LOCUS       NM_001107744            6389 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus nucleoporin 160 (Nup160), mRNA.
ACCESSION   NM_001107744 XM_001077803 XM_230286
VERSION     NM_001107744.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6389)
  AUTHORS   Braun,D.A., Lovric,S., Schapiro,D., Schneider,R., Marquez,J.,
            Asif,M., Hussain,M.S., Daga,A., Widmeier,E., Rao,J., Ashraf,S.,
            Tan,W., Lusk,C.P., Kolb,A., Jobst-Schwan,T., Schmidt,J.M.,
            Hoogstraten,C.A., Eddy,K., Kitzler,T.M., Shril,S., Moawia,A.,
            Schrage,K., Khayyat,A.I.A., Lawson,J.A., Gee,H.Y., Warejko,J.K.,
            Hermle,T., Majmundar,A.J., Hugo,H., Budde,B., Motameny,S.,
            Altmuller,J., Noegel,A.A., Fathy,H.M., Gale,D.P., Waseem,S.S.,
            Khan,A., Kerecuk,L., Hashmi,S., Mohebbi,N., Ettenger,R.,
            Serdaroglu,E., Alhasan,K.A., Hashem,M., Goncalves,S., Ariceta,G.,
            Ubetagoyena,M., Antonin,W., Baig,S.M., Alkuraya,F.S., Shen,Q.,
            Xu,H., Antignac,C., Lifton,R.P., Mane,S., Nurnberg,P., Khokha,M.K.
            and Hildebrandt,F.
  TITLE     Mutations in multiple components of the nuclear pore complex cause
            nephrotic syndrome
  JOURNAL   J Clin Invest 128 (10), 4313-4328 (2018)
   PUBMED   30179222
REFERENCE   2  (bases 1 to 6389)
  AUTHORS   Bonnet,A. and Palancade,B.
  TITLE     Regulation of mRNA trafficking by nuclear pore complexes
  JOURNAL   Genes (Basel) 5 (3), 767-791 (2014)
   PUBMED   25184662
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6389)
  AUTHORS   Glavy,J.S., Krutchinsky,A.N., Cristea,I.M., Berke,I.C., Boehmer,T.,
            Blobel,G. and Chait,B.T.
  TITLE     Cell-cycle-dependent phosphorylation of the nuclear pore Nup107-160
            subcomplex
  JOURNAL   Proc Natl Acad Sci U S A 104 (10), 3811-3816 (2007)
   PUBMED   17360435
REFERENCE   4  (bases 1 to 6389)
  AUTHORS   Rasala,B.A., Orjalo,A.V., Shen,Z., Briggs,S. and Forbes,D.J.
  TITLE     ELYS is a dual nucleoporin/kinetochore protein required for nuclear
            pore assembly and proper cell division
  JOURNAL   Proc Natl Acad Sci U S A 103 (47), 17801-17806 (2006)
   PUBMED   17098863
REFERENCE   5  (bases 1 to 6389)
  AUTHORS   Loiodice,I., Alves,A., Rabut,G., Van Overbeek,M., Ellenberg,J.,
            Sibarita,J.B. and Doye,V.
  TITLE     The entire Nup107-160 complex, including three new members, is
            targeted as one entity to kinetochores in mitosis
  JOURNAL   Mol Biol Cell 15 (7), 3333-3344 (2004)
   PUBMED   15146057
REFERENCE   6  (bases 1 to 6389)
  AUTHORS   Vasu,S., Shah,S., Orjalo,A., Park,M., Fischer,W.H. and Forbes,D.J.
  TITLE     Novel vertebrate nucleoporins Nup133 and Nup160 play a role in mRNA
            export
  JOURNAL   J Cell Biol 155 (3), 339-354 (2001)
   PUBMED   11684705
REFERENCE   7  (bases 1 to 6389)
  AUTHORS   Belgareh,N., Rabut,G., Bai,S.W., van Overbeek,M., Beaudouin,J.,
            Daigle,N., Zatsepina,O.V., Pasteau,F., Labas,V., Fromont-Racine,M.,
            Ellenberg,J. and Doye,V.
