LOCUS       NM_001127554            1274 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus nudix hydrolase 16 (Nudt16), mRNA.
ACCESSION   NM_001127554 XM_001072855 XM_343464
VERSION     NM_001127554.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1274)
  AUTHORS   Grzela R, Nasilowska K, Lukaszewicz M, Tyras M, Stepinski J,
            Jankowska-Anyszka M, Bojarska E and Darzynkiewicz E.
  TITLE     Hydrolytic activity of human Nudt16 enzyme on dinucleotide cap
            analogs and short capped oligonucleotides
  JOURNAL   RNA 24 (5), 633-642 (2018)
   PUBMED   29483298
REFERENCE   2  (bases 1 to 1274)
  AUTHORS   Tresaugues L, Lundback T, Welin M, Flodin S, Nyman T, Silvander C,
            Graslund S and Nordlund P.
  TITLE     Structural Basis for the Specificity of Human NUDT16 and Its
            Regulation by Inosine Monophosphate
  JOURNAL   PLoS One 10 (6), e0131507 (2015)
   PUBMED   26121039
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1274)
  AUTHORS   de Mateo S, Castillo J, Estanyol JM, Ballesca JL and Oliva R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   4  (bases 1 to 1274)
  AUTHORS   Lu G, Zhang J, Li Y, Li Z, Zhang N, Xu X, Wang T, Guan Z, Gao GF
            and Yan J.
  TITLE     hNUDT16: a universal decapping enzyme for small nucleolar RNA and
            cytoplasmic mRNA
  JOURNAL   Protein Cell 2 (1), 64-73 (2011)
   PUBMED   21337011
REFERENCE   5  (bases 1 to 1274)
  AUTHORS   Song MG, Li Y and Kiledjian M.
  TITLE     Multiple mRNA decapping enzymes in mammalian cells
  JOURNAL   Mol Cell 40 (3), 423-432 (2010)
   PUBMED   21070968
REFERENCE   6  (bases 1 to 1274)
  AUTHORS   Iyama T, Abolhassani N, Tsuchimoto D, Nonaka M and Nakabeppu Y.
  TITLE     NUDT16 is a (deoxy)inosine diphosphatase, and its deficiency
            induces accumulation of single-strand breaks in nuclear DNA and
            growth arrest
  JOURNAL   Nucleic Acids Res 38 (14), 4834-4843 (2010)
   PUBMED   20385596
REFERENCE   7  (bases 1 to 1274)
  AUTHORS   Abolhassani N, Iyama T, Tsuchimoto D, Sakumi K, Ohno M, Behmanesh M
            and Nakabeppu Y.
  TITLE     NUDT16 and ITPA play a dual protective role in maintaining
            chromosome stability and cell growth by eliminating dIDP/IDP and
            dITP/ITP from nucleotide pools in mammals
  JOURNAL   Nucleic Acids Res 38 (9), 2891-2903 (2010)
   PUBMED   20081199
REFERENCE   8  (bases 1 to 1274)
  AUTHORS   Taylor MJ and Peculis BA.
  TITLE     Evolutionary conservation supports ancient origin for Nudt16, a
            nuclear-localized, RNA-binding, RNA-decapping enzyme
  JOURNAL   Nucleic Acids Res 36 (18), 6021-6034 (2008)
   PUBMED   18820299
REFERENCE   9  (bases 1 to 1274)
  AUTHORS   Peculis BA, Reynolds K and Cleland M.
  TITLE     Metal determines efficiency and substrate specificity of the
            nuclear NUDIX decapping proteins X29 and H29K (Nudt16)
  JOURNAL   J Biol Chem 282 (34), 24792-24805 (2007)
   PUBMED   17567574
REFERENCE   10 (bases 1 to 1274)
  AUTHORS   Ghosh T, Peterson B, Tomasevic N and Peculis BA.
  TITLE     Xenopus U8 snoRNA binding protein is a conserved nuclear decapping
            enzyme
  JOURNAL   Mol Cell 13 (6), 817-828 (2004)
   PUBMED   15053875
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC166915.1.
