LOCUS       NM_001100691            7793 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus nuclear mitotic apparatus protein 1 (Numa1),
            mRNA.
ACCESSION   NM_001100691 XM_001068093 XM_218972
VERSION     NM_001100691.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7793)
  AUTHORS   Chu,X., Chen,X., Wan,Q., Zheng,Z. and Du,Q.
  TITLE     Nuclear Mitotic Apparatus (NuMA) Interacts with and Regulates
            Astrin at the Mitotic Spindle
  JOURNAL   J Biol Chem 291 (38), 20055-20067 (2016)
   PUBMED   27462074
REFERENCE   2  (bases 1 to 7793)
  AUTHORS   Seldin,L., Muroyama,A. and Lechler,T.
  TITLE     NuMA-microtubule interactions are critical for spindle orientation
            and the morphogenesis of diverse epidermal structures
  JOURNAL   Elife 5, e12504 (2016)
   PUBMED   26765568
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7793)
  AUTHORS   Chiu,C.W.N., Monat,C., Robitaille,M., Lacomme,M., Daulat,A.M.,
            Macleod,G., McNeill,H., Cayouette,M. and Angers,S.
  TITLE     SAPCD2 Controls Spindle Orientation and Asymmetric Divisions by
            Negatively Regulating the Galphai-LGN-NuMA Ternary Complex
  JOURNAL   Dev Cell 36 (1), 50-62 (2016)
   PUBMED   26766442
REFERENCE   4  (bases 1 to 7793)
  AUTHORS   Ohta,S., Hamada,M., Sato,N. and Toramoto,I.
  TITLE     Polyglutamylated Tubulin Binding Protein C1orf96/CSAP Is Involved
            in Microtubule Stabilization in Mitotic Spindles
  JOURNAL   PLoS One 10 (11), e0142798 (2015)
   PUBMED   26562023
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7793)
  AUTHORS   Yan,K., Li,L., Wang,X., Hong,R., Zhang,Y., Yang,H., Lin,M.,
            Zhang,S., He,Q., Zheng,D., Tang,J., Yin,Y. and Shao,G.
  TITLE     The deubiquitinating enzyme complex BRISC is required for proper
            mitotic spindle assembly in mammalian cells
  JOURNAL   J Cell Biol 210 (2), 209-224 (2015)
   PUBMED   26195665
REFERENCE   6  (bases 1 to 7793)
  AUTHORS   Hilditch-Maguire,P., Trettel,F., Passani,L.A., Auerbach,A.,
            Persichetti,F. and MacDonald,M.E.
  TITLE     Huntingtin: an iron-regulated protein essential for normal nuclear
            and perinuclear organelles
  JOURNAL   Hum Mol Genet 9 (19), 2789-2797 (2000)
   PUBMED   11092755
REFERENCE   7  (bases 1 to 7793)
  AUTHORS   Merdes,A., Heald,R., Samejima,K., Earnshaw,W.C. and Cleveland,D.W.
  TITLE     Formation of spindle poles by dynein/dynactin-dependent transport
            of NuMA
  JOURNAL   J Cell Biol 149 (4), 851-862 (2000)
   PUBMED   10811826
REFERENCE   8  (bases 1 to 7793)
  AUTHORS   Ferhat,L., Cook,C., Kuriyama,R. and Baas,P.W.
  TITLE     The nuclear/mitotic apparatus protein NuMA is a component of the
            somatodendritic microtubule arrays of the neuron
  JOURNAL   J Neurocytol 27 (12), 887-899 (1998)
   PUBMED   10659681
REFERENCE   9  (bases 1 to 7793)
  AUTHORS   Tang,T.K., Tang,C.J., Chao,Y.J. and Wu,C.W.
  TITLE     Nuclear mitotic apparatus protein (NuMA): spindle association,
            nuclear targeting and differential subcellular localization of
            various NuMA isoforms
  JOURNAL   J Cell Sci 107 (Pt 6), 1389-1402 (1994)
   PUBMED   7962183
REFERENCE   10 (bases 1 to 7793)
  AUTHORS   Compton,D.A., Szilak,I. and Cleveland,D.W.
