LOCUS       NM_001108389            3456 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus ORC ubiquitin ligase 1 (Obi1), mRNA.
ACCESSION   NM_001108389 XM_001077027 XM_341373
VERSION     NM_001108389.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3456)
  AUTHORS   Coulombe P, Nassar J, Peiffer I, Stanojcic S, Sterkers Y, Delamarre
            A, Bocquet S and Mechali M.
  TITLE     The ORC ubiquitin ligase OBI1 promotes DNA replication origin
            firing
  JOURNAL   Nat Commun 10 (1), 2426 (2019)
   PUBMED   31160578
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3456)
  AUTHORS   Zheng S, Damoiseaux R, Chen L and Black DL.
  TITLE     A broadly applicable high-throughput screening strategy identifies
            new regulators of Dlg4 (Psd-95) alternative splicing
  JOURNAL   Genome Res 23 (6), 998-1007 (2013)
   PUBMED   23636947
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473951.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_341373.3, XM_001077027.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132261,
                              SAMD00132262 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3456
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15q22"
     gene            1..3456
                     /gene="Obi1"
                     /gene_synonym="RGD1564706; Rnf219"
                     /note="ORC ubiquitin ligase 1"
                     /db_xref="GeneID:361088"
                     /db_xref="RGD:1564706"
     exon            1..140
                     /gene="Obi1"
                     /gene_synonym="RGD1564706; Rnf219"
                     /inference="alignment:Splign:2.1.0"
     CDS             69..2243
                     /gene="Obi1"
                     /gene_synonym="RGD1564706; Rnf219"
                     /EC_number="2.3.2.27"
                     /note="ring finger protein 219"
                     /codon_start=1
                     /product="ORC ubiquitin ligase 1"
                     /protein_id="NP_001101859.1"
                     /db_xref="GeneID:361088"
                     /db_xref="RGD:1564706"
                     /translation="MAQTVQNVTLSLTLPITCHICLGKVRQPVVCTNNHVFCSICIDL
                     WLKNNSQCPACRVPITTENPCKEIIGGTSESEPMLSHTVRRHLRRTRLELLHREYEDE
                     IDCLQKEVEELKSKNLSLESQIKTILDPLALMQGSQNEDKHPMADNPSKIDPESVVEW
                     KKKLRTANEIYEKVKDDVDKLKEANKKLKLENGGLLRENLRLKAEVDNRSPQKFGRFT
                     VAALQSKVEQYERETNRLKKALERSDKYIEELESQVAQLRHSEETEEGMGALCQRAPS
                     ADGKGPKGSDDVAASKNPSEGAGKQAGSANSASHLATPSSSRLADTSSARQESTSRTE
                     PNCLQNKDRYPKPTEAQLGARETPMDTYLERQWGSKPSDCAPYKEEELYGLQASCTPL
                     SLSCLQLNTPENRENPVIKAGGSKKHANHLRKLVFDDFCDSPNTCNNNSSEDDRSGNE
                     KKSDCFASSKTEFWDCCSTSYAQSLEFDGSEGNTIANPVGEVPSKLSEKSGFCLSKRL
                     SCIRSLEMNRTRTSSEASMDAAYLDKISELDSMMSESDNSKSPCNNGFKSVESEGSSK
                     SPQGREFLEEPDKLQEGAKLSLPKNALEADGLEGGSEWKPSSFFLLSPSDHEMSEDFS
                     LHTTSHSGASEVKSQNCLFQTEFSQGVQLLSSSQGLFEDQRFGSSLFKMSSDMQSLPG
                     PLQSPWSAAFVSEKRSKNGNQSAKRKIQSSLSNASPSKATKS"
     exon            141..276
                     /gene="Obi1"
                     /gene_synonym="RGD1564706; Rnf219"
                     /inference="alignment:Splign:2.1.0"
     exon            277..368
                     /gene="Obi1"
                     /gene_synonym="RGD1564706; Rnf219"
                     /inference="alignment:Splign:2.1.0"
     exon            369..617
                     /gene="Obi1"
                     /gene_synonym="RGD1564706; Rnf219"
                     /inference="alignment:Splign:2.1.0"
     exon            618..706
                     /gene="Obi1"
                     /gene_synonym="RGD1564706; Rnf219"
                     /inference="alignment:Splign:2.1.0"
     exon            707..3456
                     /gene="Obi1"
                     /gene_synonym="RGD1564706; Rnf219"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcattcccag cgtggcgaag agctgctgtc ggcgggactt ccgtgttggc gggattctga
       61 acgctgccat ggctcagacc gtgcagaacg ttacattgtc cctcactctg cccatcacgt