  TITLE     An evolutionarily conserved NPC subcomplex, which redistributes in
            part to kinetochores in mammalian cells
  JOURNAL   J Cell Biol 154 (6), 1147-1160 (2001)
   PUBMED   11564755
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473949.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001077803.1, XM_230286.4.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..6389
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q24"
     gene            1..6389
                     /gene="Nup160"
                     /note="nucleoporin 160"
                     /db_xref="GeneID:311182"
                     /db_xref="RGD:1311052"
     exon            1..264
                     /gene="Nup160"
                     /inference="alignment:Splign:2.1.0"
     exon            265..738
                     /gene="Nup160"
                     /inference="alignment:Splign:2.1.0"
     CDS             639..4778
                     /gene="Nup160"
                     /codon_start=1
                     /product="nuclear pore complex protein Nup160"
                     /protein_id="NP_001101214.1"
                     /db_xref="GeneID:311182"
                     /db_xref="RGD:1311052"
                     /translation="MAAAGSLERSFVELSGAERERPRHFREFTVCDLGTANAAFGAVK
                     YSESAGGFYYVESGKLFSITRNRFIHWKTSGDTLELVEESLDLNLLNNAVRLKFQNYS
                     LLPGGVHVSETQNHVIILILTNHTVHRLILPHPSRMYRSELVTESQMQSIFTDIGKVD
                     FKDPCNYQLIPTVPGLSPSSTTSAAWLSSDGEALFALPSASGGIFVLKLPPYDIPGIA
                     SVVELKQSSVMQRLLTGWMPTAIRGDHGPSDRALSLAVHCVEHDAFIFALCQDHKLRM
                     WSYKDQMCLMVADMLEYVPVNKDLRLTAGTGHKLRLAYSPSMGLYLGIYMHAPKRGQF
                     CIFQLVSTESSRYSLDHISSLFTSQETLVDFALTSTDIWALWHDAENQTIVKYINFEH
                     NVAGQWNPVFMQSLPEEEIVIRDDQDPRIFCRGTERNLDLSWSELKKEITLAVENELQ
                     GSVTEYEFSQDEFRTLQQEFWCKFYACCLQYQEALSHPLALHLNPLTNMVCLLKKGYL
                     SFLVPSSLVDHLYLLPDEHLLTEDETTISDDADVARDVLCLIKCLRMIGESVTMDMAV
                     LMETSCYNLQSPEKAAEHILEDLITIDVENVMEDICSKLQEIRNPVHAIGLLIREMDY
                     ETEVEMEKGFDPAQPLNVRMNLSQLYGSSTAGYIVCRGVYKIASTRFLICRDLLILQQ
                     LLTRLGDAVILGAGQLFQAQQDLLHRTAPLLLSYYLIKWSSQCLATDVPVDTLESNLQ
                     HLSVLELTDSGALMANKLVSSPQTIMELFFQEVARKHIISHLFSQPKAPLSQTGLNWP
                     EMVTAVTGYLLQLLWPSNPGCLFLECLMGNCQYVQLQDYIQLLHPWCQVNVGSCRFML
                     GRCYLVTGEVQKALECFCQAASEVGKEEFLDRLIRTEDGEIVSTPKLQYYDKVLRLLD
                     VVGLPELVIQLATSAITEAGDDWKSQATLRTCIFKHHLDLGHNSQAYEALTQIPDSSR
                     QLDCLRQLVVVLCERSQLQDLVEFPYVNLHNEVVGIIESRARAVDLMTHNYYELLYAF
                     HIYRHNYRKAGTVMFEYGMRLGREVRTLGGLEKQGNCYLAAINCLRLIRPEYAWIVQP
                     ASGAVSDRPGASPKRNHDGECTAAPTNRQIEILELEDLEKECSLARIRLTLARHDPSA
                     IAIAGSSSAKEMSTLLVQAGLFDTAISLCQTFKLPLTPVFEGLAFKCIKLQFGGEAAQ
                     GEAWAWLAANQLSSVITTKESSATDEAWRLLSTYLERYKVQNNLYHHCVINKLLSHGV
                     PLPNWLINSYKKVDAAELLRLYLNYDLLEEAVDLVSEYVDAVLGKGHQYFGIEFPLSA
