LOCUS       NM_181363               1066 bp    mRNA    linear   ROD 23-APR-2024
DEFINITION  Rattus norvegicus nudix hydrolase 6 (Nudt6), mRNA.
ACCESSION   NM_181363
VERSION     NM_181363.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1066)
  AUTHORS   Uzay,B., Bahadir-Varol,A., Hokelekli,F.O., Yilmaz,M., Esen,E.C.,
            Basar,K., Ayhan,Y., Dalkara,T. and Eren-Kocak,E.
  TITLE     FGF2 gene's antisense protein, NUDT6, plays a depressogenic role by
            promoting inflammation and suppressing neurogenesis without
            altering FGF2 signalling
  JOURNAL   J Physiol 602 (7), 1427-1442 (2024)
   PUBMED   38468384
  REMARK    GeneRIF: FGF2 gene's antisense protein, NUDT6, plays a
            depressogenic role by promoting inflammation and suppressing
            neurogenesis without altering FGF2 signalling.
REFERENCE   2  (bases 1 to 1066)
  AUTHORS   Baguma-Nibasheka,M., Li,A.W. and Murphy,P.R.
  TITLE     The fibroblast growth factor-2 antisense gene inhibits nuclear
            accumulation of FGF-2 and delays cell cycle progression in C6
            glioma cells
  JOURNAL   Mol Cell Endocrinol 267 (1-2), 127-136 (2007)
   PUBMED   17306451
  REMARK    GeneRIF: The results suggest that the endogenous FGF antisense RNA
            may play a significant functional role in the regulation of FGF-2
            dependent cell proliferation in FGF-2 expressing cells.
REFERENCE   3  (bases 1 to 1066)
  AUTHORS   Asa,S.L., Ramyar,L., Murphy,P.R., Li,A.W. and Ezzat,S.
  TITLE     The endogenous fibroblast growth factor-2 antisense gene product
            regulates pituitary cell growth and hormone production
  JOURNAL   Mol Endocrinol 15 (4), 589-599 (2001)
   PUBMED   11266510
REFERENCE   4  (bases 1 to 1066)
  AUTHORS   Li,A.W. and Murphy,P.R.
  TITLE     Expression of alternatively spliced FGF-2 antisense RNA transcripts
            in the central nervous system: regulation of FGF-2 mRNA translation
  JOURNAL   Mol Cell Endocrinol 162 (1-2), 69-78 (2000)
   PUBMED   10854699
REFERENCE   5  (bases 1 to 1066)
  AUTHORS   Knee,R., Li,A.W. and Murphy,P.R.
  TITLE     Characterization and tissue-specific expression of the rat basic
            fibroblast growth factor antisense mRNA and protein
  JOURNAL   Proc Natl Acad Sci U S A 94 (10), 4943-4947 (1997)
   PUBMED   9144169
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Nov 27, 2020 this sequence version replaced NM_181363.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U58289.1, SRR26360186.635928.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840129 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-256               JAXUCZ010000002.1  122234044-122234299 c
            257-460             JAXUCZ010000002.1  122230530-122230733 c
            461-516             JAXUCZ010000002.1  122226090-122226145 c
            517-571             JAXUCZ010000002.1  122223510-122223564 c
            572-1066            JAXUCZ010000002.1  122218967-122219461 c
FEATURES             Location/Qualifiers
     source          1..1066
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q25"
     gene            1..1066
                     /gene="Nudt6"
                     /gene_synonym="Gfg"
                     /note="nudix hydrolase 6"
                     /db_xref="GeneID:207120"
                     /db_xref="RGD:621356"
     exon            1..256
                     /gene="Nudt6"
                     /gene_synonym="Gfg"
                     /inference="alignment:Splign:2.1.0"
     CDS             28..969
                     /gene="Nudt6"
                     /gene_synonym="Gfg"
                     /note="nudix motif 6; antisense basic fibroblast growth
                     factor; nudix (nucleoside diphosphate linked moiety
                     X)-type motif 6"
                     /codon_start=1
                     /product="nucleoside diphosphate-linked moiety X motif 6"
                     /protein_id="NP_852028.1"
                     /db_xref="GeneID:207120"
                     /db_xref="RGD:621356"
                     /translation="MWWASRARWLFSALLDVGGVGLRARRRTASSGLEITGSCGGELQ
                     GELDRFGGISVHLSRHRTLHRLDAAAFRRLLQAAIQQWRAEGRIAAWLHIPILQSHFI
                     APAASLGFCFHHAEPHLSTLTLWLGEGPSRLPGYATHQVGVAGAVFDVSTRKVLVVQD
                     RNKLKNMWKFPGGLSEPGEDIGDTAVREVFEETGVKSEFRSLLSIRQQHRSPGAFGMS
                     DMYLICRLQPRSFTINFCQQECLKCEWMDLESLARTKHTTPITSRVARLLLYGHREGF
                     DKIDLSMEELPAVYTGLFYKLYHRGLPERYKAEMGTD"
     exon            257..460
                     /gene="Nudt6"
                     /gene_synonym="Gfg"
                     /inference="alignment:Splign:2.1.0"
     exon            461..516
                     /gene="Nudt6"
                     /gene_synonym="Gfg"
                     /inference="alignment:Splign:2.1.0"
     exon            517..571
                     /gene="Nudt6"
                     /gene_synonym="Gfg"
                     /inference="alignment:Splign:2.1.0"
     exon            572..1066
                     /gene="Nudt6"
                     /gene_synonym="Gfg"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgagcgtctg aaaggcaagg tgcaacaatg tggtgggcga gcagagcgcg atggttgttc
       61 tcggctttgc tcgacgtggg cggagtcgga ctccgggcta ggcggcgcac tgcctcgagc
      121 ggcctggaga tcacgggctc ctgcgggggc gagctacaag gcgagctgga cagatttggg
      181 ggcatctcgg tgcacttgtc gcggcaccgc accctgcacc ggctggatgc cgccgccttc
      241 cggaggctct tgcaggccgc cattcagcag tggcgagcgg aaggaaggat cgctgcatgg
      301 ctgcacatcc ccatcctgca gagccacttc atcgcccctg ctgcctctct gggcttctgc
      361 ttccaccacg cagagccgca cttgtcaacg ctgactctgt ggttgggaga aggacccagc
      421 agactcccgg ggtatgccac acaccaagta ggggttgcag gtgccgtatt tgatgttagc
      481 accaggaaag tactggttgt acaagatcga aataaattga aaaacatgtg gaagtttcca
      541 ggaggcctgt cagagcctgg agaagatatt ggagacacag cagtccgaga ggtgtttgaa
      601 gagactggtg tcaagtcaga attcaggtct ctgttgagca tccggcagca acacaggagc
      661 cctggggcct ttgggatgtc agacatgtac ctgatctgcc gcctgcagcc gcgttccttc
      721 accatcaact tctgccagca ggaatgcttg aagtgtgaat ggatggatct agaaagcctg
      781 gccaggacta aacacacaac ccccatcacc agcagggtgg ctaggctact actatacgga
      841 cacagggaag ggtttgacaa gattgacctc agcatggagg aactccctgc agtatacaca
      901 ggcctgttct acaagctcta ccacagggga ctgcctgaga ggtacaaggc cgaaatggga
      961 acagattgaa tgccagcctt cctcacatac ttgatttcca gggtagaaat tcacaaatgt
     1021 atatatgttt aaatcctctt ttcaaataaa ggaaatacgt gacaaa
//
