LOCUS       NM_053830               3101 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus nucleoporin 107 (Nup107), mRNA.
ACCESSION   NM_053830
VERSION     NM_053830.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3101)
  AUTHORS   Guan,Y., Gao,X., Tang,Q., Huang,L., Gao,S., Yu,S., Huang,J., Li,J.,
            Zhou,D., Zhang,Y., Shi,D., Liang,D., Liu,Y., Li,L., Cui,Y., Xu,L.
            and Chen,Y.H.
  TITLE     Nucleoporin 107 facilitates the nuclear export of Scn5a mRNA to
            regulate cardiac bioelectricity
  JOURNAL   J Cell Mol Med 23 (2), 1448-1457 (2019)
   PUBMED   30506890
  REMARK    GeneRIF: The analysis for the protein production demonstrated
            Nup107-facilitated transport of Scn5a mRNA. Using RIP-PCR and
            luciferase assay, we found that the 5'-UTR of Scn5a mRNA was not
            involved in the interaction, whereas the spatial interaction
            between Nup107 protein and Scn5a mRNA was formed when Scn5a mRNA
            passing through the nuclear pore.
REFERENCE   2  (bases 1 to 3101)
  AUTHORS   Braun,D.A., Lovric,S., Schapiro,D., Schneider,R., Marquez,J.,
            Asif,M., Hussain,M.S., Daga,A., Widmeier,E., Rao,J., Ashraf,S.,
            Tan,W., Lusk,C.P., Kolb,A., Jobst-Schwan,T., Schmidt,J.M.,
            Hoogstraten,C.A., Eddy,K., Kitzler,T.M., Shril,S., Moawia,A.,
            Schrage,K., Khayyat,A.I.A., Lawson,J.A., Gee,H.Y., Warejko,J.K.,
            Hermle,T., Majmundar,A.J., Hugo,H., Budde,B., Motameny,S.,
            Altmuller,J., Noegel,A.A., Fathy,H.M., Gale,D.P., Waseem,S.S.,
            Khan,A., Kerecuk,L., Hashmi,S., Mohebbi,N., Ettenger,R.,
            Serdaroglu,E., Alhasan,K.A., Hashem,M., Goncalves,S., Ariceta,G.,
            Ubetagoyena,M., Antonin,W., Baig,S.M., Alkuraya,F.S., Shen,Q.,
            Xu,H., Antignac,C., Lifton,R.P., Mane,S., Nurnberg,P., Khokha,M.K.
            and Hildebrandt,F.
  TITLE     Mutations in multiple components of the nuclear pore complex cause
            nephrotic syndrome
  JOURNAL   J Clin Invest 128 (10), 4313-4328 (2018)
   PUBMED   30179222
REFERENCE   3  (bases 1 to 3101)
  AUTHORS   Weinberg-Shukron,A., Renbaum,P., Kalifa,R., Zeligson,S.,
            Ben-Neriah,Z., Dreifuss,A., Abu-Rayyan,A., Maatuk,N., Fardian,N.,
            Rekler,D., Kanaan,M., Samson,A.O., Levy-Lahad,E., Gerlitz,O. and
            Zangen,D.
  TITLE     A mutation in the nucleoporin-107 gene causes XX gonadal dysgenesis
  JOURNAL   J Clin Invest 125 (11), 4295-4304 (2015)
   PUBMED   26485283
REFERENCE   4  (bases 1 to 3101)
  AUTHORS   Miyake,N., Tsukaguchi,H., Koshimizu,E., Shono,A., Matsunaga,S.,
            Shiina,M., Mimura,Y., Imamura,S., Hirose,T., Okudela,K., Nozu,K.,
            Akioka,Y., Hattori,M., Yoshikawa,N., Kitamura,A., Cheong,H.I.,
            Kagami,S., Yamashita,M., Fujita,A., Miyatake,S., Tsurusaki,Y.,
            Nakashima,M., Saitsu,H., Ohashi,K., Imamoto,N., Ryo,A., Ogata,K.,
            Iijima,K. and Matsumoto,N.
