LOCUS       NM_001007733            1366 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus nudix hydrolase 5 (Nudt5), mRNA.
ACCESSION   NM_001007733 XM_341559
VERSION     NM_001007733.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1366)
  AUTHORS   Wright,R.H., Lioutas,A., Le Dily,F., Soronellas,D., Pohl,A.,
            Bonet,J., Nacht,A.S., Samino,S., Font-Mateu,J., Vicent,G.P.,
            Wierer,M., Trabado,M.A., Schelhorn,C., Carolis,C., Macias,M.J.,
            Yanes,O., Oliva,B. and Beato,M.
  TITLE     ADP-ribose-derived nuclear ATP synthesis by NUDIX5 is required for
            chromatin remodeling
  JOURNAL   Science 352 (6290), 1221-1225 (2016)
   PUBMED   27257257
REFERENCE   2  (bases 1 to 1366)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   3  (bases 1 to 1366)
  AUTHORS   Ito,R., Sekiguchi,M., Setoyama,D., Nakatsu,Y., Yamagata,Y. and
            Hayakawa,H.
  TITLE     Cleavage of oxidized guanine nucleotide and ADP sugar by human
            NUDT5 protein
  JOURNAL   J Biochem 149 (6), 731-738 (2011)
   PUBMED   21389046
REFERENCE   4  (bases 1 to 1366)
  AUTHORS   Song,M.G., Li,Y. and Kiledjian,M.
  TITLE     Multiple mRNA decapping enzymes in mammalian cells
  JOURNAL   Mol Cell 40 (3), 423-432 (2010)
   PUBMED   21070968
REFERENCE   5  (bases 1 to 1366)
  AUTHORS   Kamiya,H., Hori,M., Arimori,T., Sekiguchi,M., Yamagata,Y. and
            Harashima,H.
  TITLE     NUDT5 hydrolyzes oxidized deoxyribonucleoside diphosphates with
            broad substrate specificity
  JOURNAL   DNA Repair (Amst) 8 (10), 1250-1254 (2009)
   PUBMED   19699693
REFERENCE   6  (bases 1 to 1366)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   7  (bases 1 to 1366)
  AUTHORS   Zha,M., Guo,Q., Zhang,Y., Yu,B., Ou,Y., Zhong,C. and Ding,J.
  TITLE     Molecular mechanism of ADP-ribose hydrolysis by human NUDT5 from
            structural and kinetic studies
  JOURNAL   J Mol Biol 379 (3), 568-578 (2008)
   PUBMED   18462755
REFERENCE   8  (bases 1 to 1366)
  AUTHORS   Zha,M., Zhong,C., Peng,Y., Hu,H. and Ding,J.
  TITLE     Crystal structures of human NUDT5 reveal insights into the
            structural basis of the substrate specificity
  JOURNAL   J Mol Biol 364 (5), 1021-1033 (2006)
   PUBMED   17052728
REFERENCE   9  (bases 1 to 1366)
  AUTHORS   Yang,H., Slupska,M.M., Wei,Y.F., Tai,J.H., Luther,W.M., Xia,Y.R.,
            Shih,D.M., Chiang,J.H., Baikalov,C., Fitz-Gibbon,S., Phan,I.T.,
            Conrad,A. and Miller,J.H.
  TITLE     Cloning and characterization of a new member of the Nudix
            hydrolases from human and mouse
  JOURNAL   J Biol Chem 275 (12), 8844-8853 (2000)
   PUBMED   10722730
REFERENCE   10 (bases 1 to 1366)
  AUTHORS   Gasmi,L., Cartwright,J.L. and McLennan,A.G.
  TITLE     Cloning, expression and characterization of YSA1H, a human
            adenosine 5'-diphosphosugar pyrophosphatase possessing a MutT motif
  JOURNAL   Biochem J 344 Pt 2 (Pt 2), 331-337 (1999)
   PUBMED   10567213
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC079176.1.
