LOCUS       NM_031074               6595 bp    mRNA    linear   ROD 11-OCT-2020
DEFINITION  Rattus norvegicus nucleoporin 98 and 96 precursor (Nup98), mRNA.
ACCESSION   NM_031074 XM_001061438 XM_001068584 XM_001068834 XM_574504
VERSION     NM_031074.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6595)
  AUTHORS   Capitanio JS, Montpetit B and Wozniak RW.
  TITLE     Human Nup98 regulates the localization and activity of DExH/D-box
            helicase DHX9
  JOURNAL   Elife 6, e18825 (2017)
   PUBMED   28221134
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6595)
  AUTHORS   Bonnet A and Palancade B.
  TITLE     Regulation of mRNA trafficking by nuclear pore complexes
  JOURNAL   Genes (Basel) 5 (3), 767-791 (2014)
   PUBMED   25184662
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6595)
  AUTHORS   Natalizio BJ and Wente SR.
  TITLE     Postage for the messenger: designating routes for nuclear mRNA
            export
  JOURNAL   Trends Cell Biol 23 (8), 365-373 (2013)
   PUBMED   23583578
  REMARK    Review article
REFERENCE   4  (bases 1 to 6595)
  AUTHORS   Krull S, Dorries J, Boysen B, Reidenbach S, Magnius L, Norder H,
            Thyberg J and Cordes VC.
  TITLE     Protein Tpr is required for establishing nuclear pore-associated
            zones of heterochromatin exclusion
  JOURNAL   EMBO J 29 (10), 1659-1673 (2010)
   PUBMED   20407419
REFERENCE   5  (bases 1 to 6595)
  AUTHORS   Glavy JS, Krutchinsky AN, Cristea IM, Berke IC, Boehmer T, Blobel G
            and Chait BT.
  TITLE     Cell-cycle-dependent phosphorylation of the nuclear pore Nup107-160
            subcomplex
  JOURNAL   Proc Natl Acad Sci U S A 104 (10), 3811-3816 (2007)
   PUBMED   17360435
REFERENCE   6  (bases 1 to 6595)
  AUTHORS   Fontoura BM, Blobel G and Matunis MJ.
  TITLE     A conserved biogenesis pathway for nucleoporins: proteolytic
            processing of a 186-kilodalton precursor generates Nup98 and the
            novel nucleoporin, Nup96
  JOURNAL   J Cell Biol 144 (6), 1097-1112 (1999)
   PUBMED   10087256
REFERENCE   7  (bases 1 to 6595)
  AUTHORS   Grandi P, Dang T, Pane N, Shevchenko A, Mann M, Forbes D and Hurt
            E.
  TITLE     Nup93, a vertebrate homologue of yeast Nic96p, forms a complex with
            a novel 205-kDa protein and is required for correct nuclear pore
            assembly
  JOURNAL   Mol Biol Cell 8 (10), 2017-2038 (1997)
   PUBMED   9348540
REFERENCE   8  (bases 1 to 6595)
  AUTHORS   Moroianu J, Hijikata M, Blobel G and Radu A.
  TITLE     Mammalian karyopherin alpha 1 beta and alpha 2 beta heterodimers:
            alpha 1 or alpha 2 subunit binds nuclear localization signal and
            beta subunit interacts with peptide repeat-containing nucleoporins
  JOURNAL   Proc Natl Acad Sci U S A 92 (14), 6532-6536 (1995)
   PUBMED   7604027
REFERENCE   9  (bases 1 to 6595)
  AUTHORS   Radu A, Moore MS and Blobel G.
  TITLE     The peptide repeat domain of nucleoporin Nup98 functions as a
            docking site in transport across the nuclear pore complex
  JOURNAL   Cell 81 (2), 215-222 (1995)
   PUBMED   7736573
REFERENCE   10 (bases 1 to 6595)
  AUTHORS   Radu A, Blobel G and Moore MS.
