LOCUS       NM_001011925            2714 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus nucleoporin 93 (Nup93), mRNA.
ACCESSION   NM_001011925 XM_214639
VERSION     NM_001011925.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2714)
  AUTHORS   Pan,L., Song,X.W., Song,J.C., Shi,C.Y., Wang,Z.K., Huang,S.Q.,
            Guo,Z.F., Li,S.H., Zhao,X.X. and Ge,J.B.
  TITLE     Downregulation of NUP93 aggravates hypoxia-induced death of
            cardiomyocytes in vitro through abnormal regulation of gene
            transcription
  JOURNAL   Acta Pharmacol Sin 44 (5), 969-983 (2023)
   PUBMED   36807413
  REMARK    GeneRIF: Downregulation of NUP93 aggravates hypoxia-induced death
            of cardiomyocytes in vitro through abnormal regulation of gene
            transcription.
REFERENCE   2  (bases 1 to 2714)
  AUTHORS   Braun,D.A., Sadowski,C.E., Kohl,S., Lovric,S., Astrinidis,S.A.,
            Pabst,W.L., Gee,H.Y., Ashraf,S., Lawson,J.A., Shril,S., Airik,M.,
            Tan,W., Schapiro,D., Rao,J., Choi,W.I., Hermle,T., Kemper,M.J.,
            Pohl,M., Ozaltin,F., Konrad,M., Bogdanovic,R., Buscher,R.,
            Helmchen,U., Serdaroglu,E., Lifton,R.P., Antonin,W. and
            Hildebrandt,F.
  TITLE     Mutations in nuclear pore genes NUP93, NUP205 and XPO5 cause
            steroid-resistant nephrotic syndrome
  JOURNAL   Nat Genet 48 (4), 457-465 (2016)
   PUBMED   26878725
REFERENCE   3  (bases 1 to 2714)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   4  (bases 1 to 2714)
  AUTHORS   Krull,S., Thyberg,J., Bjorkroth,B., Rackwitz,H.R. and Cordes,V.C.
  TITLE     Nucleoporins as components of the nuclear pore complex core
            structure and Tpr as the architectural element of the nuclear
            basket
  JOURNAL   Mol Biol Cell 15 (9), 4261-4277 (2004)
   PUBMED   15229283
REFERENCE   5  (bases 1 to 2714)
  AUTHORS   Hase,M.E. and Cordes,V.C.
  TITLE     Direct interaction with nup153 mediates binding of Tpr to the
            periphery of the nuclear pore complex
  JOURNAL   Mol Biol Cell 14 (5), 1923-1940 (2003)
   PUBMED   12802065
  REMARK    Erratum:[Mol Biol Cell. 2003 Aug;14(8):preceding Table of Contents]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC081925.1.
            
            On Feb 11, 2005 this sequence version replaced XM_214639.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081925.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2714
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19p12"
     gene            1..2714
                     /gene="Nup93"
                     /note="nucleoporin 93"
                     /db_xref="GeneID:291874"
                     /db_xref="RGD:1311525"
     exon            1..63
                     /gene="Nup93"
                     /inference="alignment:Splign:2.1.0"
     exon            64..256
                     /gene="Nup93"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..2537
                     /gene="Nup93"
                     /note="nucleoporin Nup93; 93 kDa nucleoporin; nucleoporin
                     93kDa"
                     /codon_start=1
                     /product="nuclear pore complex protein Nup93"
                     /protein_id="NP_001011925.1"
                     /db_xref="GeneID:291874"
                     /db_xref="RGD:1311525"
                     /translation="MDTEGFGELLQQAEQLAAETEGISELPHVERNLQEIQQAGERLR
