LOCUS       NM_001164157            3662 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus NUS1 dehydrodolichyl diphosphate synthase subunit
            (Nus1), mRNA.
ACCESSION   NM_001164157 XM_001058252 XM_215387
VERSION     NM_001164157.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3662)
  AUTHORS   Yang Q, Zhang C, Xie H, Tang L, Liu D, Qiu Q, Luo D, Liu K, Xu JY,
            Tian H, Lu L, Xu GT and Zhang J.
  TITLE     Silencing Nogo-B improves the integrity of blood-retinal barrier in
            diabetic retinopathy via regulating Src, PI3K/Akt and ERK pathways
  JOURNAL   Biochem Biophys Res Commun 581, 96-102 (2021)
   PUBMED   34662809
  REMARK    GeneRIF: Silencing Nogo-B improves the integrity of blood-retinal
            barrier in diabetic retinopathy via regulating Src, PI3K/Akt and
            ERK pathways.
REFERENCE   2  (bases 1 to 3662)
  AUTHORS   Zhang Y, Huo W, Wen Y and Li H.
  TITLE     Silencing Nogo-B receptor inhibits penile corpus cavernosum
            vascular smooth muscle cell apoptosis of rats with diabetic
            erectile dysfunction by down-regulating ICAM-1
  JOURNAL   PLoS One 14 (8), e0220715 (2019)
   PUBMED   31442237
  REMARK    GeneRIF: The results found that capillaries and vascular smooth
            muscle cell content reduced, and nogo-B receptor and ICAM-1 were
            elevated in rats with diabetic erectile dysfunction.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3662)
  AUTHORS   Liu M, Zhao D, Wu X, Guo S, Yan L, Zhao S, Li H, Wang Y and Rong F.
  TITLE     miR-466 and NUS1 Regulate the AKT/Nuclear Factor kappa B (NFkappaB)
            Signaling Pathway in Intrauterine Adhesions in a Rat Model
  JOURNAL   Med Sci Monit 25, 4094-4103 (2019)
   PUBMED   31154456
  REMARK    GeneRIF: NUS1 was upregulated in IUAs tissues, and the high
            expression level of NUS1 was positively correlated with the
            severity of IUAs. NUS1 promoted cell proliferation in vitro. NUS1
            overexpression on cell migration and invasion promoted the EMT
            process in vitro and in vivo.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3662)
  AUTHORS   Grabinska KA, Edani BH, Park EJ, Kraehling JR and Sessa WC.
  TITLE     A conserved C-terminal RXG motif in the NgBR subunit of
            cis-prenyltransferase is critical for prenyltransferase activity
  JOURNAL   J Biol Chem 292 (42), 17351-17361 (2017)
   PUBMED   28842490
REFERENCE   5  (bases 1 to 3662)
  AUTHORS   Jo HN, Kang H, Lee A, Choi J, Chang W, Lee MS and Kim J.
  TITLE     Endothelial miR-26a regulates VEGF-Nogo-B receptor-mediated
            angiogenesis
  JOURNAL   BMB Rep 50 (7), 384-389 (2017)
   PUBMED   28602162
REFERENCE   6  (bases 1 to 3662)
  AUTHORS   Park EJ, Grabinska KA, Guan Z, Stranecky V, Hartmannova H, Hodanova
            K, Baresova V, Sovova J, Jozsef L, Ondruskova N, Hansikova H,
            Honzik T, Zeman J, Hulkova H, Wen R, Kmoch S and Sessa WC.
  TITLE     Mutation of Nogo-B receptor, a subunit of cis-prenyltransferase,
            causes a congenital disorder of glycosylation
  JOURNAL   Cell Metab 20 (3), 448-457 (2014)
   PUBMED   25066056
REFERENCE   7  (bases 1 to 3662)
  AUTHORS   Harrison KD, Miao RQ, Fernandez-Hernando C, Suarez Y, Davalos A and
            Sessa WC.
  TITLE     Nogo-B receptor stabilizes Niemann-Pick type C2 protein and
            regulates intracellular cholesterol trafficking
  JOURNAL   Cell Metab 10 (3), 208-218 (2009)
   PUBMED   19723497
REFERENCE   8  (bases 1 to 3662)
  AUTHORS   Shultz MA, Zhang L, Gu YZ, Baker GL, Fannuchi MV, Padua AM, Gurske
            WA, Morin D, Penn SG, Jovanovich SB, Plopper CG and Buckpitt AR.
  TITLE     Gene expression analysis in response to lung toxicants: I.
            Sequencing and microarray development
  JOURNAL   Am J Respir Cell Mol Biol 30 (3), 296-310 (2004)
   PUBMED   12947022
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB720603.1, BQ782237.1, CK363676.1, CO405351.1, DY312007.1,
            FM091992.1, CF107108.1 and CB718508.1.
