LOCUS       NP_001011925             819 aa            linear   ROD 27-APR-2025
DEFINITION  nuclear pore complex protein Nup93 [Rattus norvegicus].
ACCESSION   NP_001011925 XP_214639
VERSION     NP_001011925.1
DBSOURCE    REFSEQ: accession NM_001011925.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 819)
  AUTHORS   Pan,L., Song,X.W., Song,J.C., Shi,C.Y., Wang,Z.K., Huang,S.Q.,
            Guo,Z.F., Li,S.H., Zhao,X.X. and Ge,J.B.
  TITLE     Downregulation of NUP93 aggravates hypoxia-induced death of
            cardiomyocytes in vitro through abnormal regulation of gene
            transcription
  JOURNAL   Acta Pharmacol Sin 44 (5), 969-983 (2023)
   PUBMED   36807413
  REMARK    GeneRIF: Downregulation of NUP93 aggravates hypoxia-induced death
            of cardiomyocytes in vitro through abnormal regulation of gene
            transcription.
REFERENCE   2  (residues 1 to 819)
  AUTHORS   Braun,D.A., Sadowski,C.E., Kohl,S., Lovric,S., Astrinidis,S.A.,
            Pabst,W.L., Gee,H.Y., Ashraf,S., Lawson,J.A., Shril,S., Airik,M.,
            Tan,W., Schapiro,D., Rao,J., Choi,W.I., Hermle,T., Kemper,M.J.,
            Pohl,M., Ozaltin,F., Konrad,M., Bogdanovic,R., Buscher,R.,
            Helmchen,U., Serdaroglu,E., Lifton,R.P., Antonin,W. and
            Hildebrandt,F.
  TITLE     Mutations in nuclear pore genes NUP93, NUP205 and XPO5 cause
            steroid-resistant nephrotic syndrome
  JOURNAL   Nat Genet 48 (4), 457-465 (2016)
   PUBMED   26878725
REFERENCE   3  (residues 1 to 819)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   4  (residues 1 to 819)
  AUTHORS   Krull,S., Thyberg,J., Bjorkroth,B., Rackwitz,H.R. and Cordes,V.C.
  TITLE     Nucleoporins as components of the nuclear pore complex core
            structure and Tpr as the architectural element of the nuclear
            basket
  JOURNAL   Mol Biol Cell 15 (9), 4261-4277 (2004)
   PUBMED   15229283
REFERENCE   5  (residues 1 to 819)
  AUTHORS   Hase,M.E. and Cordes,V.C.
  TITLE     Direct interaction with nup153 mediates binding of Tpr to the
            periphery of the nuclear pore complex
  JOURNAL   Mol Biol Cell 14 (5), 1923-1940 (2003)
   PUBMED   12802065
  REMARK    Erratum:[Mol Biol Cell. 2003 Aug;14(8):preceding Table of Contents]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC081925.1.
            
            On Feb 11, 2005 this sequence version replaced XP_214639.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081925.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..819
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19p12"
     Protein         1..819
                     /product="nuclear pore complex protein Nup93"
                     /note="nucleoporin Nup93; 93 kDa nucleoporin; nucleoporin
                     93kDa"
                     /calculated_mol_wt=93171
     Site            49
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q8N1F7; propagated from
                     UniProtKB/Swiss-Prot (Q66HC5.1)"
     Site            52
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8N1F7; propagated from
                     UniProtKB/Swiss-Prot (Q66HC5.1)"
     Site            66
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8N1F7; propagated from
                     UniProtKB/Swiss-Prot (Q66HC5.1)"
     Site            72
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8N1F7; propagated from
                     UniProtKB/Swiss-Prot (Q66HC5.1)"
     Site            75
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8N1F7; propagated from
                     UniProtKB/Swiss-Prot (Q66HC5.1)"
     Site            80
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8N1F7; propagated from
                     UniProtKB/Swiss-Prot (Q66HC5.1)"
     Region          218..810
                     /region_name="Nic96"
                     /note="Nup93/Nic96; pfam04097"
                     /db_xref="CDD:461172"
     Site            430
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8N1F7; propagated from
                     UniProtKB/Swiss-Prot (Q66HC5.1)"
     Site            767
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8N1F7; propagated from
                     UniProtKB/Swiss-Prot (Q66HC5.1)"
     CDS             1..819
                     /gene="Nup93"
                     /coded_by="NM_001011925.1:78..2537"
                     /db_xref="GeneID:291874"
                     /db_xref="RGD:1311525"
ORIGIN      
        1 mdtegfgell qqaeqlaaet egiselphve rnlqeiqqag erlrsrtltr tsqetadvka
       61 svllgsrgld ishisqrles lsaattfepl epvkdtdiqg flknekdnal lsaieesrkr
      121 tfgmaeeyhr esmlveweqv kqrilhtlla sgedaldftq esepsyvsdv sppgrsslds
      181 iemayarqiy iynekivsgh lqpnlvdlca svaelddksi sdmwamvkqm tdvvltpatd
      241 alksrssvev rmdfvkqalg yleqsyknyt lvtvfgnlhq aqlggvpgty qlvrsflnik
      301 lpapspglqd geveghpvwa liyycmrcgd llaasqvvsr aqhqlgefkt wfqeymnskd
      361 rrlspatenk lrlhyrralr nntdpykrav yciigrcdit dnqsevadkt edylwlklnq
      421 vcfdddgtss pqdrltlsqf qkqlledyge shftvnqqpf lyfqvlflta qfeaaiaflf
      481 rmerlrchav hvalvlfelk lllkssgqsa qllshepgdp pcmrrlnfvr llmlytrkfe
      541 stdprealqy fyflrdekds qgenmflrcv selviesref dmilgklend gsrkpgvidk
      601 ftsdtkpiin kvasvaenkg lfeeaaklyd laknadkvle lmnkllspvv pqisapqsnk
      661 erlknmalsi aeryraqgis ankfvdstfy llldlitffd eyhsghidra fdiidrlklv
      721 plnqesmeer vaafrnfsde irhnlsevll atmnilftqf krlkgtspss atrpqrvied
      781 rdsqlrsqar alitfagmip yrtsgdtnar lvqmevlmn
//
