LOCUS       NM_001398697            2762 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus NUMB-like, endocytic adaptor protein (Numbl),
            transcript variant 1, mRNA.
ACCESSION   NM_001398697 XM_006228567
VERSION     NM_001398697.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2762)
  AUTHORS   Zhu,L., Yan,Y., Ke,K., Wu,X., Gao,Y., Shen,A., Li,J., Kang,L.,
            Zhang,G., Wu,Q. and Yang,H.
  TITLE     Dynamic change of Numbl expression after sciatic nerve crush and
            its role in Schwann cell differentiation
  JOURNAL   J Neurosci Res 90 (8), 1557-1565 (2012)
   PUBMED   22437994
  REMARK    GeneRIF: peripheral nerve injury induced a downregulation of Numbl
            in the sciatic nerve, which was associated with Schwann cell
            differentiation.
REFERENCE   2  (bases 1 to 2762)
  AUTHORS   Gao,Z., Chi,F.L., Huang,Y.B., Yang,J.M., Cong,N. and Li,W.
  TITLE     Expression of Numb and Numb-like in the development of mammalian
            auditory sensory epithelium
  JOURNAL   Neuroreport 22 (2), 49-54 (2011)
   PUBMED   21150807
  REMARK    GeneRIF: We show that NUMBL is expressed in the rat auditory
            sensory epithelium during cochlear development
REFERENCE   3  (bases 1 to 2762)
  AUTHORS   Zhou,L., Ma,Q., Shi,H. and Huo,K.
  TITLE     NUMBL interacts with TRAF6 and promotes the degradation of TRAF6
  JOURNAL   Biochem Biophys Res Commun 392 (3), 409-414 (2010)
   PUBMED   20079715
REFERENCE   4  (bases 1 to 2762)
  AUTHORS   Ma,Q., Zhou,L., Shi,H. and Huo,K.
  TITLE     NUMBL interacts with TAB2 and inhibits TNFalpha and
            IL-1beta-induced NF-kappaB activation
  JOURNAL   Cell Signal 20 (6), 1044-1051 (2008)
   PUBMED   18299187
REFERENCE   5  (bases 1 to 2762)
  AUTHORS   Rasin,M.R., Gazula,V.R., Breunig,J.J., Kwan,K.Y., Johnson,M.B.,
            Liu-Chen,S., Li,H.S., Jan,L.Y., Jan,Y.N., Rakic,P. and Sestan,N.
  TITLE     Numb and Numbl are required for maintenance of cadherin-based
            adhesion and polarity of neural progenitors
  JOURNAL   Nat Neurosci 10 (7), 819-827 (2007)
   PUBMED   17589506
REFERENCE   6  (bases 1 to 2762)
  AUTHORS   Huang,E.J., Li,H., Tang,A.A., Wiggins,A.K., Neve,R.L., Zhong,W.,
            Jan,L.Y. and Jan,Y.N.
  TITLE     Targeted deletion of numb and numblike in sensory neurons reveals
            their essential functions in axon arborization
  JOURNAL   Genes Dev 19 (1), 138-151 (2005)
   PUBMED   15598981
REFERENCE   7  (bases 1 to 2762)
  AUTHORS   Pece,S., Serresi,M., Santolini,E., Capra,M., Hulleman,E.,
            Galimberti,V., Zurrida,S., Maisonneuve,P., Viale,G. and Di
            Fiore,P.P.
  TITLE     Loss of negative regulation by Numb over Notch is relevant to human
            breast carcinogenesis
  JOURNAL   J Cell Biol 167 (2), 215-221 (2004)
   PUBMED   15492044
REFERENCE   8  (bases 1 to 2762)
  AUTHORS   Li,H.S., Wang,D., Shen,Q., Schonemann,M.D., Gorski,J.A.,
            Jones,K.R., Temple,S., Jan,L.Y. and Jan,Y.N.
  TITLE     Inactivation of Numb and Numblike in embryonic dorsal forebrain
            impairs neurogenesis and disrupts cortical morphogenesis
  JOURNAL   Neuron 40 (6), 1105-1118 (2003)
   PUBMED   14687546
REFERENCE   9  (bases 1 to 2762)
  AUTHORS   Petersen,P.H., Zou,K., Hwang,J.K., Jan,Y.N. and Zhong,W.
  TITLE     Progenitor cell maintenance requires numb and numblike during mouse
            neurogenesis
  JOURNAL   Nature 419 (6910), 929-934 (2002)
   PUBMED   12410312
REFERENCE   10 (bases 1 to 2762)
  AUTHORS   Zhong,W., Jiang,M.M., Weinmaster,G., Jan,L.Y. and Jan,Y.N.