  TITLE     Biallelic Mutations in Nuclear Pore Complex Subunit NUP107 Cause
            Early-Childhood-Onset Steroid-Resistant Nephrotic Syndrome
  JOURNAL   Am J Hum Genet 97 (4), 555-566 (2015)
   PUBMED   26411495
REFERENCE   5  (bases 1 to 3101)
  AUTHORS   Bonnet,A. and Palancade,B.
  TITLE     Regulation of mRNA trafficking by nuclear pore complexes
  JOURNAL   Genes (Basel) 5 (3), 767-791 (2014)
   PUBMED   25184662
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3101)
  AUTHORS   Krull,S., Thyberg,J., Bjorkroth,B., Rackwitz,H.R. and Cordes,V.C.
  TITLE     Nucleoporins as components of the nuclear pore complex core
            structure and Tpr as the architectural element of the nuclear
            basket
  JOURNAL   Mol Biol Cell 15 (9), 4261-4277 (2004)
   PUBMED   15229283
REFERENCE   7  (bases 1 to 3101)
  AUTHORS   Hase,M.E. and Cordes,V.C.
  TITLE     Direct interaction with nup153 mediates binding of Tpr to the
            periphery of the nuclear pore complex
  JOURNAL   Mol Biol Cell 14 (5), 1923-1940 (2003)
   PUBMED   12802065
  REMARK    Erratum:[Mol Biol Cell. 2003 Aug;14(8):preceding Table of Contents]
REFERENCE   8  (bases 1 to 3101)
  AUTHORS   Vasu,S., Shah,S., Orjalo,A., Park,M., Fischer,W.H. and Forbes,D.J.
  TITLE     Novel vertebrate nucleoporins Nup133 and Nup160 play a role in mRNA
            export
  JOURNAL   J Cell Biol 155 (3), 339-354 (2001)
   PUBMED   11684705
REFERENCE   9  (bases 1 to 3101)
  AUTHORS   Belgareh,N., Rabut,G., Bai,S.W., van Overbeek,M., Beaudouin,J.,
            Daigle,N., Zatsepina,O.V., Pasteau,F., Labas,V., Fromont-Racine,M.,
            Ellenberg,J. and Doye,V.
  TITLE     An evolutionarily conserved NPC subcomplex, which redistributes in
            part to kinetochores in mammalian cells
  JOURNAL   J Cell Biol 154 (6), 1147-1160 (2001)
   PUBMED   11564755
REFERENCE   10 (bases 1 to 3101)
  AUTHORS   Radu,A., Blobel,G. and Wozniak,R.W.
  TITLE     Nup107 is a novel nuclear pore complex protein that contains a
            leucine zipper
  JOURNAL   J Biol Chem 269 (26), 17600-17605 (1994)
   PUBMED   8021268
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB733157.1, JAXUCZ010000007.1, CB775175.1, CV120917.1, EV764995.1,
            CB792533.1, C07146.1, CK844566.1 and BQ191246.1.
