LOCUS       NM_001012028            1813 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Rattus norvegicus NUF2 component of NDC80 kinetochore complex
            (Nuf2), mRNA.
ACCESSION   NM_001012028 XM_222860
VERSION     NM_001012028.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1813)
  AUTHORS   Sun,Z.Y., Wang,W., Gao,H. and Chen,Q.F.
  TITLE     Potential therapeutic targets of the nuclear division cycle 80
            (NDC80) complexes genes in lung adenocarcinoma
  JOURNAL   J Cancer 11 (10), 2921-2934 (2020)
   PUBMED   32226507
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1813)
  AUTHORS   Wang,Y., Tan,P.Y., Handoko,Y.A., Sekar,K., Shi,M., Xie,C.,
            Jiang,X.D., Dong,Q.Z., Goh,B.K.P., Ooi,L.L., Gao,Z. and Hui,K.M.
  TITLE     NUF2 is a valuable prognostic biomarker to predict early recurrence
            of hepatocellular carcinoma after surgical resection
  JOURNAL   Int J Cancer 145 (3), 662-670 (2019)
   PUBMED   30653265
  REMARK    Erratum:[Int J Cancer. 2021 Mar 15;148(6):E7. doi:
            10.1002/ijc.33440.. PMID: 33398879]
REFERENCE   3  (bases 1 to 1813)
  AUTHORS   Xu,W., Wang,Y., Wang,Y., Lv,S., Xu,X. and Dong,X.
  TITLE     Screening of differentially expressed genes and identification of
            NUF2 as a prognostic marker in breast cancer
  JOURNAL   Int J Mol Med 44 (2), 390-404 (2019)
   PUBMED   31198978
REFERENCE   4  (bases 1 to 1813)
  AUTHORS   Sun,J., Chen,J., Wang,Z., Deng,Y., Liu,L. and Liu,X.
  TITLE     [Expression of NUF2 in breast cancer and its clinical significance]
  JOURNAL   Nan Fang Yi Ke Da Xue Xue Bao 39 (5), 591-597 (2019)
   PUBMED   31140425
REFERENCE   5  (bases 1 to 1813)
  AUTHORS   Chen,X., Li,W., Xiao,L. and Liu,L.
  TITLE     Nuclear division cycle 80 complex is associated with malignancy and
            predicts poor survival of hepatocellular carcinoma
  JOURNAL   Int J Clin Exp Pathol 12 (4), 1233-1247 (2019)
   PUBMED   31933938
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1813)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   7  (bases 1 to 1813)
  AUTHORS   Kaneko,N., Miura,K., Gu,Z., Karasawa,H., Ohnuma,S., Sasaki,H.,
            Tsukamoto,N., Yokoyama,S., Yamamura,A., Nagase,H., Shibata,C.,
            Sasaki,I. and Horii,A.
  TITLE     siRNA-mediated knockdown against CDCA1 and KNTC2, both frequently
            overexpressed in colorectal and gastric cancers, suppresses cell
            proliferation and induces apoptosis
  JOURNAL   Biochem Biophys Res Commun 390 (4), 1235-1240 (2009)
   PUBMED   19878654
REFERENCE   8  (bases 1 to 1813)
  AUTHORS   Ohnuma,S., Miura,K., Horii,A., Fujibuchi,W., Kaneko,N., Gotoh,O.,
            Nagasaki,H., Mizoi,T., Tsukamoto,N., Kobayashi,T., Kinouchi,M.,
            Okabe,M., Sasaki,H., Shiiba,K., Miyagawa,K. and Sasaki,I.
  TITLE     Cancer-associated splicing variants of the CDCA1 and MSMB genes
            expressed in cancer cell lines and surgically resected gastric
            cancer tissues
  JOURNAL   Surgery 145 (1), 57-68 (2009)
   PUBMED   19081476
REFERENCE   9  (bases 1 to 1813)
  AUTHORS   Hayama,S., Daigo,Y., Kato,T., Ishikawa,N., Yamabuki,T.,
            Miyamoto,M., Ito,T., Tsuchiya,E., Kondo,S. and Nakamura,Y.
