LOCUS       NP_001162031            2067 aa            linear   ROD 30-MAR-2024
DEFINITION  nuclear pore complex protein Nup214 [Rattus norvegicus].
ACCESSION   NP_001162031 XP_001077983 XP_238325
VERSION     NP_001162031.1
DBSOURCE    REFSEQ: accession NM_001168559.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 2067)
  AUTHORS   Bonnet,A. and Palancade,B.
  TITLE     Regulation of mRNA trafficking by nuclear pore complexes
  JOURNAL   Genes (Basel) 5 (3), 767-791 (2014)
   PUBMED   25184662
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 2067)
  AUTHORS   Natalizio,B.J. and Wente,S.R.
  TITLE     Postage for the messenger: designating routes for nuclear mRNA
            export
  JOURNAL   Trends Cell Biol 23 (8), 365-373 (2013)
   PUBMED   23583578
  REMARK    Review article
REFERENCE   3  (residues 1 to 2067)
  AUTHORS   Zemp,I. and Kutay,U.
  TITLE     Nuclear export and cytoplasmic maturation of ribosomal subunits
  JOURNAL   FEBS Lett 581 (15), 2783-2793 (2007)
   PUBMED   17509569
  REMARK    Review article
REFERENCE   4  (residues 1 to 2067)
  AUTHORS   Xu,L., Kang,Y., Col,S. and Massague,J.
  TITLE     Smad2 nucleocytoplasmic shuttling by nucleoporins CAN/Nup214 and
            Nup153 feeds TGFbeta signaling complexes in the cytoplasm and
            nucleus
  JOURNAL   Mol Cell 10 (2), 271-282 (2002)
   PUBMED   12191473
REFERENCE   5  (residues 1 to 2067)
  AUTHORS   Bogerd,H.P., Wiegand,H.L., Yang,J. and Cullen,B.R.
  TITLE     Mutational definition of functional domains within the Rev homolog
            encoded by human endogenous retrovirus K
  JOURNAL   J Virol 74 (20), 9353-9361 (2000)
   PUBMED   11000203
REFERENCE   6  (residues 1 to 2067)
  AUTHORS   Farjot,G., Sergeant,A. and Mikaelian,I.
  TITLE     A new nucleoporin-like protein interacts with both HIV-1 Rev
            nuclear export signal and CRM-1
  JOURNAL   J Biol Chem 274 (24), 17309-17317 (1999)
   PUBMED   10358091
REFERENCE   7  (residues 1 to 2067)
  AUTHORS   Bastos,R., Ribas de Pouplana,L., Enarson,M., Bodoor,K. and Burke,B.
  TITLE     Nup84, a novel nucleoporin that is associated with CAN/Nup214 on
            the cytoplasmic face of the nuclear pore complex
  JOURNAL   J Cell Biol 137 (5), 989-1000 (1997)
   PUBMED   9166401
REFERENCE   8  (residues 1 to 2067)
  AUTHORS   van Deursen,J., Boer,J., Kasper,L. and Grosveld,G.
  TITLE     G2 arrest and impaired nucleocytoplasmic transport in mouse embryos
            lacking the proto-oncogene CAN/Nup214
  JOURNAL   EMBO J 15 (20), 5574-5583 (1996)
   PUBMED   8896451
REFERENCE   9  (residues 1 to 2067)
  AUTHORS   Radu,A., Blobel,G. and Moore,M.S.
  TITLE     Identification of a protein complex that is required for nuclear
            protein import and mediates docking of import substrate to distinct
            nucleoporins
  JOURNAL   Proc Natl Acad Sci U S A 92 (5), 1769-1773 (1995)
   PUBMED   7878057
REFERENCE   10 (residues 1 to 2067)
  AUTHORS   Kraemer,D., Wozniak,R.W., Blobel,G. and Radu,A.