  TITLE     Primary structure of NuMA, an intranuclear protein that defines a
            novel pathway for segregation of proteins at mitosis
  JOURNAL   J Cell Biol 116 (6), 1395-1408 (1992)
   PUBMED   1541636
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On or before Sep 9, 2012 this sequence version replaced
            XM_001068093.3, XM_218972.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the genome
            assembly. The genomic coordinates used for the transcript record
            were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760389 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-127               JAXUCZ010000001.1  165738252-165738378
            128-201             JAXUCZ010000001.1  165745051-165745124
            202-287             JAXUCZ010000001.1  165753038-165753123
            288-367             JAXUCZ010000001.1  165759902-165759981
            368-450             JAXUCZ010000001.1  165760944-165761026
            451-531             JAXUCZ010000001.1  165761910-165761990
            532-619             JAXUCZ010000001.1  165762530-165762617
            620-737             JAXUCZ010000001.1  165763983-165764100
            738-895             JAXUCZ010000001.1  165764460-165764617
            896-1013            JAXUCZ010000001.1  165764880-165764997
            1014-1131           JAXUCZ010000001.1  165765083-165765200
            1132-1272           JAXUCZ010000001.1  165765497-165765637
            1273-1395           JAXUCZ010000001.1  165766835-165766957
            1396-4749           JAXUCZ010000001.1  165767054-165770407
            4750-4818           JAXUCZ010000001.1  165776844-165776912
            4819-4938           JAXUCZ010000001.1  165778375-165778494
            4939-5157           JAXUCZ010000001.1  165778583-165778801
            5158-5315           JAXUCZ010000001.1  165778907-165779064
            5316-5562           JAXUCZ010000001.1  165780107-165780353
            5563-5791           JAXUCZ010000001.1  165781166-165781394
            5792-5928           JAXUCZ010000001.1  165781988-165782124
            5929-6105           JAXUCZ010000001.1  165782283-165782459
            6106-6222           JAXUCZ010000001.1  165782662-165782778
            6223-6426           JAXUCZ010000001.1  165782872-165783075
            6427-7793           JAXUCZ010000001.1  165783482-165784848
FEATURES             Location/Qualifiers
     source          1..7793
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     gene            1..7793
                     /gene="Numa1"
                     /note="nuclear mitotic apparatus protein 1"
                     /db_xref="GeneID:308870"
                     /db_xref="RGD:1308777"
     exon            1..127
                     /gene="Numa1"
                     /inference="alignment:Splign:2.1.0"
     exon            128..201
                     /gene="Numa1"
                     /inference="alignment:Splign:2.1.0"
     CDS             160..6438
                     /gene="Numa1"
                     /codon_start=1
                     /product="nuclear mitotic apparatus protein 1"
