LOCUS       NM_057120                862 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus nudix hydrolase 1 (Nudt1), mRNA.
ACCESSION   NM_057120
VERSION     NM_057120.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 862)
  AUTHORS   Vitry,G., Paulin,R., Grobs,Y., Lampron,M.C., Shimauchi,T.,
            Lemay,S.E., Tremblay,E., Habbout,K., Awada,C., Bourgeois,A.,
            Nadeau,V., Paradis,R., Breuils-Bonnet,S., Roux-Dalvai,F.,
            Orcholski,M., Potus,F., Provencher,S., Boucherat,O. and Bonnet,S.
  TITLE     Oxidized DNA Precursors Cleanup by NUDT1 Contributes to Vascular
            Remodeling in Pulmonary Arterial Hypertension
  JOURNAL   Am J Respir Crit Care Med 203 (5), 614-627 (2021)
   PUBMED   33021405
  REMARK    GeneRIF: Oxidized DNA Precursors Cleanup by NUDT1 Contributes to
            Vascular Remodeling in Pulmonary Arterial Hypertension.
REFERENCE   2  (bases 1 to 862)
  AUTHORS   Xu,M., Zhao,Q., Shao,D., Liu,H., Qi,J. and Qin,C.
  TITLE     Chenodeoxycholic Acid Derivative HS-1200 Inhibits
            Hepatocarcinogenesis and Improves Liver Function in
            Diethylnitrosamine-Exposed Rats by Downregulating MTH1
  JOURNAL   Biomed Res Int 2017, 1465912 (2017)
   PUBMED   28261604
  REMARK    GeneRIF: MTH1 is downregulated by HS-1200, which inhibits
            hepatocarcinogenesis and improves liver function
REFERENCE   3  (bases 1 to 862)
  AUTHORS   Takagi,Y., Setoyama,D., Ito,R., Kamiya,H., Yamagata,Y. and
            Sekiguchi,M.
  TITLE     Human MTH3 (NUDT18) protein hydrolyzes oxidized forms of guanosine
            and deoxyguanosine diphosphates: comparison with MTH1 and MTH2
  JOURNAL   J Biol Chem 287 (25), 21541-21549 (2012)
   PUBMED   22556419
REFERENCE   4  (bases 1 to 862)
  AUTHORS   Song,X.N., Zhang,L.Q., Liu,D.G., Lin,J., Zheng,J.D., Dai,D.P.,
            Hei,A.L., Hayakawa,H., Sekiguchi,M. and Cai,J.P.
  TITLE     Oxidative damage to RNA and expression patterns of MTH1 in the
            hippocampi of senescence-accelerated SAMP8 mice and Alzheimer's
            disease patients
  JOURNAL   Neurochem Res 36 (8), 1558-1565 (2011)
   PUBMED   21538080
REFERENCE   5  (bases 1 to 862)
  AUTHORS   Song,M.G., Li,Y. and Kiledjian,M.
  TITLE     Multiple mRNA decapping enzymes in mammalian cells
  JOURNAL   Mol Cell 40 (3), 423-432 (2010)
   PUBMED   21070968
REFERENCE   6  (bases 1 to 862)
  AUTHORS   Takahashi,S., Hirose,M., Tamano,S., Ozaki,M., Orita,S., Ito,T.,
            Takeuchi,M., Ochi,H., Fukada,S., Kasai,H. and Shirai,T.
  TITLE     Immunohistochemical detection of 8-hydroxy-2'-deoxyguanosine in
            paraffin-embedded sections of rat liver after carbon tetrachloride
            treatment
  JOURNAL   Toxicol Pathol 26 (2), 247-252 (1998)
   PUBMED   9547863
REFERENCE   7  (bases 1 to 862)
  AUTHORS   Kakuma,T., Nishida,J., Tsuzuki,T. and Sekiguchi,M.
  TITLE     Mouse MTH1 protein with 8-oxo-7,8-dihydro-2'-deoxyguanosine
            5'-triphosphatase activity that prevents transversion mutation.
            cDNA cloning and tissue distribution
  JOURNAL   J Biol Chem 270 (43), 25942-25948 (1995)
   PUBMED   7592783
REFERENCE   8  (bases 1 to 862)
  AUTHORS   Cai,J.P., Kakuma,T., Tsuzuki,T. and Sekiguchi,M.
  TITLE     cDNA and genomic sequences for rat 8-oxo-dGTPase that prevents
            occurrence of spontaneous mutations due to oxidation of guanine
            nucleotides
  JOURNAL   Carcinogenesis 16 (10), 2343-2350 (1995)
   PUBMED   7586133
REFERENCE   9  (bases 1 to 862)
  AUTHORS   Kang,D., Nishida,J., Iyama,A., Nakabeppu,Y., Furuichi,M.,
            Fujiwara,T., Sekiguchi,M. and Takeshige,K.