            
            On or before Aug 14, 2009 this sequence version replaced
            XM_001058252.1, XM_215387.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CK363676.1, DV214413.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-523               CB720603.1         1-523
            524-1069            BQ782237.1         18-563              c
            1070-1209           CK363676.1         589-728
            1210-1734           CO405351.1         109-633
            1735-2210           DY312007.1         216-691
            2211-2756           FM091992.1         131-676
            2757-3289           CF107108.1         120-652
            3290-3662           CB718508.1         15-387              c
FEATURES             Location/Qualifiers
     source          1..3662
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20q11"
     gene            1..3662
                     /gene="Nus1"
                     /gene_synonym="RGD1307879"
                     /note="NUS1 dehydrodolichyl diphosphate synthase subunit"
                     /db_xref="GeneID:294400"
                     /db_xref="RGD:1307879"
     exon            1..506
                     /gene="Nus1"
                     /gene_synonym="RGD1307879"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..973
                     /gene="Nus1"
                     /gene_synonym="RGD1307879"
                     /EC_number="2.5.1.87"
                     /note="nogo-B receptor; nuclear undecaprenyl pyrophosphate
                     synthase 1 homolog"
                     /codon_start=1
                     /product="dehydrodolichyl diphosphate synthase complex
                     subunit NUS1"
                     /protein_id="NP_001157629.1"
                     /db_xref="GeneID:294400"
                     /db_xref="RGD:1307879"
                     /translation="MTGLYELVWRVLHLLFCLYRTLTSWLRVRFGTWNWIWRRCCRAA
                     SAAVLAPLGFTLRKLPAVGRNRRHHRHPHRGPGPAATHPRLRWRADGRSLQKLPVHMG
                     LVITEEVQEPSFSDIASLVVWCMAVGISYISVYDHQGIFKRNNSRLMDEILKQQQELL
                     GQDCSKYSAEFANSNDKDDQVLNCPSAVKVLSPEDGKADIVRAAQDFCQSVAQQQRRP
                     TELGVELLDSLLSSHGFPDPDLVLKFGPVDSTLGFLPWQIRLTEIISLPSHSNISYED
                     LFSALRQYAACEQRLGK"
     exon            507..632
                     /gene="Nus1"
                     /gene_synonym="RGD1307879"
                     /inference="alignment:Splign:2.1.0"
     exon            633..782
                     /gene="Nus1"
                     /gene_synonym="RGD1307879"
                     /inference="alignment:Splign:2.1.0"
     exon            783..882
                     /gene="Nus1"
                     /gene_synonym="RGD1307879"
                     /inference="alignment:Splign:2.1.0"
     exon            883..3645
                     /gene="Nus1"
                     /gene_synonym="RGD1307879"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tggcccgcgc cggccgctgg ggcggataaa accccgtcgc gccgcgggtg agggccggag
       61 ggaggagact gtgcccgagc gccacaggag tatgacgggg ctgtacgagc tggtgtggcg
      121 ggtgctgcac ttgctgttct gcctgtaccg cacgctcacc tcctggctcc gcgttcgctt
      181 cggcacatgg aactggatct ggcggcgctg ctgtcgcgcc gcctccgccg cggtcctagc
      241 gccgctcggc ttcacgctcc gcaagctccc ggccgtcggc aggaaccggc gtcatcaccg
      301 gcacccgcac cggggaccgg gaccggccgc cacccacccc cggctgcgct ggcgcgcgga
      361 cggccggtcc ctgcagaagc tgccggtgca catgggcctg gtgatcaccg aggaagtgca
      421 agagcccagc ttctcagaca tcgccagcct cgtggtgtgg tgtatggccg tggggatctc
      481 ctacattagc gtctacgacc accaaggtat tttcaagaga aataattcca gattgatgga
      541 tgaaatttta aaacaacagc aggaactttt gggccaagat tgttccaaat actcagcaga
      601 gtttgcaaat agtaacgaca aagacgatca agttttaaat tgcccatcgg cggtgaaggt