                     TAPMVWLPYSSIDQLLQALGENSANSHNIILSQKILDKLEDYQQKVDKATRDLLYRRD
                     L"
     exon            739..850
                     /gene="Nup160"
                     /inference="alignment:Splign:2.1.0"
     exon            851..1061
                     /gene="Nup160"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1284
                     /gene="Nup160"
                     /inference="alignment:Splign:2.1.0"
     exon            1285..1363
                     /gene="Nup160"
                     /inference="alignment:Splign:2.1.0"
     exon            1364..1478
                     /gene="Nup160"
                     /inference="alignment:Splign:2.1.0"
     exon            1479..1637
                     /gene="Nup160"
                     /inference="alignment:Splign:2.1.0"
     exon            1638..1715
                     /gene="Nup160"
                     /inference="alignment:Splign:2.1.0"
     exon            1716..1813
                     /gene="Nup160"
                     /inference="alignment:Splign:2.1.0"
     exon            1814..1898
                     /gene="Nup160"
                     /inference="alignment:Splign:2.1.0"
     exon            1899..1982
                     /gene="Nup160"
                     /inference="alignment:Splign:2.1.0"
     exon            1983..2153
                     /gene="Nup160"
                     /inference="alignment:Splign:2.1.0"
     exon            2154..2253
                     /gene="Nup160"
                     /inference="alignment:Splign:2.1.0"
     exon            2254..2419
                     /gene="Nup160"
                     /inference="alignment:Splign:2.1.0"
     exon            2420..2547
                     /gene="Nup160"
                     /inference="alignment:Splign:2.1.0"
     exon            2548..2708
                     /gene="Nup160"
                     /inference="alignment:Splign:2.1.0"
     exon            2709..2842
                     /gene="Nup160"
                     /inference="alignment:Splign:2.1.0"
     exon            2843..2913
                     /gene="Nup160"
                     /inference="alignment:Splign:2.1.0"
     exon            2914..3073
                     /gene="Nup160"
                     /inference="alignment:Splign:2.1.0"
     exon            3074..3143
                     /gene="Nup160"
                     /inference="alignment:Splign:2.1.0"
     exon            3144..3242
                     /gene="Nup160"
                     /inference="alignment:Splign:2.1.0"
     exon            3243..3362
                     /gene="Nup160"
                     /inference="alignment:Splign:2.1.0"
     exon            3363..3458
                     /gene="Nup160"
                     /inference="alignment:Splign:2.1.0"
     exon            3459..3553
                     /gene="Nup160"
                     /inference="alignment:Splign:2.1.0"
     exon            3554..3650
                     /gene="Nup160"
                     /inference="alignment:Splign:2.1.0"
     exon            3651..3756
                     /gene="Nup160"