  TITLE     Activation of CDCA1-KNTC2, members of centromere protein complex,
            involved in pulmonary carcinogenesis
  JOURNAL   Cancer Res 66 (21), 10339-10348 (2006)
   PUBMED   17079454
REFERENCE   10 (bases 1 to 1813)
  AUTHORS   Bharadwaj,R., Qi,W. and Yu,H.
  TITLE     Identification of two novel components of the human NDC80
            kinetochore complex
  JOURNAL   J Biol Chem 279 (13), 13076-13085 (2004)
   PUBMED   14699129
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC078993.1.
            
            On Feb 11, 2005 this sequence version replaced XM_222860.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC078993.1, SRR8487231.104770.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1813
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q24"
     gene            1..1813
                     /gene="Nuf2"
                     /gene_synonym="Cdca1"
                     /note="NUF2 component of NDC80 kinetochore complex"
                     /db_xref="GeneID:304951"
                     /db_xref="RGD:1307952"
     exon            1..110
                     /gene="Nuf2"
                     /gene_synonym="Cdca1"
                     /inference="alignment:Splign:2.1.0"
     exon            111..253
                     /gene="Nuf2"
                     /gene_synonym="Cdca1"
                     /inference="alignment:Splign:2.1.0"
     CDS             131..1525
                     /gene="Nuf2"
                     /gene_synonym="Cdca1"
                     /note="cell division cycle-associated protein 1; NDC80
                     kinetochore complex component NUF2; cell division cycle
                     associated 1; NUF2, NDC80 kinetochore complex component,
                     homolog"
                     /codon_start=1
                     /product="kinetochore protein Nuf2"
                     /protein_id="NP_001012028.1"
                     /db_xref="GeneID:304951"
                     /db_xref="RGD:1307952"
                     /translation="METLSFPRYNIAEIVVHIRNKLLTGADGKNLSKSDFLPNPKPEV
                     LYMIYMRALQLVYGVRLEHFYMMPVNIEVMYPHIMEGFLPVSNLFFHLDSFMPICRVN
                     DFEIADILYPKANRTSRFLSGIINFIHFRETCLEKYEEFLLQNKSSVDKIQQLSNAHQ
                     EALMKLEKLNSVPVEEQEEFKQLKDDIQELQHLLNQDFRQKTTLLQERYTKMKSDFSE
                     KTKHVNELKLSVVSLKEVQDSLKSKIVDSPEKLKNYKEKMKDTVQKLRSAREEVMEKY
                     DIYRDSVDCLPSCQLEVQLYQKKSQDLADNREKLSSILKESLNLEGQIDSDSSELKKL
                     KTEENSLIRLMTLKKERLATMQFKINKKQEDVKQYKRTMIEDCNKVQEKRDAVCEQVT
                     AINQDIHKIKSGIQQLRDAEKREKLKSQEILVDLKSALEKYHEGIEKTTEECCTRIGG
                     KTAELKRRMFKMPP"
     exon            254..328
                     /gene="Nuf2"
                     /gene_synonym="Cdca1"
                     /inference="alignment:Splign:2.1.0"
     exon            329..405
                     /gene="Nuf2"
                     /gene_synonym="Cdca1"
                     /inference="alignment:Splign:2.1.0"
     exon            406..467
                     /gene="Nuf2"
                     /gene_synonym="Cdca1"
                     /inference="alignment:Splign:2.1.0"
     exon            468..565
                     /gene="Nuf2"
                     /gene_synonym="Cdca1"
                     /inference="alignment:Splign:2.1.0"
     exon            566..639
                     /gene="Nuf2"
                     /gene_synonym="Cdca1"
