LOCUS       NM_012994               2500 bp    mRNA    linear   ROD 06-OCT-2024
DEFINITION  Rattus norvegicus neurexophilin 1 (Nxph1), mRNA.
ACCESSION   NM_012994
VERSION     NM_012994.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2500)
  AUTHORS   Esclassan,F., Francois,J., Phillips,K.G., Loomis,S. and Gilmour,G.
  TITLE     Phenotypic characterization of nonsocial behavioral impairment in
            neurexin 1alpha knockout rats
  JOURNAL   Behav Neurosci 129 (1), 74-85 (2015)
   PUBMED   25420124
  REMARK    GeneRIF: NRXN1alpha KO rats were found to present with large and
            persistent nonsocial deficits, including hyperactivity, deficits in
            simple instrumental learning, latent inhibition, and
            spatial-dependent learning.
REFERENCE   2  (bases 1 to 2500)
  AUTHORS   Reissner,C., Stahn,J., Breuer,D., Klose,M., Pohlentz,G., Mormann,M.
            and Missler,M.
  TITLE     Dystroglycan binding to alpha-neurexin competes with
            neurexophilin-1 and neuroligin in the brain
  JOURNAL   J Biol Chem 289 (40), 27585-27603 (2014)
   PUBMED   25157101
  REMARK    GeneRIF: Dystroglycan binding to alpha-neurexin competes with
            neurexophilin-1 and neuroligin in the brain.
REFERENCE   3  (bases 1 to 2500)
  AUTHORS   Clarris,H.J., McKeown,S. and Key,B.
  TITLE     Expression of neurexin ligands, the neuroligins and the
            neurexophilins, in the developing and adult rodent olfactory bulb
  JOURNAL   Int J Dev Biol 46 (4), 649-652 (2002)
   PUBMED   12141453
  REMARK    GeneRIF: Study on the expression of NXPH1 in the developing and
            adult olfactory bulb
REFERENCE   4  (bases 1 to 2500)
  AUTHORS   Missler,M., Hammer,R.E. and Sudhof,T.C.
  TITLE     Neurexophilin binding to alpha-neurexins. A single LNS domain
            functions as an independently folding ligand-binding unit
  JOURNAL   J Biol Chem 273 (52), 34716-34723 (1998)
   PUBMED   9856994
REFERENCE   5  (bases 1 to 2500)
  AUTHORS   Petrenko,A.G., Ullrich,B., Missler,M., Krasnoperov,V., Rosahl,T.W.
            and Sudhof,T.C.
  TITLE     Structure and evolution of neurexophilin
  JOURNAL   J Neurosci 16 (14), 4360-4369 (1996)
   PUBMED   8699246
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC105770.1.
            
            On Oct 9, 2005 this sequence version replaced NM_012994.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC105770.1, CB786646.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132303, SAMD00132304
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2500
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q21"
     gene            1..2500
                     /gene="Nxph1"
                     /note="neurexophilin 1"
                     /db_xref="GeneID:25501"
                     /db_xref="RGD:3218"
     exon            1..336
                     /gene="Nxph1"
                     /inference="alignment:Splign:2.1.0"
     exon            337..500
                     /gene="Nxph1"
                     /inference="alignment:Splign:2.1.0"
     CDS             447..1262
                     /gene="Nxph1"
                     /note="neurophilin"
                     /codon_start=1
                     /product="neurexophilin-1 precursor"
                     /protein_id="NP_037126.1"
                     /db_xref="GeneID:25501"
                     /db_xref="RGD:3218"
                     /translation="MQAACWYVLLLLQPTVYLVTCANLTNGGKSELLKSGNSKSTLKH
                     IWTESSKDLSISRLLSQTFRGKENGTDLDLRYDTPEPYSEQDLWDWLRNSTDLQEPRP