  TITLE     Identification of a protein complex that is required for nuclear
            protein import and mediates docking of import substrate to distinct
            nucleoporins
  JOURNAL   Proc Natl Acad Sci U S A 92 (5), 1769-1773 (1995)
   PUBMED   7878057
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            AABR07004912.1.
            
            [WARNING] On Jun 28, 2023 this sequence was replaced by
            NM_031074.3.
            
            On or before Sep 28, 2008 this sequence version replaced
            XM_001068834.1, XM_001068584.1, XM_574504.2, XM_001061438.1,
            NM_031074.1.
            
            Summary: nuclear pore complex protein; involved in nuclear pore
            complex docking and transport [RGD, Feb 2006].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed/partial sample support SAMD00052296,
                              SAMD00052297 [ECO:0000350]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-152               AABR07004912.1     195887-196038       c
            153-256             AABR07004912.1     180480-180583       c
            257-358             AABR07004912.1     179678-179779       c
            359-535             AABR07004912.1     179389-179565       c
            536-675             AABR07004912.1     176841-176980       c
            676-783             AABR07004912.1     173666-173773       c
            784-964             AABR07004912.1     172878-173058       c
            965-1128            AABR07004912.1     172139-172302       c
            1129-1266           AABR07004912.1     170744-170881       c
            1267-1405           AABR07004912.1     167911-168049       c
            1406-1498           AABR07004912.1     163638-163730       c
            1499-1639           AABR07004912.1     156808-156948       c
            1640-1773           AABR07004912.1     151063-151196       c
            1774-1961           AABR07004912.1     147545-147732       c
            1962-2078           AABR07004912.1     141772-141888       c
            2079-2377           AABR07004912.1     138380-138678       c
            2378-2491           AABR07004912.1     137705-137818       c
            2492-2630           AABR07004912.1     136949-137087       c
            2631-2808           AABR07004912.1     135588-135765       c
            2809-2973           AABR07004912.1     133586-133750       c
            2974-3156           AABR07004912.1     127129-127311       c
            3157-3310           AABR07004912.1     126420-126573       c
            3311-3740           AABR07004912.1     122902-123331       c
            3741-3970           AABR07004912.1     121077-121306       c
            3971-4237           AABR07004912.1     113842-114108       c
            4238-4395           AABR07004912.1     112781-112938       c
            4396-4539           AABR07004912.1     110988-111131       c
            4540-4682           AABR07004912.1     109738-109880       c
            4683-4904           AABR07004912.1     106847-107068       c
            4905-5146           AABR07004912.1     105910-106151       c
            5147-5301           AABR07004912.1     105301-105455       c
