LOCUS       NM_001009493            4015 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus 2'-5'-oligoadenylate synthetase 3 (Oas3), mRNA.
ACCESSION   NM_001009493
VERSION     NM_001009493.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4015)
  AUTHORS   Pieragostino,D., Agnifili,L., Fasanella,V., D'Aguanno,S.,
            Mastropasqua,R., Di Ilio,C., Sacchetta,P., Urbani,A. and Del
            Boccio,P.
  TITLE     Shotgun proteomics reveals specific modulated protein patterns in
            tears of patients with primary open angle glaucoma naive to therapy
  JOURNAL   Mol Biosyst 9 (6), 1108-1116 (2013)
   PUBMED   23580065
REFERENCE   2  (bases 1 to 4015)
  AUTHORS   Lin,R.J., Yu,H.P., Chang,B.L., Tang,W.C., Liao,C.L. and Lin,Y.L.
  TITLE     Distinct antiviral roles for human 2',5'-oligoadenylate synthetase
            family members against dengue virus infection
  JOURNAL   J Immunol 183 (12), 8035-8043 (2009)
   PUBMED   19923450
REFERENCE   3  (bases 1 to 4015)
  AUTHORS   Brehin,A.C., Casademont,I., Frenkiel,M.P., Julier,C.,
            Sakuntabhai,A. and Despres,P.
  TITLE     The large form of human 2',5'-Oligoadenylate Synthetase (OAS3)
            exerts antiviral effect against Chikungunya virus
  JOURNAL   Virology 384 (1), 216-222 (2009)
   PUBMED   19056102
REFERENCE   4  (bases 1 to 4015)
  AUTHORS   Perelygin,A.A., Zharkikh,A.A., Scherbik,S.V. and Brinton,M.A.
  TITLE     The mammalian 2'-5' oligoadenylate synthetase gene family: evidence
            for concerted evolution of paralogous Oas1 genes in Rodentia and
            Artiodactyla
  JOURNAL   J Mol Evol 63 (4), 562-576 (2006)
   PUBMED   17024523
REFERENCE   5  (bases 1 to 4015)
  AUTHORS   Kakuta,S., Shibata,S. and Iwakura,Y.
  TITLE     Genomic structure of the mouse 2',5'-oligoadenylate synthetase gene
            family
  JOURNAL   J Interferon Cytokine Res 22 (9), 981-993 (2002)
   PUBMED   12396720
REFERENCE   6  (bases 1 to 4015)
  AUTHORS   Rebouillat,D., Hovnanian,A., Marie,I. and Hovanessian,A.G.
  TITLE     The 100-kDa 2',5'-oligoadenylate synthetase catalyzing
            preferentially the synthesis of dimeric pppA2'p5'A molecules is
            composed of three homologous domains
  JOURNAL   J Biol Chem 274 (3), 1557-1565 (1999)
   PUBMED   9880533
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY250706.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY250706.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680412, SAMN06680413
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4015
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     gene            1..4015
                     /gene="Oas3"
                     /note="2'-5'-oligoadenylate synthetase 3"
                     /db_xref="GeneID:494202"
                     /db_xref="RGD:1359319"
     exon            1..201
                     /gene="Oas3"
                     /inference="alignment:Splign:2.1.0"
     CDS             28..3441
