LOCUS       NP_001163900             156 aa            linear   ROD 31-MAR-2024
DEFINITION  nucleoredoxin-like protein 2 [Rattus norvegicus].
ACCESSION   NP_001163900 XP_001054275 XP_001070068
VERSION     NP_001163900.1
DBSOURCE    REFSEQ: accession NM_001170429.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 156)
  AUTHORS   Wolloscheck,T., Kunst,S., Kelleher,D.K. and Spessert,R.
  TITLE     Transcriptional regulation of nucleoredoxin-like genes takes place
            on a daily basis in the retina and pineal gland of rats
  JOURNAL   Vis Neurosci 32, E002 (2015)
   PUBMED   26239254
  REMARK    GeneRIF: This study demonstrated that the Nxnl2 were seen to
            display daily rhythms with steadily increasing values during the
            light phase and peak expression around dark onset in preparations
            of whole retina.
REFERENCE   2  (residues 1 to 156)
  AUTHORS   Jaillard,C., Mouret,A., Niepon,M.L., Clerin,E., Yang,Y.,
            Lee-Rivera,I., Ait-Ali,N., Millet-Puel,G., Cronin,T., Sedmak,T.,
            Raffelsberger,W., Kinzel,B., Trembleau,A., Poch,O., Bennett,J.,
            Wolfrum,U., Lledo,P.M., Sahel,J.A. and Leveillard,T.
  TITLE     Nxnl2 splicing results in dual functions in neuronal cell survival
            and maintenance of cell integrity
  JOURNAL   Hum Mol Genet 21 (10), 2298-2311 (2012)
   PUBMED   22343139
REFERENCE   3  (residues 1 to 156)
  AUTHORS   Chalmel,F., Leveillard,T., Jaillard,C., Lardenois,A., Berdugo,N.,
            Morel,E., Koehl,P., Lambrou,G., Holmgren,A., Sahel,J.A. and Poch,O.
  TITLE     Rod-derived Cone Viability Factor-2 is a novel
            bifunctional-thioredoxin-like protein with therapeutic potential
  JOURNAL   BMC Mol Biol 8, 74 (2007)
   PUBMED   17764561
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000017.1.
            
            On or before Dec 19, 2009 this sequence version replaced
            XP_001070068.1, XP_001054275.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22582416.820066.1,
                                           SRR22582416.1467649.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760433, SAMEA5760434
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..156
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p14"
     Protein         1..156
                     /product="nucleoredoxin-like protein 2"
                     /EC_number="1.8.1.8"
                     /calculated_mol_wt=17590
     Region          10..144
                     /region_name="TryX_like_family"
                     /note="Tryparedoxin (TryX)-like family; composed of TryX
                     and related proteins including nucleoredoxin (NRX),
                     rod-derived cone viability factor (RdCVF) and the nematode
                     homolog described as a 16-kD class of TRX. Most members of
                     this family, except RdCVF, are...; cd02964"
                     /db_xref="CDD:239262"
     Site            order(38,41)
                     /site_type="active"
                     /note="catalytic residues [active]"
                     /db_xref="CDD:239262"
     CDS             1..156
                     /gene="Nxnl2"
                     /gene_synonym="Rdcvf2"
                     /coded_by="NM_001170429.1:1..471"
                     /db_xref="GeneID:689232"
                     /db_xref="RGD:1594820"
ORIGIN      
        1 mvdvlggrrl mtregtlvea eaalqnkvva lyfaagrcap srdftpllcd fytelvsear
       61 rpapfevvfv sadrsaeeml dfmrelhgsw lalpfhdpyr helkkrydit vipkvvvikq
      121 ngavitnkgr kqirerglac fqnwveaadv fqnfsg
//
