LOCUS       NM_022521               2178 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus ornithine aminotransferase (Oat), mRNA; nuclear
            gene for mitochondrial product.
ACCESSION   NM_022521
VERSION     NM_022521.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2178)
  AUTHORS   da Silva,R., Levillain,O., Brosnan,J.T., Araneda,S. and
            Brosnan,M.E.
  TITLE     The effect of portacaval anastomosis on the expression of glutamine
            synthetase and ornithine aminotransferase in perivenous hepatocytes
  JOURNAL   Can J Physiol Pharmacol 91 (5), 362-368 (2013)
   PUBMED   23656379
  REMARK    GeneRIF: The portacaval shunt caused a marked decrease in glutamine
            synthetase activity and an increase in ornithine aminotransferase
            activity.
REFERENCE   2  (bases 1 to 2178)
  AUTHORS   Doimo,M., Desbats,M.A., Baldoin,M.C., Lenzini,E., Basso,G.,
            Murphy,E., Graziano,C., Seri,M., Burlina,A., Sartori,G.,
            Trevisson,E. and Salviati,L.
  TITLE     Functional analysis of missense mutations of OAT, causing gyrate
            atrophy of choroid and retina
  JOURNAL   Hum Mutat 34 (1), 229-236 (2013)
   PUBMED   23076989
REFERENCE   3  (bases 1 to 2178)
  AUTHORS   Levillain,O., Hus-Citharel,A., Garvi,S., Peyrol,S., Reymond,I.,
            Mutin,M. and Morel,F.
  TITLE     Ornithine metabolism in male and female rat kidney: mitochondrial
            expression of ornithine aminotransferase and arginase II
  JOURNAL   Am J Physiol Renal Physiol 286 (4), F727-F738 (2004)
   PUBMED   14871882
  REMARK    GeneRIF: Almost all OAT protein was localized in cortical and
            medullary proximal straight tubules and in proximal straight
            tubule, Arginase II protein distribution overlapped that of OAT
REFERENCE   4  (bases 1 to 2178)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   5  (bases 1 to 2178)
  AUTHORS   Shen,B.W., Hennig,M., Hohenester,E., Jansonius,J.N. and Schirmer,T.
  TITLE     Crystal structure of human recombinant ornithine aminotransferase
  JOURNAL   J Mol Biol 277 (1), 81-102 (1998)
   PUBMED   9514741
REFERENCE   6  (bases 1 to 2178)
  AUTHORS   Shull,J.D., Pennington,K.L., Pitot,H.C., Boryca,V.S. and
            Schulte,B.L.
  TITLE     Isolation and characterization of the rat gene encoding ornithine
            aminotransferase
  JOURNAL   Biochim Biophys Acta 1132 (2), 214-218 (1992)
   PUBMED   1390894
REFERENCE   7  (bases 1 to 2178)
  AUTHORS   Shull,J.D., Pennington,K.L., George,S.M. and Kilibarda,K.A.
  TITLE     The ornithine aminotransferase-encoding gene family of rat:
            cloning, characterization, and evolutionary relationships between a
            single expressed gene and three pseudogenes
  JOURNAL   Gene 104 (2), 203-209 (1991)
   PUBMED   1916291
REFERENCE   8  (bases 1 to 2178)
  AUTHORS   Oyama,R., Suzuki,M., Matsuzawa,T. and Titani,K.
  TITLE     Complete amino acid sequence of rat kidney ornithine
            aminotransferase: identity with liver ornithine aminotransferase
  JOURNAL   J Biochem 108 (1), 133-138 (1990)
   PUBMED   2229004
REFERENCE   9  (bases 1 to 2178)
  AUTHORS   Mitchell,G.A., Looney,J.E., Brody,L.C., Steel,G., Suchanek,M.,
            Engelhardt,J.F., Willard,H.F. and Valle,D.
