     /db_xref="GeneID:259247"
                     /db_xref="RGD:708508"
     exon            1..157
                     /gene="Obp3"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..598
                     /gene="Obp3"
                     /note="alpha2 urinary globulin; odorant-binding protein 3;
                     major urinary protein-like"
                     /codon_start=1
                     /product="alpha-2u globulin PGCL4 precursor"
                     /protein_id="NP_001029130.2"
                     /db_xref="GeneID:259247"
                     /db_xref="RGD:708508"
                     /translation="MKLLLLLLCLGLTLVCGHAEEASFERGNLDVDKLNGDWFSIVVA
                     SDKREKIEENGSMRVFVQHIDVLENSLGFTFRIKENGVCTEFSLVADKTAKDGEYFVE
                     YDGENTFTILKTDYDNYVMFHLVNVNNGETFQLMELYGRTKDLSSDIKEKFAKLCVAH
                     GITRDNIIDLTKTDRCLQA"
     exon            158..291
                     /gene="Obp3"
                     /inference="alignment:Splign:2.1.0"
     exon            292..365
                     /gene="Obp3"
                     /inference="alignment:Splign:2.1.0"
     exon            366..476
                     /gene="Obp3"
                     /inference="alignment:Splign:2.1.0"
     exon            477..578
                     /gene="Obp3"
                     /inference="alignment:Splign:2.1.0"
     exon            579..624
                     /gene="Obp3"
                     /inference="alignment:Splign:2.1.0"
     exon            625..960
                     /gene="Obp3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgggcaccat cagcagagag attgtcccga cagagaggca attctattcc ctaccaacat
       61 gaagctgttg ctgctgctgc tgtgtctggg cctgaccctg gtctgtggcc atgcagaaga
      121 agctagtttc gagagaggga acctcgatgt ggacaagctc aatggggatt ggttttctat
      181 tgtcgtggcc tctgataaaa gagaaaagat agaagagaac ggcagcatga gagtttttgt
      241 gcagcatatc gatgtcttgg agaattcctt aggcttcacg ttccgtatta aggaaaatgg
      301 agtgtgcaca gaattttctt tggttgccga caaaacagca aaggatggcg aatattttgt
      361 tgagtatgac ggagagaata catttactat acttaagaca gactatgaca attatgtcat
      421 gtttcatctc gttaatgtca acaacgggga aaccttccag ctgatggagc tctatggcag
      481 aacaaaggat ctgagttcag acatcaagga aaagtttgca aaactatgtg tggcacatgg
      541 aatcactagg gacaatatca ttgacctaac caagactgat cgctgtctcc aggcctgagg
      601 ttgaagaaag gcctgagcct ccagagtgcc tctctgtcca gaagtcaatc caagaagtgc
      661 ttaatgggtt cctttattct ttcttcctgg attactccat gctgagtgga gacttctcac
      721 caggactcca gcattaccat ttcctgtcca tggagcatcc tgagacaaat tctgcgatct
      781 gatttccatc ctgtctcaca gaaaagtgca atcccggtct ctccagcatc ttccctagtt
      841 acccaggaca acacatcgag aattaaaagc tttcttaaat ttctctttgc cccacccatg
      901 atcattccgc acaaatttct tgctcttgca gtgcaataaa tgattaccct tgcacttaaa
//