      121 gccacatttg cttggggaag gtacgtcagc ctgttgtgtg caccaacaac catgtgtttt
      181 gttccatttg tatcgacctg tggttgaaga acaacagcca atgtccagcc tgcagagtcc
      241 ccatcactac tgaaaaccca tgcaaagaga ttattggagg aaccagtgag agcgagccca
      301 tgctgagcca cactgtgaga aggcacctgc gcaggacccg gctggagttg ctccacaggg
      361 agtatgagga tgaaatagat tgtttgcaga aagaggtaga agaacttaaa agtaaaaatc
      421 tcagcttgga gtcacagatc aagaccattc tggatccttt agccttgatg cagggcagtc
      481 aaaacgaaga caaacatcca atggccgata atccaagtaa aattgaccca gaatcagtag
      541 tagaatggaa gaaaaaactc agaacagcca atgaaatata tgaaaaagtt aaagatgatg
      601 tggataagtt aaaagaggca aataaaaaat tgaagttgga aaatggtggc ctgctgaggg
      661 agaatttgcg gctgaaggct gaagttgaca acagatctcc ccaaaagttt ggaaggttta
      721 cagttgctgc tcttcagtcc aaagtagaac agtatgaacg tgaaaccaat cgcctcaaga
      781 aagctctaga acgaagcgat aaatacatag aggaactgga gtctcaggta gcacagctga
      841 ggcactcgga ggagacagag gaaggcatgg gtgccctgtg ccagagggcg ccctctgcag
      901 atggcaaggg gcccaaaggc agcgatgacg ttgcagcatc caagaatccg agtgaaggtg
      961 ctggaaagca ggctggctca gccaattcag cctctcacct ggccacaccc tcgagcagca
     1021 gactagctga caccagttct gccagacagg agagcaccag caggactgaa ccaaactgtc
     1081 tccaaaacaa agacagatac cccaagccca cagaagcaca gctgggtgcg agagagacac
     1141 cgatggacac ttatttggag cgacagtggg gcagcaagcc aagcgactgc gctccttaca
     1201 aggaggaaga gctttatggt ctccaggctt cctgcactcc cttgtcgctc agctgccttc
     1261 agctcaacac tccagaaaac agggagaacc ctgtgatcaa agcaggtggt tccaaaaagc
     1321 atgcaaacca tctcagaaaa ctggtatttg atgatttctg tgattctcca aacacctgta
     1381 ataacaattc ttcagaggac gatagaagtg gaaatgagaa gaaatcagac tgctttgctt
     1441 cctcaaagac agagttttgg gattgttgct ccacaagcta tgcccagagc ttagagtttg
     1501 atggttcaga ggggaataca attgcaaatc ctgttgggga agtaccttca aagttgagtg
     1561 agaagtcagg attctgcttg tccaagagac tgagttgtat tcgctccctg gaaatgaacc
     1621 ggacaaggac ctccagcgag gcctccatgg atgctgctta tcttgacaaa atctctgagc
     1681 tggattccat gatgtcagag tctgacaaca gcaagagccc ttgcaataac ggtttcaaat
     1741 cagtggagtc agaggggtcc tcaaagtcac ctcaaggcag ggagtttctt gaggaacctg
     1801 acaagttaca agaaggagct aaactgagtc ttcccaaaaa tgccctcgaa gctgatgggt
     1861 tagaaggtgg gagtgagtgg aaaccctcct ctttctttct cctctctcca tctgaccatg
     1921 aaatgagtga agatttttct ctccacacta cttctcattc gggagctagt gaagtcaaat
     1981 cacaaaactg tttgtttcag acagagtttt cccagggtgt tcagctgtta agcagttccc
     2041 aaggattatt cgaggatcag aggtttgggt cgtctttatt taagatgtcc tcagatatgc
     2101 agagtcttcc cggccccctt cagtctccgt ggtctgccgc cttcgtgtct gagaagagga
     2161 gcaagaatgg gaaccagtcc gcaaagcgaa agatacagag cagcctctcc aacgccagcc
     2221 catccaaggc caccaaaagc tgactcacca gggacatagc cttgtagggt ggggtgtttg
     2281 cagtgtcacc tgagtcactt cacgaagctt ctttacagtc ctgaactgac gaccttcagc
     2341 caagggtcaa gtcagaactg tgggtctacc tggctccagg gatgttgctc tgttgctttt
     2401 gtttggtcat ctttttagcc agagagctta gggagaaggt ctgacctgtc tcagtgtcat
     2461 gtgttctgct ttttcaatga atgtcctatg tatctggatt ggatccatgt tttctcagat
     2521 ctgacttgtt agatatggtg acttgttatg actcaactgc cttcaggact cgtgcttctt
     2581 agaacatttg gtattgtctg ttctgctctt taaagctttt cctagaatgg acattttatg
     2641 cctcttttta tttatgttta gtgatggcct aactattacc aaggccatgc tggaaaaatg
     2701 gcactccctt cttagaggac tcactgactt ttttaggttt tatatagtcg tttacaattt
     2761 gttgcattct gttctgtcca cttggtgtgc ctgtgtgcgt gtgtgtgtgc gtgcgtgtgc
     2821 gtgtgtatgt gtgtatgcac acgtgcacgc acacatacta gtgtgaatga gcacattgta
     2881 tgaaaatact acttcaagtc gtttgtatct gcttaccttt gagcgtatgc atatgcgtgt
     2941 gggtgtaagt tagaatcatt ctgtattgga aggcacagag cagctgggtc tggaggaact
     3001 taaacatcta gcttttcccc aaatgtgtag gtagaaatgc agtctgttcc gtgtctgatc
     3061 tgtcctgtca cggtgagcct ttgtgtagta aagttctgtt tgcatgtcac tgctcactgg
     3121 ggcagctgta agcatggggg cctttccact tgctccactc tccaaccaga gaacaaacag
     3181 cctctgactg gctagtgact atctattatg tagaagattt tttttaaatg aaaagtaaca
     3241 agtgtgagtg ggacagtgag agcgaagcac agccgttagt gtaggcttta aaagtatgtt
     3301 attttaatgt gttccgtatg ccaacataga cgataaaaat gtctgctgca ttctagtaac
     3361 gtgttatctg atgtgcgatg aacattttac atgtattgtc ttaccttaac actgcatgct
     3421 tttttatgta attaaataaa ggatgccaca tgcact
//