  TITLE     Human ornithine-delta-aminotransferase. cDNA cloning and analysis
            of the structural gene
  JOURNAL   J Biol Chem 263 (28), 14288-14295 (1988)
   PUBMED   3170546
REFERENCE   10 (bases 1 to 2178)
  AUTHORS   Mitchell,G.A., Brody,L.C., Looney,J., Steel,G., Suchanek,M.,
            Dowling,C., Der Kaloustian,V., Kaiser-Kupfer,M. and Valle,D.
  TITLE     An initiator codon mutation in ornithine-delta-aminotransferase
            causing gyrate atrophy of the choroid and retina
  JOURNAL   J Clin Invest 81 (2), 630-633 (1988)
   PUBMED   3339136
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC061551.1.
            
            On Aug 31, 2012 this sequence version replaced NM_022521.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061551.1, M11842.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2178              BC061551.1         4-2181
FEATURES             Location/Qualifiers
     source          1..2178
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q41"
     gene            1..2178
                     /gene="Oat"
                     /gene_synonym="rOAT"
                     /note="ornithine aminotransferase"
                     /db_xref="GeneID:64313"
                     /db_xref="RGD:621724"
     exon            1..70
                     /gene="Oat"
                     /gene_synonym="rOAT"
                     /inference="alignment:Splign:2.1.0"
     exon            71..305
                     /gene="Oat"
                     /gene_synonym="rOAT"
                     /inference="alignment:Splign:2.1.0"
     CDS             107..1426
                     /gene="Oat"
                     /gene_synonym="rOAT"
                     /EC_number="2.6.1.13"
                     /note="ornithine aminotransferase, mitochondrial;
                     ornithine--oxo-acid aminotransferase; ornithine
                     aminotransferase (gyrate atrophy)"
                     /codon_start=1
                     /product="ornithine aminotransferase, mitochondrial
                     precursor"
                     /protein_id="NP_071966.1"
                     /db_xref="GeneID:64313"
                     /db_xref="RGD:621724"
                     /translation="MLSKLASLQTVAALRRGLRTSVASATSVATKKTEQGPPSSEYIF
                     ERESKYGAHNYHPLPVALERGKGIYMWDVEGRQYFDFLSAYGAVSQGHCHPKIIEAMK
                     SQVDKLTLTSRAFYNNVLGEYEEYITKLFNYNKVLPMNTGVEAGETACKLARRWGYTV
                     KGIQKYKAKIVFAVGNFWGRTLSAVSSSTDPTSYDGFGPFMPGFETIPYNDLPALERA
                     LQDPNVAAFMVEPIQGEAGVIVPDPGYLTGVRELCTRHQVLFIADEIQTGLARTGRWL
                     AVDHENVRPDIVLLGKALSGGLYPVSAVLCDDDIMLTIKPGEHGSTYGGNPLGCRIAI
                     AALEVLEEEHLAENADKMGAILRKELMKLPSDVVTAVRGKGLLNAIVIRETKDCDAWK
                     VCLRLRDNGLLAKPTHGDIIRLAPPLVIKEDEIRESVEIINKTILSF"
     exon            306..530
                     /gene="Oat"
                     /gene_synonym="rOAT"
                     /inference="alignment:Splign:2.1.0"
     exon            531..626
                     /gene="Oat"
                     /gene_synonym="rOAT"
                     /inference="alignment:Splign:2.1.0"
     exon            627..754
                     /gene="Oat"
                     /gene_synonym="rOAT"
                     /inference="alignment:Splign:2.1.0"
     exon            755..877
                     /gene="Oat"
