LOCUS       NM_023098               2461 bp    mRNA    linear   ROD 03-FEB-2025
DEFINITION  Rattus norvegicus nucleoporin 62 (Nup62), mRNA.
ACCESSION   NM_023098 XM_218620
VERSION     NM_023098.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2461)
  AUTHORS   Huang,X., Yao,J., Liu,L., Chen,J., Mei,L., Huangfu,J., Luo,D.,
            Wang,X., Lin,C., Chen,X., Yang,Y., Ouyang,S., Wei,F., Wang,Z.,
            Zhang,S., Xiang,T., Neculai,D., Sun,Q., Kong,E., Tate,E.W. and
            Yang,A.
  TITLE     S-acylation of p62 promotes p62 droplet recruitment into
            autophagosomes in mammalian autophagy
  JOURNAL   Mol Cell 83 (19), 3485-3501 (2023)
   PUBMED   37802024
  REMARK    GeneRIF: S-acylation of p62 promotes p62 droplet recruitment into
            autophagosomes in mammalian autophagy.
REFERENCE   2  (bases 1 to 2461)
  AUTHORS   Chung,H., Choi,J. and Park,S.
  TITLE     Ghrelin protects adult rat hippocampal neural stem cells from
            excessive autophagy during oxygen-glucose deprivation
  JOURNAL   Endocr J 65 (1), 63-73 (2018)
   PUBMED   29057768
REFERENCE   3  (bases 1 to 2461)
  AUTHORS   Dewangan,P.S., Sonawane,P.J., Chouksey,A.R. and Chauhan,R.
  TITLE     The Nup62 Coiled-Coil Motif Provides Plasticity for Triple-Helix
            Bundle Formation
  JOURNAL   Biochemistry 56 (22), 2803-2811 (2017)
   PUBMED   28406021
  REMARK    GeneRIF: complexes of Nup62 suggest the crucial role of the
            coiled-coil motifs in providing plasticity to various modular
            assemblies
REFERENCE   4  (bases 1 to 2461)
  AUTHORS   Sharma,A., Solmaz,S.R., Blobel,G. and Melcak,I.
  TITLE     Ordered Regions of Channel Nucleoporins Nup62, Nup54, and Nup58
            Form Dynamic Complexes in Solution
  JOURNAL   J Biol Chem 290 (30), 18370-18378 (2015)
   PUBMED   26025361
  REMARK    GeneRIF: we carried out solution analysis utilizing the entire
            ordered regions of Nup62, Nup54, and Nup58, and demonstrate that
            they form a dynamic 'triple complex'
REFERENCE   5  (bases 1 to 2461)
  AUTHORS   Kinoshita,Y., Hunter,R.G., Gray,J.D., Mesias,R., McEwen,B.S.,
            Benson,D.L. and Kohtz,D.S.
  TITLE     Role for NUP62 depletion and PYK2 redistribution in dendritic
            retraction resulting from chronic stress
  JOURNAL   Proc Natl Acad Sci U S A 111 (45), 16130-16135 (2014)
   PUBMED   25349423
  REMARK    GeneRIF: Role for NUP62 depletion and PYK2 redistribution in
            dendritic retraction resulting from chronic stress
REFERENCE   6  (bases 1 to 2461)
  AUTHORS   D'Onofrio,M., Lee,M.D., Starr,C.M., Miller,M. and Hanover,J.A.
  TITLE     The gene encoding rat nuclear pore glycoprotein p62 is intronless
  JOURNAL   J Biol Chem 266 (18), 11980-11985 (1991)
   PUBMED   2050692
REFERENCE   7  (bases 1 to 2461)
  AUTHORS   Cordes,V., Waizenegger,I. and Krohne,G.
  TITLE     Nuclear pore complex glycoprotein p62 of Xenopus laevis and mouse:
            cDNA cloning and identification of its glycosylated region
  JOURNAL   Eur J Cell Biol 55 (1), 31-47 (1991)
   PUBMED   1915419
REFERENCE   8  (bases 1 to 2461)
  AUTHORS   Carmo-Fonseca,M., Kern,H. and Hurt,E.C.