                     SRTLTRTSQETADVKASVLLGSRGLDISHISQRLESLSAATTFEPLEPVKDTDIQGFL
                     KNEKDNALLSAIEESRKRTFGMAEEYHRESMLVEWEQVKQRILHTLLASGEDALDFTQ
                     ESEPSYVSDVSPPGRSSLDSIEMAYARQIYIYNEKIVSGHLQPNLVDLCASVAELDDK
                     SISDMWAMVKQMTDVVLTPATDALKSRSSVEVRMDFVKQALGYLEQSYKNYTLVTVFG
                     NLHQAQLGGVPGTYQLVRSFLNIKLPAPSPGLQDGEVEGHPVWALIYYCMRCGDLLAA
                     SQVVSRAQHQLGEFKTWFQEYMNSKDRRLSPATENKLRLHYRRALRNNTDPYKRAVYC
                     IIGRCDITDNQSEVADKTEDYLWLKLNQVCFDDDGTSSPQDRLTLSQFQKQLLEDYGE
                     SHFTVNQQPFLYFQVLFLTAQFEAAIAFLFRMERLRCHAVHVALVLFELKLLLKSSGQ
                     SAQLLSHEPGDPPCMRRLNFVRLLMLYTRKFESTDPREALQYFYFLRDEKDSQGENMF
                     LRCVSELVIESREFDMILGKLENDGSRKPGVIDKFTSDTKPIINKVASVAENKGLFEE
                     AAKLYDLAKNADKVLELMNKLLSPVVPQISAPQSNKERLKNMALSIAERYRAQGISAN
                     KFVDSTFYLLLDLITFFDEYHSGHIDRAFDIIDRLKLVPLNQESMEERVAAFRNFSDE
                     IRHNLSEVLLATMNILFTQFKRLKGTSPSSATRPQRVIEDRDSQLRSQARALITFAGM
                     IPYRTSGDTNARLVQMEVLMN"
     exon            257..374
                     /gene="Nup93"
                     /inference="alignment:Splign:2.1.0"
     exon            375..437
                     /gene="Nup93"
                     /inference="alignment:Splign:2.1.0"
     exon            438..566
                     /gene="Nup93"
                     /inference="alignment:Splign:2.1.0"
     exon            567..641
                     /gene="Nup93"
                     /inference="alignment:Splign:2.1.0"
     exon            642..731
                     /gene="Nup93"
                     /inference="alignment:Splign:2.1.0"
     exon            732..871
                     /gene="Nup93"
                     /inference="alignment:Splign:2.1.0"
     exon            872..1004
                     /gene="Nup93"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1162
                     /gene="Nup93"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1328
                     /gene="Nup93"
                     /inference="alignment:Splign:2.1.0"
     exon            1329..1422
                     /gene="Nup93"
                     /inference="alignment:Splign:2.1.0"
     exon            1423..1614
                     /gene="Nup93"
                     /inference="alignment:Splign:2.1.0"
     exon            1615..1741
                     /gene="Nup93"
                     /inference="alignment:Splign:2.1.0"
     exon            1742..1814
                     /gene="Nup93"
                     /inference="alignment:Splign:2.1.0"
     exon            1815..1859
                     /gene="Nup93"
                     /inference="alignment:Splign:2.1.0"
     exon            1860..1976
                     /gene="Nup93"
                     /inference="alignment:Splign:2.1.0"
     exon            1977..2095
                     /gene="Nup93"
                     /inference="alignment:Splign:2.1.0"
     exon            2096..2213
                     /gene="Nup93"
                     /inference="alignment:Splign:2.1.0"
     exon            2214..2297
                     /gene="Nup93"
                     /inference="alignment:Splign:2.1.0"
     exon            2298..2426
                     /gene="Nup93"
                     /inference="alignment:Splign:2.1.0"
     exon            2427..2695
                     /gene="Nup93"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaagcggcgg cggcggcgta gtgaagtagc cgggagctgg cggcgagcag gcggcagagc
