LOCUS       NM_001109899            1828 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus ornithine decarboxylase antizyme 2 (Oaz2),
            transcript variant 1, mRNA.
ACCESSION   NM_001109899 XR_009104
VERSION     NM_001109899.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1828)
  AUTHORS   Ramos-Molina B, Lambertos A, Lopez-Contreras AJ, Kasprzak JM,
            Czerwoniec A, Bujnicki JM, Cremades A and Penafiel R.
  TITLE     Structural and degradative aspects of ornithine decarboxylase
            antizyme inhibitor 2
  JOURNAL   FEBS Open Bio 4, 510-521 (2014)
   PUBMED   24967154
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1828)
  AUTHORS   Olsen RR and Zetter BR.
  TITLE     Evidence of a role for antizyme and antizyme inhibitor as
            regulators of human cancer
  JOURNAL   Mol Cancer Res 9 (10), 1285-1293 (2011)
   PUBMED   21849468
  REMARK    Review article
REFERENCE   3  (bases 1 to 1828)
  AUTHORS   Lopez-Contreras AJ, Sanchez-Laorden BL, Ramos-Molina B, de la
            Morena ME, Cremades A and Penafiel R.
  TITLE     Subcellular localization of antizyme inhibitor 2 in mammalian
            cells: Influence of intrinsic sequences and interaction with
            antizymes
  JOURNAL   J Cell Biochem 107 (4), 732-740 (2009)
   PUBMED   19449338
REFERENCE   4  (bases 1 to 1828)
  AUTHORS   Lopez-Contreras AJ, Ramos-Molina B, Cremades A and Penafiel R.
  TITLE     Antizyme inhibitor 2 (AZIN2/ODCp) stimulates polyamine uptake in
            mammalian cells
  JOURNAL   J Biol Chem 283 (30), 20761-20769 (2008)
   PUBMED   18508777
REFERENCE   5  (bases 1 to 1828)
  AUTHORS   Kanerva K, Makitie LT, Pelander A, Heiskala M and Andersson LC.
  TITLE     Human ornithine decarboxylase paralogue (ODCp) is an antizyme
            inhibitor but not an arginine decarboxylase
  JOURNAL   Biochem J 409 (1), 187-192 (2008)
   PUBMED   17900240
REFERENCE   6  (bases 1 to 1828)
  AUTHORS   Ivanov IP and Atkins JF.
  TITLE     Ribosomal frameshifting in decoding antizyme mRNAs from yeast and
            protists to humans: close to 300 cases reveal remarkable diversity
            despite underlying conservation
  JOURNAL   Nucleic Acids Res 35 (6), 1842-1858 (2007)
   PUBMED   17332016
  REMARK    Review article
REFERENCE   7  (bases 1 to 1828)
  AUTHORS   Lopez-Contreras AJ, Lopez-Garcia C, Jimenez-Cervantes C, Cremades A
            and Penafiel R.
  TITLE     Mouse ornithine decarboxylase-like gene encodes an antizyme
            inhibitor devoid of ornithine and arginine decarboxylating activity
  JOURNAL   J Biol Chem 281 (41), 30896-30906 (2006)
   PUBMED   16916800
REFERENCE   8  (bases 1 to 1828)
  AUTHORS   Mangold U.
  TITLE     The antizyme family: polyamines and beyond
  JOURNAL   IUBMB Life 57 (10), 671-676 (2005)
   PUBMED   16223706
  REMARK    Review article
REFERENCE   9  (bases 1 to 1828)
  AUTHORS   Cros N, Tkatchenko AV, Pisani DF, Leclerc L, Leger JJ, Marini JF
            and Dechesne CA.
  TITLE     Analysis of altered gene expression in rat soleus muscle atrophied
            by disuse
  JOURNAL   J Cell Biochem 83 (3), 508-519 (2001)
   PUBMED   11596118
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from FQ211793.1, FQ134463.1 and
            BQ195681.1.
            
            On Aug 1, 2014 this sequence version replaced NM_001109899.1.
            
            Summary: The protein encoded by this gene belongs to the ornithine
            decarboxylase antizyme family, which plays a role in cell growth
            and proliferation by regulating intracellular polyamine levels.
