LOCUS       NM_001399571            2710 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus nucleoredoxin (Nxn), mRNA.
ACCESSION   NM_001399571 XM_006246907
VERSION     NM_001399571.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2710)
  AUTHORS   White,J.J., Mazzeu,J.F., Coban-Akdemir,Z., Bayram,Y.,
            Bahrambeigi,V., Hoischen,A., van Bon,B.W.M., Gezdirici,A.,
            Gulec,E.Y., Ramond,F., Touraine,R., Thevenon,J., Shinawi,M.,
            Beaver,E., Heeley,J., Hoover-Fong,J., Durmaz,C.D., Karabulut,H.G.,
            Marzioglu-Ozdemir,E., Cayir,A., Duz,M.B., Seven,M., Price,S.,
            Ferreira,B.M., Vianna-Morgante,A.M., Ellard,S., Parrish,A.,
            Stals,K., Flores-Daboub,J., Jhangiani,S.N., Gibbs,R.A.,
            Brunner,H.G., Sutton,V.R., Lupski,J.R. and Carvalho,C.M.B.
  CONSRTM   Baylor-Hopkins Center for Mendelian Genomics
  TITLE     WNT Signaling Perturbations Underlie the Genetic Heterogeneity of
            Robinow Syndrome
  JOURNAL   Am J Hum Genet 102 (1), 27-43 (2018)
   PUBMED   29276006
REFERENCE   2  (bases 1 to 2710)
  AUTHORS   Wilson,R., Geyer,S.H., Reissig,L., Rose,J., Szumska,D., Hardman,E.,
            Prin,F., McGuire,C., Ramirez-Solis,R., White,J., Galli,A.,
            Tudor,C., Tuck,E., Mazzeo,C.I., Smith,J.C., Robertson,E.,
            Adams,D.J., Mohun,T. and Weninger,W.J.
  TITLE     Highly variable penetrance of abnormal phenotypes in embryonic
            lethal knockout mice
  JOURNAL   Wellcome Open Res 1, 1 (2017)
   PUBMED   27996060
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2710)
  AUTHORS   Funato,Y., Terabayashi,T., Sakamoto,R., Okuzaki,D., Ichise,H.,
            Nojima,H., Yoshida,N. and Miki,H.
  TITLE     Nucleoredoxin sustains Wnt/beta-catenin signaling by retaining a
            pool of inactive dishevelled protein
  JOURNAL   Curr Biol 20 (21), 1945-1952 (2010)
   PUBMED   20970343
REFERENCE   4  (bases 1 to 2710)
  AUTHORS   Kurooka,H., Kato,K., Minoguchi,S., Takahashi,Y., Ikeda,J., Habu,S.,
            Osawa,N., Buchberg,A.M., Moriwaki,K., Shisa,H. and Honjo,T.
  TITLE     Cloning and characterization of the nucleoredoxin gene that encodes
            a novel nuclear protein related to thioredoxin
  JOURNAL   Genomics 39 (3), 331-339 (1997)
   PUBMED   9119370
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Jan 12, 2022 this sequence version replaced XM_006246907.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.64276.1,
                                           SRR23984936.82038.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-471               JAXUCZ010000010.1  61745337-61745807   c
            472-589             JAXUCZ010000010.1  61627526-61627643   c
            590-723             JAXUCZ010000010.1  61624146-61624279   c
            724-824             JAXUCZ010000010.1  61623628-61623728   c
            825-931             JAXUCZ010000010.1  61621832-61621938   c
            932-1111            JAXUCZ010000010.1  61613318-61613497   c
            1112-1236           JAXUCZ010000010.1  61611764-61611888   c
            1237-2710           JAXUCZ010000010.1  61607557-61609030   c
FEATURES             Location/Qualifiers
     source          1..2710
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q24"
     gene            1..2710
                     /gene="Nxn"
                     /note="nucleoredoxin"
                     /db_xref="GeneID:360577"
                     /db_xref="RGD:1310489"
     exon            1..471
                     /gene="Nxn"
                     /inference="alignment:Splign:2.1.0"
     CDS             112..1419
                     /gene="Nxn"
                     /EC_number="1.8.1.8"
                     /codon_start=1
                     /product="nucleoredoxin"
                     /protein_id="NP_001386500.1"
                     /db_xref="GeneID:360577"
                     /db_xref="RGD:1310489"
                     /translation="MSVFLEELLGDKLVTGGGEEVDVHSLGARGIALLGLYFGCSLSA
                     PCAQLSASLAAFYSRLRGDAAAGPGAGAGAGAAAEPEPRHRLEIVFVSSDQDQRQWQD
                     FVRDMPWLALPYKEKHRKLKLWNKYRVSNIPSLIFLDATTGKVVCRNGLLVIRDDPEG
                     LEFPWGPKPFREVIAGPLLRNNGQSLESSSLEGSHVGVYFSAHWCPPCRSLTRVLVES
                     YRKIKEAGQKFEIIFVSADRSEESFKQYFSEMPWLAVPYTDEARRSRLNRLYGIQGIP
                     TLIVLDPQGEVITRQGRVEVLNDEDCREFPWHPKPVLELSDSNAVQLNEGPCLVLFVD