       61 cagcatctgc atctccaatg gatactgagg gatttggtga gctccttcag caagctgaac
      121 agcttgctgc tgagaccgaa ggcatctctg agcttccaca tgtagaacga aatttacagg
      181 agatccagca agcgggtgag cgcctgcgtt cccgtaccct cacacgaaca tcccaggaga
      241 cagcagatgt caaggcatca gttcttctcg ggtcacgtgg acttgacata tcccacatct
      301 cccagagact ggagagtctg agtgcagcca ccacttttga acctctcgag cctgtgaagg
      361 acacggacat tcagggcttc ctgaagaatg agaaagataa tgccttgctg tctgctatcg
      421 aagagtcccg gaagaggacc tttggcatgg ctgaggagta tcatcgagag tcaatgctgg
      481 tcgagtggga acaggtgaaa caaagaattc tgcatacgct gctggcatca ggggaggatg
      541 cccttgactt cacccaagaa agtgagccga gttacgtcag cgatgtgagt cctcctggcc
      601 gaagctctct ggatagcatt gagatggcct atgcccggca gatctacatc tataatgaga
      661 agatcgtgag tggacaccta cagcccaacc tggtggacct gtgtgcctct gtcgcagagc
      721 tggatgacaa gagcatttct gacatgtggg ccatggtaaa acaaatgaca gatgtggtcc
      781 tgacaccggc aactgacgcc ctgaagagcc gaagcagtgt ggaagtgcgc atggattttg
      841 tcaagcaggc cttgggatac cttgagcaga gttataaaaa ttacaccctt gtgactgtct
      901 ttggaaacct gcatcaggca cagctgggcg gtgtgcctgg gacttaccag ctggttcgca
      961 gttttctaaa cattaagttg ccagctccct caccaggact tcaggatgga gaggtagaag
     1021 gccatccggt ctgggcgtta atttattact gcatgcgctg tggagacctg cttgctgcat
     1081 cacaagtcgt cagtcgagcc cagcaccagc tgggggaatt taaaacctgg ttccaggaat
     1141 acatgaacag caaggataga agattgtctc cagctactga gaacaaactc cggcttcact
     1201 accgcagagc cctcaggaac aacacagacc cctacaagcg agctgtgtac tgtatcattg
     1261 ggagatgcga catcaccgac aaccagagcg aagtagcaga caagaccgag gactacctgt
     1321 ggttaaaact gaaccaggtg tgtttcgatg atgacggcac cagctcgcca caagacaggc
     1381 tcactctctc acagttccag aagcagctgc tagaggacta tggcgagtcc cacttcacgg
     1441 tgaaccagca gcccttcctc tacttccaag tgctgttcct gactgcacag tttgaagctg
     1501 ccattgcctt tctcttccgc atggagcggc tgcgctgcca tgctgtccat gtggccctgg
     1561 tgctgtttga gctaaagctg cttttaaagt cctccgggca gagtgctcag ctcctcagcc
     1621 acgagcctgg tgaccctccc tgcatgcgac ggctgaactt tgtgcgtcta ctcatgctct
     1681 acacccgcaa gtttgagtcc acggacccaa gagaagccct gcagtacttt tacttcctca
     1741 gggatgagaa agacagtcaa ggagaaaaca tgtttctgcg ctgtgtgagt gagcttgtga
     1801 tagaaagtcg agagtttgat atgattcttg ggaagctaga gaatgacgga agtagaaagc
     1861 ctggagtcat agataagttt accagtgaca caaagcctat tatcaacaaa gttgcttccg
     1921 tggcagaaaa taaaggacta tttgaagaag cagccaagct ttatgacctt gccaagaatg
     1981 cggacaaggt gctggagctg atgaacaagc tgctaagccc tgtggtccca cagatcagcg
     2041 ccccacagtc taacaaggaa aggctgaaga acatggccct ctccattgca gagcggtaca
     2101 gggctcaggg aataagtgca aataagtttg tggactctac gttctatctc ctcttggacc
     2161 tgatcacctt ttttgacgaa tatcacagtg gtcatattga cagagccttc gatattatcg
     2221 accgcttgaa gctggtgcct ctgaatcagg aaagtatgga agaaagggtg gctgccttca
     2281 gaaacttcag tgacgaaatc aggcacaacc tctcggaagt tcttctcgcc accatgaaca
     2341 tcctgttcac acagtttaag aggctcaagg gaacaagccc atcttcagca accaggcccc
     2401 agcgagtcat cgaagaccgt gactctcaac tccgaagtca agccagagcc ctgattacct
     2461 ttgctgggat gataccgtac cggacgtctg gggacactaa tgccaggctg gtgcagatgg
     2521 aggtcctgat gaattaagcg ctgtgtgatg gggtctgagg ttgcacagtc tattaggcat
     2581 gtggccagct ggtgtgggtt tccagttccg tttctgttgt gttgtgtttt gttttttgta
     2641 ttatgtattt ttgtcaatac caataaattt ctttgattta tatttctttt aaaaaaaaaa
     2701 aaaaaaaaaa aaaa
//