                     /gene_synonym="rOAT"
                     /inference="alignment:Splign:2.1.0"
     exon            878..1006
                     /gene="Oat"
                     /gene_synonym="rOAT"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..1120
                     /gene="Oat"
                     /gene_synonym="rOAT"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..1265
                     /gene="Oat"
                     /gene_synonym="rOAT"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..2148
                     /gene="Oat"
                     /gene_synonym="rOAT"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gacgcgccgg gctgccacat cgggcttcgt ggctgaaata cagtcagtgt cgcttagcgg
       61 acgctgtcag gtctctctgc acttccattc ctgaaggacc cacacaatgc tttccaaact
      121 agcaagtctg cagactgttg ccgctctgcg tcgaggactc cgcacctcag tcgcctctgc
      181 cacatctgtt gcaacgaaga agacagagca aggcccacca tcctctgagt acatttttga
      241 acgggaatct aaatatggtg cacacaatta ccatccttta cctgtagccc tggagagagg
      301 aaaaggcatt tatatgtggg atgtggaagg caggcagtac ttcgacttcc tgagtgctta
      361 tggtgctgtc agccaaggac actgccaccc aaagatcata gaagccatga agagtcaggt
      421 ggacaagctg acattaacat ctcgggcttt ctataacaat gtccttggtg aatatgagga
      481 gtacatcacc aagcttttca actacaacaa agttcttcct atgaatacag gagtggaggc
      541 cggagagact gcgtgtaagc ttgctcgccg ttggggctac accgtgaaag gcatccagaa
      601 atacaaagca aagatcgttt ttgctgttgg aaacttttgg ggtcggacgc tgtctgcagt
      661 ctccagttcc acagatccga ccagttatga tggctttgga cccttcatgc caggctttga
      721 aaccatccca tataacgatc tgcctgcgct agagcgtgct cttcaggatc ccaatgttgc
      781 tgctttcatg gtggagccca tccagggtga agcgggtgtt atcgttccag atccaggata
      841 cctgacggga gttcgagaac tttgcacccg gcaccaggtc ctgtttattg ctgatgaaat
      901 acagacagga ttggctagaa ctggtcgatg gctagctgtg gatcatgaga atgtcagacc
      961 tgacatagtt cttcttggga aggccctttc tggtggctta tatcccgtgt ctgcagtgct
     1021 gtgtgatgat gacataatgc tgaccattaa accaggcgag cacggctcca cgtatggcgg
     1081 caacccacta ggctgccgaa ttgctattgc ggctcttgag gttttagaag aagagcatct
     1141 tgctgaaaac gcagacaaga tgggtgccat cttgagaaag gagctcatga agctgccatc
     1201 tgatgttgtg actgctgtga gagggaaagg gttgctaaat gccatcgtca tccgagaaac
     1261 caaagattgt gacgcttgga aggtgtgcct gcgactccga gataatgggc ttctggccaa
     1321 gccaacccat ggtgatatca tccggcttgc ccctccactt gtgatcaaag aggatgagat
     1381 ccgggagtca gtggagatca tcaacaagac catcttgtcc ttctgagagt aggaactctg
     1441 gggagccatc ttcagatggg gctcttgtga aactctgctt gggatgggca gattcggctt
     1501 gtctgtctcc taaaagacaa ttttttgaat atgtattata tatttcagtt gatgcatagt
     1561 ggagtgacac ctaggaacct gcaggtggct gcgtgacaca agagtgagag cgagaggcat
     1621 ctctttgtta aagtttgact gtgtgggagc tttctaagga gaaacagatc tatctgcata
     1681 cagcctgcag agtcctgccg taatttacat gtgtctttac atcttccttg ctggcatgaa
     1741 tgttttgtat ttggaagttt ttttctgaga tactacataa gaaactgttg aatcattata
     1801 atcaatgaat ggtaagatga ttgagggttg agcatatgta aaatactagt ttaaagtaca
     1861 ctttgcattg gccaacagca gaatgtatta tatagtttct gagaattcat taccaaatta
     1921 tactttaagt gcttgattgc aatttgtaaa acatttattt tcagtatttc tttgaataaa
     1981 gcttcatttt tctttatacc ccaaaagagt attttgtatt tatcttttgg taataatcag
     2041 tgtattattt cacccctatg actggcattt catcccctat tgagatcact gggtgtgttt
     2101 caggcttttt attctaaata aagctatgac cagttcatat ctgtacagaa aaaaaaaaaa
     2161 aaaaaaaaaa aaaaaaaa
//