            
            On Oct 11, 2007 this sequence version replaced NM_053830.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments and orthologous data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L31840.1, SRR26643292.29407.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                CB733157.1         12-34
            24-125              JAXUCZ010000007.1  55278204-55278305   c
            126-225             CB733157.1         36-135
            226-414             CB775175.1         61-249
            415-515             CB733157.1         325-425
            516-617             JAXUCZ010000007.1  55278204-55278305   c
            618-721             JAXUCZ010000007.1  55275021-55275124   c
            722-752             JAXUCZ010000007.1  55272295-55272325   c
            753-1394            CV120917.1         1-642
            1395-1928           EV764995.1         241-774
            1929-2215           CB792533.1         97-383
            2216-2270           JAXUCZ010000007.1  55252324-55252378   c
            2271-2431           JAXUCZ010000007.1  55249659-55249819   c
            2432-2482           JAXUCZ010000007.1  55248619-55248669   c
            2483-2777           C07146.1           10-304
            2778-3183           CK844566.1         16-421              c
            3184-3202           BQ191246.1         1-19                c
FEATURES             Location/Qualifiers
     source          1..3101
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q22"
     gene            1..3101
                     /gene="Nup107"
                     /note="nucleoporin 107"
                     /db_xref="GeneID:116555"
                     /db_xref="RGD:621160"
     exon            1..76
                     /gene="Nup107"
                     /inference="alignment:Splign:2.1.0"
     CDS             69..2846
                     /gene="Nup107"
                     /note="p105; nucleoporin Nup107; 107 kDa nucleoporin"
                     /codon_start=1
                     /product="nuclear pore complex protein Nup107"
                     /protein_id="NP_446282.2"
                     /db_xref="GeneID:116555"
                     /db_xref="RGD:621160"
                     /translation="MDRSGFGGMSSPVIRDPEVTRTARKHSAHKRVLIQANQDENFGT
                     TTPRSQIIPRTPSSFRQPFTPPSRSLLRHPDISYIFGTEGRSPRHIQSSGYLGNLSMV
                     TNLDDSNWAAAFSSQRLGFYTNTEHHSMTEDINLSTVMLREDDPGEAASMSMFSDFLQ
                     SFLKHSSTTVFDLVEEYENICASQVNILSKIVSRATPGLQKFSKTASMLWLLQQEMVT
                     WRLLASLYRDRIQSSLEEENMFAIAGINASEKTVVEALFQRDTLVRQSQLVVDWLESI
                     AKDEIGDFSDNIEFYAKSVYWENTLHSLKQRQLLSYIGSTRPLVTELDPDAPIRQKMP
                     LDDLDREDEVRLLKYLFTLIRAGMTEEAQRLCKRCGQAWRAATLEGWKLHHDPNVNGG
                     TELEPVEGNPYRRIWKISCWRMAEDELFNKYERAIYAALSGNLKQLLPVCDTWEDTVW
                     AYFRVMVDSLVEQEIRTSVMTLDETEELPREYMEANWTLEKVFEELQATDKKRVLEEN
                     QEHYHVVQKFLILGDIDGLMDEFSKWLSKSRSSLPGHLLRFMTHLILFFRTLGLQTKE
                     EVSIEVLKTYIQLLINEKHTNLIAFYTCHLPQDLAVAQYALFLEGVTECEQRHQCLEL
                     AKEADLDVATITKTVVENIRKKDNGEFSHHDLAPSLDTATTEEDRLKIDVIDWLVFDP
                     AQRAEALRQGNAIMRKFLALKKHEAAKEVFVKIPQDSIAEIYNQWEEQGMESPLPAED
                     DNAIREHLCIRAYLEAHETFNEWFKHMNSAPQKPTLLSQATFTEKVAHEHKEKKYEMD
                     HNIWKGHLDALTADVKEKMYNVLLFVDGGWMVDVREDAEEDPERAHQMVLLRKLCLPM
                     LCFLLHTILHSTGQYQECLQLADMVSSERHKLYLVFSKEELRKLLQKLRESSLMLLDQ
                     GLDPLGYEIQS"
     exon            77..168