            5302-5413           AABR07004912.1     102321-102432       c
            5414-6595           AABR07004912.1     101053-102234       c
FEATURES             Location/Qualifiers
     source          1..6595
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="mixed"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     gene            1..6595
                     /gene="Nup98"
                     /note="nucleoporin 98 and 96 precursor"
                     /db_xref="GeneID:81738"
                     /db_xref="RGD:71033"
     exon            1..152
                     /gene="Nup98"
                     /inference="alignment:Splign:2.0.8"
     exon            153..256
                     /gene="Nup98"
                     /inference="alignment:Splign:2.0.8"
     CDS             181..5631
                     /gene="Nup98"
                     /note="nucleoporin 98kDa; nucleoporin Nup98; 98 kDa
                     nucleoporin; nuclear pore complex protein Nup98; nuclear
                     pore complex protein Nup98-Nup96"
                     /codon_start=1
                     /product="nuclear pore complex protein Nup98-Nup96
                     proprotein"
                     /protein_id="NP_112336.2"
                     /db_xref="GeneID:81738"
                     /db_xref="RGD:71033"
                     /translation="MFNKSFGTPFGGGTGGFGTTSTFGQNTGFGTTSGGAFGTSAFGS
                     SNNTGGLFGNSQTKPGGLFGTSSFSQPATSTSTGFGFGTSTGTSNSLFGTANTGTSLF
                     SSQNNAFAQNKPTGFGNFGTSTSSGGLFGTTNTTSNPFGNTSGSLFGPSSFTAAPTGT
                     TIKFNPPTGTDTMVKAGVSTNISTKHQCITAMKEYESKSLEELRLEDYQANRKGPQNQ
                     VGAGTTTGLFGSSPATSSATGLFSSSTTNSAFSYGQNKTAFGTSTTGFGTNPGGLFGQ
                     QNQQTTSLFSKPFGQATTTPNTGFSFGNTSTLGQPSTNTMGLFGVTQASQPGGLFGTA
                     TNTSTGTAFGTGTGLFGQPNTGFGAVGSTLFGNNKLTTFGTSTTSAPSFGTTSGGLFG
                     NKPTLTLGTNTNTSNFGFGTNNSGSSIFGSKPAAGTLGTGLGTGFGTALGAGQASLFG
                     NNQPKIGGPLGTGAFGAPGFNTSTAILGFGAPQAPVALTDPNASAAQQAVLQQHLNSL
                     TYSPFGDSPLFRNPMSDPKKKEERLKPTNPAAQKALTTPTHYKLTPRPATRVRPKALQ
                     TTGTAKSHLFDGLDDDEPSLANGAFMPKKSIKKLVLKNLNNSNLFSPVNHDSEDLASP
                     SEYPENGERFSFLSKPVDENHQQDGDDDSLVSRFYTNPIAKPIPQTPESAGNKNNSSS
                     NVEDTFIALNMRAALRNGLEGSSEETSFHDESLQDDRDEIENSAFQIHPAGIVLTKVG
                     YYTIPSMDDLAKITNEKGECIVSDFTIGRKGYGSIYFEGDVNLTNLNLDDIVHIRRKE
                     VIVYVDDNQKPPVGEGLNRKAEVTLDGVWPTDKTSRCLIKSPDRLADINYEGRLEAVS
                     RKQGAQFKEYRPETGSWVFKVSHFSKYGLQDSDEEEEEHPPKTTSKKLKTAPLPPAGQ
                     ATTFQMTLNGKPAPPPQSQSPEVEQLGRVVELDSDMVDITQEPVPDSVLEESVPEDQE
                     PVSASTQIASSLGINPHVLQIMKASLLVDEEDVDAMEQRFGHFPSRGDTAQEICSPRL
                     PISASHSSKSRSIVGGLLQSKFASGTFLSPSASVQECRTPRTSSLMNVPSTSPWSVPL
                     PLATVFTVPSPAPEVPLKTVGIRRQPGLVPLEKSITYGKGKLLMDMALFMGRSFRVGW
                     GPNWTLANSGEQLHGSHELENHQVAESMEYGFLPNPVAVKSLSESPFKVHLEKLGLRQ
                     RKLDEDLQLYQTPLELKLKHSTVHVDELCPLIVPNPGVSVIHGYADWVKKSPRDLLEL
                     PIVKHWSLTWTLCEALWGHLKELDSQLDEPSEYIQTLERRRAFSRWLSHTAAPQIEEE