                     /inference="alignment:Splign:2.1.0"
     exon            640..736
                     /gene="Nuf2"
                     /gene_synonym="Cdca1"
                     /inference="alignment:Splign:2.1.0"
     exon            737..799
                     /gene="Nuf2"
                     /gene_synonym="Cdca1"
                     /inference="alignment:Splign:2.1.0"
     exon            800..937
                     /gene="Nuf2"
                     /gene_synonym="Cdca1"
                     /inference="alignment:Splign:2.1.0"
     exon            938..1078
                     /gene="Nuf2"
                     /gene_synonym="Cdca1"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1254
                     /gene="Nuf2"
                     /gene_synonym="Cdca1"
                     /inference="alignment:Splign:2.1.0"
     exon            1255..1390
                     /gene="Nuf2"
                     /gene_synonym="Cdca1"
                     /inference="alignment:Splign:2.1.0"
     exon            1391..1785
                     /gene="Nuf2"
                     /gene_synonym="Cdca1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggcgggcct cgcatagaaa ggcggctggt ttgaaaagtg acaacggccg gtggatttta
       61 ggagtttgct cggtttgtaa ctgctctttg gtgagctact gggactgcag actaggagga
      121 gactcccaaa atggaaactc tgtccttccc cagatacaac atagctgaga ttgtagttca
      181 tattcgcaat aaactgttaa ctggagcgga tggcaaaaac ctctccaaga gcgattttct
      241 tccaaacccg aagcctgaag tcctgtacat gatttacatg agagccttac agttagtgta
      301 tggggtccgg ctggagcatt tctacatgat gccggtgaac atagaagtca tgtatccaca
      361 tataatggag ggcttcttac cggtcagcaa tttgttcttc cacctggact cgtttatgcc
      421 catttgccgg gtgaatgact ttgagatcgc cgatattctt tatccaaaag caaaccggac
      481 aagtcgtttt ttaagtggca ttatcaactt tattcacttc agagaaacat gcctggagaa
      541 gtatgaagaa tttcttttgc aaaataaatc ctctgtggac aaaatacagc agttaagcaa
      601 tgcacaccag gaagcattga tgaaactgga aaaactcaat tcggttcccg tggaggagca
      661 ggaagagttc aaacagctga aggatgacat ccaggagctg cagcacttgc tgaatcaaga
      721 cttcagacag aaaacgacac tgctgcagga gagatatacc aaaatgaaat cagatttttc
      781 agagaaaacc aagcatgtta atgagctaaa gttgtcagta gtttctttga aagaagttca
      841 agacagtttg aaaagcaaaa ttgtggattc tccagagaag ctgaagaact ataaagagaa
      901 gatgaaggac accgtccaga agctccgcag tgccagggaa gaagtgatgg aaaagtatga
      961 tatctataga gattctgtgg attgcttgcc ttcctgtcag ctggaggtgc agttatatca
     1021 aaagaaatca caggaccttg cagataatag ggagaaacta agcagtatct taaaggagag
     1081 cctgaacctg gagggccaga ttgatagtga ttcatcagaa ctaaagaaac tgaagactga
     1141 agagaactcc ctcataagac tgatgactct aaagaaggag agacttgcta ccatgcagtt
     1201 caaaataaac aagaagcagg aggatgtgaa acagtacaag cggaccatga ttgaagattg
     1261 caataaagtt caagaaaaaa gagatgctgt ctgcgagcaa gtaaccgcca ttaatcaaga
     1321 catccacaag attaaatctg ggattcagca gctaagagac gccgaaaaac gggagaaact
     1381 gaagtctcag gaaatcttgg tagacttgaa aagtgctttg gagaagtacc atgagggcat
     1441 cgagaagacg acggaggagt gctgcactag aataggaggg aagactgccg agctgaagag
     1501 gaggatgttc aaaatgccgc cctgatcaac agccacccga aaacggcctt tcgctttctg
     1561 tttggagtag ttatattgaa gctaatagaa ggaccgcagt ctcagctaac tagcgtgggt
     1621 accattggtt ctctgtcctt ttatgaccat gtgctccctg tgtttttttc ttggtgatgg
     1681 ggatacaact cagggccttg caggctacac tgacttgcct ccctaggctc taatgtacca
     1741 tgtactatgt aggcttttgc tacaattaaa gtaacgtgta cagctaaaaa aaaaaaaaaa
     1801 aaaaaaaaaa aaa
//