                     /inference="alignment:Splign:2.1.0"
     exon            3757..3917
                     /gene="Nup160"
                     /inference="alignment:Splign:2.1.0"
     exon            3918..3978
                     /gene="Nup160"
                     /inference="alignment:Splign:2.1.0"
     exon            3979..4089
                     /gene="Nup160"
                     /inference="alignment:Splign:2.1.0"
     exon            4090..4213
                     /gene="Nup160"
                     /inference="alignment:Splign:2.1.0"
     exon            4214..4315
                     /gene="Nup160"
                     /inference="alignment:Splign:2.1.0"
     exon            4316..4457
                     /gene="Nup160"
                     /inference="alignment:Splign:2.1.0"
     exon            4458..4583
                     /gene="Nup160"
                     /inference="alignment:Splign:2.1.0"
     exon            4584..4688
                     /gene="Nup160"
                     /inference="alignment:Splign:2.1.0"
     exon            4689..6389
                     /gene="Nup160"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acagctatga tctcatcaaa gcagccacca cattgtatgt ccaggaggca gtttttacag
       61 cactcctccc tgttcatctc ttacattcct tcttatatta tagatatttt gaatatgtga
      121 ggaaaatgac tcttaacatc aagttcccca aaacatattt cactcattcc atagactagg
      181 ctagccgtaa actcacagag atctacctgt atctgccttc tgtgtgctga gggtcaagat
      241 gtgagccact aagcccaaca acagaggttg ggtaacaact tacaagccaa cactctaacg
      301 gaggggaagg tgaccgctag ctgctaatgt gcctgtcagg cctcttccct cgccgcccgc
      361 ccccgcccgt ttttcaaaat gaaaacacac acagccccgc ccctgctcta ggcggtcggg
      421 aaagggcgcc gcggccgccg ccggctccaa aatgaccgct agtggaggca tcttcctccc
      481 gcttcagcct ctctctcgcg gtgaaaagcc acaaccgatc ctcagaccca cggtcctcgg
      541 ccagcgaaag tctcacaggc ccgccctgcg ccacaccccc ggaagtgacg tcgacgtgac
      601 ccgcccttgt cccgtcgggc ctcgcgacgc gcgggaagat ggcggcggcg ggatccctgg
      661 aacggagctt cgtggagctg agcggagctg aacgcgaaag gcccaggcac tttcgggaat
      721 tcacagtgtg cgaccttggg actgcaaatg ctgcgtttgg agcagtgaaa tacagtgaga
      781 gcgcaggagg cttctattat gtggaaagtg gcaagttatt ctccatcacc agaaacaggt
      841 tcattcattg gaagacttcc ggggatacat tggagctggt ggaggaatca ctggacttaa
      901 atttgttgaa taatgctgtt cgcctaaaat tccaaaatta cagcctctta cccggtgggg
      961 ttcatgtctc tgagacccag aatcatgtga taatcttgat attaaccaat catacagtac
     1021 acagattaat tttaccacac ccatcccgta tgtacagaag cgagctggta actgaaagtc
     1081 agatgcaatc aatatttact gacattggaa aagttgattt caaagatcct tgcaactatc
     1141 agttaattcc aacagtgcct ggactgtccc cgagttccac cacttctgca gcctggctta
     1201 gcagtgatgg ggaggctctg tttgctctac cgtctgcttc tggtggcatc tttgttctta
     1261 agctgcctcc ttatgacata cctgggatag catcagttgt ggaactgaaa cagagttcag
     1321 tgatgcagcg gttactcaca ggctggatgc ccacagctat aaggggtgac catgggcctt
     1381 cagatcgtgc cctgagtctt gctgttcatt gtgttgaaca tgatgccttt atttttgccc
     1441 tatgtcagga tcataaacta cggatgtggt cttataagga ccaaatgtgc ctgatggtgg
