LOCUS       NM_001009715            2274 bp    mRNA    linear   ROD 10-DEC-2024
DEFINITION  Rattus norvegicus 2'-5' oligoadenylate synthetase 2 (Oas2), mRNA.
ACCESSION   NM_001009715 XM_344120
VERSION     NM_001009715.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2274)
  AUTHORS   Oakes,S.R., Gallego-Ortega,D., Stanford,P.M., Junankar,S.,
            Au,W.W.Y., Kikhtyak,Z., von Korff,A., Sergio,C.M., Law,A.M.K.,
            Castillo,L.E., Allerdice,S.L., Young,A.I.J., Piggin,C., Whittle,B.,
            Bertram,E., Naylor,M.J., Roden,D.L., Donovan,J., Korennykh,A.,
            Goodnow,C.C., O'Bryan,M.K. and Ormandy,C.J.
  TITLE     A mutation in the viral sensor 2'-5'-oligoadenylate synthetase 2
            causes failure of lactation
  JOURNAL   PLoS Genet 13 (11), e1007072 (2017)
   PUBMED   29117179
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2274)
  AUTHORS   Archambaud,C., Nahori,M.A., Soubigou,G., Becavin,C., Laval,L.,
            Lechat,P., Smokvina,T., Langella,P., Lecuit,M. and Cossart,P.
  TITLE     Impact of lactobacilli on orally acquired listeriosis
  JOURNAL   Proc Natl Acad Sci U S A 109 (41), 16684-16689 (2012)
   PUBMED   23012479
REFERENCE   3  (bases 1 to 2274)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   4  (bases 1 to 2274)
  AUTHORS   Lin,R.J., Yu,H.P., Chang,B.L., Tang,W.C., Liao,C.L. and Lin,Y.L.
  TITLE     Distinct antiviral roles for human 2',5'-oligoadenylate synthetase
            family members against dengue virus infection
  JOURNAL   J Immunol 183 (12), 8035-8043 (2009)
   PUBMED   19923450
REFERENCE   5  (bases 1 to 2274)
  AUTHORS   Perelygin,A.A., Zharkikh,A.A., Scherbik,S.V. and Brinton,M.A.
  TITLE     The mammalian 2'-5' oligoadenylate synthetase gene family: evidence
            for concerted evolution of paralogous Oas1 genes in Rodentia and
            Artiodactyla
  JOURNAL   J Mol Evol 63 (4), 562-576 (2006)
   PUBMED   17024523
REFERENCE   6  (bases 1 to 2274)
  AUTHORS   Sarkar,S.N., Kessler,S.P., Rowe,T.M., Pandey,M., Ghosh,A.,
            Elco,C.P., Hartmann,R., Pal,S. and Sen,G.C.
  TITLE     Natural mutations in a 2'-5' oligoadenylate synthetase transgene
            revealed residues essential for enzyme activity
  JOURNAL   Biochemistry 44 (18), 6837-6843 (2005)
   PUBMED   15865429
REFERENCE   7  (bases 1 to 2274)
  AUTHORS   Kakuta,S., Shibata,S. and Iwakura,Y.
  TITLE     Genomic structure of the mouse 2',5'-oligoadenylate synthetase gene
            family
  JOURNAL   J Interferon Cytokine Res 22 (9), 981-993 (2002)
   PUBMED   12396720
REFERENCE   8  (bases 1 to 2274)
  AUTHORS   Hartmann,R., Walko,G. and Justesen,J.
  TITLE     Inhibition of 2'-5' oligoadenylate synthetase by divalent metal
            ions
  JOURNAL   FEBS Lett 507 (1), 54-58 (2001)
   PUBMED   11682059
REFERENCE   9  (bases 1 to 2274)
  AUTHORS   Sarkar,S.N., Ghosh,A., Wang,H.W., Sung,S.S. and Sen,G.C.
  TITLE     The nature of the catalytic domain of 2'-5'-oligoadenylate
            synthetases
  JOURNAL   J Biol Chem 274 (36), 25535-25542 (1999)
   PUBMED   10464285
REFERENCE   10 (bases 1 to 2274)
  AUTHORS   Sarkar,S.N., Bandyopadhyay,S., Ghosh,A. and Sen,G.C.
