LOCUS       NM_001109010            3880 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus nudix hydrolase 12 (Nudt12), mRNA.
ACCESSION   NM_001109010 XM_001071036 XM_346080
VERSION     NM_001109010.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3880)
  AUTHORS   Grudzien-Nogalska E, Wu Y, Jiao X, Cui H, Mateyak MK, Hart RP, Tong
            L and Kiledjian M.
  TITLE     Structural and mechanistic basis of mammalian Nudt12 RNA deNADding
  JOURNAL   Nat Chem Biol 15 (6), 575-582 (2019)
   PUBMED   31101919
REFERENCE   2  (bases 1 to 3880)
  AUTHORS   Abdelraheim SR, Spiller DG and McLennan AG.
  TITLE     Mammalian NADH diphosphatases of the Nudix family: cloning and
            characterization of the human peroxisomal NUDT12 protein
  JOURNAL   Biochem J 374 (Pt 2), 329-335 (2003)
   PUBMED   12790796
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473997.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_346080.3, XM_001071036.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN16676807
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3880
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q36"
     gene            1..3880
                     /gene="Nudt12"
                     /note="nudix hydrolase 12"
                     /db_xref="GeneID:367323"
                     /db_xref="RGD:1310902"
     exon            1..101
                     /gene="Nudt12"
                     /inference="alignment:Splign:2.1.0"
     exon            102..313
                     /gene="Nudt12"
                     /inference="alignment:Splign:2.1.0"
     CDS             108..1496
                     /gene="Nudt12"
                     /EC_number="3.6.1.22"
                     /note="nudix-type motif 12; peroxisomal NADH
                     pyrophosphatase NUDT12; nudix (nucleoside diphosphate
                     linked moiety X)-type motif 12"
                     /codon_start=1
                     /product="NAD-capped RNA hydrolase NUDT12"
                     /protein_id="NP_001102480.1"
                     /db_xref="GeneID:367323"
                     /db_xref="RGD:1310902"
                     /translation="MSSVKRNPKREIISELHSSAAEGDVAKLAGILSHSPSLLNETSE
                     NGWTALMYAARNGHPDAVQFLLEKGCDRSSVNKSRQTALDIAVFWGYKHIANLLANAK
                     GGKKPWFLTSDVDGCENYFSRTLLDRRSDKRTNSDWLQAKESHPTTVYILFSDLNPLV
                     TLGGNKESSQQPEVRLCQLNYADIKDYLAQPEKITLVFLGVELEMRKGSHAHAGGVPE
                     GEEDGLVAWFVLGIEPGAAEEFKQRHENCYFLHPPMPALLQLKEKEAGVVAQARSVLA
                     WHSRYKFCPTCGSTTKIEEGGYKRVCVRENCPSLHGVHNTSYPRVDPVVIMQVIHPDG
                     TKCLLGRQKRFPPGMFTCLAGFIEPGETIEDAVRREVGEESGVKVGHVQYVSCQPWPM
                     PSSLMIGCLAVAVSTEIKVDKNEIEDARWFTREQVVDVLTKGKQQAFFVPPSRAIAHQ
                     LIKHWVGMNPSL"
     exon            314..903
                     /gene="Nudt12"
                     /inference="alignment:Splign:2.1.0"
     exon            904..1071
                     /gene="Nudt12"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1185
                     /gene="Nudt12"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1385
                     /gene="Nudt12"
                     /inference="alignment:Splign:2.1.0"
     exon            1386..3880
                     /gene="Nudt12"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccccggaagt ccggaaggct gcctccagca ctgggaaaac tgacaactga gtttgacgcg
       61 gagtcttctg tcccggccgc ggtttctttg gtcactcttg ggaagaaatg tcttctgtca
      121 aaagaaatcc caaaagggaa ataatttctg aactccacag ttcagccgca gaaggagacg
      181 tcgcgaagtt agcaggaatt ctcagtcatt ctccatctct tctcaacgag acttctgaaa
      241 acggatggac tgctttaatg tatgccgcca ggaacgggca tccggatgct gtccagtttc
      301 tgcttgagaa aggatgtgac agatcgtctg tcaataaatc gaggcaaacc gccctggata
      361 ttgcggtatt ttggggttat aagcatatag ctaacttatt ggctaacgcc aaaggaggga
      421 agaagccctg gttcctaacc agtgacgtag acggatgtga aaattatttt agcagaacac
      481 tgctggaccg gaggagtgac aaaaggacta attctgactg gctgcaagct aaagagagcc
      541 accccaccac agtttatatc cttttctctg acttgaaccc cctggttact ctaggtggta
