LOCUS       NM_012991               2996 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus nucleoporin 50 (Nup50), mRNA.
ACCESSION   NM_012991 XM_579363
VERSION     NM_012991.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2996)
  AUTHORS   Hase,M.E. and Cordes,V.C.
  TITLE     Direct interaction with nup153 mediates binding of Tpr to the
            periphery of the nuclear pore complex
  JOURNAL   Mol Biol Cell 14 (5), 1923-1940 (2003)
   PUBMED   12802065
  REMARK    Erratum:[Mol Biol Cell. 2003 Aug;14(8):preceding Table of Contents]
REFERENCE   2  (bases 1 to 2996)
  AUTHORS   Smitherman,M., Lee,K., Swanger,J., Kapur,R. and Clurman,B.E.
  TITLE     Characterization and targeted disruption of murine Nup50, a
            p27(Kip1)-interacting component of the nuclear pore complex
  JOURNAL   Mol Cell Biol 20 (15), 5631-5642 (2000)
   PUBMED   10891500
REFERENCE   3  (bases 1 to 2996)
  AUTHORS   Guan,T., Kehlenbach,R.H., Schirmer,E.C., Kehlenbach,A., Fan,F.,
            Clurman,B.E., Arnheim,N. and Gerace,L.
  TITLE     Nup50, a nucleoplasmically oriented nucleoporin with a role in
            nuclear protein export
  JOURNAL   Mol Cell Biol 20 (15), 5619-5630 (2000)
   PUBMED   10891499
REFERENCE   4  (bases 1 to 2996)
  AUTHORS   Fan,F., Liu,C.P., Korobova,O., Heyting,C., Offenberg,H.H., Trump,G.
            and Arnheim,N.
  TITLE     cDNA cloning and characterization of Npap60: a novel rat nuclear
            pore-associated protein with an unusual subcellular localization
            during male germ cell differentiation
  JOURNAL   Genomics 40 (3), 444-453 (1997)
   PUBMED   9073512
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Nov 26, 2020 this sequence version replaced NM_012991.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U41845.2, SRR26643293.42583.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-309               JAXUCZ010000007.1  117927882-117928190
            310-388             JAXUCZ010000007.1  117931523-117931601
            389-472             JAXUCZ010000007.1  117933612-117933695
            473-659             JAXUCZ010000007.1  117937861-117938047
            660-1319            JAXUCZ010000007.1  117939160-117939819
            1320-1401           JAXUCZ010000007.1  117941368-117941449
            1402-1520           JAXUCZ010000007.1  117942239-117942357
            1521-2996           JAXUCZ010000007.1  117943680-117945155
FEATURES             Location/Qualifiers
     source          1..2996
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..2996
                     /gene="Nup50"
                     /gene_synonym="Npap60; Rtp60"
                     /note="nucleoporin 50"
                     /db_xref="GeneID:25497"
                     /db_xref="RGD:3191"
     exon            1..309
                     /gene="Nup50"
                     /gene_synonym="Npap60; Rtp60"
                     /inference="alignment:Splign:2.1.0"
     exon            310..388
                     /gene="Nup50"
                     /gene_synonym="Npap60; Rtp60"
                     /inference="alignment:Splign:2.1.0"
     CDS             320..1723
                     /gene="Nup50"
                     /gene_synonym="Npap60; Rtp60"
                     /note="nucleoporin 50 kDa; nucleoporin Nup50; 50 kDa
                     nucleoporin; nucleoprotein 50; Nucleoprotein 50kD; nuclear
                     pore associated protein"
                     /codon_start=1
                     /product="nuclear pore complex protein Nup50"
                     /protein_id="NP_037123.2"
                     /db_xref="GeneID:25497"
                     /db_xref="RGD:3191"
                     /translation="MAKRVAEKELTDRNWDEEDEVEEMGTFSVASEEVMKNRAVKKAK
                     RRNIGFESDSGGAFKGFKGLVVPSGGGGFSGFGGGSGGKPLEGLTNGNSTDSATPFSS
                     AKTAAEPKAAFGSFAVNGPTTLVDKKISSPKCNSSNQPPSSGPASSTSCTGNTYHKQL
                     AGLNCSVRDWIVKHVNTNPLCDLTPIFKDYERYLATIEKQLENGGSSSSESQTDRATA
                     AMEPPSLFGSTKLQQDSPFSFHGNKAEDTSEKLEFTAEKKSDAAQGATSASFNFGKKI
                     ESSVLGSLSSGSLTGFSFSPGNSSLFGKDAAQSKAASSPFSAKASESQAGGSSSECRD
                     GEEEESDEPPKVVVTEVKEEDAFYSKKCKLFYKKDNEFKEKGVGTLHLKPTATQKTQL
                     LVRADTNLGNILLNVLIPPNMPCTRTGKNNVLIVCVPNPPLDEKQPTLPVTMLIRVKT
                     SEDADELHKILLQKKDV"
     exon            389..472
                     /gene="Nup50"
                     /gene_synonym="Npap60; Rtp60"
                     /inference="alignment:Splign:2.1.0"
     exon            473..659
                     /gene="Nup50"