  TITLE     Intracellular localization of 8-oxo-dGTPase in human cells, with
            special reference to the role of the enzyme in mitochondria
  JOURNAL   J Biol Chem 270 (24), 14659-14665 (1995)
   PUBMED   7782328
REFERENCE   10 (bases 1 to 862)
  AUTHORS   Sakumi,K., Furuichi,M., Tsuzuki,T., Kakuma,T., Kawabata,S., Maki,H.
            and Sekiguchi,M.
  TITLE     Cloning and expression of cDNA for a human enzyme that hydrolyzes
            8-oxo-dGTP, a mutagenic substrate for DNA synthesis
  JOURNAL   J Biol Chem 268 (31), 23524-23530 (1993)
   PUBMED   8226881
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Nov 26, 2020 this sequence version replaced NM_057120.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D49977.1, SRR26360181.1385825.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN12840127,
                                           SAMN12840129 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-166               JAXUCZ010000012.1  19419555-19419720   c
            167-312             JAXUCZ010000012.1  19418765-19418910   c
            313-862             JAXUCZ010000012.1  19416411-19416960   c
FEATURES             Location/Qualifiers
     source          1..862
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q11"
     gene            1..862
                     /gene="Nudt1"
                     /gene_synonym="Mth1"
                     /note="nudix hydrolase 1"
                     /db_xref="GeneID:117260"
                     /db_xref="RGD:621080"
     exon            1..166
                     /gene="Nudt1"
                     /gene_synonym="Mth1"
                     /inference="alignment:Splign:2.1.0"
     CDS             15..485
                     /gene="Nudt1"
                     /gene_synonym="Mth1"
                     /EC_number="3.6.1.56"
                     /note="nudix-type motif 1; 7,8-dihydro-8-oxoguanine
                     triphosphatase; nudix motif 1; nucleoside
                     diphosphate-linked moiety X motif 1; mutT human homolog
                     (8-oxo-dGTPase); 2-hydroxy-dATP diphosphatase; nudix
                     (nucleoside diphosphate linked moiety X)-type motif 1;
                     methylated purine nucleoside triphosphate hydrolase"
                     /codon_start=1
                     /product="oxidized purine nucleoside triphosphate
                     hydrolase"
                     /protein_id="NP_476461.1"
                     /db_xref="GeneID:117260"
                     /db_xref="RGD:621080"
                     /translation="MSTSRLYTLVLVLQPQRVLLGMKKRGFGAGRWNGFGGKVQEGET
                     IEDGAKRELLEESGLRVDTLHKVGHISFEFVGSPELMDVHIFSTDHVHGTPTESEEMR
                     PQWFQLDQIPFADMWPDDSYWFPLLLQKKKFCGHFKFHGQDTILSYSLREVDEF"
     exon            167..312
                     /gene="Nudt1"
                     /gene_synonym="Mth1"
                     /inference="alignment:Splign:2.1.0"
     exon            313..862
                     /gene="Nudt1"
                     /gene_synonym="Mth1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggacccagga gagcatgagc acctccaggc tttataccct cgtgctggta ctacagcctc
       61 agcgagttct cctgggcatg aagaagaggg gctttggtgc tggccgctgg aatggcttcg
      121 ggggcaaggt gcaggaagga gagaccattg aggatggggc taagagggag cttctggaag
      181 aaagtggtct gagagtggat acactgcaca aggtaggcca tatctcattt gagtttgtgg
      241 gctcccccga gctgatggac gtgcatatct tctctaccga ccacgtgcat gggacgccca
      301 cagagagtga agaaatgcgc cctcagtggt tccaactgga ccagatcccc tttgccgaca
      361 tgtggccgga cgacagctac tggttcccac tcctgcttca gaagaagaag ttctgtggac
      421 acttcaagtt ccatggtcag gacaccatcc tcagttactc cctgcgggag gtggatgagt
      481 tctaatacag agagaggtct gactggttct agccattccg gttgcaacac agccactgca
      541 agctgtcact ccaaggacac aggcaggggc tggtattttc tgtttgcaag gtgtcccgag
      601 gttgaaatgt aaaatgtcac caatacacca atatgtttca attcttcatc cccgcctact
      661 ggtcctgttt tagaaggttg tggcaccttt aggagccaga gccctgatga cagaactgag
      721 tcactggggg ttggagagat ggaggatgga ccgtaaggct ttataggtga gctcacactc
      781 ctgctactgt gtctgtcatg ccttccacga tggactgtat ccccttgatg gatgagccaa
      841 aatgaaccac ggctccccta aa
//
