LOCUS       NM_001411955            3518 bp    mRNA    linear   ROD 28-AUG-2024
DEFINITION  Rattus norvegicus NUMB, endocytic adaptor protein (Numb),
            transcript variant 4, mRNA.
ACCESSION   NM_001411955 XM_039111830
VERSION     NM_001411955.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3518)
  AUTHORS   Lv,Z., Ding,Y. and Zhang,W.
  TITLE     NUMB attenuates posttraumatic osteoarthritis by inhibiting BTRC and
            inactivating the NF-kappaB pathway
  JOURNAL   J Orthop Surg Res 19 (1), 502 (2024)
   PUBMED   39175086
  REMARK    GeneRIF: NUMB attenuates posttraumatic osteoarthritis by inhibiting
            BTRC and inactivating the NF-kappaB pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3518)
  AUTHORS   Wang,G., Zhang,Z., Li,J., Han,J. and Lu,C.
  TITLE     The PTB and PRR domains of numb regulate neurite outgrowth by
            influencing voltage-gated calcium channel expression and kinetics
  JOURNAL   Brain Res Bull 207, 110876 (2024)
   PUBMED   38215950
  REMARK    GeneRIF: The PTB and PRR domains of numb regulate neurite outgrowth
            by influencing voltage-gated calcium channel expression and
            kinetics.
REFERENCE   3  (bases 1 to 3518)
  AUTHORS   Xu,Y.N., Xu,W., Zhang,X., Wang,D.Y., Zheng,X.R., Liu,W., Chen,J.M.,
            Chen,G.F., Liu,C.H., Liu,P. and Mu,Y.P.
  TITLE     BM-MSCs overexpressing the Numb enhance the therapeutic effect on
            cholestatic liver fibrosis by inhibiting the ductular reaction
  JOURNAL   Stem Cell Res Ther 14 (1), 45 (2023)
   PUBMED   36941658
  REMARK    GeneRIF: BM-MSCs overexpressing the Numb enhance the therapeutic
            effect on cholestatic liver fibrosis by inhibiting the ductular
            reaction.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3518)
  AUTHORS   Xu,Y.N., Xu,W., Chen,J.M., Liu,W., Chen,G.F., Zhang,H., Liu,P. and
            Mu,Y.P.
  TITLE     [Overexpression of Numb gene can inhibit the progression of biliary
            liver fibrosis in adult liver]
  JOURNAL   Zhonghua Gan Zang Bing Za Zhi 30 (11), 1175-1181 (2022)
   PUBMED   36891694
  REMARK    GeneRIF: [Overexpression of Numb gene can inhibit the progression
            of biliary liver fibrosis in adult liver].
REFERENCE   5  (bases 1 to 3518)
  AUTHORS   Xu,W., Xu,Y.N., Zhang,X., Xu,Y., Jian,X., Chen,J.M., Chen,G.F.,
            Zhang,H., Liu,P. and Mu,Y.P.
  TITLE     Hepatic stem cell Numb gene is a potential target of Huang Qi
            Decoction against cholestatic liver fibrosis
  JOURNAL   Sci Rep 10 (1), 17486 (2020)
   PUBMED   33060633
  REMARK    GeneRIF: Hepatic stem cell Numb gene is a potential target of Huang
            Qi Decoction against cholestatic liver fibrosis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3518)
  AUTHORS   Kubu,C.J., Orimoto,K., Morrison,S.J., Weinmaster,G., Anderson,D.J.
            and Verdi,J.M.
  TITLE     Developmental changes in Notch1 and numb expression mediated by
            local cell-cell interactions underlie progressively increasing
            delta sensitivity in neural crest stem cells
  JOURNAL   Dev Biol 244 (1), 199-214 (2002)
   PUBMED   11900468
  REMARK    GeneRIF: neural crest stem cells become increasingly sensitive to
            the Notch ligand Delta-Fc and this transition is correlated with an
            increase in the relative ratio of expression of Notch and Numb
            (Delta-Fc)
REFERENCE   7  (bases 1 to 3518)
  AUTHORS   Nie,J., McGill,M.A., Dermer,M., Dho,S.E., Wolting,C.D. and
            McGlade,C.J.