                     /protein_id="NP_001094161.1"
                     /db_xref="GeneID:308870"
                     /db_xref="RGD:1308777"
                     /translation="MTLHATRASTLLSWVNSLHVADPVETVLQLQDCSIFIKIINSIH
                     DTKEGQQILQQPLPERLDFVCSFLQKNRKHPSSTQCLVSVQKVMEGSEMELAKMVMLF
                     LYHSTMSSRNPRDWEQFEYGVQAELAVILKFMLDHEDSPNLTEDLENFLEKVPSTYPS
                     TLSEELSPPSHQAKRKIRFLEIQRIASSSSENNFLSGSPSSPVGDILQTPQFQMRRLK
                     KQLADERNNRDELELELSESLKLLTEKDAQIAMMQQRIDHLALLNEKQAASPQEPSEL
                     EELRGKNESLTVRLHETLKQCQNLKTEKNQMDRKISQLSEENGDLSFKVREFANHLQQ
                     LQGAFNDLIEEHSKASQEWAEKQAHLESELSTALQDKKCLEEKSEILQEKISQLEDRA
                     AQLQGSPAPEKGEVLGDALQLDTLKQEAAKLATDNTELQARVETLECERGKQEAQLLA
                     ERGHFEEEKRQLASLVADLQSSVSNLSQAKEELQQASQAQGAQLTAQLASLTALNATL
                     QQQDQELTSLKEQAKKEQAQMLQTLQEQEQAAQGLRQQVEQLSSSLKLKEQQLEEAAK
                     EQEAARQDHAQQLATIVEAREASVRERDAARQQLETLEKEKDAKLESLQQQLQASNEA
                     RDTAQTSVTQAQREKAELSQKIGELHACIEAAHQEQRQAQAHVTELEAQLKAEQQKAT
                     EREKVVQEKVQLQEQLQALEETLKIVRGSLEEEKCRAADALKEQQRHATEMEAETRHL
                     MEQREQEQKELEQEKAERKGLEARLQQLEEAHQAETEALRHELAGATAAQHGAESERE
                     QLLREVESWQKRVEARQQEEARYGAMFQEQLMALKGEHGKIGQEEQKEAGEIHGEGQT
                     GQQQSQLAQLHACLAKALQQVQEKEARAQKLLDDLSALREKMAATNKEVACLKALVLK
                     AGEQQAAASHELKEPPRAGNQESDWEEEQARPLGSTQAALKAVQREAEQMGGELERLR
                     AALMQSQGQQQEVRGQQEREVARLTQERGQAQADLAQEKAAKAELEMRLQNTLNEQRV
                     EFAALQEALTHAMTEKEGKDQELAKLREQEAAQISELKALQQTLEELKKKEKEHPTGG
                     ARGEDASGDGPGSQLHTPGKTEAPGPEVEALRAEISKLERQWQQQQQQVEGLTHSLES
                     ERACRAEQDKALETLQGQLEEKARELGHNQAASASAQRELQALRAKAQDHSKAEEEWK
                     AQVARGQQEAERKSSLISSLEEEVSILNRQVLEKEGESKELKRLVVAESEKSQKLEER
                     LRLLQVETASSSARAAERSSALREEVQSLREEVEKQRVVSENLRQELASQAERAEESG
                     QELKAWQEKFFQKEQALSALQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRFREE
                     IEQSKQAAGGLQAELMRAQRELGELGSLRQKIVEQERAAQQLRAEKASYAEQLSMLKK
                     AHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRTDAETHLAEMRQEAQS
                     TSRELEVMTAKYESAKVKVLEERQRFQEERQKLTAQVEELNKKLTESEQASRVQQQKL
                     KAFQAQGGESQQEVQCLQTQLSELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQE
                     LREQLQDLEQLQKDNKELRSETERLGRELQQAGLKTKEAEQACRHLTAQVRSLEAQVA
                     HADQQLRDLGKFQVATDALKSREPQVKPQLDLSIDSLDLSLEEGTPCSVASKLPRTQP
                     DGTSVPGEPASPISQRLPPKVESLESLYFTPIPARGQAPLETSLDSLGDAFPDSGRKT
                     RSARRRTTQIINITMTKKLELEEPDSANSSFYSTQSAPASQANLRATSSTQSLARLGS
                     PDDSNSALLSLPGYRPTTRSSARRSQTRTSSGAPHGRNSFYMGTCQDEPEQVDDWNRI
                     AELQQRNRVCPPHLKTCYPLESRPALSLATITDEEMKTGDPRETLRRASMQPAQIAEG
                     AGITTRQQRKRVSSETHQGPGTPESKKATSCFPRPMTPRDRHEGRKQNSTADAQKKAA
                     PVLKQSDRRQSMAFSILNTPKKLGNSLLRRGTSKKTPAKVSPNPRSGTRRSPRIATTT
                     AGAATAATTPRAKGKAKH"
     exon            202..287