  TITLE     Differential expression of mammalian Numb, Numblike and Notch1
            suggests distinct roles during mouse cortical neurogenesis
  JOURNAL   Development 124 (10), 1887-1897 (1997)
   PUBMED   9169836
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Dec 21, 2021 this sequence version replaced XM_006228567.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC129073.1, SRR26643429.1320.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-184               JAXUCZ010000001.1  91677644-91677827
            185-269             JAXUCZ010000001.1  91681041-91681125
            270-409             JAXUCZ010000001.1  91683796-91683935
            410-484             JAXUCZ010000001.1  91685741-91685815
            485-559             JAXUCZ010000001.1  91685911-91685985
            560-700             JAXUCZ010000001.1  91687852-91687992
            701-890             JAXUCZ010000001.1  91693206-91693395
            891-1196            JAXUCZ010000001.1  91695515-91695820
            1197-1319           JAXUCZ010000001.1  91698330-91698452
            1320-2762           JAXUCZ010000001.1  91699973-91701415
FEATURES             Location/Qualifiers
     source          1..2762
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..2762
                     /gene="Numbl"
                     /note="NUMB-like, endocytic adaptor protein"
                     /db_xref="GeneID:292732"
                     /db_xref="RGD:1307579"
     exon            1..184
                     /gene="Numbl"
                     /inference="alignment:Splign:2.1.0"
     CDS             161..2005
                     /gene="Numbl"
                     /note="isoform 1 is encoded by transcript variant 1;
                     numb-like protein; numb homolog-like"
                     /codon_start=1
                     /product="numb-like protein isoform 1"
                     /protein_id="NP_001385626.1"
                     /db_xref="GeneID:292732"
                     /db_xref="RGD:1307579"
                     /translation="MSRSAAASGGPRRPDQHLPPAPCGASGPPETFRTESDGAGTMNK
                     LRQSLRRRKPAYVPEASRPHQWQADEDAVRKGTCSFPVRYLGHVEVEESRGMHVCEDA
                     VKKLKAMGRKSVKSVLWVSADGLRVVDDKTKDLLVDQTIEKVSFCAPDRNLDKAFSYI
                     CRDGTTRRWICHCFLALKDSGERLSHAVGCAFAACLERKQRREKECGVTAAFDASRTS
                     FAREGSFRLSGGGRPAEREAGDKKKAEAAAAPAVAPGPAQPGHVSPTPATTSPGEKGE
                     AGTPVAAGTTAAAIPRRHAPLEQLVRQGSFRGFPALSQKNSPFKRQLSLRLNELPSTL
                     QRRTDFQVKGTVPEMEPPGTGDSDGISALCTQISSSFASAGAPVPGPPSATTGTSAWG
                     EPSVPAATAFQPGHKRTPSEAERWLEEVSQVAKAQQQQQQQQQQQQQQQQQQQQQQQQ
                     QATSVPPMPTMAPTLQPFSTPVGPFDTAAAQVAVFLPPTHMQPPFVPAYPGLGYPPMP
                     RVPVVGITPSQMVANAFCSAAQLQPQPATLLGKAGAFPPPTAPSAPGGQARPRPNGAP
                     WPPEPAPAPAPELDPFEAQWAALEGKPAVEKPSNPFSGDLQKTFEIEL"
     exon            185..269
                     /gene="Numbl"
                     /inference="alignment:Splign:2.1.0"
     exon            270..409
                     /gene="Numbl"
                     /inference="alignment:Splign:2.1.0"
     exon            410..484
                     /gene="Numbl"
                     /inference="alignment:Splign:2.1.0"
     exon            485..559
                     /gene="Numbl"
                     /inference="alignment:Splign:2.1.0"
     exon            560..700
                     /gene="Numbl"
                     /inference="alignment:Splign:2.1.0"
     exon            701..890
                     /gene="Numbl"
                     /inference="alignment:Splign:2.1.0"
     exon            891..1196
                     /gene="Numbl"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..1319