  TITLE     Human nucleoporin p62 and the essential yeast nuclear pore protein
            NSP1 show sequence homology and a similar domain organization
  JOURNAL   Eur J Cell Biol 55 (1), 17-30 (1991)
   PUBMED   1915414
REFERENCE   9  (bases 1 to 2461)
  AUTHORS   Starr,C.M., D'Onofrio,M., Park,M.K. and Hanover,J.A.
  TITLE     Primary sequence and heterologous expression of nuclear pore
            glycoprotein p62
  JOURNAL   J Cell Biol 110 (6), 1861-1871 (1990)
   PUBMED   2190987
REFERENCE   10 (bases 1 to 2461)
  AUTHORS   D'Onofrio,M., Starr,C.M., Park,M.K., Holt,G.D., Haltiwanger,R.S.,
            Hart,G.W. and Hanover,J.A.
  TITLE     Partial cDNA sequence encoding a nuclear pore protein modified by
            O-linked N-acetylglucosamine
  JOURNAL   Proc Natl Acad Sci U S A 85 (24), 9595-9599 (1988)
   PUBMED   3200844
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CK600248.1 and BC128709.1.
            
            On May 25, 2007 this sequence version replaced NM_023098.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CK600248.1, FN802488.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-683               CK600248.1         1-683
            684-2461            BC128709.1         588-2365
FEATURES             Location/Qualifiers
     source          1..2461
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..2461
                     /gene="Nup62"
                     /gene_synonym="Np62"
                     /note="nucleoporin 62"
                     /db_xref="GeneID:65274"
                     /db_xref="RGD:619938"
     exon            1..59
                     /gene="Nup62"
                     /gene_synonym="Np62"
                     /inference="alignment:Splign:2.1.0"
     exon            60..2370
                     /gene="Nup62"
                     /gene_synonym="Np62"
                     /inference="alignment:Splign:2.1.0"
     CDS             136..1713
                     /gene="Nup62"
                     /gene_synonym="Np62"
                     /note="62 kDa nucleoporin; nucleoporin Nup62; nuclear pore
                     glycoprotein 62"
                     /codon_start=1
                     /product="nuclear pore glycoprotein p62"
                     /protein_id="NP_075586.1"
                     /db_xref="GeneID:65274"
                     /db_xref="RGD:619938"
                     /translation="MSGFNFGGTGAPAGGFTFGTAKTATTTPATGFSFSASGTGTGGF
                     NFGTPSQPAATTPSTSLFSLATQTSTTQTPGFNFGTTPASGGTGFSLGISTPKLSLSS
                     TAATPATANTGSFGLGSSTLTNAISGASTSSQGTAPTGFVFGSSTTSAPSTGTTGFSF
                     TSGSASQPGASGFNIGSVGSLAQPTALSGSPFTPATLATTTAGATQPAAATPTAATTS
                     AGSTLFASIAAAPASSSTTVLSLSAPATTAATPTAGTLGFSLKAPGAAPGASTTSTTT
                     TTTTTTTTASTSSSTTTTGFALSLKPLVPAGPSSVAATALPASSTAVGTTTGPAMTYA
                     QLESLINKWSLELEDQERHFLQQATQVNAWDRTLIENGEKITSLHREVEKVKLDQKRL
                     DQELDFILSQQKELEDLLSPLEESVKEQSGTIYLQHADEEREKTYKLAENIDAQLKRM
                     AQDLKDIIEHLNMAGGPADTSDPLQQICKILNAHMDSLQWVDQSSALLQRRVEEASRV
                     CESRRKEQERSLRIAFD"
ORIGIN      