                     VSLTRRDSPIEAVFSYLTGSRISEACCLAQQSGDHRLALLLSQLVGSQSVRELLTMQL
                     ADWHQLQADSFIHDERLRIFALLAGKPVWQLSEQKQINVCSQLDWKRTLAIHLWYLLP
                     PTASISRALSMYEEAFQNTCEGDKYACPPLPSYLEGSGCVVEEEKDPQRPLQDVCFHL
                     LKLYSDRHYGLNQLLEPRSITADPLDYRLSWHLWEVLRALNYTHLSEQCEGVLQASYA
                     GQLESEGLWEWAIFVFLHIDNSGMREKAVRELLTRHCQLSETPESWAKETFLTQKLCV
                     PAEWIHEAKAVRAHMESNKHLEALYLFKAGHWNRCHKLVVRHLASDAIINENYDYLKG
                     FLEDLAPPERSSLIQDWETSGLVYLDYIRVIEMLHRIQQVDCSGYELEHLHTKVTSLC
                     NRIEQIPCYNAKDRLAQSDMAKRVANLLRVVLSLQHTPDATSNSTPDPQRVPLRLLAP
                     HIGRLPMPEDYALEELRGLTQSYLRELTVGSQ"
     exon            257..358
                     /gene="Nup98"
                     /inference="alignment:Splign:2.0.8"
     exon            359..535
                     /gene="Nup98"
                     /inference="alignment:Splign:2.0.8"
     exon            536..675
                     /gene="Nup98"
                     /inference="alignment:Splign:2.0.8"
     exon            676..783
                     /gene="Nup98"
                     /inference="alignment:Splign:2.0.8"
     exon            784..964
                     /gene="Nup98"
                     /inference="alignment:Splign:2.0.8"
     exon            965..1128
                     /gene="Nup98"
                     /inference="alignment:Splign:2.0.8"
     exon            1129..1266
                     /gene="Nup98"
                     /inference="alignment:Splign:2.0.8"
     exon            1267..1405
                     /gene="Nup98"
                     /inference="alignment:Splign:2.0.8"
     exon            1406..1498
                     /gene="Nup98"
                     /inference="alignment:Splign:2.0.8"
     exon            1499..1639
                     /gene="Nup98"
                     /inference="alignment:Splign:2.0.8"
     exon            1640..1773
                     /gene="Nup98"
                     /inference="alignment:Splign:2.0.8"
     exon            1774..1961
                     /gene="Nup98"
                     /inference="alignment:Splign:2.0.8"
     exon            1962..2078
                     /gene="Nup98"
                     /inference="alignment:Splign:2.0.8"
     exon            2079..2377
                     /gene="Nup98"
                     /inference="alignment:Splign:2.0.8"
     exon            2378..2491
                     /gene="Nup98"
                     /inference="alignment:Splign:2.0.8"
     exon            2492..2630
                     /gene="Nup98"
                     /inference="alignment:Splign:2.0.8"
     exon            2631..2808
                     /gene="Nup98"
                     /inference="alignment:Splign:2.0.8"
     exon            2809..2973
                     /gene="Nup98"
                     /inference="alignment:Splign:2.0.8"
     exon            2974..3156
                     /gene="Nup98"
                     /inference="alignment:Splign:2.0.8"
     exon            3157..3310
                     /gene="Nup98"
                     /inference="alignment:Splign:2.0.8"
     exon            3311..3740
                     /gene="Nup98"