            Expression of antizymes requires +1 ribosomal frameshifting, which
            is enhanced by high levels of polyamines. Antizymes in turn bind to
            and inhibit ornithine decarboxylase (ODC), the key enzyme in
            polyamine biosynthesis; thus, completing the auto-regulatory
            circuit. This gene encodes antizyme 2, the second member of the
            antizyme family. Like antizyme 1, antizyme 2 has broad tissue
            distribution, inhibits ODC activity and polyamine uptake, and
            stimulates ODC degradation in vivo; however, it fails to promote
            ODC degradation in vitro. Antizyme 2 is expressed at lower levels
            than antizyme 1, but is evolutionary more conserved, suggesting it
            likely has an important biological role. Studies also show
            different subcellular localization of antizymes 1 and 2, indicating
            specific function for each antizyme in discrete compartments of the
            cell. Alternatively spliced transcript variants have been found for
            this gene. [provided by RefSeq, Dec 2014].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ211793.1, FQ214772.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ribosomal slippage     :: inferred from conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1365              FQ211793.1         1-1365
            1366-1808           FQ134463.1         30-472              c
            1809-1828           BQ195681.1         1-20                c
FEATURES             Location/Qualifiers
     source          1..1828
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..1828
                     /gene="Oaz2"
                     /gene_synonym="RGD1562933"
                     /note="ornithine decarboxylase antizyme 2"
                     /db_xref="GeneID:501454"
                     /db_xref="RGD:1562933"
     exon            1..187
                     /gene="Oaz2"
                     /gene_synonym="RGD1562933"
                     /inference="alignment:Splign:2.1.0"
     CDS             join(168..263,265..738)
                     /gene="Oaz2"
                     /gene_synonym="RGD1562933"
                     /ribosomal_slippage
                     /note="protein translation is dependent on
                     polyamine-induced +1 ribosomal frameshift; isoform 1 is
                     encoded by transcript variant 1"
                     /codon_start=1
                     /product="ornithine decarboxylase antizyme 2 isoform 1"
                     /protein_id="NP_001103369.1"
                     /db_xref="GeneID:501454"
                     /db_xref="RGD:1562933"
                     /translation="MINTQDSSILPLSNCPQLQCCRHIVPGPLWCSDAPHPLSKIPGG
                     RGGGRDPSLSALIYKDEKLTVTQDLPVSDGKPHIVHFQYEVTEVKVSSWDAVLSSQSL
                     FVEIPDGLLADGSKEGLLALLEFAEEKMKVNYVFICFRKGREDRAPLLKTFSFLGFEI
                     VRPGHPCVPSRPDVMFMVYPLDQNLSDED"
     exon            188..345
                     /gene="Oaz2"
                     /gene_synonym="RGD1562933"
                     /inference="alignment:Splign:2.1.0"
     regulatory      270..319
                     /regulatory_class="recoding_stimulatory_region"
                     /gene="Oaz2"
                     /gene_synonym="RGD1562933"
                     /note="recoding_pseudoknot"
                     /function="stimulates +1 ribosomal frameshifting"
     exon            346..521
                     /gene="Oaz2"
                     /gene_synonym="RGD1562933"
                     /inference="alignment:Splign:2.1.0"
     exon            522..607
                     /gene="Oaz2"
                     /gene_synonym="RGD1562933"
                     /inference="alignment:Splign:2.1.0"
     exon            608..1810
                     /gene="Oaz2"
                     /gene_synonym="RGD1562933"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1788..1793
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Oaz2"
                     /gene_synonym="RGD1562933"
     polyA_site      1810
                     /gene="Oaz2"
                     /gene_synonym="RGD1562933"
ORIGIN      
        1 agttggaggc aggcgctcgc tgaggcaaga ggagggctct cggcccgcgg cctgacaggg
       61 acttagcccg cagagaccgg cccgcgcgcg cgaccccaca cccacccact cgtccaccta
      121 cccactcccc gcgccgcctc ctcccaccct gagcagagcc accgaggatg ataaacaccc
      181 aggacagtag tattttgcct ttgagtaact gtccccagct ccagtgctgc aggcacattg
      241 ttccagggcc tctgtggtgc tcctgatgcc cctcacccac tgtcgaagat ccccggtggg
      301 cgagggggcg gcagggatcc ttctctctca gctctaatat ataaggacga gaagctcact
      361 gtaacccagg atctccccgt gagcgatgga aaacctcaca ttgtgcactt ccagtatgag
      421 gtcaccgagg tgaaggtgtc ttcctgggat gcagtcctgt ccagccagag cctgtttgta
      481 gaaatcccag atggattatt agctgatggg agcaaagaag gattattagc actgctagag
      541 tttgctgagg agaagatgaa agtgaactac gtcttcatct gcttcaggaa gggccgggaa
      601 gacagagctc cactcctgaa gacgttcagc ttcttgggct ttgagattgt gcgtccaggt
      661 catccctgtg tcccctctcg gccagatgtg atgtttatgg tttaccccct ggaccagaac
      721 ttgtctgatg aggactaatg gtcacagagg atgctttgcc caagagccac agtgggggaa
      781 gcggggaagt taggcagcct tgggacagag gagagggttt ctggctgtct agggaaggac
      841 attgaggggc tcaggttgag ggttgcccat tgtgttctcg gagttgactc gttgaaattg
      901 ttttccataa agaacagtat aagcatatta ttcacatgta atcaccaata gtaaatgaag
      961 atgtttatga actggcatta gaagcttttt aaacttcgct gtgatgtgct ccatctaccc
     1021 caagggagga cattgcctgg agggggaggg attgcctggt ctaggacaag gtctggaggg
     1081 ctgttgggca ggactgtcag gctcaggtcg gtctccttgg agttgggctt tcttttgatt
     1141 tttaagactt aggtattttc tttctttgct tcttgtcatc caggggctcc tgagtatagg
     1201 cttttagctc ctgggcagtg tccttgggtt gtgtttgaca ctccaccttg agcttccggc
     1261 attttgtgtc tggcctggtg taagcaggtc tgaccttgct ttctttacag cttagtgtta
     1321 ttcaggcatt tggttaagct ggctgagtct gtttaatgtt acccgtgcat tttacatagg
     1381 ggcactgaaa ctcatccccc acaccagggc ttttttgggg gtgcctgggc cttaagaaac
     1441 tagccaaact acatctcaag ttaccaccag agttcttgcc tctgtggcct gggcctcaag
     1501 atctctttcc tagcaagaac agagagaaag aataccaaac tcagggcctg gggtttgtgg
     1561 gggaatctgt aactggatgc ctctggctgg ccaagcatag tactgactgc ctctgtaaca
     1621 ggttcagaac agagccgagg ctgcaggacc gaggggtagg gctgggttgc agaaatgacc
     1681 agccttttac tgctttcacc aaacggcttg ttctaaagaa aaaagggaga gagagctaca
     1741 ttgggtgtgg gggtgtcagg gaggcaagtg tgttgtgtta ctgtgtcaat aaactgattt
     1801 aaagttgtgg aaaaaaaaaa aaaaaaaa
//