  TITLE     LNX functions as a RING type E3 ubiquitin ligase that targets the
            cell fate determinant Numb for ubiquitin-dependent degradation
  JOURNAL   EMBO J 21 (1-2), 93-102 (2002)
   PUBMED   11782429
REFERENCE   8  (bases 1 to 3518)
  AUTHORS   Zhong,W., Jiang,M.M., Schonemann,M.D., Meneses,J.J., Pedersen,R.A.,
            Jan,L.Y. and Jan,Y.N.
  TITLE     Mouse numb is an essential gene involved in cortical neurogenesis
  JOURNAL   Proc Natl Acad Sci U S A 97 (12), 6844-6849 (2000)
   PUBMED   10841580
REFERENCE   9  (bases 1 to 3518)
  AUTHORS   Fernandez-Chacon,R., Alvarez de Toledo,G., Hammer,R.E. and
            Sudhof,T.C.
  TITLE     Analysis of SCAMP1 function in secretory vesicle exocytosis by
            means of gene targeting in mice
  JOURNAL   J Biol Chem 274 (46), 32551-32554 (1999)
   PUBMED   10551807
REFERENCE   10 (bases 1 to 3518)
  AUTHORS   Verdi,J.M., Schmandt,R., Bashirullah,A., Jacob,S., Salvino,R.,
            Craig,C.G., Program,A.E., Lipshitz,H.D. and McGlade,C.J.
  TITLE     Mammalian NUMB is an evolutionarily conserved signaling adapter
            protein that specifies cell fate
  JOURNAL   Curr Biol 6 (9), 1134-1145 (1996)
   PUBMED   8805372
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Sep 13, 2022 this sequence version replaced XM_039111830.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.2103601.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-74                JAXUCZ010000006.1  109284390-109284463 c
            75-202              JAXUCZ010000006.1  109247916-109248043 c
            203-343             JAXUCZ010000006.1  109207960-109208100 c
            344-418             JAXUCZ010000006.1  109197868-109197942 c
            419-451             JAXUCZ010000006.1  109191621-109191653 c
            452-526             JAXUCZ010000006.1  109178699-109178773 c
            527-667             JAXUCZ010000006.1  109176445-109176585 c
            668-872             JAXUCZ010000006.1  109172697-109172901 c
            873-1163            JAXUCZ010000006.1  109169916-109170206 c
            1164-1313           JAXUCZ010000006.1  109167729-109167878 c
            1314-1460           JAXUCZ010000006.1  109165406-109165552 c
            1461-3518           JAXUCZ010000006.1  109162499-109164556 c
FEATURES             Location/Qualifiers
     source          1..3518
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q31"
     gene            1..3518
                     /gene="Numb"
                     /note="NUMB, endocytic adaptor protein"
                     /db_xref="GeneID:29419"
                     /db_xref="RGD:620107"
     exon            1..74
                     /gene="Numb"
                     /inference="alignment:Splign:2.1.0"
     exon            75..202
                     /gene="Numb"
                     /inference="alignment:Splign:2.1.0"
     exon            203..343
                     /gene="Numb"
                     /inference="alignment:Splign:2.1.0"
     CDS             218..2176
                     /gene="Numb"
                     /note="isoform 3 is encoded by transcript variant 4; numb
                     gene homolog; protein numb homolog"
                     /codon_start=1
                     /product="protein numb homolog isoform 3"