      661 gctgtcccca gaagacggaa aagccgacat tgtgcgagcc gcccaggact tttgccagtc
      721 agtagcccag cagcagagga ggccgacgga gctgggtgta gagctgctcg acagcttact
      781 gagttcacat ggcttccctg atcctgactt agtgttgaag tttggtcctg tggacagcac
      841 gttaggcttt cttccctggc aaatcagatt gactgagatc atctctttgc cttctcactc
      901 aaacatcagc tatgaggacc ttttctccgc cctccggcag tatgcagctt gtgaacagcg
      961 tctggggaag taatggtccc tgcttgcata atttgacttc aggcttttgg agaaaaggac
     1021 ccaagtgact gatgtttaca aagtacctat aaaactctgt acacacctag ttcatattcc
     1081 tcataattta tcaacaaaca caaaaaagtg tcttacttga gagcaaatga gtgtgcgtgt
     1141 gtgtgtatgc gtgtgtgtgt gtgtgtgtgt gtgtatgtgt gcgcgcgagc gtgtgtgtgt
     1201 gcgcgtgcgt gtgtgtgtgt gtgtatgcgt gtgtgtgtgt gtgtgtgtgt atgtgtgtgc
     1261 gcgtgcgtgt gtgtgtgcgc gtgcgtgtgt atggaataaa tttataaatg gggcacattg
     1321 gcgaatggag tacacagtct ggggttcaag cgagagctgc ggtgcgtgtc ttaggaactg
     1381 agatttcacg catagaggct tccgttcctg ctacttccct gtttgtctgg ggagtagggg
     1441 gagtaagtag gactgattta gttgtctgtg gtgggtgggg atactttttg ttcagtcttt
     1501 tttagtgacc aaactttaat ttttaagaat aatatattga ttggcttact aaggggaagt
     1561 actctaatct tgagtggcat tcagaggctc tggatgttca catgctgaac atttgcttac
     1621 ccgctgagca aagatttcct cagatttccg tccatttcat ttctttgttc gagtaaacag
     1681 tgtgacttga gaggattgct gtggtgtctg ttctgggcta tagggatcat ttgaaaaaaa
     1741 aaatcttgca atatttgatg tacagaatat aagacattta aatattgaat tagacactca
     1801 aaaaccaaca aagtgaataa acaatcatct aaaagatgga aaatctctta aaggacagtt
     1861 ttgatttcct cctttgtgta aagagtagtg tgctggatag tacccaaagc atttaagaag
     1921 cgtttccatt agctttttat ttaaaaatga acacttgaga gaagttacca cggcagctcg
     1981 cattctgaag taaccggctc ctcttgagcg gcacctgggg ttctctcctc ccagtgagtc
     2041 tcagcgacaa cactgtgatg gttaaaggat ggaggcctgc atcgccaaac tggaagcata
     2101 attgaacctg gtcttctgtg ttctagagaa cagcactggc cctgacagga ttgaattctt
     2161 gataaatggt taatgttttt ttcttacact gctaatctct ggatggaaac cattctttat
     2221 ggatggacag ttttcagaaa acttttacca acaggtatac aagagtcatg aacatttaga
     2281 ataaagcaat ttcaatacta ggcctcagac ttctgaaaaa aagatatcaa aggaaatggg
     2341 tttggaatgt atggtctgga attgcttgtc agactctaaa gaagatgtgt ttcagctttg
     2401 gattacaaac cccatttatg atttttaaat atacttgaaa taaaacgatt aaaatgaatt
     2461 ttggtccagt gacattactt tgcacttctt ttcttttgta caaaatttta aagacttaat
     2521 ttattgccaa aatgctgtgt aaatttacag tgtgtaatct aaaggttgtt agagaactcc
     2581 ccagttctgt tcctctgtgc tgtgtgtggt ctgtgttcct ctggttttat tcctctgggg
     2641 atgggggatg gggcagagtg gtgtgtattt aaggcaattt aaggcctttt ataaatacaa
     2701 taggtataaa tgtcctttat agaccttctg gggtatgcac agctttaata aattaaattt
     2761 actggactca attgaaataa gaggactcaa ggtttgttat aatgaagtgt gtcaaattac
     2821 cctttggaat agagccaaaa tcctagagtt gagtttttat acttccttcc acacaacaaa
     2881 acagattcat agcctatgac ccaagactgt ggccttaggg acagttgttt aagcaagtca
     2941 agtgttctga acttatatat aggccttcca gatcctctca caggaggcca actactaacg
     3001 cagtctctac actttgaaaa gcactgatca gtcttcagtt cctgccaaat caccccaagt
     3061 tagctatcat caaaactctt tgtgctccca aaaacttcgt gtccatgtgt ttcaaagggc
     3121 gttcccttta aatcgtttcc cttgacatgc tccacagtga caaagacacc aagtcaaact
     3181 cactcagcag atggcatggg gcatgtgaag aaatggaggg attaccttcc ttctaaagtc
     3241 cgactgtaga ttgctcccta aaactgaaca gttattgttt gacggtgaaa tgctgatcat
     3301 aatgtgaata gcagattctg gcgtgttgtg actaaggctc gagaatgccc gttctgacaa
     3361 aatgttccaa tattaacgaa cagtgccaaa cacactgtgc atatccatga gtttccatcc
     3421 ggatgtatgt tgattagtta ctcccttctg tgtgacggtc ctatgcttag agtcagtgag
     3481 gtccttgtaa cgtttgttat gcttgtagat tttggcaact tgtaaataat gtgtatagcg
     3541 agtttttatg attaaggaat caaatttatt gaattttatt attgaaagtt gaaataagat
     3601 gtatgaacaa aaaaaatcaa taaaagaata tactcttttc acggaaaaaa aaaaaaaaaa
     3661 aa
//