                     SEDDGESEAAKQLIQPIAEKIIAKYKAKEEEAPLLFFVAGEDDMTDSLRDYTNLPEAA
                     PLLTILDMSARAKYVMDVEEITPAIVETFVNDFLAEKLKPEPI"
     exon            472..589
                     /gene="Nxn"
                     /inference="alignment:Splign:2.1.0"
     exon            590..723
                     /gene="Nxn"
                     /inference="alignment:Splign:2.1.0"
     exon            724..824
                     /gene="Nxn"
                     /inference="alignment:Splign:2.1.0"
     exon            825..931
                     /gene="Nxn"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1111
                     /gene="Nxn"
                     /inference="alignment:Splign:2.1.0"
     exon            1112..1236
                     /gene="Nxn"
                     /inference="alignment:Splign:2.1.0"
     exon            1237..2710
                     /gene="Nxn"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctctcagcct ccgctgccgc cgctgcctcc gcccgccgcg cggaccagcg agccgggtag
       61 ctgtcgcgag cccacccgcc cgcccgcgtg ccggggctgc ggtgggccag gatgtcggtc
      121 ttcttggagg agctgctggg agacaagctg gtgacgggcg gtggcgagga ggtggacgtg
      181 cactcgctgg gcgcccgcgg catcgcgctg ctggggctct acttcgggtg cagcctgagc
      241 gccccctgcg cgcagctcag cgccagcctg gccgccttct acagccgcct gcgaggggac
      301 gcggcggccg ggccgggggc cggggcgggg gcaggcgcgg ccgcggagcc agagccccgg
      361 caccgcctgg agatcgtctt cgtgtcctcg gaccaagacc agcggcagtg gcaggacttc
      421 gtgcgggaca tgccatggct ggcgctgccc tacaaggaga agcaccggaa gcttaaactt
      481 tggaacaaat accgagtctc caacattcca tcgctaatat tcctagatgc cactactggg
      541 aaggtcgtgt gcaggaacgg gctcctggtg atccgagatg acccagaagg tctggaattc
      601 ccttggggac ctaaaccctt ccgggaagtt atcgctgggc ccttgcttag aaacaacggg
      661 cagtctctgg aaagcagcag ccttgagggg tctcacgtgg gagtctattt ctctgcacac
      721 tggtgtccac cctgccgaag ccttaccaga gtgctggtgg aatcctaccg gaagatcaag
      781 gaggcaggcc agaagtttga gatcatcttt gttagtgcag acaggtcaga ggagtctttc
      841 aaacagtact ttagtgagat gccgtggctc gctgtcccct acactgatga ggcccggcgg
      901 tctcgtctca accgactgta tgggatccaa ggcatcccca cgctcatcgt gctggacccg
      961 cagggggaag tgatcactcg gcagggccgg gtggaggtgc tcaatgacga ggactgcagg
     1021 gagttcccat ggcacccgaa gcccgtgctg gagctctctg actccaacgc tgtgcagctc
     1081 aatgagggtc cctgcctcgt cctttttgta gactctgagg acgatggaga gtctgaggca
     1141 gccaaacagc tgatccagcc aatagctgag aagatcatcg ccaagtacaa agccaaagaa
     1201 gaggaggcgc cgctgttgtt ctttgtggcc ggggaggatg acatgactga ctccctgaga
     1261 gattacacca acctccccga ggcggcacct ttgctcacca ttctggacat gtcagcccgg
     1321 gccaagtacg tgatggatgt agaggagatc accccagcca ttgtggagac ttttgtgaat
     1381 gacttcctag cagaaaagct caaaccagag cccatctagt gggctctggc ctcctgagac
     1441 agtatttaac acagtcttct ccctttcctc ccctctgccc ttggactttt ccagcgtgtc
     1501 ctgaatcaca caacccaagt gtccaacctc tgtggtgcct tgtttctgca ctaacaactc
     1561 agctagcacc caagggtgca catcctcacg gtggcagcag atcccaccgt gtttggagac
     1621 ggcttgggat ccgtgaggat ggcatgacca gctagcacca agactgccac ctctcctggc
     1681 tcctggtgga ggaccttcca gggtcttctg cagagagagc aagtgaggac aatggattga
     1741 ggccctactc tgactctggg atcagtacac acaaccctaa gccagaggga actctcccgt
     1801 gacacccgta cctgtgggag ttacagaagg gccatggcct cagcagacat cagctgagag
     1861 ctgtcggcga ctgctttgta aggacataat ctttcttggt ctaagggaaa accagcgcat
     1921 cagtgggttc ttgggcgggg gacctccaaa tctataagga aactgtgggt gtttgttttg
     1981 gtgggaaaat gaatagccaa gctaacagtt catagaacgc ttactgtgtg attagttact
     2041 tcatcttatc tttctccctt actcttggcc atccccaggt ttctacccat acaaaaacct
     2101 cccactgtcc tggaatttta gtaatgaatt ctccccttgg acaccttccc aagactcaac
     2161 cctgagtccc cacacaagtg ttgcctagct gctgggggct tctctgtggg ccagttctat
     2221 gccagaggca cctgcagtct cgagttccgt tttcttttca aactggatcc aaaaggcgat
     2281 gagcctgtaa aatgggctgt gcttcagaga gcagggaggg cactgggcat gacaaccgga
     2341 gttggccctg acctcctttg cttggcccac gtagctgaac tgacaatgga aacaccagcc
     2401 atgctcttag ggtctgggct ttggtttagg gattcccagg acttaaatct gtcacagtct
     2461 ggtgtcaggg acttcaaagc atctgggcct caccctcagt tccacccaac actttacaag
     2521 cccaaaccat ttattttgca aagcccagtt gtcccctcaa gcccccaaca agctatcgac
     2581 actgctgctc cttgctgaat cggattgttg gcttgtagtt cagaggaaca aaattagttg
     2641 gtaatcactc tattgggtgt tgccagcctg aagtgcaatc acctagaaag aaataaaaca
     2701 gaaaaagcag
//
