LOCUS       NM_001009681            1980 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Rattus norvegicus 2'-5'-oligoadenylate synthetase-like (Oasl),
            mRNA.
ACCESSION   NM_001009681 XM_222230
VERSION     NM_001009681.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1980)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   2  (bases 1 to 1980)
  AUTHORS   Schoggins,J.W., Wilson,S.J., Panis,M., Murphy,M.Y., Jones,C.T.,
            Bieniasz,P. and Rice,C.M.
  TITLE     A diverse range of gene products are effectors of the type I
            interferon antiviral response
  JOURNAL   Nature 472 (7344), 481-485 (2011)
   PUBMED   21478870
  REMARK    Erratum:[Nature. 2015 Sep 3;525(7567):144. doi:
            10.1038/nature14554.. PMID: 26153858]
REFERENCE   3  (bases 1 to 1980)
  AUTHORS   Ishibashi,M., Wakita,T. and Esumi,M.
  TITLE     2',5'-Oligoadenylate synthetase-like gene highly induced by
            hepatitis C virus infection in human liver is inhibitory to viral
            replication in vitro
  JOURNAL   Biochem Biophys Res Commun 392 (3), 397-402 (2010)
   PUBMED   20074559
REFERENCE   4  (bases 1 to 1980)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   5  (bases 1 to 1980)
  AUTHORS   Marques,J., Anwar,J., Eskildsen-Larsen,S., Rebouillat,D.,
            Paludan,S.R., Sen,G., Williams,B.R.G. and Hartmann,R.
  TITLE     The p59 oligoadenylate synthetase-like protein possesses antiviral
            activity that requires the C-terminal ubiquitin-like domain
  JOURNAL   J Gen Virol 89 (Pt 11), 2767-2772 (2008)
   PUBMED   18931074
REFERENCE   6  (bases 1 to 1980)
  AUTHORS   Eskildsen,S., Justesen,J., Schierup,M.H. and Hartmann,R.
  TITLE     Characterization of the 2'-5'-oligoadenylate synthetase
            ubiquitin-like family
  JOURNAL   Nucleic Acids Res 31 (12), 3166-3173 (2003)
   PUBMED   12799444
REFERENCE   7  (bases 1 to 1980)
  AUTHORS   Kakuta,S., Shibata,S. and Iwakura,Y.
  TITLE     Genomic structure of the mouse 2',5'-oligoadenylate synthetase gene
            family
  JOURNAL   J Interferon Cytokine Res 22 (9), 981-993 (2002)
   PUBMED   12396720
REFERENCE   8  (bases 1 to 1980)
  AUTHORS   Rebouillat,D., Marie,I. and Hovanessian,A.G.
  TITLE     Molecular cloning and characterization of two related and
            interferon-induced 56-kDa and 30-kDa proteins highly similar to
            2'-5' oligoadenylate synthetase
  JOURNAL   Eur J Biochem 257 (2), 319-330 (1998)
   PUBMED   9826176
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY227756.1.
            
            On Jan 13, 2005 this sequence version replaced XM_222230.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY227756.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5756307,
                                           SAMEA5760383 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1980
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     gene            1..1980
                     /gene="Oasl"
                     /gene_synonym="Oasl1"
                     /note="2'-5'-oligoadenylate synthetase-like"
                     /db_xref="GeneID:304545"
                     /db_xref="RGD:1308586"
     exon            1..206
                     /gene="Oasl"
                     /gene_synonym="Oasl1"
                     /inference="alignment:Splign:2.1.0"
     CDS             9..1547
                     /gene="Oasl"
                     /gene_synonym="Oasl1"
                     /note="59 kDa 2'-5'-oligoadenylate synthase-like protein;
                     2'-5' oligoadenylate synthetase-like 1"
                     /codon_start=1
                     /product="2'-5'-oligoadenylate synthase-like protein 1"
                     /protein_id="NP_001009681.1"
                     /db_xref="GeneID:304545"
                     /db_xref="RGD:1308586"
                     /translation="MAVAQELYSFPASKLDSFVAQWLQPTREWKEEVLETVQTVEQFL
