LOCUS       NM_001039004            1074 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Rattus norvegicus nudix hydrolase 21 (Nudt21), mRNA.
ACCESSION   NM_001039004
VERSION     NM_001039004.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1074)
  AUTHORS   Brumbaugh,J., Di Stefano,B., Wang,X., Borkent,M., Forouzmand,E.,
            Clowers,K.J., Ji,F., Schwarz,B.A., Kalocsay,M., Elledge,S.J.,
            Chen,Y., Sadreyev,R.I., Gygi,S.P., Hu,G., Shi,Y. and
            Hochedlinger,K.
  TITLE     Nudt21 Controls Cell Fate by Connecting Alternative Polyadenylation
            to Chromatin Signaling
  JOURNAL   Cell 172 (1-2), 106-120 (2018)
   PUBMED   29249356
  REMARK    Erratum:[Cell. 2018 Jan 25;172(3):629-631. doi:
            10.1016/j.cell.2017.12.035.. PMID: 29373832]
REFERENCE   2  (bases 1 to 1074)
  AUTHORS   Zhu,Y., Wang,X., Forouzmand,E., Jeong,J., Qiao,F., Sowd,G.A.,
            Engelman,A.N., Xie,X., Hertel,K.J. and Shi,Y.
  TITLE     Molecular Mechanisms for CFIm-Mediated Regulation of mRNA
            Alternative Polyadenylation
  JOURNAL   Mol Cell 69 (1), 62-74 (2018)
   PUBMED   29276085
REFERENCE   3  (bases 1 to 1074)
  AUTHORS   Gruber,A.R., Martin,G., Keller,W. and Zavolan,M.
  TITLE     Means to an end: mechanisms of alternative polyadenylation of
            messenger RNA precursors
  JOURNAL   Wiley Interdiscip Rev RNA 5 (2), 183-196 (2014)
   PUBMED   24243805
  REMARK    Review article
REFERENCE   4  (bases 1 to 1074)
  AUTHORS   Gruber,A.R., Martin,G., Keller,W. and Zavolan,M.
  TITLE     Cleavage factor Im is a key regulator of 3' UTR length
  JOURNAL   RNA Biol 9 (12), 1405-1412 (2012)
   PUBMED   23187700
REFERENCE   5  (bases 1 to 1074)
  AUTHORS   Fukumitsu,H., Soumiya,H. and Furukawa,S.
  TITLE     Knockdown of pre-mRNA cleavage factor Im 25 kDa promotes neurite
            outgrowth
  JOURNAL   Biochem Biophys Res Commun 425 (4), 848-853 (2012)
   PUBMED   22898046
  REMARK    GeneRIF: Taken together, these results indicate that endogenous
            CFIm may promote neuritogenesis in developing neurons by
            coordinating events upstream of NGF-induced RhoA inactivation.
REFERENCE   6  (bases 1 to 1074)
  AUTHORS   Shimazu,T., Horinouchi,S. and Yoshida,M.
  TITLE     Multiple histone deacetylases and the CREB-binding protein regulate
            pre-mRNA 3'-end processing
  JOURNAL   J Biol Chem 282 (7), 4470-4478 (2007)
   PUBMED   17172643
REFERENCE   7  (bases 1 to 1074)
  AUTHORS   Kubo,T., Wada,T., Yamaguchi,Y., Shimizu,A. and Handa,H.
  TITLE     Knock-down of 25 kDa subunit of cleavage factor Im in Hela cells
            alters alternative polyadenylation within 3'-UTRs
  JOURNAL   Nucleic Acids Res 34 (21), 6264-6271 (2006)
   PUBMED   17098938
REFERENCE   8  (bases 1 to 1074)
  AUTHORS   Venkataraman,K., Brown,K.M. and Gilmartin,G.M.
  TITLE     Analysis of a noncanonical poly(A) site reveals a tripartite
            mechanism for vertebrate poly(A) site recognition
  JOURNAL   Genes Dev 19 (11), 1315-1327 (2005)
   PUBMED   15937220
REFERENCE   9  (bases 1 to 1074)
  AUTHORS   Dettwiler,S., Aringhieri,C., Cardinale,S., Keller,W. and
            Barabino,S.M.
  TITLE     Distinct sequence motifs within the 68-kDa subunit of cleavage
            factor Im mediate RNA binding, protein-protein interactions, and
            subcellular localization
  JOURNAL   J Biol Chem 279 (34), 35788-35797 (2004)
   PUBMED   15169763
REFERENCE   10 (bases 1 to 1074)
  AUTHORS   Ruegsegger,U., Beyer,K. and Keller,W.
