LOCUS       NM_001106049            2566 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus nudix hydrolase 15 (Nudt15), mRNA.
ACCESSION   NM_001106049 XM_001071270 XM_008770862 XM_214236
VERSION     NM_001106049.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2566)
  AUTHORS   Moriyama,T., Nishii,R., Perez-Andreu,V., Yang,W., Klussmann,F.A.,
            Zhao,X., Lin,T.N., Hoshitsuki,K., Nersting,J., Kihira,K.,
            Hofmann,U., Komada,Y., Kato,M., McCorkle,R., Li,L., Koh,K.,
            Najera,C.R., Kham,S.K., Isobe,T., Chen,Z., Chiew,E.K., Bhojwani,D.,
            Jeffries,C., Lu,Y., Schwab,M., Inaba,H., Pui,C.H., Relling,M.V.,
            Manabe,A., Hori,H., Schmiegelow,K., Yeoh,A.E., Evans,W.E. and
            Yang,J.J.
  TITLE     NUDT15 polymorphisms alter thiopurine metabolism and hematopoietic
            toxicity
  JOURNAL   Nat Genet 48 (4), 367-373 (2016)
   PUBMED   26878724
REFERENCE   2  (bases 1 to 2566)
  AUTHORS   Carter,M., Jemth,A.S., Hagenkort,A., Page,B.D., Gustafsson,R.,
            Griese,J.J., Gad,H., Valerie,N.C., Desroses,M., Bostrom,J., Warpman
            Berglund,U., Helleday,T. and Stenmark,P.
  TITLE     Crystal structure, biochemical and cellular activities demonstrate
            separate functions of MTH1 and MTH2
  JOURNAL   Nat Commun 6, 7871 (2015)
   PUBMED   26238318
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2566)
  AUTHORS   Takagi,Y., Setoyama,D., Ito,R., Kamiya,H., Yamagata,Y. and
            Sekiguchi,M.
  TITLE     Human MTH3 (NUDT18) protein hydrolyzes oxidized forms of guanosine
            and deoxyguanosine diphosphates: comparison with MTH1 and MTH2
  JOURNAL   J Biol Chem 287 (25), 21541-21549 (2012)
   PUBMED   22556419
REFERENCE   4  (bases 1 to 2566)
  AUTHORS   Yu,Y., Cai,J.P., Tu,B., Wu,L., Zhao,Y., Liu,X., Li,L., McNutt,M.A.,
            Feng,J., He,Q., Yang,Y., Wang,H., Sekiguchi,M. and Zhu,W.G.
  TITLE     Proliferating cell nuclear antigen is protected from degradation by
            forming a complex with MutT Homolog2
  JOURNAL   J Biol Chem 284 (29), 19310-19320 (2009)
   PUBMED   19419956
REFERENCE   5  (bases 1 to 2566)
  AUTHORS   Cai,J.P., Ishibashi,T., Takagi,Y., Hayakawa,H. and Sekiguchi,M.
  TITLE     Mouse MTH2 protein which prevents mutations caused by 8-oxoguanine
            nucleotides
  JOURNAL   Biochem Biophys Res Commun 305 (4), 1073-1077 (2003)
   PUBMED   12767940
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000015.1.
            
            On or before Aug 2, 2021 this sequence version replaced
            XM_008770862.3, NM_001106049.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.683379.1,
                                           SRR26643429.49187.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676787 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-281               JAXUCZ010000015.1  55123103-55123383   c
            282-478             JAXUCZ010000015.1  55121268-55121464   c
            479-2566            JAXUCZ010000015.1  55117312-55119399   c
FEATURES             Location/Qualifiers
     source          1..2566
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15q11"
     gene            1..2566
                     /gene="Nudt15"
                     /note="nudix hydrolase 15"
                     /db_xref="GeneID:290365"
                     /db_xref="RGD:1308292"
     exon            1..281
                     /gene="Nudt15"
                     /inference="alignment:Splign:2.1.0"
     CDS             127..639
                     /gene="Nudt15"
                     /EC_number="3.6.1.55"
                     /note="probable 7,8-dihydro-8-oxoguanine triphosphatase
                     NUDT15; probable 8-oxo-dGTP diphosphatase NUDT15; nudix
                     (nucleoside diphosphate linked moiety X)-type motif 15"
                     /codon_start=1
                     /product="nucleotide triphosphate diphosphatase NUDT15"