            
            On Nov 29, 2004 this sequence version replaced XM_341559.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079176.1, CK474906.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1366
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17q12.3"
     gene            1..1366
                     /gene="Nudt5"
                     /note="nudix hydrolase 5"
                     /db_xref="GeneID:361274"
                     /db_xref="RGD:1359284"
     exon            1..107
                     /gene="Nudt5"
                     /inference="alignment:Splign:2.1.0"
     exon            108..212
                     /gene="Nudt5"
                     /inference="alignment:Splign:2.1.0"
     CDS             150..809
                     /gene="Nudt5"
                     /EC_number="3.6.1.13"
                     /EC_number="3.6.1.58"
                     /EC_number="2.7.7.96"
                     /note="nudix motif 5; nucleoside diphosphate-linked moiety
                     X motif 5; nudix-type motif 5; 8-oxo-dGDP phosphatase;
                     nudix (nucleoside diphosphate linked moiety X)-type motif
                     5; nuclear ATP-synthesis protein NUDIX5"
                     /codon_start=1
                     /product="ADP-sugar pyrophosphatase"
                     /protein_id="NP_001007734.1"
                     /db_xref="GeneID:361274"
                     /db_xref="RGD:1359284"
                     /translation="METQEPKDSSPPTEQRILSEELISEGKWVKFEKTTYMDPTGKTR
                     TWETVKLTTRKGKSADAVSVIPVLQRTLHHECIVLVKQFRPPMGGYCLEFPAGLIEDG
                     ESPEAAALRELEEETGYKGDIAECSPAVCMDPGLSNCTTHVVTVTINGDDAGNVRPKP
                     KPGDGEFVEVISLPKNDLLTRLDALGAEDRLTVDARVYAYALALKHANAKPFEVPFLK
                     F"
     exon            213..280
                     /gene="Nudt5"
                     /inference="alignment:Splign:2.1.0"
     exon            281..330
                     /gene="Nudt5"
                     /inference="alignment:Splign:2.1.0"
     exon            331..438
                     /gene="Nudt5"
                     /inference="alignment:Splign:2.1.0"
     exon            439..534
                     /gene="Nudt5"
                     /inference="alignment:Splign:2.1.0"
     exon            535..636
                     /gene="Nudt5"
                     /inference="alignment:Splign:2.1.0"
     exon            637..645
                     /gene="Nudt5"
                     /inference="alignment:Splign:2.1.0"
     exon            646..699
                     /gene="Nudt5"
                     /inference="alignment:Splign:2.1.0"
     exon            700..1344
                     /gene="Nudt5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcctgtgtc gctatcggtg gcgcctgatt ctacggagac tgcagcttct gtctgatcct
       61 ttttcctttc ctcctccatc ccttccacat cccacagctt agtgtagctt gaccttccac
      121 cagaggactg tggagaccaa caggttgaaa tggagaccca agaaccaaaa gactcttctc
      181 cccccaccga gcagcgcatt ctttcagagg agttgatctc agaaggaaaa tgggtcaaat
      241 ttgaaaaaac aacttacatg gaccccaccg gtaaaactag aacctgggaa acagtgaagc
      301 ttacgaccag gaagggaaaa tctgctgatg ccgtgtcagt cataccagtc ctgcaaagaa
      361 cgcttcatca tgagtgcatt gtcctggtga agcagttccg gcccccgatg ggcggctact
      421 gcctggagtt cccagcaggg ctcatcgaag acggggaaag cccagaagcg gctgctctgc
      481 gggagctgga ggaagagact ggctacaaag gtgacattgc tgaatgctct ccagctgtgt
      541 gtatggatcc aggcttgtca aactgcacca cacacgttgt gacagtgacc atcaatggag
      601 atgacgcagg aaatgtaagg ccgaaaccca aaccagggga cggagagttt gtggaagtga
      661 tttctttacc aaagaatgat ctgctgacga gacttgacgc tctgggtgca gaagaccgtc
      721 ttacagtgga cgccagggtc tacgcctatg ctctggcgct gaaacatgcc aacgccaagc
      781 ccttcgaagt gcccttcctc aaattttaag gccaaggagg acactggcca tgctttgtaa
      841 atgaaaccgt gaggccttca ttcttcaatg tattcaatta agtttaatgt agatcataaa
      901 tcggcttttt cataaaataa aagcagcaca gactgcatgt ggtatggaat tataattaca
      961 gagaatataa ccttcattta aacttgttaa tactcatgga aatgacgtat agttaggtat
     1021 gtttaaattt cttctacctc acctggccta gaaggtgagg gtatttctca ggaatagact
     1081 cgagctccaa attaggtcaa ctatttttac cctcaattcc taaaataaaa attatgcact
     1141 taagtctgca gatagctatt tattagactc agtttaaaaa ttagaaggtt gggtttttgt
     1201 tttgagacag ggtatcactg ggtagccctg gctagcctgg aacttatttt gtagaccagg
     1261 ctggctttga actcaagaga ttcatctgtc tctgtctctc taaagttctg ggaataaaga
     1321 tgtatagcac cacatgtggc aaaaaaaaaa aaaaaaaaaa aaaaaa
//