                     /inference="alignment:Splign:2.0.8"
     exon            3741..3970
                     /gene="Nup98"
                     /inference="alignment:Splign:2.0.8"
     exon            3971..4237
                     /gene="Nup98"
                     /inference="alignment:Splign:2.0.8"
     exon            4238..4395
                     /gene="Nup98"
                     /inference="alignment:Splign:2.0.8"
     exon            4396..4539
                     /gene="Nup98"
                     /inference="alignment:Splign:2.0.8"
     exon            4540..4682
                     /gene="Nup98"
                     /inference="alignment:Splign:2.0.8"
     exon            4683..4904
                     /gene="Nup98"
                     /inference="alignment:Splign:2.0.8"
     exon            4905..5146
                     /gene="Nup98"
                     /inference="alignment:Splign:2.0.8"
     exon            5147..5301
                     /gene="Nup98"
                     /inference="alignment:Splign:2.0.8"
     exon            5302..5413
                     /gene="Nup98"
                     /inference="alignment:Splign:2.0.8"
     exon            5414..6595
                     /gene="Nup98"
                     /inference="alignment:Splign:2.0.8"
ORIGIN      
        1 gacggcgtgt gacgcagtcg ggcctctacg cgctgcgccc gaagcggcgg tcggtggcgg
       61 cggcggtggc gacggtttcc tggcggtcgc gcgctgctct ggtgagcggc gggtgacgga
      121 aggacctggg ctctcactcc agacacaccg ctctttctga agcaaacact cgttttgaag
      181 atgtttaaca aatcatttgg aacccccttt gggggtggta cagggggctt tggtacaacg
      241 tcaacatttg gacaaaatac tggctttggt actactagtg gaggagcatt tggaacatct
      301 gcatttggtt ctagcaataa tactggaggc ttatttggta attcacagac caaaccagga
      361 ggactgtttg gtaccagttc atttagccag ccagcaacct ccacaagcac tggttttggg
      421 tttggcacat caacaggaac atcaaatagt ttgtttggaa ctgcaaatac agggaccagt
      481 cttttctcat cccagaacaa tgcatttgca caaaataaac caactggatt tgggaatttt
      541 ggaaccagta ctagcagtgg aggactcttt ggaactacaa ataccacctc taatcctttt
      601 ggtaacacat ctggctccct ctttgggcca agtagtttta cagcagcacc tacaggaact
      661 accatcaaat ttaatcctcc cactggtaca gatactatgg tcaaagctgg agttagcact
      721 aacatcagca ccaagcatca gtgtattact gccatgaaag aatatgaaag caagtcatta
      781 gaggagcttc gtttggagga ctatcaggct aaccggaaag gcccacagaa ccaagtgggg
      841 gcaggtacca caactggctt atttgggtct tctccagcga cttccagtgc aacaggactc
      901 ttcagctctt ccaccactaa ttcagccttt tcatatggtc agaacaaaac tgcctttgga
      961 actagcacaa ctggatttgg gacaaatcca ggtggcctct ttggccaaca gaatcaacag
     1021 actaccagtc tcttcagcaa accatttggc caggctacaa ccaccccaaa tactggcttt
     1081 tcctttggta ataccagcac ccttggacaa ccaagcacca atactatggg cctatttgga
     1141 gtaacccaag cctcacagcc aggaggtctt tttgggaccg ctacaaacac cagcactggg
     1201 acagcatttg ggacaggaac aggtctcttt gggcagccca atactggatt tggtgcagtt
     1261 ggttcgacgc tgtttggcaa taacaagctt acaacttttg gaaccagcac aaccagtgct
     1321 ccctcatttg gtacaaccag tggcgggctc ttcggtaaca aaccaaccct gactttagga
     1381 accaatacaa acacttccaa ttttggtttt ggcacaaata acagtgggag tagtattttt
     1441 ggaagtaagc cagcagccgg gactctggga acaggacttg gtacaggatt tggaacagct
