LOCUS       NM_207596                905 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus nudix hydrolase 2 (Nudt2), mRNA.
ACCESSION   NM_207596 XM_216370
VERSION     NM_207596.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 905)
  AUTHORS   Carmi-Levy,I., Yannay-Cohen,N., Kay,G., Razin,E. and Nechushtan,H.
  TITLE     Diadenosine tetraphosphate hydrolase is part of the transcriptional
            regulation network in immunologically activated mast cells
  JOURNAL   Mol Cell Biol 28 (18), 5777-5784 (2008)
   PUBMED   18644867
  REMARK    GeneRIF: evidence provided that Ap(4)A hydrolase is responsible for
            Ap(4)A degradation following immunologic activation of mast cells;
            observations show involvement of Ap(4)A hydrolase in gene
            regulation can also occur in activated cardiac cells.
REFERENCE   2  (bases 1 to 905)
  AUTHORS   Bessman,M.J., Frick,D.N. and O'Handley,S.F.
  TITLE     The MutT proteins or 'Nudix' hydrolases, a family of versatile,
            widely distributed, 'housecleaning' enzymes
  JOURNAL   J Biol Chem 271 (41), 25059-25062 (1996)
   PUBMED   8810257
  REMARK    Review article
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Nov 27, 2020 this sequence version replaced NM_207596.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC058156.1, SRR26643286.16145.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                JAXUCZ010000005.1  61424176-61424211
            37-170              JAXUCZ010000005.1  61435360-61435493
            171-905             JAXUCZ010000005.1  61438281-61439015
FEATURES             Location/Qualifiers
     source          1..905
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q22"
     gene            1..905
                     /gene="Nudt2"
                     /note="nudix hydrolase 2"
                     /db_xref="GeneID:297998"
                     /db_xref="RGD:1303023"
     exon            1..36
                     /gene="Nudt2"
                     /inference="alignment:Splign:2.1.0"
     exon            37..170
                     /gene="Nudt2"
                     /inference="alignment:Splign:2.1.0"
     CDS             44..487
                     /gene="Nudt2"
                     /EC_number="3.6.1.17"
                     /note="bis(5'-nucleosyl)-tetraphosphatase; ap4Aase; nudix
                     motif 2; ap4A hydrolase; diadenosine tetraphosphatase;
                     nucleoside diphosphate-linked moiety X motif 2;
                     diadenosine 5',5'''-P1,P4-tetraphosphate asymmetrical
                     hydrolase; nudix (nucleoside diphosphate linked moiety
                     X)-type motif 2"
                     /codon_start=1
                     /product="bis(5'-nucleosyl)-tetraphosphatase
                     [asymmetrical]"
                     /protein_id="NP_997479.1"
                     /db_xref="GeneID:297998"
                     /db_xref="RGD:1303023"
                     /translation="MALRACGLIIFRRHLIPKVDNTTIEFLLLQASDGIHHWTPPKGH
                     VDPGENDLETALRETQEETGIEASQLIVLEGFRRELNYVARKKPKTVIYWLAEVKDYD
                     VEIRLSQEHQAYRWLGLDEACQLAQFEEMKATLQEGHQFLCSTPA"
     exon            171..905
                     /gene="Nudt2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagaaccgcc tcctgcctcc tgccttcgtg ctgcggatag atcatggccc tgagggcatg
       61 tggcttgatc atcttccgaa gacaccttat tcccaaggtg gacaacacaa caattgaatt
      121 tctgctgctg caggcgtcgg atggcattca tcactggact cctcccaaag gccatgtgga
      181 ccccggcgag aatgacttag aaacagccct gagagagact caggaggaaa caggcataga
      241 agcaagccag ctgatcgtcc ttgaggggtt cagaagggag ctcaattatg tggcgaggaa
      301 gaagcctaaa acagtcattt actggctagc agaagtgaaa gactatgatg tagagatccg
      361 cctctcccag gagcatcaag cctaccgctg gctagggctg gatgaggcct gccagttggc
      421 tcagttcgag gagatgaagg caacgctcca agaaggacac cagtttctct gctccacacc
      481 agcctgagct gaccagaaca aatgcttcca tggcatcctt aagggttttt gagatgagcc
      541 taccctttcc atccagggaa ggatgcgctg gccttgggct tgctacagcc gagagcagat
      601 aggttagtga aattaaataa ctccacactc agccaggaag ccctggattc aatccctagc
      661 atagaaaata attactttaa aaagaagagc aagggggttg gggatttagc tcagcggtag
      721 agcacttgcc tagcaagcgc aaggccctgg gttcggtccc cagctccgaa aaaaagaaaa
      781 ggagaaaaaa aaaaaagaac aaggaagatg gattttagca aaggaggggt acagtcctta
      841 aaatgccagc cctaaagtac ctctttatca tttataaata aacttcaagc aacttacatg
      901 ccctt
//
