LOCUS       NM_001006991            1429 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus nudix hydrolase 9 (Nudt9), mRNA; nuclear gene for
            mitochondrial product.
ACCESSION   NM_001006991 XM_223157
VERSION     NM_001006991.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1429)
  AUTHORS   Gonzalez-Begne,M., Lu,B., Han,X., Hagen,F.K., Hand,A.R.,
            Melvin,J.E. and Yates,J.R.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   2  (bases 1 to 1429)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   3  (bases 1 to 1429)
  AUTHORS   Shen,B.W., Perraud,A.L., Scharenberg,A. and Stoddard,B.L.
  TITLE     The crystal structure and mutational analysis of human NUDT9
  JOURNAL   J Mol Biol 332 (2), 385-398 (2003)
   PUBMED   12948489
REFERENCE   4  (bases 1 to 1429)
  AUTHORS   Perraud,A.L., Shen,B., Dunn,C.A., Rippe,K., Smith,M.K.,
            Bessman,M.J., Stoddard,B.L. and Scharenberg,A.M.
  TITLE     NUDT9, a member of the Nudix hydrolase family, is an evolutionarily
            conserved mitochondrial ADP-ribose pyrophosphatase
  JOURNAL   J Biol Chem 278 (3), 1794-1801 (2003)
   PUBMED   12427752
REFERENCE   5  (bases 1 to 1429)
  AUTHORS   Lin,S., Gasmi,L., Xie,Y., Ying,K., Gu,S., Wang,Z., Jin,H., Chao,Y.,
            Wu,C., Zhou,Z., Tang,R., Mao,Y. and McLennan,A.G.
  TITLE     Cloning, expression and characterisation of a human Nudix hydrolase
            specific for adenosine 5'-diphosphoribose (ADP-ribose)
  JOURNAL   Biochim Biophys Acta 1594 (1), 127-135 (2002)
   PUBMED   11825615
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC083722.1.
            
            On Nov 22, 2004 this sequence version replaced XM_223157.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083722.1, SRR8487226.26809.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1429
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p22"
     gene            1..1429
                     /gene="Nudt9"
                     /note="nudix hydrolase 9"
                     /db_xref="GeneID:305149"
                     /db_xref="RGD:1359522"
     exon            1..201
                     /gene="Nudt9"
                     /inference="alignment:Splign:2.1.0"
     CDS             95..1147
                     /gene="Nudt9"
                     /EC_number="3.6.1.13"
                     /note="nudix-type motif 9; ADPR-PPase; nudix motif 9;
                     ADP-ribose diphosphatase; ADP-ribose phosphohydrolase;
                     adenosine diphosphoribose pyrophosphatase; nucleoside
                     diphosphate-linked moiety X motif 9; nudix (nucleoside
                     diphosphate linked moiety X)-type motif 9"
                     /codon_start=1
                     /product="ADP-ribose pyrophosphatase, mitochondrial"
                     /protein_id="NP_001006992.1"
                     /db_xref="GeneID:305149"
                     /db_xref="RGD:1359522"
                     /translation="MAGRSLGKAVATVSLSVALASVTVRSSGCRAIPAPRNPFPSCGF
                     HLKANIMSGSNGVKDNSHNKARTSPYPGSKVERSKVPNEKVGWLVEWQDYNPVEYTAV
                     SVLAGPQWADPQISESSFSPRFNEKDGHVERKSQNGLYEIENGRPRNPAGRTGLVGRG
                     LLGRWGPNHAADPIITRWKRDESGNKITHPVSGKCILQFVAIKRKDCGEWAIPGGMVD
                     PGEKISATLKREFGEEALNSLQKSSAEKREIEEKLHALFSQEHLVIYKGYVDDPRNTD
                     NAWMETEAVNYHDETGETMDNLTLEAGDDAGKVKWVDISDQLKLYASHSQFIKLVAEK
                     RDAHWSEDCAADSHGL"
     exon            202..441
                     /gene="Nudt9"
                     /inference="alignment:Splign:2.1.0"
     exon            442..537
                     /gene="Nudt9"
                     /inference="alignment:Splign:2.1.0"
     exon            538..624
                     /gene="Nudt9"
                     /inference="alignment:Splign:2.1.0"
     exon            625..736
                     /gene="Nudt9"
                     /inference="alignment:Splign:2.1.0"
     exon            737..883
                     /gene="Nudt9"
                     /inference="alignment:Splign:2.1.0"
     exon            884..968
                     /gene="Nudt9"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1394
                     /gene="Nudt9"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctagtgcccg ctggttgctg gtgtgaggct cgcggcgggg ctcccggcga ggtcggacac
       61 ctcagacccc tcgccggccg ctcgcctggc gccgatggct ggccgctccc tggggaaggc
      121 ggtagccacc gtgtcgctct cggtggccct cgcgtccgta actgtccggt cctcaggctg
      181 ccgcgccatc cccgcaccca gaaacccatt tccatcctgt gggtttcacc ttaaagccaa
      241 catcatgtct ggttctaatg gtgtcaaaga caattcccac aacaaggccc ggacatctcc
      301 ttacccaggt tcaaaagtcg agcgaagcaa ggttcccaat gagaaggtgg gctggcttgt
      361 tgagtggcag gactacaacc cagtggagta caccgcggtc tctgtgttgg ctggacccca
      421 gtgggcagac cctcagatca gcgagagtag cttctctccc agatttaatg agaaggacgg
      481 gcatgtggag aggaagagcc agaacggcct gtacgagatt gagaacggga ggcccagaaa
      541 tcctgcaggg aggacaggac tagttggccg gggtcttctg gggagatggg gcccaaatca
      601 tgcagcagat cctattataa ccaggtggaa gagggacgag agcgggaaca agatcacaca
      661 ccctgtctct gggaaatgca tcttgcagtt cgtcgccatc aaaaggaaag actgcggaga
      721 gtgggcgatc ccagggggga tggtggaccc cggagagaag atcagtgcca cactgaaaag
      781 ggagtttggt gaggaagccc tgaactcgtt acagaagtcc agtgcggaga agagggagat
      841 cgaggagaag ctgcacgcac tcttcagcca ggagcatctt gtgatatata agggctatgt
      901 cgacgaccct cggaacactg acaacgcatg gatggagact gaggcagtga actaccatga
      961 tgagacaggg gagacgatgg acaacctcac gctggaggct ggagatgatg cggggaaggt
     1021 gaagtgggtg gacatcagcg accagctcaa gctgtatgcc agtcactcac agttcatcaa
     1081 actcgtggca gagaagcgag atgcccactg gagcgaggac tgtgctgctg acagccacgg
     1141 gctatagcct gtccccgcga gccagccggc aggggctgcg ctgcagaagc agtgctgcag
     1201 aactgacact caaaggccgc ctggaaatgc ttgcaacaag gcgaggtgcc tgaaccgatg
     1261 aggaacactg aagttccgcc ttctcctcaa gagattagag actgtcgttt tgtatatatt
     1321 taagcatgtc tgaacaaaat ttaaataact aacgttcttt gaaaagttgt agttgcaata
     1381 aatataaaac cccaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaa
//