  TITLE     Purification and characterization of human cleavage factor Im
            involved in the 3' end processing of messenger RNA precursors
  JOURNAL   J Biol Chem 271 (11), 6107-6113 (1996)
   PUBMED   8626397
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC098748.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC098748.1, FQ229498.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1074
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19p12"
     gene            1..1074
                     /gene="Nudt21"
                     /gene_synonym="Cpsf5"
                     /note="nudix hydrolase 21"
                     /db_xref="GeneID:291877"
                     /db_xref="RGD:1305766"
     exon            1..197
                     /gene="Nudt21"
                     /gene_synonym="Cpsf5"
                     /inference="alignment:Splign:2.1.0"
     CDS             82..765
                     /gene="Nudt21"
                     /gene_synonym="Cpsf5"
                     /note="nudix motif 21; nucleoside diphosphate-linked
                     moiety X motif 21; cleavage and polyadenylation specific
                     factor 5; nudix (nucleoside diphosphate linked moiety
                     X)-type motif 21"
                     /codon_start=1
                     /product="cleavage and polyadenylation specificity factor
                     subunit 5"
                     /protein_id="NP_001034093.1"
                     /db_xref="GeneID:291877"
                     /db_xref="RGD:1305766"
                     /translation="MSVVPPNRSQTGWPRGVNQFGNKYIQQTKPLTLERTINLYPLTN
                     YTFGTKEPLYEKDSSVAARFQRMREEFDKIGMRRTVEGVLIVHEHRLPHVLLLQLGTT
                     FFKLPGGELNPGEDEVEGLKRLMTEILGRQDGVLQDWVIDDCIGNWWRPNFEPPQYPY
                     IPAHITKPKEHKKLFLVQLQEKALFAVPKNYKLVAAPLFELYDNAPGYGPIISSLPQL
                     LSRFNFIYN"
     exon            198..398
                     /gene="Nudt21"
                     /gene_synonym="Cpsf5"
                     /inference="alignment:Splign:2.1.0"
     exon            399..462
                     /gene="Nudt21"
                     /gene_synonym="Cpsf5"
                     /inference="alignment:Splign:2.1.0"
     exon            463..552
                     /gene="Nudt21"
                     /gene_synonym="Cpsf5"
                     /inference="alignment:Splign:2.1.0"
     exon            553..628
                     /gene="Nudt21"
                     /gene_synonym="Cpsf5"
                     /inference="alignment:Splign:2.1.0"
     exon            629..743
                     /gene="Nudt21"
                     /gene_synonym="Cpsf5"
                     /inference="alignment:Splign:2.1.0"
     exon            744..1049
                     /gene="Nudt21"
                     /gene_synonym="Cpsf5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcagataac cgctgcccgc cccgcggtcg tctccccggg cccccgcttt ctacaggtct
       61 ccagtgtcgg agctattcag catgtctgtg gtgccgccca atcgctcgca gacgggctgg
      121 ccccgggggg tcaaccaatt cggtaacaag tacatccagc aaaccaagcc cctcaccctg
      181 gagcgcacca ttaacctgta cccacttacc aactatactt ttggtacaaa ggagcccctc
      241 tatgaaaagg acagctctgt ggcggccaga tttcagcgca tgcgggagga atttgataag
      301 attgggatga gaaggactgt agaaggggtt ctgatcgtac acgagcaccg cctgccccac
      361 gtgctactgc tacagctggg aacaaccttc ttcaaactac ctggcggtga acttaaccca
      421 ggagaagatg aagttgaagg actaaaacgc ttaatgacag agatactggg tcgtcaagat
      481 ggagtcctgc aagactgggt catcgatgac tgcattggga actggtggag accaaatttt
      541 gaacctcctc agtacccgta tattcctgca catataacaa agcccaagga acataagaag
      601 ttgtttctgg ttcagcttca agagaaagcc ttgtttgcgg tccctaagaa ttacaagctg
      661 gtagctgcac cgttgtttga actgtacgac aatgctccgg gatacggacc catcatttct
      721 agtcttcctc agctgctgag caggtttaat tttatataca actgaacttc tcctgtacac
      781 agaagtaaaa gaagccgtct ctgtgagcac agcttacaca tgtagaagaa taactgtaga
      841 acaagttttg gttttctctt gttccctaaa ttgccaccac cttcctgttt gaagagtaaa
      901 attaatatga actagatagt ggtataaaca tgtgacagtg ttcattaact tttggttctc
      961 atacattttt ttttgtacat taaaaaaagt gaatttctta tttgtattat ttttttttta
     1021 agtttctcat taaactctga aaagtcttaa aaaaaaaaaa aaaaaaaaaa aaaa
//