                     /gene="Numa1"
                     /inference="alignment:Splign:2.1.0"
     exon            288..367
                     /gene="Numa1"
                     /inference="alignment:Splign:2.1.0"
     exon            368..450
                     /gene="Numa1"
                     /inference="alignment:Splign:2.1.0"
     exon            451..531
                     /gene="Numa1"
                     /inference="alignment:Splign:2.1.0"
     exon            532..619
                     /gene="Numa1"
                     /inference="alignment:Splign:2.1.0"
     exon            620..737
                     /gene="Numa1"
                     /inference="alignment:Splign:2.1.0"
     exon            738..895
                     /gene="Numa1"
                     /inference="alignment:Splign:2.1.0"
     exon            896..1013
                     /gene="Numa1"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..1131
                     /gene="Numa1"
                     /inference="alignment:Splign:2.1.0"
     exon            1132..1272
                     /gene="Numa1"
                     /inference="alignment:Splign:2.1.0"
     exon            1273..1395
                     /gene="Numa1"
                     /inference="alignment:Splign:2.1.0"
     exon            1396..4749
                     /gene="Numa1"
                     /inference="alignment:Splign:2.1.0"
     exon            4750..4818
                     /gene="Numa1"
                     /inference="alignment:Splign:2.1.0"
     exon            4819..4938
                     /gene="Numa1"
                     /inference="alignment:Splign:2.1.0"
     exon            4939..5157
                     /gene="Numa1"
                     /inference="alignment:Splign:2.1.0"
     exon            5158..5315
                     /gene="Numa1"
                     /inference="alignment:Splign:2.1.0"
     exon            5316..5562
                     /gene="Numa1"
                     /inference="alignment:Splign:2.1.0"
     exon            5563..5791
                     /gene="Numa1"
                     /inference="alignment:Splign:2.1.0"
     exon            5792..5928
                     /gene="Numa1"
                     /inference="alignment:Splign:2.1.0"
     exon            5929..6105
                     /gene="Numa1"
                     /inference="alignment:Splign:2.1.0"
     exon            6106..6222
                     /gene="Numa1"
                     /inference="alignment:Splign:2.1.0"
     exon            6223..6426
                     /gene="Numa1"
                     /inference="alignment:Splign:2.1.0"
     exon            6427..7793
                     /gene="Numa1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcagctatc cggacaggac agcgaggcct gcgctccgcg gctagaaact gcctaggctg
       61 tttgtttaga aggctgagtg ggaggagcag gcacacagca tgacatcttg gccttactac
      121 gcagaaggtg ggttggagtg actggctgga atcacaaaga tgacactcca tgccacccgc
      181 gcatctactc tcctctcttg ggtgaacagt ctgcatgttg ctgacccagt ggagacagtg
      241 ctgcagctcc aggactgcag catcttcatc aagattatta acagcatcca tgacactaaa