                     /gene="Nup107"
                     /inference="alignment:Splign:2.1.0"
     exon            169..255
                     /gene="Nup107"
                     /inference="alignment:Splign:2.1.0"
     exon            256..371
                     /gene="Nup107"
                     /inference="alignment:Splign:2.1.0"
     exon            372..516
                     /gene="Nup107"
                     /inference="alignment:Splign:2.1.0"
     exon            517..620
                     /gene="Nup107"
                     /inference="alignment:Splign:2.1.0"
     exon            621..748
                     /gene="Nup107"
                     /inference="alignment:Splign:2.1.0"
     exon            749..797
                     /gene="Nup107"
                     /inference="alignment:Splign:2.1.0"
     exon            798..869
                     /gene="Nup107"
                     /inference="alignment:Splign:2.1.0"
     exon            870..958
                     /gene="Nup107"
                     /inference="alignment:Splign:2.1.0"
     exon            959..1037
                     /gene="Nup107"
                     /inference="alignment:Splign:2.1.0"
     exon            1038..1151
                     /gene="Nup107"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1242
                     /gene="Nup107"
                     /inference="alignment:Splign:2.1.0"
     exon            1243..1319
                     /gene="Nup107"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1379
                     /gene="Nup107"
                     /inference="alignment:Splign:2.1.0"
     exon            1380..1525
                     /gene="Nup107"
                     /inference="alignment:Splign:2.1.0"
     exon            1526..1574
                     /gene="Nup107"
                     /inference="alignment:Splign:2.1.0"
     exon            1575..1644
                     /gene="Nup107"
                     /inference="alignment:Splign:2.1.0"
     exon            1645..1763
                     /gene="Nup107"
                     /inference="alignment:Splign:2.1.0"
     exon            1764..1802
                     /gene="Nup107"
                     /inference="alignment:Splign:2.1.0"
     exon            1803..1953
                     /gene="Nup107"
                     /inference="alignment:Splign:2.1.0"
     exon            1954..2066
                     /gene="Nup107"
                     /inference="alignment:Splign:2.1.0"
     exon            2067..2169
                     /gene="Nup107"
                     /inference="alignment:Splign:2.1.0"
     exon            2170..2330
                     /gene="Nup107"
                     /inference="alignment:Splign:2.1.0"
     exon            2331..2456
                     /gene="Nup107"
                     /inference="alignment:Splign:2.1.0"
     exon            2457..2570
                     /gene="Nup107"
                     /inference="alignment:Splign:2.1.0"
     exon            2571..2738
                     /gene="Nup107"
                     /inference="alignment:Splign:2.1.0"
     exon            2739..3084
                     /gene="Nup107"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctgaaacgc ggtggctgga ctgtaatcaa agttgcaagg ttctatctag gtggagacgg
       61 ctgcggccat ggacaggagt ggcttcgggg gaatgtcatc ccctgtgatc cgagacccag
      121 aggttacgag gactgcacgg aagcatagtg ctcacaaaag agttttaatt caggccaacc
      181 aagatgaaaa ttttggtact actacaccaa gaagccagat tattcctcga actccaagct
      241 catttcgaca accttttact ccaccaagcc gaagtttact aagacaccca gatatatcct