        1 aggcaacggc ggcggcggcc tcagttgaag agtcggtgtg agcagagagt gaagtcgcga
       61 catcttccca aggttgcaga cgctgacgga tttgccccag agtcgaagta actgccacct
      121 ggaaattcca cagccatgag tgggtttaac tttggaggca ccggggctcc tgctggcggc
      181 tttacatttg ggaccgcaaa gactgcgacc accacacccg ccactggctt ttccttctct
      241 gcttctggca ccggcaccgg agggtttaat tttgggactc cctcccagcc agctgcgacc
      301 accccttcca ccagcctctt ctcacttgcc acacagacct caaccacaca gaccccagga
      361 ttcaactttg gaacaacacc tgcttctggg ggaacaggct tctccctggg gatcagcacc
      421 ccaaagctca gcctaagtag cacagccgcc acaccagcca cagccaacac tggcagcttt
      481 gggcttggca gcagtactct taccaatgcc atctcaggtg ccagcacctc cagccagggg
      541 acagccccca ctggctttgt ctttggctct tctaccacct ctgctccgtc caccggcacc
      601 acgggattct cattcaccag tggcagtgca tcccagcctg gagcctccgg cttcaacatt
      661 ggctctgtgg gtagtttggc ccagcccaca gcactgtctg gctctccctt cactccagcc
      721 actctggcga caactacggc aggagcaaca cagccagctg ctgctacacc cactgctgcc
      781 accaccagtg cagggtctac actgtttgct tcaatagctg ctgctcctgc ctcatccagt
      841 actacagtgc tttccctctc agctccagcg acaactgcag ccactcctac tgctgggact
      901 ttgggcttca gcctcaaggc ccctggagca gctcctggtg cctccaccac cagcaccacc
      961 actactacta ccaccaccac tactactgcc tccacctcct cctccaccac gaccactggc
     1021 tttgccttaa gcctgaaacc cctggtgcca gctggcccca gcagcgtggc agctactgct
     1081 ctgcctgcct ccagcacagc agttgggact acgacgggtc cagcaatgac ctacgcgcag
     1141 ctggaaagcc tgatcaacaa gtggagtctg gagctggagg accaggagcg gcacttcctg
     1201 cagcaggcca cgcaggtcaa tgcctgggac cgcacactga ttgagaatgg ggagaagatc
     1261 accagcctgc accgagaggt ggaaaaggtg aagctggatc agaagcgtct ggaccaggag
     1321 ctggacttta tcctgtcaca gcagaaggag ctggaagacc ttctgagccc gttagaggag
     1381 tcagtgaagg agcaaagtgg caccatctac cttcagcatg ctgatgagga gcgtgagaag
     1441 acctacaagc tggctgagaa catcgatgct cagctcaagc gcatggccca ggacctcaag
     1501 gacattattg agcacctgaa catggctggt ggccctgcag acaccagtga cccactgcag
     1561 cagatctgca agatcctcaa tgcacacatg gactcccttc agtgggtgga ccagagctct
     1621 gccctgctgc agaggagggt ggaggaggcc agccgtgtgt gtgagagccg gcgcaaggaa
     1681 caggaacgca gcctgcgcat tgcctttgac tagccataca tgagttgggg gtgggggtac
     1741 ctcttttgtt gtagggctgc tggctttggg gtggttgtat tgttgagaaa aatgctcttt
     1801 ggtttggttc cctgttatca gaagtggttt gcgaaggcat gatgtcatgg atgtaataac
     1861 ctgtgtgctc tggagacagg tgtgaaggtc actgaactct aggccagcat ttaaagaaca
     1921 agggcaaact catcctttag ccactccaat acaactgtga cagtgggatg gcatgctcca
     1981 gagatgttgg ccaagaaact cacctggaat ggagacatgg cttctgtgct tccctgcttc
     2041 tctaactccc atctaaccca tgtcctccag agcctgtgct gcacaaagca gagtcaccaa
     2101 gggagactga gcttaacacc ggtttgcact ggctacccct ctcacccctc tcttgtgagc
     2161 ttctgtggca gggactgact gctgatagtt ctttgagaac agagtggctg cggatttgct
     2221 tctgaatgtc ccagtgtcaa accttagatt catagtgttg aaggctggca gttatgtctg
     2281 gtctatttta tttctccaca ctctactgta gcctctatgg tccctgatca aaacattgct
     2341 tttctaaata aagaaaacat tgtgaaatca aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     2401 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     2461 a
//
