LOCUS       NP_001009681             512 aa            linear   ROD 09-FEB-2025
DEFINITION  2'-5'-oligoadenylate synthase-like protein 1 [Rattus norvegicus].
ACCESSION   NP_001009681 XP_222230
VERSION     NP_001009681.1
DBSOURCE    REFSEQ: accession NM_001009681.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 512)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   2  (residues 1 to 512)
  AUTHORS   Schoggins,J.W., Wilson,S.J., Panis,M., Murphy,M.Y., Jones,C.T.,
            Bieniasz,P. and Rice,C.M.
  TITLE     A diverse range of gene products are effectors of the type I
            interferon antiviral response
  JOURNAL   Nature 472 (7344), 481-485 (2011)
   PUBMED   21478870
  REMARK    Erratum:[Nature. 2015 Sep 3;525(7567):144. doi:
            10.1038/nature14554.. PMID: 26153858]
REFERENCE   3  (residues 1 to 512)
  AUTHORS   Ishibashi,M., Wakita,T. and Esumi,M.
  TITLE     2',5'-Oligoadenylate synthetase-like gene highly induced by
            hepatitis C virus infection in human liver is inhibitory to viral
            replication in vitro
  JOURNAL   Biochem Biophys Res Commun 392 (3), 397-402 (2010)
   PUBMED   20074559
REFERENCE   4  (residues 1 to 512)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   5  (residues 1 to 512)
  AUTHORS   Marques,J., Anwar,J., Eskildsen-Larsen,S., Rebouillat,D.,
            Paludan,S.R., Sen,G., Williams,B.R.G. and Hartmann,R.
  TITLE     The p59 oligoadenylate synthetase-like protein possesses antiviral
            activity that requires the C-terminal ubiquitin-like domain
  JOURNAL   J Gen Virol 89 (Pt 11), 2767-2772 (2008)
   PUBMED   18931074
REFERENCE   6  (residues 1 to 512)
  AUTHORS   Eskildsen,S., Justesen,J., Schierup,M.H. and Hartmann,R.
  TITLE     Characterization of the 2'-5'-oligoadenylate synthetase
            ubiquitin-like family
  JOURNAL   Nucleic Acids Res 31 (12), 3166-3173 (2003)
   PUBMED   12799444
REFERENCE   7  (residues 1 to 512)
  AUTHORS   Kakuta,S., Shibata,S. and Iwakura,Y.
  TITLE     Genomic structure of the mouse 2',5'-oligoadenylate synthetase gene
            family
  JOURNAL   J Interferon Cytokine Res 22 (9), 981-993 (2002)
   PUBMED   12396720
REFERENCE   8  (residues 1 to 512)
  AUTHORS   Rebouillat,D., Marie,I. and Hovanessian,A.G.
  TITLE     Molecular cloning and characterization of two related and
            interferon-induced 56-kDa and 30-kDa proteins highly similar to
            2'-5' oligoadenylate synthetase
  JOURNAL   Eur J Biochem 257 (2), 319-330 (1998)
   PUBMED   9826176
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY227756.1.
            
            On Jan 13, 2005 this sequence version replaced XP_222230.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY227756.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5756307,
                                           SAMEA5760383 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..512
                     /organism="Rattus norvegicus"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     Protein         1..512
                     /product="2'-5'-oligoadenylate synthase-like protein 1"
                     /note="59 kDa 2'-5'-oligoadenylate synthase-like protein;
                     2'-5' oligoadenylate synthetase-like 1"
                     /calculated_mol_wt=58886
     Region          29..209
                     /region_name="NT_2-5OAS_ClassI-CCAase"
                     /note="Nucleotidyltransferase (NT) domain of
                     2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I
                     CCA-adding enzyme; cd05400"
                     /db_xref="CDD:143390"
     Site            order(67..69,72,74..76,81,83,133..134,137,152,195,199,202)
                     /site_type="active"
                     /db_xref="CDD:143390"
     Site            order(68..69,81,83,134,195,199,202)
                     /site_type="other"
                     /note="NTP binding site [chemical binding]"
                     /db_xref="CDD:143390"
     Site            order(81,83,152)
                     /site_type="metal-binding"
                     /note="metal binding triad [ion binding]"
                     /db_xref="CDD:143390"
     Region          167..348
                     /region_name="OAS1_C"
                     /note="2'-5'-oligoadenylate synthetase 1, domain 2,
                     C-terminus; pfam10421"
                     /db_xref="CDD:463087"
     Region          351..424
                     /region_name="Ubl1_OASL"
                     /note="ubiquitin-like (Ubl) domain 1 found in
                     2'-5'-oligoadenylate synthase-like protein (OASL) and
                     similar proteins; cd01811"
                     /db_xref="CDD:340509"
     Region          430..501
                     /region_name="Ubl1_cv_Nsp3_N-like"
                     /note="first ubiquitin-like (Ubl) domain located at the
                     N-terminus of coronavirus SARS-CoV non-structural protein
                     3 (Nsp3) and related proteins; cl28922"
                     /db_xref="CDD:475130"
     CDS             1..512
                     /gene="Oasl"
                     /gene_synonym="Oasl1"
                     /coded_by="NM_001009681.1:9..1547"
                     /db_xref="GeneID:304545"
                     /db_xref="RGD:1308586"
ORIGIN      
        1 mavaqelysf paskldsfva qwlqptrewk eevletvqtv eqflrqenfr gergpaqdvr
       61 vlkvlkvgcf gngtvlrstt dvelvvflsc fhsfqeeakh hqavlrliqk rmsycrdlld
      121 lglsnlsvie evpsslifti qtretwepit vtivpafral gpscpnsaev yvnlikangy
      181 pgnfspsfse lqrsfvkhrp tklksllrlv khwyqqyvrd kcpranlppl yalelltvya
      241 weagtqedsn frldeglatv mellqdhell ciywtkyytl qhpvierfvr rqlkgerpii
      301 ldpadpthnv aqgyrwdiva qrasqclkqd ccyddrdapv pswtvkrapy iqvtvqqwgh
      361 pdlilwvnpy epikklkeki rlsrgysglq rlsfqepggq rqlirsqcsl ayygifcdtq
      421 iclldtispe iqvfvknpdg gshayaihpl dfvlslkqqi edrqglqsqe qqlefqgrvl
      481 edwfdfksyg iqdsitiils rkregkapsa ps
//