      301 acatttttgg gacggaaggg aggtctcccc ggcatataca gtcttctggg tatttgggaa
      361 atctttccat ggtgactaac cttgatgaca gcaactgggc agctgcattc tcatcccagc
      421 gtttagggtt ctacacaaac acggagcacc atagtatgac tgaggacata aacctaagta
      481 ctgtcatgct acgggaggat gaccctggag aggctgcatc catgagtatg ttctctgatt
      541 tcctgcagtc tttcttgaag cactcttcaa ccacagtctt tgatcttgta gaagagtatg
      601 aaaatatttg tgctagtcag gtgaacatcc tgagtaaaat cgtgagccga gcaacgcctg
      661 gactgcagaa gttctccaag acagccagca tgctctggct tctccagcag gagatggtca
      721 cgtggaggct gcttgcctct ttgtatagag acagaataca gtcttcatta gaagaggaaa
      781 atatgtttgc aattgctggt atcaatgcca gtgagaagac ggttgtggaa gcgctgtttc
      841 agagggacac gctggtccga cagagccagt tggtggtaga ttggctagag agcattgcca
      901 aagatgaaat tggagatttc tcagacaata ttgagtttta tgcaaaatca gtatattggg
      961 aaaatacact ccactcctta aaacagcggc agctgctgtc ttatatagga agtacccgtc
     1021 ctcttgtcac tgagctggac ccagatgctc ccattagaca gaaaatgccg ctggatgatc
     1081 tggacagaga agatgaagtc agactgctga agtacctctt cactctaatc cgtgctggga
     1141 tgaccgagga ggcacagagg ctctgtaaac ggtgcgggca agcatggaga gctgcaaccc
     1201 tggaaggatg gaagctgcac cacgacccca acgtgaatgg agggacagag ctagagcctg
     1261 tcgaagggaa tccatataga cggatctgga agattagttg ctggagaatg gctgaagatg
     1321 aactttttaa taaatacgaa agagcgattt atgcagcact cagtgggaat ctcaagcagc
     1381 tccttccggt ctgtgacacc tgggaagaca cagtgtgggc ctatttccgg gtgatggtgg
     1441 acagcctggt ggagcaggag attcgcacct cagtcatgac cctagatgaa actgaggagc
     1501 tccctcggga gtacatggaa gcgaattgga ccttagaaaa agtttttgaa gagcttcaag
     1561 ccactgataa gaagagagtt ctggaagaga atcaagaaca ttaccatgta gtccagaaat
     1621 tccttatcct gggagacatt gatggtttga tggatgaatt tagcaaatgg ctgtccaaga
     1681 gcagaagcag tctacctgga cacctcctcc gttttatgac tcacctcatt ctgtttttcc
     1741 gcaccctggg actgcagacc aaagaagaag tttccattga agttctaaag acgtatatac
     1801 agctgttaat caatgagaag cacacaaacc tcatagcgtt ctatacctgt catctgcctc
     1861 aagaccttgc ggttgcccaa tacgccttgt ttttggaggg tgttacggag tgtgagcagc
     1921 ggcaccagtg cctggagctg gctaaggagg cagatttgga tgttgcgact ataacaaaaa
     1981 ctgtagttga aaatattcgg aagaaagata atggtgaatt cagtcaccat gacctggctc
     2041 catccctgga tactgccact actgaggagg accgtttgaa gatcgatgtg attgactggc
     2101 tggtgtttga cccagcgcag agagccgaag ccctgagaca aggcaacgcc atcatgagga
     2161 agttcttagc attaaagaaa catgaagctg caaaagaagt gtttgtgaaa attcctcagg
     2221 attccatcgc agaaatctat aatcagtggg aggagcaagg catggagagc cctcttcctg
     2281 ccgaggatga taacgctatc cgagagcact tgtgtatcag agcttatctg gaagcccatg
     2341 aaaccttcaa tgagtggttt aaacatatga attcggctcc tcagaaacct acactgctgt
     2401 cccaggcgac ttttacagag aaagtggctc acgagcacaa agaaaagaag tacgagatgg
     2461 atcataatat ttggaaagga catttggatg ctctaactgc tgatgtgaag gagaaaatgt
     2521 acaacgtctt attgtttgtt gatggaggat ggatggtgga tgtcagagag gacgctgagg
     2581 aagacccgga acgagctcat cagatggttt tgctgagaaa gctctgtctc cccatgctgt
     2641 gcttcctgct tcacaccata ctgcacagca ccgggcaata ccaggagtgc ctgcagctgg
     2701 ccgacatggt gtcctctgag cgccacaagc tctatctggt attttctaag gaagaactaa
     2761 ggaaactgct gcagaagtta agggagtcct cgctgatgct cctagaccag gggcttgacc
     2821 cgctcggcta tgaaatccag tcataattca ccattctctg cgcccgtgac tacaagagga
     2881 tgcctgcttg cttggctgtg ttgcttagtt ggttggtttt ggtcagatat acatatttgt
     2941 aattattggt ttatttgttt gtttgtttcc tttggcattc ttggggaaaa tgtaaaattt
     3001 tggcttttga attttgtatt atatcagtat ttccttatgt attttttaaa gaaattatac
     3061 aaaataaatt ttttgttcta tagaaaaaaa aaaaaaaaaa a
//
