LOCUS       NM_138913               1400 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus 2'-5' oligoadenylate synthetase 1A (Oas1a), mRNA.
ACCESSION   NM_138913
VERSION     NM_138913.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1400)
  AUTHORS   Leisching,G., Cole,V., Ali,A.T. and Baker,B.
  TITLE     OAS1, OAS2 and OAS3 restrict intracellular M. tb replication and
            enhance cytokine secretion
  JOURNAL   Int J Infect Dis 80S, S77-S84 (2019)
   PUBMED   30822544
REFERENCE   2  (bases 1 to 1400)
  AUTHORS   Sarmiento,L., Frisk,G., Anagandula,M., Hodik,M., Barchetta,I.,
            Netanyah,E., Cabrera-Rode,E. and Cilio,C.M.
  TITLE     Echovirus 6 Infects Human Exocrine and Endocrine Pancreatic Cells
            and Induces Pro-Inflammatory Innate Immune Response
  JOURNAL   Viruses 9 (2), 25 (2017)
   PUBMED   28146100
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1400)
  AUTHORS   Kim,S., Kim,M.J., Park,D.Y., Chung,H.J., Kim,C.H., Yoon,J.H. and
            Kim,H.J.
  TITLE     Mitochondrial reactive oxygen species modulate innate immune
            response to influenza A virus in human nasal epithelium
  JOURNAL   Antiviral Res 119, 78-83 (2015)
   PUBMED   25930096
REFERENCE   4  (bases 1 to 1400)
  AUTHORS   Go,M.J., Hwang,J.Y., Kim,Y.J., Hee Oh,J., Kim,Y.J., Heon Kwak,S.,
            Soo Park,K., Lee,J., Kim,B.J., Han,B.G., Cho,M.C., Cho,Y.S. and
            Lee,J.Y.
  TITLE     New susceptibility loci in MYL2, C12orf51 and OAS1 associated with
            1-h plasma glucose as predisposing risk factors for type 2 diabetes
            in the Korean population
  JOURNAL   J Hum Genet 58 (6), 362-365 (2013)
   PUBMED   23575436
REFERENCE   5  (bases 1 to 1400)
  AUTHORS   Donovan,J., Dufner,M. and Korennykh,A.
  TITLE     Structural basis for cytosolic double-stranded RNA surveillance by
            human oligoadenylate synthetase 1
  JOURNAL   Proc Natl Acad Sci U S A 110 (5), 1652-1657 (2013)
   PUBMED   23319625
REFERENCE   6  (bases 1 to 1400)
  AUTHORS   Hartmann,R., Walko,G. and Justesen,J.
  TITLE     Inhibition of 2'-5' oligoadenylate synthetase by divalent metal
            ions
  JOURNAL   FEBS Lett 507 (1), 54-58 (2001)
   PUBMED   11682059
REFERENCE   7  (bases 1 to 1400)
  AUTHORS   Truve,E., Aaspollu,A., Honkanen,J., Puska,R., Mehto,M., Hassi,A.,
            Teeri,T.H., Kelve,M., Seppanen,P. and Saarma,M.
  TITLE     Transgenic potato plants expressing mammalian 2'-5' oligoadenylate
            synthetase are protected from potato virus X infection under field
            conditions
  JOURNAL   Biotechnology (N Y) 11 (9), 1048-1052 (1993)
   PUBMED   7764002
REFERENCE   8  (bases 1 to 1400)
  AUTHORS   Shiojiri,S., Fukunaga,R., Ichii,Y. and Sokawa,Y.
  TITLE     Structure and expression of a cloned cDNA for human
            (2'-5')oligoadenylate synthetase
  JOURNAL   J Biochem 99 (5), 1455-1464 (1986)
   PUBMED   3754863
REFERENCE   9  (bases 1 to 1400)
  AUTHORS   Wathelet,M., Moutschen,S., Cravador,A., DeWit,L., Defilippi,P.,
            Huez,G. and Content,J.
  TITLE     Full-length sequence and expression of the 42 kDa 2-5A synthetase
            induced by human interferon
  JOURNAL   FEBS Lett 196 (1), 113-120 (1986)
   PUBMED   3753689
REFERENCE   10 (bases 1 to 1400)
  AUTHORS   Shimizu,N. and Sokawa,Y.
  TITLE     (2'-5')Oligoadenylate synthetase in pig spleen: isolation and
            characterization
  JOURNAL   J Biochem 94 (5), 1421-1428 (1983)
   PUBMED   6654863
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            [WARNING] On Mar 12, 2025 this sequence was replaced by
            NM_138913.3.
            
            On Nov 27, 2020 this sequence version replaced NM_138913.1.