                     /gene_synonym="Npap60; Rtp60"
                     /inference="alignment:Splign:2.1.0"
     exon            660..1319
                     /gene="Nup50"
                     /gene_synonym="Npap60; Rtp60"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1401
                     /gene="Nup50"
                     /gene_synonym="Npap60; Rtp60"
                     /inference="alignment:Splign:2.1.0"
     exon            1402..1520
                     /gene="Nup50"
                     /gene_synonym="Npap60; Rtp60"
                     /inference="alignment:Splign:2.1.0"
     exon            1521..2996
                     /gene="Nup50"
                     /gene_synonym="Npap60; Rtp60"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcagtagctg gatgagggcg ttgcttgcct cctccctttt ttttctccga ttggttctga
       61 ggggtatatt cgagttgcaa aatggcggcc ccgagcgctc tcttcagcgt tcagtagcag
      121 cttcaggctg agcggatgtc tcttctcctc agtttcggac tcagagacac gcggctcccg
      181 actcctgctg atcacgaagt ccttgaaggc gctcaacgca ccggaatctc ccagcggccg
      241 cgaccgccgc ctcggccctg ctctccgcgg cgccggaact cagcgtgatc tgcggcggcc
      301 gtctaggagg ttcacaaaaa tggcgaagag agttgcggag aaggaattaa cagataggaa
      361 ttgggatgaa gaagatgaag ttgaagagat gggaacattc tcagtggcca gtgaggaagt
      421 catgaagaac agagccgtga agaaggcaaa gcgtaggaat attggctttg aatctgatag
      481 cggaggagcc tttaaaggtt tcaaagggtt ggttgtgcct tctggaggag gagggttttc
      541 tggatttggt ggtggctctg gagggaagcc tctggaagga ctgacaaatg gaaacagcac
      601 agacagtgcc acgcccttct ccagtgcaaa gacagcagcg gagcctaagg cagcctttgg
      661 ttcttttgct gtgaatggcc ctactacttt ggtggataaa aagatctcca gtcctaaatg
      721 caatagcagc aatcagccgc cctcctccgg cccagcctcc agtacctcct gcactgggaa
      781 tacctatcat aagcagttgg ctggcttgaa ctgctctgtc cgggattgga tagtgaagca
      841 tgttaacaca aacccacttt gtgacctgac gcccattttt aaagactacg agagatactt
      901 agcgacgatc gagaagcagc tggagaatgg gggtagcagc agctcagaga gccagacaga
      961 cagggcgacg gctgcaatgg agcctccttc cctttttggt tcaacaaaac tacagcaaga
     1021 ttcaccattt tcatttcatg gcaacaaagc ggaggacaca tctgaaaagt tggagtttac
     1081 agcagaaaag aaatcggacg cagcacaagg agcaacaagt gcctcgttta attttggcaa
     1141 gaaaattgag agctcagttt tgggctcttt aagctctggc tccctaactg ggttttcatt
     1201 ctctcctgga aactctagtt tatttggtaa agatgctgcc cagagtaaag cagcctcttc
     1261 accgttttct gctaaagcat ccgagagtca agcaggaggc agcagcagtg agtgcagaga
     1321 tggtgaagaa gaggagagtg acgagccacc caaggtggtg gtgactgaag tgaaggaaga
     1381 ggatgctttc tactccaaaa aatgtaaact attttacaag aaagacaatg aatttaaaga
     1441 gaagggtgtg gggaccctgc atttaaaacc cacagcgact cagaagaccc agctcttggt
     1501 gcgggcagac accaacctag gcaacattct gctgaatgtt ctgatcccac ccaatatgcc
     1561 gtgcacccgg acagggaaga acaatgtcct tatcgtctgt gtccccaacc ccccacttga
     1621 tgagaagcag cccactctcc cggtcaccat gctgattcgg gtgaagacga gcgaggatgc
     1681 cgatgagttg cacaagattt tactgcagaa aaaggacgtc tgagcactga ggctgaccag
     1741 ggcacgtcac catgttgctg cttccctttg cccctaaact tagtcacatt ctttcctctt
     1801 tgtactgtga cattctgaga acttctaggt aacttgaaac ttttgtgagg aagattaagg
     1861 ccaataaatc ctttcagtgt gtcgaagctc ttctcccttc ctaagaacta agcaaaatac
     1921 attggagtga aaagtttggg aagatttttt aatgtcgatt cattgagtaa actaacctaa
     1981 gtgattctta cggactgtaa tcagggtacc agttagctct ccaaaggctc cctcaggcag
     2041 ccacgggtgc cactctcttc ctgccctggg agactcaatg gcagtgtcca cagagttcca
     2101 gaagacgcct gctcccctcc tgtgggcttg tttggtccgt gactagcact cctgccaaat
     2161 accacaccgg cacactgtaa ccgcgcttgt tctgtttcct tctgagcgga actgtgggtc
     2221 ctggggatct ctgtccttag cctgtttttg acaggtgctg gcctttgacc tggaactact
     2281 tgactgaacc aggcactgcc tttccatggg aagagagggc aggtagtggc ttgtcgggga
     2341 gctggcgagg tatagactgg gttttgtcgt ttatccatga ggtgctctta cttgcttacc
     2401 tccctagtta acatggatgg gggctgtcag gaataatgga ttttattaaa agcacaaatt
     2461 tggtagcatt tttaaaatat catttctata ccacaaacaa gcctttattt taaaagaaaa
     2521 aagtgaaatt gtgctgaaaa gggttgtatg ctcgtggccg tttgtgccct ggggacctgg
     2581 tggtcacaat ctgaatggag ccctgtcaga gggtgctcgt gagaaggaag agtgtgggag
     2641 tggagacggc tcattcggcc tgtgacttca gacagcagca tgttattcag cgtctgaaaa
     2701 gcccaatttc atttttacct ttttacggat gaggtattct tgagtctgcc cacttggaag
     2761 agagccatgg ttctacacgc cattcatgcc acttgagagc ggtgaggtta ccgatactag
     2821 cattctctca aggccagaca tcagttaaat gcaaggtttg ttgacgagct ggtcacggct
     2881 ccctcctaac cccagtgccg gaaagctgag gcaggaagac cgtgcgagtt cacaacagcc
     2941 tgagctacgc agtaggaccc ctccccctaa aataaaataa aagtttgatg tctaaa
//