     1501 cttggtgctg gacaggcatc tttgtttgga aacaaccaac ctaagattgg agggcctctt
     1561 ggtacaggag cctttggggc ccctggattt aatacttcga ctgccatttt gggctttggc
     1621 gccccccagg ccccagtagc tttgacagat ccaaatgctt ctgctgccca gcaggctgtt
     1681 ctccagcagc acctcaatag tctaacatac tcaccctttg gagactcccc tctcttccgg
     1741 aatcctatgt cagatcctaa gaagaaagaa gagagactga aaccaaccaa tccagcagct
     1801 cagaaagctc ttacaacccc tactcattat aaacttacac ctcgccctgc caccagagtc
     1861 agaccaaagg ctttgcaaac aacaggtaca gccaaatcac atctctttga tgggctggat
     1921 gacgatgaac catctctagc caacggagcg tttatgccta aaaagagcat caagaagttg
     1981 gttttgaaaa atcttaacaa tagcaatctc ttttctcctg ttaatcatga ttcagaagat
     2041 ctagcttcac cctctgagta tccagaaaat ggagagagat tcagcttcct gagcaaacct
     2101 gttgatgaga accatcagca ggatggagat gatgactctc ttgtatcacg attttacact
     2161 aatcctattg ccaaacctat tccacaaact ccagagagtg ctggaaacaa aaataacagt
     2221 agcagcaatg tggaagacac tttcattgct ttgaacatgc gtgctgcttt gcgaaatgga
     2281 ctggaaggaa gcagtgaaga aacgtctttc catgatgagt cattgcaaga tgaccgagac
     2341 gagatagaaa acagtgcttt ccaaatccat ccagcaggca ttgttctcac aaaagttggt
     2401 tattatacta ttccatctat ggatgacctt gctaaaatta ccaatgagaa aggagaatgc
     2461 attgtttctg acttcaccat tggccgtaaa gggtatggct caatctattt tgaaggagat
     2521 gtgaatttga caaatctaaa tttggatgac attgtgcata tccggaggaa agaagttatt
     2581 gtctatgtag atgataacca aaagccacct gtgggtgaag gactaaatag gaaggctgaa
     2641 gttactttgg atggagtttg gccaacagat aaaacatccc ggtgtttaat aaagagtcca
     2701 gatcgacttg ctgatatcaa ttatgagggg agattagaag cagtctcaag aaagcaaggg
     2761 gcccaattca aggagtatcg gcctgaaact ggttcttggg tgtttaaggt ttcccatttt
     2821 tctaagtatg gccttcagga ttctgatgaa gaggaggagg aacacccacc caaaactact
     2881 tcaaagaagc tgaagactgc ccctttgccc cctgcaggcc aggcaaccac tttccagatg
     2941 actcttaatg gcaaacctgc acccccacct cagagccaga gcccagaagt ggagcagtta
     3001 gggagggttg tggagctgga cagcgacatg gtagatatca cgcaggagcc agttccggat
     3061 tcggtgttag aagagagtgt acctgaggat caggagcccg tgtccgcatc aacacagatc
     3121 gcgtcttcac tgggaattaa tccacatgtg ttacagatca tgaaagcatc cttgcttgtg
     3181 gatgaagaag acgtagatgc catggagcag cgcttcggtc acttcccttc cagaggagac
     3241 actgctcagg agatctgctc ccctagactc cccatttcag cctcccactc ctcaaaatcc
     3301 cgctccatag ttggtgggtt gctccaatca aaatttgcaa gtggaacttt tctttcacca
     3361 agtgcctccg tgcaagaatg tcgcacaccc agaacatcat ctctaatgaa cgtcccatcc
     3421 acatccccct ggtctgtccc tctacccctg gccactgtgt tcacagtgcc cagcccagcc
     3481 cctgaagttc ccctaaaaac agtggggata cgcaggcaac caggcctagt ccctcttgaa
     3541 aaatccatta catatggcaa gggaaaactc ttgatggaca tggccttatt catgggacgt
     3601 tcatttcggg ttggctgggg tcccaactgg actcttgcaa atagtggaga acaactgcat
     3661 ggctctcatg aactggaaaa tcatcaggtt gccgagtcta tggaatacgg attcctgccc
     3721 aatccagtag ctgttaaatc tctatctgaa tccccattca aagttcattt ggaaaaactc
     3781 ggcttgagac agaggaagct ggatgaggat ctgcagttat accagacacc tctagagctc
     3841 aaattaaaac atagcactgt gcatgtagat gagctgtgtc ctctcatcgt ccccaatcct
     3901 ggggtttcag tcattcatgg ttatgcagat tgggttaaga aatcacccag agatttactg
     3961 gaactaccaa ttgtgaagca ctggagcctg acgtggacat tatgtgaagc cctatggggc
     4021 cacctgaagg agcttgacag ccagctggat gagcccagtg aatacattca gactctggag