      301 gaggggcaac aaatcctaca gcagccactg ccggaaagac tagactttgt ttgcagtttt
      361 ctacagaaaa atcggaagca tccttcatct acacaatgcc tggtatctgt gcagaaagtg
      421 atggagggct ccgagatgga actggccaag atggtaatgc tatttttata tcactccacc
      481 atgagctcca gaaacccccg ggactgggag cagtttgaat atggggttca ggctgagttg
      541 gctgtcatcc tgaagtttat gctggatcac gaggattcac ctaaccttac tgaggacttg
      601 gagaatttct tggagaaagt tccttccacc taccccagca ccctctctga agagctttct
      661 ccacccagcc accaggccaa gaggaagatt cgcttcctag aaatacagag gattgcttca
      721 tcttccagtg agaacaactt cctctcaggg tctccatcct cccctgtggg cgacatcctg
      781 cagaccccac agttccagat gaggcgactg aagaagcagc tggcagatga gaggaacaac
      841 agggatgagc tggagctaga gctgtctgag agcctcaagc tcctcaccga gaaggacgct
      901 cagatcgcca tgatgcagca gcgcatcgac cacctggctc tgctgaatga gaagcaggca
      961 gccagccccc aggagcccag cgaacttgag gagctccgtg gcaagaatga aagcctcact
     1021 gtgcgtctgc atgagacttt gaagcagtgt cagaacctga agaccgagaa gaaccagatg
     1081 gatcgaaaga ttagccagct ttctgaggag aacggggacc tttcctttaa ggtgcgagag
     1141 tttgcaaacc acttgcaaca actgcagggt gcgttcaacg acctgataga ggagcacagc
     1201 aaggcttctc aggagtgggc agagaagcag gctcatctgg aaagtgagct cagcacagcc
     1261 ctccaggata agaaatgtct ggaagagaag agtgagatcc ttcaggagaa gatttcccag
     1321 ctggaggatc gagcagctca gctgcagggg agccctgccc cggagaaggg tgaggtgctg
     1381 ggtgacgcct tgcagctgga taccctgaaa caagaggcag ccaaacttgc cacagataac
     1441 acagagctcc aagcccgcgt agagactctg gagtgtgagc gtggtaaaca ggaagcccag
     1501 ctgcttgctg agcggggcca ctttgaagaa gagaagcggc agctggccag cttggttgct
     1561 gacctgcaga gctccgtctc taacctcagc caggccaaag aggagctgca gcaagcctcc
     1621 caggctcagg gggctcagct cactgcccag ctggcctctc tgacagcact gaatgccacc
     1681 ctgcagcagc aagatcaaga gctgaccagc ctgaaagaac aggccaaaaa ggaacaggct
     1741 cagatgttac agaccttgca agagcaagaa caggctgccc agggcctccg ccagcaggtg
     1801 gagcagctga gcagcagcct gaagctgaag gagcagcaat tggaagaggc agccaaggag
     1861 caggaggcag ccaggcagga tcacgcccag caactggcca ccattgttga ggctcgagag
     1921 gcctctgtaa gggagcgaga tgctgctcgc cagcagctag aaacattgga gaaggagaag
     1981 gatgccaagc tggagagcct gcagcagcaa cttcaggctt ctaatgaagc cagggacact
     2041 gcgcagacct cggtcacaca ggcccagcgg gaaaaggcag agctgagcca aaagatagga
     2101 gaactccatg cctgcattga agctgcccac caggaacagc gtcaggccca agctcacgtg
     2161 acagagctag aggcccagct gaaggctgag cagcaaaaag caactgagag agaaaaggtg
     2221 gtgcaggaga aggtccagct ccaggagcag ctccaggccc ttgaggagac tttgaagatt
     2281 gtcagaggta gccttgaaga agagaaatgc agggctgcag atgccctgaa ggagcagcag
     2341 cgccacgcca ctgagatgga ggcagagact cgacacctga tggagcagcg ggagcaggag
     2401 cagaaggagt tagagcagga gaaggctgag cgaaaggggc tggaggcccg gctacagcag
     2461 cttgaagagg ctcatcaggc cgagactgaa gccttgcgac atgagctagc aggggccaca
     2521 gctgctcagc acggagctga gagtgagcgt gagcagctcc tcagggaggt tgagagctgg
     2581 cagaagcggg ttgaagccag acagcaagag gaggcaaggt atggtgccat gttccaggaa
     2641 cagctgatgg ccttgaaagg ggagcatgga aagattggcc aagaagaaca gaaggaggca
     2701 ggagagatcc acggtgaagg ccagacaggc cagcagcaga gtcagctagc tcagcttcat
     2761 gcctgtttgg caaaagccct tcagcaggtc caggagaaag aagcgagagc acagaagctg