            
            Sequence Note: This sequence has been modified as follows: removed
            18 bp suspected to be vector contamination from the 5' end.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Z18877.1, SRR26643429.43390.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMN06621351
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-230               JAXUCZ010000012.1  41330466-41330695
            231-519             JAXUCZ010000012.1  41332063-41332351
            520-704             JAXUCZ010000012.1  41334998-41335182
            705-937             JAXUCZ010000012.1  41338519-41338751
            938-1091            JAXUCZ010000012.1  41339378-41339531
            1092-1400           JAXUCZ010000012.1  41340818-41341126
FEATURES             Location/Qualifiers
     source          1..1400
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     gene            1..1400
                     /gene="Oas1a"
                     /gene_synonym="Oas1; Oas1g"
                     /note="2'-5' oligoadenylate synthetase 1A"
                     /db_xref="GeneID:192281"
                     /db_xref="RGD:621760"
     exon            1..230
                     /gene="Oas1a"
                     /gene_synonym="Oas1; Oas1g"
                     /inference="alignment:Splign:2.1.0"
     CDS             48..1124
                     /gene="Oas1a"
                     /gene_synonym="Oas1; Oas1g"
                     /EC_number="2.7.7.84"
                     /note="2'-5'-oligoadenylate synthetase 1;
                     2'-5'-oligoadenylate synthase 1; 2'-5' oligoadenylate
                     synthetase 1G; 2-5A synthetase 1; (2-5')oligo(A)
                     synthetase 1; 2-5A synthase 1; (2-5')oligo(A) synthase 1;
                     2',5'-oligoadenylate synthetase 1, 40/46kDa; 25
                     oligoadenylate synthetase; 2-5A synthase 1A;
                     (2-5')oligo(A) synthase 1A"
                     /codon_start=1
                     /product="2'-5'-oligoadenylate synthase 1A"
                     /protein_id="NP_620268.2"
                     /db_xref="GeneID:192281"
                     /db_xref="RGD:621760"
                     /translation="MEQELRSTPSWKLDKFIEVYLLPNTSFRDDVKSAINVLCDFLKE
                     RCFRDTVHPVRVSKVVKGGSSGKGTTLKGKSDADLVVFLNNFTSFEDQLNRRGEFIKE
                     IKKQLYEVQREKHFRVKFEVQSSWWPNPRALSFKLSAPHLQQEVEFDVLPAYDVLGHV
                     SLYSNPDPKIYTILISECISLGKEGEFSTCFTELQRNFLKQRPTKLKSLIRLVKHWYQ
                     LCKEKLGKPLPPQYALELLTVYAWERGNGITEFNTAQGFRTILELVTKYQQLRIYWTK
                     YYDFQHPDVSKYLHRQLRKSRPVILDPADPTGNVAGGNQEGWRRLASEARLWLQYPCF
                     MNRGGSPVSSWEVPVDEAWSCILL"
     exon            231..519
                     /gene="Oas1a"
                     /gene_synonym="Oas1; Oas1g"
                     /inference="alignment:Splign:2.1.0"
     exon            520..704
                     /gene="Oas1a"
                     /gene_synonym="Oas1; Oas1g"
                     /inference="alignment:Splign:2.1.0"
     exon            705..937
                     /gene="Oas1a"
                     /gene_synonym="Oas1; Oas1g"
                     /inference="alignment:Splign:2.1.0"
     exon            938..1091
                     /gene="Oas1a"
                     /gene_synonym="Oas1; Oas1g"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1400
                     /gene="Oas1a"
                     /gene_synonym="Oas1; Oas1g"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgagacaca ggacctgcag gctgcagagg caaaagctcc ggaggtcatg gagcaggaac
       61 tcaggagcac cccgtcctgg aagctggaca agttcataga ggtttacctc cttccaaaca
      121 ccagcttccg tgatgatgtc aaatcagcta tcaatgtcct gtgtgatttc ctgaaggaga
      181 gatgcttccg agatactgtc cacccagtga gggtctccaa ggtggtgaag ggcggctcct
      241 caggcaaagg caccacactc aagggcaagt cagacgctga cctggtggtg ttccttaaca
      301 atttcaccag ctttgaggat cagttaaaca gacggggaga gttcatcaag gaaattaaga
      361 aacagctgta tgaggttcag cgtgaaaaac attttagagt gaagtttgag gtccagagtt
      421 catggtggcc caacccccgg gctctgagct tcaagctgag tgcaccacac ctccaacagg
      481 aggtggagtt tgatgtgctt ccagcctatg atgtcctagg tcatgttagc ctctacagca
      541 atcctgatcc caagatctac accatcctca tctccgaatg tatctccctg gggaaggagg
      601 gcgagttctc tacctgcttc acggagctcc agaggaactt cctgaagcag cgcccaacca
      661 agcttaagag tctcatccgc ctggtcaagc actggtacca actgtgtaag gagaagctgg
      721 ggaagccgct gcccccacag tacgccctgg agctgctcac ggtctatgcc tgggaacgtg
      781 gaaatggaat tactgagttc aacacagctc agggcttccg gacaatcttg gaactggtca
      841 caaagtacca gcagcttcga atctactgga caaagtatta tgactttcaa cacccagatg
      901 tctccaaata cctacacaga cagctcagaa aatccaggcc tgtgatcctg gaccctgctg
      961 acccaacagg gaacgtggct ggtgggaacc aagaaggctg gcggcggttg gcctcagagg
     1021 cgaggctgtg gctgcagtac ccatgtttta tgaacagggg tggttcccca gtgagctcct
     1081 gggaagtgcc ggtggatgag gcctggtcat gcatcctgct gtgaacccag cagcaccagc
     1141 ccaggaggct ccggagtcag gggcacgtgc tgctctgctg caggaccttg acacagtgag
     1201 ggagggcccc actcgggatc acagtccatg cttctgatgc ccgcccgcca tgtttgaata
     1261 ctgtccaatc acagacagcc ttcctcaaca gattcagaag gggcggaaag aactcaagct
     1321 tgacttccat ctgaccgtcc acctgttggg aggttctgtc caaccatgtc tgtcaacaac
     1381 aataaagtac agcaggtgcc
//