                     /gene="Oas3"
                     /EC_number="2.7.7.84"
                     /note="2-5A synthase 3; (2-5')oligo(A) synthase 3"
                     /codon_start=1
                     /product="2'-5'-oligoadenylate synthase 3"
                     /protein_id="NP_001009493.1"
                     /db_xref="GeneID:494202"
                     /db_xref="RGD:1359319"
                     /translation="MDLYHTPAGALDKLVAHSLHPAPEFTAAVRRALGSLDNVLRKNG
                     AGGLQRPRVIRIIKGGAHARGTALRGGTDVELVIFLDCLRSFGDQKTCHTEILGAIQA
                     LLESWGCNPGPGLTFEFSGPKASGILQFRLASVDQENWIDVSLVPAFDALGQLHSEVK
                     PTPNVYSSLLSSHCQAGEHSACFTELRKNFVNIRPVKLKNLILLVKHWYRQVQTQVVR
                     ATLPPSYALELLTIFAWEQGCRKDAFSLAQGLRTVLALIQRNKHLCIFWTENYGFEDP
                     AVGEFLRRQLKRPRPVILDPADPTWDLGNGTAWCWDVLAKEAEYSFNQQCFKEASGAL
                     VQPWEGPGLPCAGILDLGHPIQQGAKHALEDNNGHLAVQPMKESLQPSNPARGLPETA
                     TKISAMPDPTVTETHKSLKKSVHPKTVSETVVNPSSHVWITQSTASSNTPPGHSSMST
                     AGSQMGPDLSQIPSKELDSFIQDHLRPSSQFQQQVRQAIDTILCCLREKCVDKVLRVS
                     KGGSFGRGTDLRGKCDVELVIFYKTLGDFKGQNSHQTEILCDMQAQLQRWCQNPAPGL
                     SLQFIEQKSNALHLQLVPTNLSNRVDLSVLPAFDAVGPLKSGAKPLPETYSSLLSSGC
                     QAGEHAACFAELRRNFINTRPAKLRSLMLLVKHWYRQVAARFEGGETAGAALPPAYAL
                     ELLTVFAWEQGCGEQKFSMAEGLRTVLRLVQQHQSLCIYWTVNYSVQDPAIRAHLLRQ
                     LRKARPLILDPADPTWNMDQGNWKLLAQEAAALESQVCLQSRDGNLVPPWDVMPALLH
                     QTPAQNLDKFICEFLQPDRHFLTQVKRAVDTICSFLKENCFRNSTIKVLKVVKGGSSA
                     KGTALQGRSDADLVVFLSCFRQFSEQGSHRAEIIAEIQAQLEACQQKQRFDVKFEISK
                     RKNPRVLSFTLTSKTLLGQSVDFDVLPAFDALGQLKSGSRPDPRVYTDLIQSYSNAGE
                     FSTCFTELQRDFISSRPTKLKSLIRLVKHWYQQCNKTVKGKGSLPPQHGLELLTVYAW
                     ERGSQNPQFNMAEGFRTVLELIGQYRQLCVYWTINYGAEDETIGDFLKMQLQKPRPVI
                     LDPADPTGNLGHNARWDLLAKEAAAYTSALCCMDKDGNPIKPWPVKAAV"
     exon            202..484
                     /gene="Oas3"
                     /inference="alignment:Splign:2.1.0"
     exon            485..660
                     /gene="Oas3"
                     /inference="alignment:Splign:2.1.0"
     exon            661..896
                     /gene="Oas3"
                     /inference="alignment:Splign:2.1.0"
     exon            897..1050
                     /gene="Oas3"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1554
                     /gene="Oas3"
                     /inference="alignment:Splign:2.1.0"
     exon            1555..1834
                     /gene="Oas3"
                     /inference="alignment:Splign:2.1.0"
     exon            1835..2010
                     /gene="Oas3"
                     /inference="alignment:Splign:2.1.0"
     exon            2011..2261
                     /gene="Oas3"
                     /inference="alignment:Splign:2.1.0"
     exon            2262..2406