            
            On or before May 23, 2008 this sequence version replaced
            XM_001072855.1, XM_343464.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166915.1, FQ098774.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840115, SAMN14984038
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1274
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..1274
                     /gene="Nudt16"
                     /gene_synonym="RGD1311387"
                     /note="nudix hydrolase 16"
                     /db_xref="GeneID:363129"
                     /db_xref="RGD:1311387"
     exon            1..140
                     /gene="Nudt16"
                     /gene_synonym="RGD1311387"
                     /inference="alignment:Splign:2.1.0"
     CDS             3..590
                     /gene="Nudt16"
                     /gene_synonym="RGD1311387"
                     /EC_number="3.6.1.62"
                     /note="nudix (nucleoside diphosphate linked moiety X)-type
                     motif 16"
                     /codon_start=1
                     /product="U8 snoRNA-decapping enzyme"
                     /protein_id="NP_001121026.1"
                     /db_xref="GeneID:363129"
                     /db_xref="RGD:1311387"
                     /translation="MEGDRKVELSEALALGPGWRHACHALLYAPDPRKLFGRIPMRFA
                     VLMQMRFDGRLGFPGGFVDAQDSCLEDGLNRELREELGDAVSAFRVERSDYQSSRIAA
                     RPRVVAHFYAKRLTLEQLQAVEARAPLAKDHGLEVLGLVRVPLYIMRDGEGGLPAFLE
                     NSFIGAAREQLLEALRDLKLLDPGTVAKLKIPDSK"
     exon            141..410
                     /gene="Nudt16"
                     /gene_synonym="RGD1311387"
                     /inference="alignment:Splign:2.1.0"
     exon            411..1263
                     /gene="Nudt16"
                     /gene_synonym="RGD1311387"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agatggaagg ggatcggaaa gtggagctca gcgaagccct ggcgctcggg ccaggctggc
       61 gccacgcctg ccatgcgctt ctctacgcgc ccgacccccg caagctgttt ggccgcatcc
      121 cgatgcgctt cgcggtgctg atgcagatgc gcttcgacgg gcgactgggc ttccctggcg
      181 gcttcgtgga cgcacaggac agctgcctgg aggacgggct gaaccgtgaa ctgcgcgagg
      241 agctgggcga tgcggtgtct gccttccgcg tcgaacgctc ggactaccaa agctcacgca
      301 tcgctgccag accgcgcgtg gtggcccact tctatgccaa acgcctgacg ctggaacagc
      361 tgcaggctgt ggaagccagg gcacctctag ccaaggacca cgggctggag gtgctgggcc
      421 tggtgcgggt acccctgtac atcatgcgtg atggtgaggg aggcctgccc gcctttctgg
      481 agaattcctt cattggtgct gcccgggagc agctactgga agcccttcgg gacttgaaac
      541 ttctggatcc cggcactgtt gcaaaactca agatcccaga ttctaagtag agtcggccca
      601 gcatggaccc ctggaaccca agttgaaggc catggtatga gggagggaga ggaaaaggga
      661 gagagggaca cgttttctct taggggtctg agggattgca gatgttgcca cattaacaac
      721 agaggtggcg aggcagtgtt ttcagcggcg gaccttgtct ggtggcatta gagataaagg
      781 gcctttgtag actctcagag tccttgctta tggacggaca gacagcctgg aagctccagg
      841 tatgcatatg tgtagtctgc ggtcacacac agcatggcac actgccatct gtccggttta
      901 accctgatgt agcatttggc acatcccacc tcctcctgat aaacgggagg ggttcttacc
      961 catctgctgc aaggctgctg cccagcgtcc agcccatgcc tgttagggaa gcaaaagagg
     1021 aggctcctct ctgagaatgg ccctgtgtta cctggggctt gagcaaagta gtgggtttca
     1081 gaatgtggcc taaggaccta cccagtcctg cattcctact gagggttgga acgtgtcagg
     1141 ggcttcttgc gttgaaccga ggcctgagac ctcactcctg atgcgtgtct tcctgagtgt
     1201 tcaccctcgt gctccctgtt tgtctctgtt tagcatgccc tgccaaaaaa aaaaaaaaaa
     1261 aaaaaaaaaa aaaa
//