     1501 ctgatatgct ggaatatgtc cctgtaaaca aagaccttcg gctcactgca ggaacaggac
     1561 ataagttacg gcttgcatat tccccttcca tggggctcta cctaggaata tacatgcatg
     1621 ctccaaaacg aggacagttc tgcattttcc agttggtgag caccgagagc agtcgctata
     1681 gtttagatca catttcttca ctgttcactt ctcaggagac actggtcgat tttgccttaa
     1741 cctcaacgga tatctgggcc ctgtggcatg atgctgagaa ccaaacaatt gtgaaatata
     1801 tcaactttga acataatgtt gcaggtcagt ggaatccagt ttttatgcag tctctaccag
     1861 aagaagaaat tgtcatcaga gacgatcaag accccagaat tttctgccgg ggtactgaga
     1921 ggaacttgga tctttcatgg agtgaactaa aaaaggaaat tactttagct gttgaaaatg
     1981 agctccaagg aagtgtaacc gagtatgaat tctcccagga tgaatttcgt actttacaac
     2041 aggaattctg gtgcaagttc tatgcctgct gtctccagta tcaggaagcc ctctcccacc
     2101 ctcttgctct acatttgaat cctctcacaa acatggtgtg ccttctgaag aaagggtacc
     2161 tgtctttcct ggtcccatct tccttagtag atcatttata tctcctgcct gatgagcacc
     2221 ttctgacaga ggatgagacg accatatcgg atgatgcaga tgtggcacgg gatgtcttat
     2281 gtcttatcaa atgcctccgg atgattgggg agtcagttac catggatatg gcagttttga
     2341 tggaaaccag ttgttacaac ttgcagtctc cagagaaggc tgcagaacac attttggaag
     2401 atttgatcac tattgatgta gaaaatgtga tggaagacat ttgtagtaaa ctgcaagaga
     2461 tcagaaaccc cgtccatgcc attgggcttc tcatacggga aatggattat gaaacggaag
     2521 tggagatgga aaagggattc gatccagctc agcctttgaa tgttcgaatg aatctttccc
     2581 agctctatgg tagtagcaca gcaggatata ttgtgtgcag aggtgtgtat aaaattgcca
     2641 gcactcgctt cctgatctgc cgagacctct tgatcttaca gcagctgttg acaagactag
     2701 gagatgcagt gatcttagga gctggtcagc tctttcaagc tcagcaagac ctgctgcatc
     2761 gcacagctcc cctgctcttg tcttattacc tcattaagtg gtcaagtcag tgcttggcaa
     2821 ccgatgtccc agttgacaca ctggagtcta atctacaaca tttgtcagta ctggaactaa
     2881 ctgattctgg tgccttaatg gcaaataaat tggtctctag ccctcagaca attatggagt
     2941 tattcttcca agaagttgca agaaaacata ttatatctca tctcttctct cagcccaaag
     3001 cccctctaag ccaaactgga ctgaattggc ctgaaatggt tactgcagtt accggctatt
     3061 tgttacagct tttatggcct agcaatcctg gttgtctctt tctagaatgt ttgatgggaa
     3121 attgccagta tgtacaattg caggattaca tccaactact gcatccctgg tgtcaagtca
     3181 atgttggatc atgtcgcttt atgctgggac ggtgttacct agttacagga gaagtacaga
     3241 aggctctgga atgtttctgt caggcagcat cggaagtggg caaagaagaa ttcttagatc
     3301 gcttgatccg aacagaggac ggggagatcg tgtccacccc caagttgcag tattatgata
     3361 aggttttacg tctgctagac gttgttggat tgcctgagct ggttattcag ctcgctacat
     3421 cagcaattac tgaagcgggt gatgactgga aaagtcaggc tactttaaga acatgcattt
     3481 tcaaacatca tttggacttg ggtcacaata gccaagcata tgaggcctta acccaaattc
     3541 ctgactccag caggcagtta gactgtttgc ggcagctggt ggtcgttctt tgtgaacgct
     3601 cccaactgca ggatcttgta gagtttccct atgtgaatct gcataatgaa gttgtgggaa
     3661 tcattgagtc gcgtgccaga gctgtggacc ttatgactca caattactat gaactcctct
     3721 atgcttttca catttaccgc cataactacc gaaaagctgg tacagtgatg tttgaatatg
     3781 gtatgcgtct tggcagagag gttcgaactc tcgggggact tgagaagcaa ggcaactgtt
     3841 acctggctgc tattaattgt ttacggctta ttcgtccaga gtatgcgtgg attgtacagc
     3901 cagcctctgg ggcagtgtct gatcgccctg gagcatctcc taagaggaat catgatggcg