  TITLE     Enzymatic characteristics of recombinant medium isozyme of 2'-5'
            oligoadenylate synthetase
  JOURNAL   J Biol Chem 274 (3), 1848-1855 (1999)
   PUBMED   9880569
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY230746.1.
            
            On Jan 13, 2005 this sequence version replaced XM_344120.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY230746.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06621351, SAMN06680440
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2274              AY230746.1         1-2274
FEATURES             Location/Qualifiers
     source          1..2274
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     gene            1..2274
                     /gene="Oas2"
                     /note="2'-5' oligoadenylate synthetase 2"
                     /db_xref="GeneID:363938"
                     /db_xref="RGD:1359697"
     exon            1..322
                     /gene="Oas2"
                     /inference="alignment:Splign:2.1.0"
     CDS             41..2242
                     /gene="Oas2"
                     /EC_number="2.7.7.84"
                     /note="2'-5'-oligoadenylate synthetase 2, 69/71kDa; 2-5A
                     synthase 2; (2-5')oligo(A) synthase 2"
                     /codon_start=1
                     /product="2'-5'-oligoadenylate synthase 2"
                     /protein_id="NP_001009715.1"
                     /db_xref="GeneID:363938"
                     /db_xref="RGD:1359697"
                     /translation="MGNWMPGWSSSGSLGVPPMPVQKLEKSVQVNLEPDEKCLSQTEV
                     SSVPSQKLEEYIQANLKPDEESLKQIDQAVDAISDLLCSEVMIDVLKVVKGGSYGRKT
                     VLRDCSDGTLVLFTGLFKQFQDQKKYQDKLLDLIEQRLKSHEKYKKSVKRKLSLLEVQ
                     VSIPGQSILLQLLPTFNPLCISENPSAQVYQNLKRSMDQVKASPGEFSDCFTTLQQRF
                     FEKYPGRLKDLILLVKHWYKQLQDKWIIPSPPPLLYALELLTVYAWEQGCQTKDFDIT
                     QGIRTVLQLISQPTNLCVYWLDNYNFEDETVRNNLLHQLNSPRPVILDPTDPTNNVGK
                     DDRFWQLLAEEAQEWLNSLRLNKPHKPCWDVLPMPFFITPSHCLDKFIKDFLQPDKVF
                     LNQIKRAVDIICSFLKETCFQNSDIKVLKIIKGGSTAKGTALQQRSDADIIVFLSSLD
                     SYDSLETERSQYVQEIRKQLEACQKAFNLGVKFDISKWMAPRVLSFTLESKSLKQSVE
                     FDVLPAYDALGQLRSDYTSRLKAYKKLIELYASQDSLKGGEFSVCFTELQRDFIETRP
                     TKLKGLIRLIKHWYKQCERKMKPKASLPPKYALELLTVYAWEHGSGTDGFDTAEGFRT
                     VLDLVIRYRQLCVFWTVNYNFEEDHMRKFLLTQIQKKRPVILDPADPTGDVGGGDRWC
                     WHLLAKEAKEWLSSSCFQVEPKSPVQPWKVPVVQTPGSCGAQIYPVVGGVY"
     exon            323..578
                     /gene="Oas2"
                     /inference="alignment:Splign:2.1.0"
     exon            579..757
                     /gene="Oas2"
                     /inference="alignment:Splign:2.1.0"
     exon            758..996
                     /gene="Oas2"
                     /inference="alignment:Splign:2.1.0"
     exon            997..1138
                     /gene="Oas2"
                     /inference="alignment:Splign:2.1.0"
     exon            1139..1312
                     /gene="Oas2"
                     /inference="alignment:Splign:2.1.0"
     exon            1313..1595
                     /gene="Oas2"
                     /inference="alignment:Splign:2.1.0"
     exon            1596..1786