     2821 ctagatgatc tctcggctct gcgggagaag atggctgcca ctaacaagga ggtggcctgc
     2881 ctgaaggcct tggtgctcaa ggcaggtgag cagcaggcag cagcctcaca tgagctcaaa
     2941 gagcccccga gggctgggaa ccaagagtct gactgggagg aagagcaggc aaggccgttg
     3001 ggtagtacac aggcagcact gaaggctgtg cagcgtgaag ctgagcaaat gggcggagag
     3061 ctggagagac tgcgggcagc actgatgcag agccaggggc agcagcaaga ggttcgtggg
     3121 cagcaggaga gggaggtagc acggctgacc caggagcggg gccaggccca agctgacctg
     3181 gctcaggaga aggcagccaa ggcagaactt gagatgcggc tgcagaacac cctcaatgag
     3241 cagcgtgtgg agtttgctgc cttacaagaa gcactgaccc atgccatgac agaaaaggaa
     3301 gggaaagacc aagagcttgc caaacttcgt gagcaagagg cagctcagat atcagagctg
     3361 aaggcgcttc agcagacttt ggaagagctg aagaagaaag agaaagagca ccccacaggg
     3421 ggtgccaggg gagaagacgc ttcaggagat ggcccaggat cccagctgca cacacctggg
     3481 aagacagagg caccaggccc tgaggtggag gctcttcggg cagagatcag taagctagag
     3541 cggcagtggc agcagcagca gcaacaggtt gaaggcctga cacacagcct ggagtccgag
     3601 cgtgcttgcc gggctgagca agacaaagcc ctggagacac tgcagggcca gttagaggag
     3661 aaggctcgag agctggggca taatcaggct gcctcagcct cagctcaaag agagttgcaa
     3721 gccctccgtg ccaaagccca ggaccacagc aaagctgagg aagagtggaa ggcccaggta
     3781 gcccgtggcc agcaggaagc tgagagaaag agcagtctta tcagcagctt ggaagaggag
     3841 gtatccatcc tgaatcgcca agtcctagag aaggagggag aaagcaagga gttgaagcgc
     3901 ctggttgtag ctgagtcaga gaagagccag aagctggaag agcggctgcg cctgcttcag
     3961 gtagaaacag ccagcagcag tgccagggca gcagaacgca gctcagctct acgggaggag
     4021 gtacagagcc tccgagaaga ggtagagaag cagcgtgtag tttctgagaa cttgaggcag
     4081 gagctggcct cacaagcgga gcgagctgag gaatcgggtc aagaattgaa ggcctggcag
     4141 gagaagtttt tccagaagga gcaagcgctc tctgccctgc agctggagca caccagcaca
     4201 caggccctgg tgagtgagct gctgcctgcc aagcaccttt gtcagcagct gcaagctgag
     4261 caggcagctg ccgagaagcg cttccgggag gagatagagc agagcaagca ggcagctggc
     4321 gggctgcagg cagagctaat gcgggctcaa cgggagcttg gagagctagg atctttgcgg
     4381 cagaagattg ttgagcagga gcgagcagcc cagcagctgc gggcagaaaa ggccagctat
     4441 gcagagcagt tgagcatgct gaagaaggcc catggcctgc tggccgagga gaaccggggg
     4501 ctgggagaac gggccaacct gggccggcag tttctagaag tagagctcga tcaagcccgg
     4561 gagaagtatg tccaggagct ggccgctgtg cgcactgatg ccgagaccca cctggctgaa
     4621 atgcggcaag aagctcagag cactagccgg gagctggagg tgatgaccgc caagtacgaa
     4681 agtgccaagg tgaaggtcct agaggagagg cagaggttcc aagaagagag gcagaaactc
     4741 actgcccagg tggaagaact gaataagaag ctgacagaga gtgaacaagc cagcagggtg
     4801 cagcagcaga agctgaaggc tttccaggcc cagggaggtg aaagccagca ggaggtccag
     4861 tgcctccaga cgcagctgag tgagctgcaa gcccagctga gccagaagga gcaggcagct
     4921 gagcactaca agctacagat ggagaaagcc aagacccatt acgatgccaa gaagcagcag
     4981 aaccaagagc tgcgggaaca gcttcaagac ctggagcagc tgcagaagga caacaaggag
     5041 ctgcggtctg agactgaacg tctgggccgt gagctgcagc aggcagggct gaagaccaag
     5101 gaagctgaac aggcttgccg gcacctcaca gcccaggtgc gcagcctgga ggcccaggtt
     5161 gcccacgcag accagcagct tcgagacctg ggcaaattcc aggtggcaac tgatgcctta
     5221 aagagccgtg agcctcaagt gaaaccccag ctggacctaa gtattgacag cctggatctg