     3961 agtgcacagc tgccccaacc aatcggcaga ttgaaattct agaattggaa gacctcgaga
     4021 aagagtgttc tttagcgcga attcgcctca cgttggcacg gcatgatcca tcagcaattg
     4081 ccattgcagg aagttcatca gcaaaggaga tgagcacgct cttggttcag gctggcctct
     4141 ttgacactgc catatcactc tgtcagactt ttaagcttcc attaacaccg gtctttgaag
     4201 ggcttgcttt caagtgcatt aagttgcagt ttggaggaga agcagcacag ggagaagcct
     4261 gggcctggct agcagccaat cagctctctt ctgtcatcac caccaaggag tccagtgcta
     4321 cagatgaagc atggaggcta ttatcaactt acttggaaag atacaaagtc cagaataact
     4381 tgtatcacca ctgtgtgatt aacaagttgt tatctcatgg agttcctctg cctaattggc
     4441 ttataaatag ttacaagaaa gtcgatgctg ctgagttgct tcgcctttac ctgaactatg
     4501 accttttaga agaagccgtg gatttggtct ctgaatatgt agatgctgta ttgggaaaag
     4561 gacatcagta ctttggaatt gagtttccac tgtcagcaac agccccgatg gtgtggctcc
     4621 catactcttc tattgaccag cttctccagg ctctgggaga gaacagtgcc aacagtcaca
     4681 acattatact gtcccagaaa attcttgaca aactagaaga ctaccaacaa aaagtcgaca
     4741 aggcaacacg agatttactg taccgccggg acttgtgatt gggatagctg ctcagccttt
     4801 gtaaccttgg tgcctcttag gcttaagact actctacaga gaccctgtcc tcagggccaa
     4861 ttttgatgac tgtaaatgat gtgtacggcg cctgagtctg cattctgcac aacataagag
     4921 aacaaaagtc aggaccgacc ctgtgcttgc ttgtggtgct aacacggttt ctgcttttca
     4981 aacttcgtct ctaacagctg cttttgtata tgattctcaa cctttttcag agtttatatt
     5041 tttttaaact accgaagcca tcctttatct gcaaacaaaa aagtcacctt cactttccat
     5101 aatagctatg attgttggct tgttatagct gaccaccaaa ctgtcactgt gtatcttctc
     5161 atttttcctt atctttttgt atttcagtgg gattgatttg gtccagaact gacatatatt
     5221 ttctgtattg caaacaaagg ctagtggttt tacatactcc tttcattatt tattgtagag
     5281 ttttcatgtg accttcaata aagtattagg tgatatgcat agattaagca taaattatga
     5341 ccaccttttt aaggaaaata tattttgaat ctggctctaa agctaaagtt gagtaaatat
     5401 cagaaaaaga ttaatgtcca ccatctataa aagaaacaga ttttcatttt caaaatgtat
     5461 ttatgtgatt tactaatcaa gctggacttg atcctacagt tagtatgata atatattgga
     5521 ccaaaacaga attttattgg tcagaatcag aaacattcgt gcaaacagac tttgggaaag
     5581 gtgaaaaata ataaaaatat cctttgattt tattctgtat attaagattt atctttcaag
     5641 ggaacagtta tacactattt gaatgaatgc cctttggctt tgtgtttttt ataaacttta
     5701 gaatttacac tatccacaac ctagttgtgt tacatagttt acagctctac agtgcttaat
     5761 atggcatgct agggattggc cccgtgattc agtcgtagtc tgaaaatagc aaaccctgtt
     5821 tcagccatat ctgaagagca acaagtaaga ggacactggt gctgcctcag cagttcacac
     5881 agcactgacg ctttccctgt gctgaccctc ctgtcaaagc agtctgatct tccatttacc
     5941 tctacccgtc tcattgtgat tccagccaga gcaatgggaa cttgtgctct cacacagttt
     6001 gcacgccact gtgggtctgt gtttgtgttt actgtaccct ttgagatttt attagtccac
     6061 agtattatga cctttgcctg tttttggtgg gttttttttt ttttcctact cttgtgattt
     6121 ttctgtcaga aagtattatt gaaaggttct ctgagaatct agagaaatgg ctcagtggtt
     6181 aggcaggctg gccatgagta agttctgttg ggccaggagt gtggatctca caatagaaca
     6241 tttgcttagc agatccaagg ctctcaattg ccagcctcag aaggtatgta gtaaaatgga
     6301 actgcaatgg ctgtaagaga tgtcgtttct gttatactga atttggtagg gctggctgcc
     6361 aaggcctctg tttaacccca ataccacag
//