  TITLE     The human CAN protein, a putative oncogene product associated with
            myeloid leukemogenesis, is a nuclear pore complex protein that
            faces the cytoplasm
  JOURNAL   Proc Natl Acad Sci U S A 91 (4), 1519-1523 (1994)
   PUBMED   8108440
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On or before Dec 12, 2009 this sequence version replaced
            XP_001077983.1, XP_238325.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760386 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2067
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3p12"
     Protein         1..2067
                     /product="nuclear pore complex protein Nup214"
                     /note="nucleoporin 214kDa"
                     /calculated_mol_wt=211257
     Region          23..>216
                     /region_name="WD40"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; cl29593"
                     /db_xref="CDD:475233"
     Region          39..86
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          96..147
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          152..189
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          155..>216
                     /region_name="ANAPC4_WD40"
                     /note="Anaphase-promoting complex subunit 4 WD40 domain;
                     pfam12894"
                     /db_xref="CDD:403945"
     Region          196..230
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          243..291
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          304..350
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          <425..688
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          <688..886
                     /region_name="COG4913"
                     /note="Uncharacterized conserved protein, contains a
                     C-terminal ATPase domain [Function unknown]"
                     /db_xref="CDD:443941"
     Region          <1126..1586
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          <1548..1775
                     /region_name="PPE"
                     /note="PPE-repeat protein [Function unknown]; COG5651"
                     /db_xref="CDD:444372"
     Region          <1784..>2003
                     /region_name="dermokine"
                     /note="cl42387"
                     /db_xref="CDD:455732"
     Region          1895..1954
                     /region_name="Nup214_FG"
                     /note="Nucleoporin Nup214 phenylalanine-glycine (FG)
                     domain; pfam18617"
                     /db_xref="CDD:408399"
     CDS             1..2067
                     /gene="Nup214"
                     /gene_synonym="RGD1304977"
                     /coded_by="NM_001168559.1:123..6326"
                     /db_xref="GeneID:296634"
                     /db_xref="RGD:1304977"
ORIGIN      
        1 mgdemdamip eremkdfqfr alkkvrifds peelpkerss vltvsnkygm lfaggtngln
       61 vfptkslliq nkpgddpnki vdtiqglnvp mkfpvhhlal scdnltlsac mmsseygsii
      121 affdvrtfsn qakplkrpft yhklsngasg mvndmkwnpt vpsmaavcla dgsisvlqvt
      181 dvvkvcatlp pssgvtcvcw spkgkqlavg kqngtvvqyl ptlqekkvip cppfyeadhp
      241 vrvldvlwig tyvftivyag adgaletcpd vvmallpkke ekhpeifvnf mepcysscte
      301 rqhhyylsyi eewdlvlaas aastevsila rqsdqtnwes wvledssrae lpvtdksdds
      361 lpvgvaidyt nevevainee ktlppapvll llstdgvlcp fyminqnpgv rsliktleli
      421 saegerqpks sgsfpstpps pqapqnldap atassplppv saaptatfpl psagggpsvf
      481 sfgpspfkss sipgepppyp tgsdssraap asgtptfsfa ppskgtlapt pavapvptsa
      541 apftfgssgf kpplestpms sapntgmkps fppstssvkv nlnekftava ssapvhssts
      601 ipsvlpfsss pkppasgpls hptplpasps smplkpsvsp spsvgrsaqt apssapstgq
      661 ksprvnppvp ksgssqaral qppvtekqrh qwkesdpvma gigeeiahfq keleelkart
      721 skacfqvgtp eemkmlrtes ddlhtflfei reateslhgd istlkttlle gfagveeare
      781 qhgrnhdsgy lhllykrpld pkseaqlqei rrlhqyvkfa vqdvndvldl ewdrhleqkk
      841 rqrrlivper etlfntlann reiinqqrkr lnhlvdslqq lrlynqtspw nrpstlstqs
      901 dtpsfdsdle hllkttiesh tkpsprvpgk lspakqaqlr nflakrktpp vrstapasls
      961 rsaflsqryy edldegssas svahpleged arptptcree eavvpvprha pvvrtpsvqp
     1021 sllpqampfa kphlihsssp aamsssists atkvipqgad ttmlatktvk hgapgpshtv
     1081 aapqaaaaaa lrrqmasqap avstltestl knvpqvvnvq elksnpspps aamgssgphs
     1141 aakaphavlt pvaasqakqg slinsfkpsg ptpvscqlss gdkavgpgta ktespvtstp
     1201 stgqlnkpfs faspgtftfg titpapsssf tatpgaappt kesnqleafs fggggkpfce
     1261 tipgnppatg ppsapstsvt ttsledsapt sskpatpetp vstassklet ppsklgellf
     1321 psslagetlg sfsglrvgqa eestkpvska sstnlagaqp akpsgfsfpa asvlgkpvep
     1381 svtssapaap vsalsastss ssatvfgsvp ltsaapsglm sfsgaslass kasfsfgnqq
     1441 tssaaaaaat pastsvapsl pasfptlsfg gllsspsass lpvssgkite eatppavpdk
     1501 sdhsevsast pslplqppsa qlpqaslqts dpvkkepvpa qttdsrpsss aslvastest
     1561 pvapggpdsk teavspastf agpgpavvaa vllgagsaas easgtpstss tvssstptpa
     1621 tetavfgtat sgssvftqpp aassssafnq lssntataps atpvfgqvaa siastaaatp
     1681 qasssgfgsp afgasapgvf gqtafgqspa fgqatsspas gfsfsqpgfs svpafgqsvs
     1741 stptstsanv fgatsstssp gsfsfgqast ntggtlfgqn nppafgqspg fgqggsvfgs
     1801 tsattstaap sgfsfcqasg fgssntgsvf gqaassggsv fgqsstssgs vfgsgnatrg
     1861 ggffsglggk psqdaanknp fssasggfgs tptpntsnlf gnsgaktfgg fgssfgeqkp
     1921 agtfssgggs vasqgfgfst pnktggfgaa pvfgspptfg gspgfggvpa fgsapaftsp
     1981 lgstggkvfg egtaaasagg fgfgsssnta sfgtlasqna ptfgslsqqt sgfgtpssgf
     2041 sgfgsgtgaf tfgssnssvq gfggwrs
//