                     RQENFRGERGPAQDVRVLKVLKVGCFGNGTVLRSTTDVELVVFLSCFHSFQEEAKHHQ
                     AVLRLIQKRMSYCRDLLDLGLSNLSVIEEVPSSLIFTIQTRETWEPITVTIVPAFRAL
                     GPSCPNSAEVYVNLIKANGYPGNFSPSFSELQRSFVKHRPTKLKSLLRLVKHWYQQYV
                     RDKCPRANLPPLYALELLTVYAWEAGTQEDSNFRLDEGLATVMELLQDHELLCIYWTK
                     YYTLQHPVIERFVRRQLKGERPIILDPADPTHNVAQGYRWDIVAQRASQCLKQDCCYD
                     DRDAPVPSWTVKRAPYIQVTVQQWGHPDLILWVNPYEPIKKLKEKIRLSRGYSGLQRL
                     SFQEPGGQRQLIRSQCSLAYYGIFCDTQICLLDTISPEIQVFVKNPDGGSHAYAIHPL
                     DFVLSLKQQIEDRQGLQSQEQQLEFQGRVLEDWFDFKSYGIQDSITIILSRKREGKAP
                     SAPS"
     exon            207..489
                     /gene="Oasl"
                     /gene_synonym="Oasl1"
                     /inference="alignment:Splign:2.1.0"
     exon            490..656
                     /gene="Oasl"
                     /gene_synonym="Oasl1"
                     /inference="alignment:Splign:2.1.0"
     exon            657..898
                     /gene="Oasl"
                     /gene_synonym="Oasl1"
                     /inference="alignment:Splign:2.1.0"
     exon            899..1046
                     /gene="Oasl"
                     /gene_synonym="Oasl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1980
                     /gene="Oasl"
                     /gene_synonym="Oasl1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgcagacat ggcagtagcc caggagcttt acagcttccc agcctccaag ctggactcct
       61 ttgtggctca gtggctgcag ccaaccagag aatggaagga ggaggtcctg gagacggtgc
      121 agacagtgga gcagttcctg aggcaggaga acttccgtgg agaacgtggc ccggcccagg
      181 atgtacgagt gctcaaggta ctcaaggtag gctgctttgg gaatggcaca gtactcagga
      241 gtaccacaga cgtggagctg gtggtgttcc tgagctgttt ccacagcttc caggaagagg
      301 ccaaacacca ccaggctgtt ctgagactga tacagaaaag gatgtcttac tgccgggacc
      361 tgctggatct cgggctcagt aacctgagtg tgattgaaga agtgcccagt agtctcatct
      421 tcactatcca gaccagggag acctgggagc ccatcactgt caccatcgtg cccgccttca
      481 gagccctggg accttcctgt cccaactccg ccgaggtcta tgtgaatctg atcaaggcta
      541 acggctaccc cggaaatttc tctccttcct tcagcgagct acagaggagc ttcgtgaagc
      601 ataggccgac taagctgaag agcctcctac ggttggtcaa acactggtac cagcagtacg
      661 tgagagacaa gtgcccccgg gccaacctgc cccccctcta tgccctggag ctgctaactg
      721 tctacgcgtg ggaagcaggt acgcaggagg attcgaactt caggctggat gaaggtctcg
      781 ccactgtcat ggagttgctc caggatcatg aactcctgtg catctactgg accaagtact
      841 acaccctgca acacccagtc attgagcgct tcgtcaggag acagctcaaa ggagaaaggc
      901 ccattatcct ggacccagca gaccccaccc acaacgtggc gcaaggctac aggtgggata
      961 tagttgctca gcgcgccagc cagtgtctga aacaggactg ttgctatgac gacagggacg
     1021 cccccgtccc cagctggact gtgaagagag caccatatat ccaggtgacc gtgcagcagt
     1081 ggggtcaccc ggatttaatc ctctgggtga acccttatga acccataaag aagctgaaag
     1141 agaaaatccg actgagccgg ggctactccg gcctgcagcg cctgtccttt caggagcccg
     1201 gcggccaacg gcagctcatc agaagccaat gctcgcttgc ctactacgga atcttctgcg
     1261 acactcagat ctgcctgctg gacaccatct cccccgagat ccaggtcttt gtgaaaaacc
     1321 cggatggtgg aagccacgcc tacgccatcc acccacttga cttcgtcctg agcctgaagc
     1381 agcagatcga agataggcag ggccttcaaa gccaggagca gcagctggag ttccagggcc
     1441 gcgtcctgga agactggttt gactttaaat cctatggcat ccaagatagt atcacgatca
     1501 tcctatccag gaagagggag gggaaagccc catctgcgcc cagctagctt cctctgcctc
     1561 ttttgctatc tcatcctaaa gtcagcctag tcacccctcc ttccggtcct cagccgggat
     1621 gatcccagca gggagccaga agggaatact gccagacgct cttgtgtgac aatgaaactc
     1681 tgcagtcacc tgtgaaatca caccaggacc tctacgctct caagactggg tcagtgaatg
     1741 gccgtcccac aaataaacta ttctcgcttg ttcttgggaa gccaaacgat cttcctaacc
     1801 aatcaaatgg accctgcttc aggttgttcc cccacacaca ccagcaacct ccatcaggtt
     1861 ggatctgaag ccttcccctg tgctcccaac cacttctgcc tgcctcagcc tatccaaggc
     1921 aaggtagggt atcaagttcc tttcaaatgg agaataaaca acctttgttt cctcccagat
//