                     RAKRRPIVKTGKFKKMFGWGDFHSNIKTVKLNLLITGKIVDHGNGTFSVYFRHNSTGQ
                     GNVSVSLVPPTKIVEFDLAQQTVIDAKDSKSFNCRIEYEKVDKATKNTLCNYDPSKTC
                     YQEQTQSHVSWLCSKPFKVICIYISFYSTDYKLVQKVCPDYNYHSDTPYFPSG"
     exon            501..2455
                     /gene="Nxph1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagcaacccg gcgcattcgt ctctctccct ttcttccttt ctccgtcgtc ttctctacct
       61 gcccctcctt ctcttgcctc ttaagtttcc tgcaccggga atccaactgt gccaagccta
      121 ggctcccgcg gatcaatcct gatcgcgacc ggggcactgg gacaacgact ctgccaaggc
      181 tggacgaggc agctggaccg gtcctcgccc gagcatggag acggagctcc agggagggca
      241 cgtcccgggc gctggagact ccaggccata gtcgctcctc catggagcct gttcagagcg
      301 gtctctgctc gctgcatttg cctccagtcc tgtgcggctg ctgagagcgc tccctgctct
      361 gtaaagtgga tgtcaggtgg atctatgttt ttgaaggaac aaagactcag ccaaggcacc
      421 gccaaggaag tttgagagga gggaggatgc aggctgcgtg ctggtacgtt cttcttctcc
      481 tgcagcccac cgtctacttg gtcacgtgtg ccaatctaac aaatggtgga aagtcggaac
      541 ttctgaagtc aggaaacagc aagtctacac taaaacacat atggacagaa agcagcaaag
      601 acttgtctat cagtcggctc ctctcacaga ctttccgtgg taaagaaaat ggcacagatt
      661 tggacctgcg ctatgacacc ccagaacctt attccgagca agacctctgg gactggttga
      721 ggaactccac agatcttcag gagcctcggc ccagggccaa aagacggccc attgttaaaa
      781 ccggcaagtt taagaaaatg ttcggatggg gtgattttca ttccaacatc aaaacagtga
      841 agctaaacct gttgataact gggaaaattg tagatcatgg caatggaacg tttagtgtgt
      901 atttcaggca taattccact ggtcaaggga atgtatctgt cagcctggtg cccccaacaa
      961 aaattgtgga attcgatttg gcacaacaaa ccgtgattga tgccaaagat tccaagtcct
     1021 tcaactgtcg tattgaatat gagaaggttg acaaggccac caagaacaca ctctgcaact
     1081 acgacccttc aaaaacctgt taccaggagc agacccaaag tcacgtgtcc tggctctgct
     1141 ctaagccctt caaggtgatc tgtatttaca tttcctttta tagtacagac tataaactag
     1201 tacagaaagt atgccctgac tacaactacc acagtgacac accttacttc ccctccggat
     1261 gaagacgaac agggcatgag actgaagcct gaggaattac aggtcatagg acagggctgt
     1321 taccttaagg aagaaggtca catctgttgc ctggaatgtg tctacactgc tgctcttgtt
     1381 gactggtgcg aacatgctag tggaaaacaa ttgatgtaat ttctgcacag tcagcttcat
     1441 ctctcagcat agttgtaaat caccatagct ctcagagtct catctgaaga catgctgtca
     1501 ctgtagagac acatgagcac ccactcctgc acatttcagc tcacatctat catggtaccc
     1561 tttgagaggg ctttcattgt cttgactcat gatggttcag gataaactat gatcaaacac
     1621 aaagaattaa ctagacagag gatgtatcta acatgccgtt atggaaatct cttttaaggt
     1681 cttgagtcca tgctaatcaa tagtccccac tcatgcattc ctactgcttg gagtagctgt
     1741 gctggtgaat actactgtag gagttatatg cttgttaaat ggaaaaaaat gtgtctttag
     1801 agctcagtat tctttatttt atgaacacaa cacagtgtag tagctttttc ccagcataca
     1861 gtaggcacat tcaaggtgat acaggatggc ttttctttct gtggagggag gagcttgttc
     1921 tgagtaaaga tgagcaaaca tttggaattt acatgtgggc agacactggg aattacagct
     1981 tttcttgcct atcaccggac ctttgcaatg ttgagaccaa ctaaggctgc ttaacacaag
     2041 ttctgatcat tatataagaa ggaaaatgcc gggcagacac catgtaagtt ataagtgtct
     2101 gtcttatctt tactacacat attgtaacaa actcaatatc ctagtcttca tttgtatgaa
     2161 tggtttgtac tgtatatagt ttaaccaagt gttatttgag ctgcttatta atattaaatt
     2221 gtacttgtct ctctgcttgt tattggttaa aaagaaaaaa ggatctaagg aatcaatttt
     2281 atcaatgtag ctgtgaactc cattaaaaaa agacaaattt aatatacaaa gcatctattc
     2341 agctcaagta ttgttgaaag ctatacatat acaacattac actgtctgta tttagatatt
     2401 ttatttctgg aaaaaatgta cataaaaata aaaccgttaa agttgagttt caataaaaaa
     2461 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
//