                     /protein_id="NP_001398884.1"
                     /db_xref="GeneID:29419"
                     /db_xref="RGD:620107"
                     /translation="MNKLRQSFRRKKDVYVPEASRPHQWQTDEEGVRTGKCSFPVKYL
                     GHVEVDESRGMHICEDAVKRLKAERKFFKGFFGKTGKKAVKAVLWVSADGLRVVDEKT
                     KDLIVDQTIEKVSFCAPDRNFDRAFSYICRDGTTRRWICHCFMAVKDTGERLSHAVGC
                     AFAACLERKQKREKECGVTATFDASRTTFTREGSFRVTTATEQAEREEIMKQLQDAKK
                     AETDKTVGPSVAPGNSAPSPSSPTSPTLDPTASLEMNNPHAIPRRHAPIEQLARQGSF
                     RGFPALSQKMSPFKRQLSLRINELPSTMQRKTDFPIKNTVPEVEGEAESISSLCSQIT
                     SAFSTPCEDPFSSAPMTKPVTLVAPQSPVLQANGTDSALHVLTAKPASTALAPVAMPV
                     RETNPWAHAPDAANKEIAAIHSGTEWGQSSGAASPGLFQAGHRRTPSEADRWLEEVSK
                     SVRAQQPQVSAAPLQPVLQPPPPAAIAPPAPPFQGHAFLTSQPVPVGVVPPLQPAFVS
                     TQSYPVANGMPYPASNVPVVGITPSQMVANVFGTAGHPQATHPHQSPSLAKQQTFPQY
                     ETSSATTSPFFKPSAQHLNGSAAFNGVDNSGLVSGNRPAQVPPGTCPVDPFEAQWAAL
                     ESKPKQRTNPSPTNPFSSDAQKAFEIEL"
     exon            344..418
                     /gene="Numb"
                     /inference="alignment:Splign:2.1.0"
     exon            419..451
                     /gene="Numb"
                     /inference="alignment:Splign:2.1.0"
     exon            452..526
                     /gene="Numb"
                     /inference="alignment:Splign:2.1.0"
     exon            527..667
                     /gene="Numb"
                     /inference="alignment:Splign:2.1.0"
     exon            668..872
                     /gene="Numb"
                     /inference="alignment:Splign:2.1.0"
     exon            873..1163
                     /gene="Numb"
                     /inference="alignment:Splign:2.1.0"
     exon            1164..1313
                     /gene="Numb"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..1460
                     /gene="Numb"
                     /inference="alignment:Splign:2.1.0"
     exon            1461..3518
                     /gene="Numb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtggtggcg cttggtgact actggcggcg gaggtagagt ctgaggcgcc ggagttgtgc
       61 agggccagcg gcagttttca gattttagag ccaaagaaca ttttccaggg gagactggcc
      121 accttggcaa ccaagatcct gacccataac cacagactgg agtactggtg ggccacagtc
      181 ctcaaatacc tgcttaagac aggttgtaaa agttaacatg aacaaactac ggcagagttt
      241 caggagaaag aaagatgttt acgtcccaga ggccagccgt ccacatcagt ggcagacaga
      301 tgaagaggga gtccgcactg gaaagtgcag cttcccagtt aagtaccttg gccacgtaga
      361 ggttgatgag tcaagaggaa tgcacatctg tgaagatgcc gtcaaaagat tgaaagctga
      421 aaggaagttc ttcaaaggct tctttggaaa aacgggaaag aaagcagtga aggccgttct
      481 gtgggtatca gcagatggac tcagagttgt ggatgaaaaa actaaggacc tcatagttga
      541 ccagacaata gaaaaagttt ctttctgcgc ccccgatagg aactttgaca gagccttttc
      601 ttacatatgt cgagatggca ccactcggcg atggatctgt cattgcttca tggctgtcaa
      661 agacacgggg gaaagactga gccatgccgt gggctgtgct tttgcagcct gtttagagcg
      721 taaacagaag cgggaaaagg agtgtggagt cactgctact ttcgatgcca gtagaaccac
      781 ttttacaaga gaaggatcat tccgtgtcac aactgccacg gaacaagctg aaagagagga
      841 gatcatgaaa cagttgcaag atgccaagaa agctgagaca gataagaccg ttggtccatc