                     /gene="Numbl"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..2762
                     /gene="Numbl"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcccgggag ccgagctggc tcgcgcgctt gcatcccgca ccagccgtcg gccccgggcc
       61 cggcccgcgt cagatcgagc cgccgccacc acagcagcag cagcactcgg gtagccgggc
      121 ccaaccgggg ccgcgggagg cgggggcgcc cgggccctgg atgtcccgca gcgcggcggc
      181 cagcggcgga cccaggagac ctgatcagca tttgccccca gccccctgtg gggcctcggg
      241 gccccctgaa accttcagga cggagtcaga cggggcgggc accatgaaca agttacggca
      301 gagtctgcgg cggaggaagc cagcctatgt gcctgaggcg tcacgcccac accagtggca
      361 ggcagatgag gatgcggtgc ggaagggcac atgcagcttc cccgttaggt acctgggcca
      421 cgtggaagtg gaggagtccc gggggatgca cgtttgtgaa gacgcggtga agaagctgaa
      481 ggcgatgggc cggaagtccg tgaagtctgt cctgtgggtg tcggctgatg ggctccgagt
      541 ggtggatgac aagaccaagg acctgctggt agaccagacc atcgagaagg tgtccttctg
      601 tgctcctgac cgcaacctgg acaaggcatt ctcctacata tgccgtgatg gcaccacacg
      661 ccgctggatc tgccactgtt tcctggccct caaggactct ggtgagaggc tgagccacgc
      721 tgtgggctgc gcgttcgctg cctgcctgga gaggaagcag cgacgggaga aggagtgcgg
      781 agtcaccgcc gccttcgatg ccagtcgcac cagctttgcc cgcgagggct ccttccgcct
      841 gtccggtggc gggcggcctg cggagcgcga ggctggggac aagaagaaag cagaagcagc
      901 agctgctcct gctgtggctc ctggccctgc ccagcctggg cacgtttctc cgacaccggc
      961 cactacatcc cctggtgaga agggagaggc gggtacccca gtggctgcag gcaccactgc
     1021 tgctgccatt ccccggcgcc atgcacctct ggaacagctg gttcgccagg gctcctttcg
     1081 tgggtttcct gccctcagcc agaagaactc acctttcaaa cgtcagctga gtctacggtt
     1141 gaatgagctg ccatccacac tgcagcgccg tacagacttc caggtgaagg gcacagtgcc
     1201 tgagatggag cctcctggta ctggtgacag cgacggcatc agtgccctgt gcacacaaat
     1261 cagctcgtct ttcgccagtg ccggagcacc agtgccaggg ccaccgtctg ccaccacagg
     1321 gacgtctgcc tggggtgagc cctctgtacc tgctgcaact gccttccagc ccgggcacaa
     1381 gcggacaccg tcggaggctg agcgatggtt ggaggaagtg tcccaggtgg ctaaggccca
     1441 acaacagcag cagcagcagc agcagcagca gcagcagcag cagcagcagc agcagcaaca
     1501 acaacagcaa caagccacct ccgtgccacc aatgcccacc atggccccca cccttcaacc
     1561 cttctccacc ccagtggggc cctttgacac tgcagctgcc caggtggctg tgttcctgcc
     1621 acccacacac atgcagcctc catttgtgcc cgcctaccca ggcctgggtt acccacccat
     1681 gccccgggtg ccagtggtgg gcatcacacc ttcacagatg gtggccaacg ccttctgctc
     1741 agctgctcag ctccagcccc aacctgccac actgcttgga aaagccgggg ccttcccccc
     1801 acctaccgca cccagtgccc ctgggggcca ggcccgtcca cgccctaatg gggctccctg
     1861 gcccccagag ccagcgcctg cccctgcccc tgagttggac ccctttgagg cccagtgggc
     1921 agctttagaa ggcaagcccg ccgtggagaa accctccaac cccttctctg gtgacttgca
     1981 gaagaccttc gagattgaac tgtagcccaa attgccctgc cccccactcc atcagaccca
     2041 ggtgtaccac actcaggagg ggaagcccag cctcttccct ggtgttgctc cctgagctgc
     2101 gcccctcaac tctccctcta agcccttctc tccaccaccc ctcacaaacc actacagaac
     2161 caatattgtg atgcctagat tttgccaaga tggaattcag ggatggaccc agcctggcta
     2221 agggaaccat ttcactgccg gacttaggct ggcgatgccc cttcgccagc catagtcacg
     2281 gaatgccctc tgttcaagct actttcccca gtttctgttg tgcccttcca ctttccagtg
     2341 ttgggcagga tggaggagtg atgcccactt aggggcactc ctgggcccac ttcgagccgg
     2401 gctcatcctc tctctctcct tgccccatac acacagcaca agctaagggc ttccattctg
     2461 cccaagctgt gttcactgcc aatgctgtgc ttgccctgcc ccctccccca ctcgggggcg
     2521 agtcttccgg agggtcaagg tctcacgggg tggggcccga ttgggggccc cggagagggg
     2581 gggggaggat gaagacgctc tgttacctca tgtccgtgcc cgctggggag gggtcccagg
     2641 agaagaagaa gggcgttgcc tggcgggtac ttttctatct tttatttcca gatttttttt
     2701 gtatctaaac ttgcagattt gtattataca aggacagcca ataaaggaag actataatgg
     2761 tg
//