     5281 agcttggagg agggaacccc gtgcagtgtc gctagcaagc tgcctcgtac ccagccagat
     5341 ggtaccagtg tcccaggaga gccagcctca cccatctccc agcgcttgcc ccccaaagtg
     5401 gaatccctgg agagtctcta cttcaccccc attcctgctc ggggtcaggc ccccttggag
     5461 accagcctgg actctctggg ggatgccttc cctgactccg gccgtaagac ccgctctgct
     5521 cgccggcgta ccacacagat catcaacatt accatgacca agaaactaga actggaggag
     5581 ccggacagcg ccaactcgtc cttctacagt acgcagtctg cccctgcttc ccaggccaac
     5641 ttgcgagcca cttcctccac tcagtctctg gcccgcttgg gctctcctga tgacagcaac
     5701 tccgcgctgc tcagcctgcc tggctaccgg cctaccaccc gaagctctgc tcggcgctcc
     5761 cagaccagga catccagtgg ggccccccac ggaaggaata gcttctacat ggggacttgc
     5821 caggacgagc ccgagcaggt ggatgactgg aaccgcatcg cggagttgca gcagcgcaac
     5881 agagtatgcc ctccgcacct gaagacctgc taccctctgg agtccaggcc tgccctgagc
     5941 ctggccacca tcactgacga ggagatgaaa accggagacc cccgggaaac cttgcgcaga
     6001 gccagcatgc agccagctca gatcgctgag ggcgctggca tcactaccag gcagcagcgt
     6061 aaacgggttt cctcggagac ccaccagggc cccggtactc ctgagtccaa gaaagctacg
     6121 agctgctttc cacgccccat gactcccagg gaccggcatg aaggacggaa gcagaacagc
     6181 actgctgatg cccagaagaa agcagctcca gttctcaagc agtcggaccg gcgtcagtca
     6241 atggctttca gcatccttaa cacacccaag aagctgggaa atagccttct acggcgagga
     6301 acttcaaaga agaccccagc aaaggtttcc cccaatcctc gcagtggaac ccgccgctct
     6361 ccacgcatcg ccaccaccac ggctggtgct gctactgctg ccaccactcc tcgggccaag
     6421 ggcaaggcaa agcattaaag agtcgatacc agtgcgtggc cccacctgcg ttgtcagcac
     6481 tgaccttgcc tggtcctttt ccttctactg tccctcagtg ccttctctca gctcccaggc
     6541 caatggcggc cagccctccc agagacttcg atgtttgcct gcaccctggc ctggtacctg
     6601 gactttcact ggtgccttct aggcatcttt cagagctggc ccaggaggct tggagcttgg
     6661 acagtgtgcg gtcttctccc tatattgcct cctgatcttt tttttttcct tgttttggaa
     6721 aaaagtctac ttttccatca taactagatt tgaggctgga ttcttgagcc cagtcttcct
     6781 tagtctctgg acctagaagg gaccattgga gaagcaggct ctactttcct gctgttctgg
     6841 tggctgggcc tagcaggggt ctttgctctt gaagcccagg attgggcatg acctggtaga
     6901 agcctctgct ctacctgctt ccatattcag ctgcctggag gatgcttttc ccaggacaga
     6961 taggtcctgg gtctcagggg tgggaggggg gcagccttca atggcagctc atacttcagc
     7021 tccccagact tgcactgggg ggatatggaa cgatgggaag gtttttaagg gccgggaatg
     7081 gatcttttct aaatgttatt acttgtaaat aaagtctatt tttctccctt gagtgctaag
     7141 ctctttgggt cagtatgaag aaaaagaggg aaattacagc tctttggagc ctgtgtttgg
     7201 tccttctacc tggccctatt tccactcacc tattggtctg gcccctgtct ctaactagta
     7261 ttatgggctg ttttctattt cagaggttca tgttattctg aatttctatt tggcagtgtc
     7321 ccgtgctccc tcctgagtca ggcagagttc ctgcagacag taccagggcc taaaaacatc
     7381 agaccttgag atgctccagc tttatgagga ctggactcgt tgtgggactg ctgagacaga
     7441 ctggcagata caattgtgat ctgaagcagc cactgtccca ccccttcctt gggaacagta
     7501 cacctgtaaa gacagacgta aatgcagata gtggtcagag ctgagtgtga atgttgctaa
     7561 tctcgactac acttgagggt taacctgttg gatcgggcgg caggcatctc aaattcatat
     7621 tgagtggagc agagctctta cttggctaag gcatcatcag gtctcagagg ttccagaata
     7681 ccagtgggat gagtaagaca ttagaaagtg ttaacagggg gttggggatt tagctcagtg
     7741 gtagagcgct tacctaggaa gcgcaaggcc ctgggttcgg tccccagctc agg
//