      601 ataaagaaag ctcgcagcag ccggaagtca ggctctgcca gctgaactac gcggacataa
      661 aggattactt ggctcagcct gagaagatca ccttggtgtt ccttggagtc gagcttgaaa
      721 tgagaaaagg ctcgcacgcc catgccggcg gagtcccaga gggagaggag gatggtttgg
      781 ttgcatggtt tgtcctcggc atagaacctg gtgcagctga ggagtttaag caaagacacg
      841 aaaactgtta ctttctccac ccgccaatgc ccgctcttct gcagttgaaa gaaaaagagg
      901 ctggggtcgt ggctcaagca agatcggtgc ttgcgtggca cagtcgatac aagttctgcc
      961 caacctgtgg cagcacaact aaaattgaag aaggtggcta caaaagagtg tgtgttcgag
     1021 aaaactgccc tagtctccat ggcgtccaca acacatctta cccgagagtt gatccagtcg
     1081 taattatgca ggtcattcat ccggatggaa ccaagtgtct tttaggccgg caaaagagat
     1141 ttccccccgg catgttcact tgtctcgctg gatttatcga gcctggggag acaatagaag
     1201 acgctgtgcg gagagaggta ggagaggaaa gtggagtcaa agttggccat gttcagtatg
     1261 tctcttgtca gccgtggcca atgccctcct ctttaatgat tggctgttta gctgtggcag
     1321 tgtctacaga aattaaagtt gacaagaatg aaatagagga tgcccgatgg ttcactagag
     1381 aacaggtggt ggatgttctt accaaaggga agcagcaagc attcttcgtg ccaccaagcc
     1441 gagctattgc acatcagtta atcaagcact gggttggcat gaaccccagt ctctaaatga
     1501 aaaatgctag cctctgtcga gtatcaccta atttttaaca ctacttatat atcaagaaag
     1561 agtagatata tgtactgatc tttagaacct tttaacgtaa aacttgggag cttcaaaaat
     1621 gttttcaggt tctttccatt attaattaca aaattcacag ttttataaac tggaatgatg
     1681 cctcaaattt tttcataaat tcggaggcag cctgtgaaca tttttgttgt gtttcccaat
     1741 tttatctcag aaaactaatt gtttgtctac caagaaagat catgttggga tgaagtgtgc
     1801 tccagaaatg aggtaaacct taatctttgt aaagagtgga ccccttgttg gagatatttg
     1861 tcaagataac tttggtgact tttgagcgtc cgtaatattt aatcatctaa ttattatctt
     1921 cctggtcttt tgtctactgg tagtactgtt gtactattag tcctagtttg atatgaccag
     1981 tgttgaaaat tattttataa ttataataat taatgtcagt attcacttat gaaatacagt
     2041 agcttggcac caacctttct catcagatcc tcagagcctt aagtagcaca ccttagaatg
     2101 gggctgctca gctctatgga tagttagtgc agtgtttcag ttttacaata tagatgcata
     2161 tattttactt gattgtcctg cagttgtctt aactacataa atttacatat gttgcctctt
     2221 tactagtctg gtagaacttg aagagagcat gaacacaata gatgttgaac atcatcattt
     2281 taatagtatg catctaagac ctagatctcc agtgcagtag gaaacagaag ctattactaa
     2341 aagtgtctgt agactaagga gccagaaaaa tggctctgtc attaaggtgc ttgctgtgca
     2401 agcatgagtc cttgagttca gattctctgc aacggtttca aaagctgtgt tcagtaccat
     2461 ccaactctaa ccccaaacct aaagaggcag agatgtgagt atcccgaggg cttgttggcc
     2521 agtcagtctg gtgaatcact aattggaata acagaccttg tctcaaaacg taaggtggaa
     2581 agatggagat ggatccaatg tgaagagcac ctgtcattcc tgtggaggac cagggtttag
     2641 ttcccaagat cctcctcagg caggacacaa cccccctgca gctacaactt caggggatcc
     2701 aacaccctct tctggcctct gcaagcatct gcatgagcat ttaatgaaga cacagacaca
     2761 taaatagaaa gattgaagaa tacacctgac ttctgtctct gccctacacc cccctacaca
     2821 cacacacaca cacgtgtgtg cacacattcc cacacacatg tgtgcacaca ttcccacaca
     2881 caggcacaca cacacaataa gtgaaaaaac tgatgatagg aagaatgaac ttagcttatc
     2941 agatgttttt aattgaaaat ttaagtataa ggcttaacat ttatttaacc taaataatgt
     3001 aactttctta gagaatttac tttactaatg aatactgttg cttagcagtt aatgaaggct
     3061 ttattaaaat cagtgctttg accaaaatag gacctacaca gaacatttat atatgtggta
     3121 atttggacct atataattat gttaaaagtt atactttgag tattatgaaa tatgatcagc
     3181 taaagttcat ctttgctcca aacatgcttt taatatttgt ctattcttat ataatgttgt
     3241 aaactctcca cgtccataat gttaaatagc aaagtaaaat acacatgtta aaaatgtaca
     3301 aatttagttt caaattccta ctgtacttgg gaaaattagt gagtaaatta ctgtgtttaa
     3361 taatcattcc taagttttga cattggagag gtgaggatgc actgtaaatt tgaaaggttg
     3421 ctttcttagc cagttctgga ggggcattag atactaatgt aacaacacat taaatgtact
     3481 ctgtgtattg tatgtgtttt aaatgttttg atgaattttt tgacacaagt ataaatttta
     3541 gcctgtatca ttggtttatt aatggtgttc ataagcaaat gtacaaatct ctctcttttg
     3601 tttttgagct ttgatttcac tgtagcccaa cgtatataat tcttggatta caggtgggat
     3661 ccaccatatc tggcaaaaga attaaaattt tgatttggtg cacaaatgta gcccaagagt
     3721 aatttacttg tgcaatgcct ccaaggtatt gggtttaaac caaagctttt ttttaatgac
     3781 tattttgaat cttaagtttt gtagtttggg gtaaaatgtg tcaacaaatg ggtttgtgag
     3841 atcttacgtt gtgaataatt aaagtcttca gacttaaagc
//