                     /gene="Oas3"
                     /inference="alignment:Splign:2.1.0"
     exon            2407..2580
                     /gene="Oas3"
                     /inference="alignment:Splign:2.1.0"
     exon            2581..2866
                     /gene="Oas3"
                     /inference="alignment:Splign:2.1.0"
     exon            2867..3042
                     /gene="Oas3"
                     /inference="alignment:Splign:2.1.0"
     exon            3043..3281
                     /gene="Oas3"
                     /inference="alignment:Splign:2.1.0"
     exon            3282..3429
                     /gene="Oas3"
                     /inference="alignment:Splign:2.1.0"
     exon            3430..4015
                     /gene="Oas3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaaactctcc tgagggcatg ggtcaacatg gacctgtacc acacgccagc cggagctctg
       61 gacaagctgg tggcccacag cctgcaccca gcccctgagt tcacagcggc tgtgcggcgt
      121 gctctggggt ccctggacaa cgtcctaagg aagaacggag ccggagggtt acagagacca
      181 agggtgataa ggatcatcaa gggaggagcc catgctcgag gcacagctct cagaggtggc
      241 actgatgtcg aactcgtcat cttcctcgac tgcctccgga gctttggcga ccagaagacc
      301 tgtcacacag agatcctggg cgccatacaa gcattgctgg agtcctgggg gtgcaaccct
      361 gggcctggcc tgacttttga gttttctggg ccaaaggcgt ctggcatctt acagtttcgc
      421 ctggcatcgg tggaccaaga aaactggata gatgttagcc tggtgcctgc cttcgatgcc
      481 ctaggacagc tccactctga agtcaagcca acacccaatg tgtactcctc cctcctcagc
      541 agccactgcc aggctgggga acactcagcc tgcttcacag agctccggaa gaactttgtg
      601 aatatccgcc cagtcaaact taagaactta atcctgctgg tcaaacactg gtaccgccag
      661 gtgcagacac aggttgtgag agccacactg ccccctagct acgcgctgga gctgctcacc
      721 atctttgcct gggagcaggg ctgtaggaag gatgccttca gcctggccca agggctccgg
      781 actgtcctgg ccttgatcca acgcaacaag catctctgca ttttctggac ggaaaactac
      841 ggcttcgaag accctgcagt tggggagttc ttgcgaaggc agcttaagag acccaggccc
      901 gtgatcctgg atccagctga cccaacatgg gacttgggca atgggacagc ctggtgctgg
      961 gatgtgcttg ccaaggaggc tgaatacagc tttaaccagc agtgcttcaa ggaggcctca
     1021 ggagcccttg tgcaaccttg ggaggggccg ggccttccat gtgctgggat cttggatttg
     1081 ggtcacccta tccaacaagg agctaagcat gcccttgaag acaacaatgg ccaccttgct
     1141 gttcagccaa tgaaagagag cctacaacca tcaaatccag cccgaggact cccagaaaca
     1201 gccaccaaga tctccgctat gccagaccca acggtcactg aaacccacaa gagcctcaaa
     1261 aaatcagtgc acccaaagac tgtcagtgaa acagtggtga atccctcaag tcatgtttgg
     1321 atcacccaga gtacagcatc ctcaaacacg cctccgggcc actctagtat gtccaccgct
     1381 gggtcacaga tgggcccaga tctgtcacag atccccagca aggagctgga ctccttcatc
     1441 caggaccacc tcaggccgag ttcccagttc cagcagcagg tgaggcaggc catcgacacc
     1501 atcctgtgct gcctccggga gaagtgtgta gacaaagtct tgagagtcag caagggtggc
     1561 tcttttggcc gtggcacaga cctcaggggc aaatgtgatg tggagcttgt catcttttat
     1621 aaaactctcg gggacttcaa gggccagaac tcacaccaga cagagatcct gtgtgacatg