      901 agtggctcct ggcaacagtg ctccatcgcc gtcctctccc acctccccaa ctctggatcc
      961 cactgcttct ttagagatga acaatcctca tgctatccca cgccggcatg caccaattga
     1021 acagcttgct cgccaaggct ctttccgggg atttcctgct cttagccaga agatgtcacc
     1081 ctttaaacgc cagctgtccc tacgcatcaa tgagctgcct tccactatgc agaggaagac
     1141 tgatttccca ataaaaaaca cagtgcctga ggtggaagga gaggcagaaa gcatcagctc
     1201 cctgtgctcc cagatcacca gtgccttcag cacaccctgt gaggacccct tctcctctgc
     1261 cccaatgacc aaaccagtga cattagtggc accacagtct cctgtgttac aagctaatgg
     1321 cactgactca gccctccatg tgcttaccgc aaagccagcc agtactgctc tagcacccgt
     1381 agcaatgcct gtccgtgaaa ccaacccttg ggcccatgcc cctgatgctg ctaacaagga
     1441 aattgcagcc atacattcgg ggactgagtg gggtcagtct tctggtgctg cctctccagg
     1501 tctcttccag gctggtcaca gacgcactcc ctctgaggct gaccgttggt tagaagaagt
     1561 atcaaaaagt gtgcgggccc agcagccgca ggtctcagcc gcccctctgc agccagttct
     1621 gcagcctcct ccgcccgctg ccattgcccc tccagcacct cctttccaag gacatgcatt
     1681 cctcacttct cagcctgtgc cagtgggtgt ggtcccaccc ctacaaccag cctttgtctc
     1741 tacccagtcc taccctgtgg ccaatgggat gccctatcca gcctctaatg tgcctgtagt
     1801 gggcatcacc ccatcccaga tggtagccaa tgtgtttggc actgcaggcc atcctcaggc
     1861 cactcatcca catcagtccc caagcctggc caagcagcag acattccctc aatatgagac
     1921 aagtagtgct accaccagtc ccttctttaa gccttctgct cagcacctca atggttctgc
     1981 agctttcaat ggtgtagaca atagcgggct agtctcagga aacagacctg cacaagtccc
     2041 tccaggcacc tgcccagtgg atccttttga ggcccagtgg gctgcactag aaagcaagcc
     2101 caagcagcgc accaacccct ctcctaccaa ccctttctcc agtgatgcac agaaggcatt
     2161 tgaaatagag ctttagatgg tccttatgat ggttctttct gtccttaggc aagggcaggg
     2221 gtgggcagag gagcaaaggg gactttgctt tccagatcag cacacttttc actcatccca
     2281 gtggtcccaa ggagcaagtc caagcacagt ccagcgaggg ctgctgtccc cagaagcgag
     2341 gcaagccttc ctggagagga ctgccctgca gctaggctag aaaccaagga agcattgcct
     2401 tctggcccct aacaagtctc tggcaacaga gaggcagaag agctgaagag gaatctgtat
     2461 tcaaagcaca tttcctggga tataaaacaa aacaggaagc aaaatgatct ccctttcttt
     2521 ttcaggccag tcaccgtccc tcccagtact gggctgtctt agagctccat ggagaacagt
     2581 gtggctggtt gaaggcaggc aggccatgct gctgggttca caggagggca tcagcagctg
     2641 cccagtagag ctgtagtctg gggataaagc tgagcttcca ttttgagtta cagaataaat
     2701 attataaata tatatatata tatatcaaaa aagccaaaat ctttattttt atgcacctag
     2761 aatattttaa atagttctca atattaaaag ctgtatgagt tgtaagtaat cttgccaaaa
     2821 gtgcgtggat tagacataag agactgtaca taagattgat ttatcattga cgcctatgga
     2881 aggaaaagga ggaagggctg gaagttgtag gcggagcctg gcttctttgt gatcactcat
     2941 cgttaactga gtagcacatt gcaaaccaat ctactgatga ccagcgcggt cgctaggcag
     3001 cacttctgat acaatgagag agtagtgttg tcctggtttc agatgtgaga ttctaacgtt
     3061 attttaatgg aatcaatcta cgctctaggg aatgtgttga atctttgtgt atcattgcaa
     3121 ttttcttatg ttaatcctct agcattaagg tgacaatgac ataatcatat ccagaaaagg
     3181 gaatgctatt gtgttggttt gtaatgtggg tcttaatggg ttctgtcctt gaagtttcat
     3241 tgctgtaagt ttcacaggga tgtgctctgt ctgtgtccct tctgccccac catgaacaga
     3301 acatcccatg ccatgcagct acttgacagt gggtaacaac atgaggtccc atctcatttt
     3361 tactttcgga cgttggcctt acaatcaaat gtaagttata tatacataca tatatatata
     3421 tatatatatt tgtactgatg aaaatttaca atctgcttta atagaataaa tgttcgtggt
     3481 agagcttctg cccatgaagg gctgttctta cttgcaaa
//