                     /protein_id="NP_001099519.1"
                     /db_xref="GeneID:290365"
                     /db_xref="RGD:1308292"
                     /translation="MATNAEQRRRPGVGVGVVVLSCEHPRCVLLGKRKGSFGAGSFQL
                     PGGHLEFGETWEECAQRETWEEAGLRLKNVRFASVVNTFVEKENYHYVTILMKGEVDV
                     THESEPRNMEPEKNESWEWVPWEEFPPLDQLFWALRCLKEQGYDPFKEDLNHLEGYRG
                     KHLEKTPKIP"
     exon            282..478
                     /gene="Nudt15"
                     /inference="alignment:Splign:2.1.0"
     exon            479..2566
                     /gene="Nudt15"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggcaacagc tgatttctga gacttctgag acaaaacaac caagaataag cggggctcca
       61 ggcagttccc gtaaacttga aggctcatgc ggagattaac gtcacttccc gggtcagtca
      121 aacgctatgg ccactaacgc ggagcagagg cggcggccgg gagttggggt cggcgtggtg
      181 gtgttgagct gcgagcatcc tcgttgcgtc cttctgggga aaaggaaagg gtcgtttgga
      241 gccggcagtt tccagcttcc tgggggccac ttggaatttg gtgagacctg ggaagaatgc
      301 gctcagaggg aaacctggga agaggctggg cttcgcctga aaaatgtgcg ctttgcttcg
      361 gtggtaaata cttttgttga gaaggagaat taccattatg tcaccatatt aatgaaagga
      421 gaggtggacg tgactcacga gtcagaacca aggaatatgg aaccagaaaa gaatgaaagt
      481 tgggagtggg ttccctggga agagtttcct cccttggacc agcttttctg ggctctccgt
      541 tgtctaaaag agcaaggcta tgatccattt aaagaggacc tgaatcacct ggaagggtac
      601 agaggaaagc accttgaaaa gacaccaaag attccttgat ttaaaaaaaa aaaaaacttc
      661 agtaaatgaa aaattctgtg tttcaggaca actcaatttt atccagagct gtgtggtcac
      721 tggtctattt gcagtctcag gagaacttgt aattcaaaaa ccttaagaac ctcttccctg
      781 ggagtcactg ggttgtcttg agacataaaa taagatgtgt agggagcttg tggttcattt
      841 tccgcattac tgtgtagtta ccattgtcag ctgcatggag gtgaacacaa cagattgcct
      901 tgctctagtg caaatagagg tcggaactca aatatggcca ttcaagttca aaagcattgt
      961 gccagcagca aaattcatca tgcttgacgg ttttcctttt cacttctagt cacttgaata
     1021 gaatttttaa atgacaattc atgtagctag agagcttaag aaaagcagta ggctgtaacc
     1081 ctctgctatc tgagagaatc catggtaaat gtgagactaa gctgtggatc ccactaacgg
     1141 ccaggtcctc tgcgtctccc tttctgagcc taagattggg gtctttgcct gttgggatta
     1201 tacagggtag tgctgtggag gatttcttag aggtcaagag ctttccagag catcacagcc
     1261 aaaggctggt tggctgctct ccatccccca cccccacccc cagccaattg taagtttact
     1321 gtaagagatt gagcagtgaa atgtctcaca gaacagcatg cggaactaca tgttgtctgc
     1381 tgtgaaagct gacacatcag gcttagctaa cgctaaagct tctaaccagc ccattcatcc
     1441 tgatgtgtcc aggcttggat tgcgtgtgcc ctcctctctc tggtcaggca tagcatagtt
     1501 ttctggctga tgtagtttct gttactgggc agtcgctggc ccttctgctg cacaggcccc
     1561 cactgtgctc ttatgtgagg cggtttttca cctctgccat ctctctgtcc tgtacaggtg
     1621 ccacgtgaac cctttcccct ttacttgtgg atcttgttct ttacccagta ttcgtttcac
     1681 atgggctaac ttttgatcgg ggcaatggag atggttgggg agtactggcc acacctcctg
     1741 tgcacagccc taacatggtt gaagaggtct gtgcctgcac agcccagtta tttttataat
     1801 ggtcagatat taacttcttc acttattcag tctcctgtat ctcaggctgg cttccagctc
     1861 tctttgtaac cgaggataac cttgaactcc caatcctgac ttgactgccc tgacgctgat
     1921 tcaatctaca tccccctctc tctaagtggc tggtgcatca ttagttttct ggttgctttg
     1981 ttctgatact gggggttaaa cttagggctt tacacataat gggcaagtgc aaaggcagta
     2041 agggaagcca gcttccttct gtcgggtcag acattgaaga gatttgccaa aatctaaaat
     2101 gactttctcg ctgagtactt tataaaaact atgttaacat gcatttgatt tttattatat
     2161 ggtcaataaa ctttcctgat cttaattttc tagtgttaaa tattatttca taggcgctta
     2221 aaaaataaaa tctgattttt aaggttttat aaaggcatcc aaacctaaga gggagctgga
     2281 cgtttagctc agtggtagat catctgcgag gttcagttca gtcctcatct ccaagttaaa
     2341 aacattatga agactatagg aaaaaaatgg cacccaaagg ggtcccgcat gagtgcacca
     2401 gcccacagct catctttctt tataagctca ctcctgtgaa ctgacatctc taacatttgt
     2461 agtttgctct tttaaaatac tgaattgtga tgtttgctaa attttcaact ttttttcaaa
     2521 gttataatgt gctacaataa atctcatctt ctcttactta taccta
//