     4081 cggagaagag ctttttcccg ctggctgtcc cacactgctg cacctcagat agaagaggaa
     4141 gtctccttaa cccgcagaga cagtcccata gaggctgtct tcagctacct cacgggcagt
     4201 agaattagtg aggcctgttg tctggcacag cagtcaggtg atcatcgcct tgcccttctt
     4261 ctgtctcagc tggtgggaag ccagtcagtc cgggagctgc tcaccatgca gttggctgat
     4321 tggcatcagc tccaggctga ctccttcatc cacgatgagc ggttgcgcat atttgccctg
     4381 ttagctggaa aaccggtgtg gcagctctca gaacagaaac aaatcaatgt atgctcccag
     4441 ctagattgga aacgaacact tgctatccat ctttggtatt tgcttccacc aactgcctcc
     4501 atttccaggg ctctcagcat gtatgaagaa gcatttcaga atacttgtga gggtgataaa
     4561 tatgcctgtc cccctcttcc ttcttacctg gagggcagtg gctgtgtggt agaggaagaa
     4621 aaagaccccc agagaccact tcaagacgtt tgctttcatc ttctaaagct ctacagtgac
     4681 agacattatg gtctcaatca gctcttggaa ccccgaagca taactgcaga tcctttggac
     4741 taccgcctaa gctggcacct ttgggaagtg ctccgtgctc ttaactatac acatctctca
     4801 gaacagtgtg agggcgtgct acaggccagt tatgctggcc agctggaaag tgaaggactc
     4861 tgggagtggg ccatctttgt ctttctgcac attgacaact caggcatgcg tgagaaggct
     4921 gttcgagaac tgctgacccg gcactgccaa ctctcagaga cccctgagtc ttgggctaag
     4981 gagactttcc ttactcagaa gctttgtgtg cctgctgagt ggattcatga ggccaaagca
     5041 gttcgtgcac acatggaatc caataagcac ttggaggccc tctatttatt taaagctggt
     5101 cactggaacc gctgccacaa actagtcgtt cggcacctag cttctgatgc cattattaat
     5161 gagaactatg actacctgaa aggtttctta gaagatctgg cacctccaga gcgcagcagc
     5221 ctaattcagg actgggaaac atctgggctt gtttacttgg attacattcg agtaattgaa
     5281 atgctccacc gtattcagca ggtggattgc tcaggctatg aactagagca cttacatacc
     5341 aaagtgactt cactgtgtaa ccggatagag cagattccgt gctacaatgc caaggatcgc
     5401 ctggctcagt cagatatggc caagcgggta gccaacttac tgcgggtagt tctgagcctt
     5461 cagcacactc ctgacgccac ctccaactcc actccggacc ctcagcgagt ccctttgcgt
     5521 cttttggctc cccacattgg caggctccct atgcctgagg actatgcctt ggaggaactg
     5581 cgaggcctta cccagtccta ccttcgagaa ctgactgttg ggagccaatg agcctggctc
     5641 ctgcccatcc gcactcgcca ccacagtctc ccacattgtt ttaattgaca ctctgccaat
     5701 ctctgggagt cctccgctcc tcttcgctgc ccttcgcagc atcctctagt tattcagggg
     5761 ttttcataat actgagcata tcctaccata gctcataagg gcttctggaa cagcaacaac
     5821 aaaaaacaca ggtctccatt gatcaacctc aagaccattc agtttttttc ttttgaaaaa
     5881 tggtcaataa aacctctttg gcagaacctc ccaaaaccca gggaattctt ttccacaccc
     5941 agagttctga ctctcacccc agatatatga ctgactgacc ttcccttact acagatttgt
     6001 ctctcaagta gatttctcag ttaacagtgt gtttgggaat caagagagtt ggaccttgtt
     6061 ctttgacata tttaagaaag aagggctgtc taccatggag gcggagatct tcaaggcttt
     6121 tactcatgcc ttgtatatcc tttggacacc atgctatcat gtgcagtggc cccaagctac
     6181 agagaacaac tcttgagaag ccccagaact gctctgaccc ttgatcatca gtcattttcc
     6241 tcgatttgcc agaggagttt agatgaagaa tgtcaagggt gttcctccct gccctcccat
     6301 ctagccaaga acatttctca gaaggtaaag ctgtcactgc gacaggtctg gctgggccca
     6361 ggggcagata gggaaggcct tcaccacatt gctgctggct atgggaagtc ccaggcacta
     6421 gcctgaaaga gcggatattt ggggctgtca cagacaatat ggccacccct gggtctttat
     6481 gcatgaagat tatgtaaagg tttttattaa aaaatatata tataaatgat ctagattatt
     6541 ttcctctttc tgaagtactt tcttaaaaaa aaaataaaat gaaatgttta tagta
//