                     /gene="Oas2"
                     /inference="alignment:Splign:2.1.0"
     exon            1787..2025
                     /gene="Oas2"
                     /inference="alignment:Splign:2.1.0"
     exon            2026..2179
                     /gene="Oas2"
                     /inference="alignment:Splign:2.1.0"
     exon            2180..2274
                     /gene="Oas2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtgctctgc ctctgtcatt cacaagccca gctagcaact atgggaaact ggatgcctgg
       61 ctggtcatcc agtgggtctt tgggggtgcc ccccatgcca gtgcagaagc tagaaaagtc
      121 tgtccaggta aaccttgaac cagatgaaaa atgtctgagt cagaccgagg tgtcctctgt
      181 accatcccag aagctagaag aatatatcca ggcaaacctc aaacccgatg aagaatctct
      241 gaagcagata gaccaggctg tggatgccat ctctgacctg ctgtgcagtg aggtgatgat
      301 cgatgtgctg aaagtggtta agggtggctc ctatggtcgg aaaacagtcc taagagactg
      361 ctccgatggt acacttgttc tcttcaccgg tctcttcaaa cagttccaag accagaagaa
      421 ataccaagat aagctccttg acttgattga acaacggctg aaaagccatg agaaatacaa
      481 gaagtcagta aaacgtaaac ttagcctcct tgaagtacaa gtgtctatac cagggcagag
      541 tatactcttg cagttgcttc caaccttcaa tcctctgtgc atcagtgaga atcccagcgc
      601 ccaggtctat cagaatctca aaagatccat ggatcaagta aaagcatcac ctggggaatt
      661 ctcagactgc ttcaccacac tgcagcagag gtttttcgag aaatatcccg ggagactgaa
      721 ggatttgatt ctattggtca agcactggta taaacagttg caggataagt ggataatacc
      781 ctcacctccg ccattgctat atgcactgga gctgcttact gtgtatgcct gggaacaggg
      841 ctgccagact aaagactttg acatcacgca aggtatcagg actgtgctgc aactcatcag
      901 tcagccgaca aacctgtgtg tctactggtt agacaattac aactttgagg atgagacagt
      961 ccggaacaac cttctgcacc agctcaactc cccaagaccg gtcatcttgg atccaaccga
     1021 cccaaccaac aatgtgggca aagatgacag gttctggcag ctactggcag aagaggctca
     1081 ggagtggctg aactctctca gactgaataa gccacacaaa ccatgttggg atgttctgcc
     1141 catgccattt ttcatcaccc caagccactg cctggacaag ttcatcaaag acttcctcca
     1201 acctgacaag gtcttcctaa accaaatcaa aagagctgtt gacattatct gttcattctt
     1261 aaaagagacc tgcttccaga attctgacat caaagtcctg aagatcatca agggaggatc
     1321 cactgccaaa ggcacagctc tgcagcagag atcagatgct gacatcatag tgttcctcag
     1381 ctcactggat agttatgact ccctagaaac tgaacgctcc cagtacgtcc aggagatccg
     1441 aaagcagtta gaagcctgcc agaaggcctt taatttaggg gtgaagtttg atatttccaa
     1501 atggatggcc cccagggtgc tgagttttac cctggaatcc aagagtctca agcaaagtgt
     1561 ggagttcgat gtccttcccg cctatgatgc actaggtcag ctgcggtctg actacacctc
     1621 caggctcaaa gcctacaaga agctcattga gctgtatgcc tcacaggaca gcctcaaagg
     1681 aggggagttt tcagtctgtt ttacagagct acagagagac ttcattgaaa ccaggcccac
     1741 caaactcaag ggtctgatcc gcctgatcaa gcactggtac aaacagtgtg aaaggaagat
     1801 gaagccaaaa gcatctttgc ctccaaagta cgcactggag ctgctcaccg tgtatgcgtg
     1861 ggagcatggc agtggcacag atggcttcga cactgctgaa ggcttccgga ccgtcctgga
     1921 cttggtcata agataccggc agctctgcgt cttctggaca gtcaattaca actttgagga
     1981 ggatcacatg aggaagttcc tactgaccca gatccagaaa aagaggcctg tgatcctgga
     2041 tccagcagat cccacaggtg atgtgggagg aggtgaccgc tggtgttggc atcttctagc
     2101 caaagaagca aaggagtggc tgtcctcctc ctgtttccaa gtggagccaa aaagccccgt
     2161 gcagccgtgg aaagtaccag tagtacagac tccaggaagc tgtggagctc agatctaccc
     2221 tgtggtgggt ggggtgtact aagagagtgc attcagctct ggagggaaaa tgct
//