     1681 caggcccagc tgcagcgctg gtgtcagaac ccagcacctg gactgagcct ccagtttatt
     1741 gaacagaagt ccaatgctct gcatcttcag ctggtgccca ccaacctcag caaccgggta
     1801 gacctcagtg tgctgcccgc ttttgatgca gtggggccgc tgaagtccgg cgccaaacct
     1861 ctacccgaga cgtactcctc cctcctcagc agcggctgcc aggctgggga gcatgcagcc
     1921 tgcttcgcag agctccgaag gaacttcata aacactcgcc ctgccaaact taggagcctg
     1981 atgctactgg tcaaacactg gtaccgccag gttgccgctc gatttgaagg aggagagaca
     2041 gcaggtgctg ctctgccccc agcctatgcc ctggagctcc tgacagtctt tgcctgggaa
     2101 caaggctgcg gagaacaaaa gtttagcatg gctgaaggcc tgcggactgt cctgaggctg
     2161 gtccagcagc accagtcact ctgtatctac tggacagtca actacagtgt gcaggaccca
     2221 gccatcagag cacaccttct ccgccagctt cggaaagcca ggcctctaat cctagaccct
     2281 gcagatccca cctggaacat ggaccagggc aactggaagt tgctggctca ggaggcggct
     2341 gccctggagt cacaagtctg ccttcagagt agggatggga atctggtgcc accatgggat
     2401 gttatgccag ccctccttca ccagaccccg gctcagaacc tggacaagtt catctgtgaa
     2461 ttcctccagc ctgaccgcca tttcctgact caggtgaaga gagcagtgga caccatatgt
     2521 tccttcctga aagaaaactg cttccggaat tctaccatca aggtgctcaa ggtggtcaag
     2581 ggtgggtctt ctgccaaagg cactgctcta caagggcgct cggatgctga cctggtggtg
     2641 ttcctcagct gcttccgcca gttctctgaa caaggcagcc atcgggcaga gatcatcgcg
     2701 gagatccagg ctcagctgga ggcgtgtcag cagaagcaga ggttcgatgt caagtttgag
     2761 atctccaaga ggaagaaccc ccgagttctc agcttcacgc tgacatccaa gacgctgcta
     2821 ggccagagcg tggacttcga tgtgctgcca gccttcgatg ctcttggtca gctgaagtcc
     2881 ggctctcggc cagatccccg ggtctacacg gacctcatcc agagctacag taatgcagga
     2941 gagttctcta cctgcttcac ggagctgcag cgggacttca ttagctcccg tcccaccaaa
     3001 ctcaagagtc tgatccgtct ggtgaaacac tggtaccaac agtgtaacaa gacagtcaag
     3061 gggaagggtt ccttgccccc ccagcacggg ctggagctcc tgactgtgta cgcctgggag
     3121 cgaggcagcc agaaccccca gttcaacatg gcggagggct tccgcacagt tctggagctg
     3181 attggccagt accgtcagct gtgcgtctat tggaccatca actacggtgc agaagacgag
     3241 accatcggag acttcctgaa gatgcagctt cagaagccca ggcctgtcat cctggaccca
     3301 gctgacccga caggcaacct aggccacaat gcccgctggg acctgcttgc caaggaggct
     3361 gcagcataca catctgccct gtgctgcatg gacaaggacg gcaaccccat caagccatgg
     3421 ccagtaaagg ccgctgtgtg aagtccagaa agatcaaaaa gtgacaccag ccctcagcaa
     3481 gggatactca gaatatctgg ccagatgtgt gtgtgtgtgt gtgtgtgtgt gtgttgtgta
     3541 ttgtgtttat ctatatatgt ttctgtgctg tgtctgtgtg tctctgtagg tggtgtgtgt
     3601 ctgtgtaccc acaggtgtct acatgtgtct gtatatatgt aagagtgtgt gtatgtatgt
     3661 atgttcacgt gtctctgtgt gtgtgcatct gtgtgtttgt atgtagtgtg tctataggtg
     3721 tatccttatg agtgtgtgtg tttgtggtgg agtgtgtgtg tgtctgtgta tctgtgggtg
     3781 tctatatgtg tctgagtgtg tgtgattatt tgtgtgttta tgtgtctgtg tatttgtgtg
     3841 tagtgagttt ataggtgcat ctgtgtgtct atatgtatat gtgtgtctat gtgtgtctat
     3901 ggtgtgtgtc cgtgtatctg tgggtgtcta tgtgtgtctg tatgtacgtg tgtgtgtgtg
     3961 tgacttgctt tgtccaaatg attgtatgta tgtatgtgtg ctcatgtggc tctgt
//
