LOCUS       NM_022799               1783 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus nuclear casein kinase and cyclin-dependent kinase
            substrate 1 (Nucks1), mRNA.
ACCESSION   NM_022799 XM_002726820 XM_003750252
VERSION     NM_022799.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1783)
  AUTHORS   Parplys,A.C., Zhao,W., Sharma,N., Groesser,T., Liang,F.,
            Maranon,D.G., Leung,S.G., Grundt,K., Dray,E., Idate,R.,
            Ostvold,A.C., Schild,D., Sung,P. and Wiese,C.
  TITLE     NUCKS1 is a novel RAD51AP1 paralog important for homologous
            recombination and genome stability
  JOURNAL   Nucleic Acids Res 43 (20), 9817-9834 (2015)
   PUBMED   26323318
REFERENCE   2  (bases 1 to 1783)
  AUTHORS   Qiu,B., Shi,X., Zhou,Q., Chen,H.S., Lim,J., Han,W. and
            Tergaonkar,V.
  TITLE     Hypothalamic NUCKS regulates peripheral glucose homoeostasis
  JOURNAL   Biochem J 469 (3), 391-398 (2015)
   PUBMED   26205492
REFERENCE   3  (bases 1 to 1783)
  AUTHORS   Kim,H.Y., Choi,B.S., Kim,S.S., Roh,T.Y., Park,J. and Yoon,C.H.
  TITLE     NUCKS1, a novel Tat coactivator, plays a crucial role in HIV-1
            replication by increasing Tat-mediated viral transcription on the
            HIV-1 LTR promoter
  JOURNAL   Retrovirology 11, 67 (2014)
   PUBMED   25116364
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1783)
  AUTHORS   Qiu,B., Shi,X., Wong,E.T., Lim,J., Bezzi,M., Low,D., Zhou,Q.,
            Akincilar,S.C., Lakshmanan,M., Swa,H.L., Tham,J.M., Gunaratne,J.,
            Cheng,K.K., Hong,W., Lam,K.S., Ikawa,M., Guccione,E., Xu,A., Han,W.
            and Tergaonkar,V.
  TITLE     NUCKS is a positive transcriptional regulator of insulin signaling
  JOURNAL   Cell Rep 7 (6), 1876-1886 (2014)
   PUBMED   24931609
REFERENCE   5  (bases 1 to 1783)
  AUTHORS   Drosos,Y., Kouloukoussa,M., Ostvold,A.C., Havaki,S., Katsantoni,E.,
            Marinos,E. and Aleporou-Marinou,V.
  TITLE     Dynamic expression of the vertebrate-specific protein Nucks during
            rodent embryonic development
  JOURNAL   Gene Expr Patterns 14 (1), 19-29 (2014)
   PUBMED   24140890
  REMARK    GeneRIF: Results show that Nucks expression increased during the
            initial stages of embryonic development, and then gradually
            decreased until birth in all tissues except the nervous tissue and
            muscle fibers.
            GeneRIF: The expression of Nucks in both proliferating and
            quiescent cells and its correlation with Bax levels and apoptosis
            strongly suggest that Nucks plays complex roles in cell
            homeostasis.
REFERENCE   6  (bases 1 to 1783)
  AUTHORS   Yu,S., Wang,H., Davis,A. and Ahmed,K.
  TITLE     Consequences of CK2 signaling to the nuclear matrix
  JOURNAL   Mol Cell Biochem 227 (1-2), 67-71 (2001)
   PUBMED   11827176
  REMARK    GeneRIF: Consequences of CK2 signaling to the nuclear matrix.
REFERENCE   7  (bases 1 to 1783)
  AUTHORS   Ostvold,A.C., Norum,J.H., Mathiesen,S., Wanvik,B., Sefland,I. and
            Grundt,K.
  TITLE     Molecular cloning of a mammalian nuclear phosphoprotein NUCKS,
            which serves as a substrate for Cdk1 in vivo
  JOURNAL   Eur J Biochem 268 (8), 2430-2440 (2001)
   PUBMED   11298763
REFERENCE   8  (bases 1 to 1783)
  AUTHORS   Ostvold,A.C., Hullstein,I. and Laland,S.G.
  TITLE     The phosphate groups of the high mobility group like protein P1
            strengthens its affinity for DNA
  JOURNAL   Biochem Biophys Res Commun 185 (3), 1091-1097 (1992)
   PUBMED   1627131
REFERENCE   9  (bases 1 to 1783)
  AUTHORS   Omeke,B.C. and Onuora,G.I.
  TITLE     Genital lesions and histopathology of male guinea-pigs infected
            with trypanosomes
  JOURNAL   Rev Elev Med Vet Pays Trop 45 (1), 27-30 (1992)
   PUBMED   1298022
REFERENCE   10 (bases 1 to 1783)
  AUTHORS   Ostvold,A.C., Holtlund,J. and Laland,S.G.
  TITLE     A novel, highly phosphorylated protein, of the high-mobility group
            type, present in a variety of proliferating and non-proliferating
            mammalian cells
  JOURNAL   Eur J Biochem 153 (3), 469-475 (1985)
   PUBMED   3000779
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC078818.1.
            
            On or before Sep 8, 2012 this sequence version replaced
            XM_002726820.2, XM_003750252.1, NM_022799.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC078818.1, AJ237669.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1783
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q13"
     gene            1..1783
                     /gene="Nucks1"
                     /gene_synonym="Nucks"
                     /note="nuclear casein kinase and cyclin-dependent kinase
                     substrate 1"
                     /db_xref="GeneID:64709"
                     /db_xref="RGD:620993"
     exon            1..192
                     /gene="Nucks1"
                     /gene_synonym="Nucks"
                     /inference="alignment:Splign:2.1.0"
     CDS             176..907
                     /gene="Nucks1"
                     /gene_synonym="Nucks"
                     /note="nuclear ubiquitous casein and cyclin-dependent
                     kinases substrate; nuclear ubiquitous casein kinase and
                     cyclin-dependent kinase substrate; nuclear ubiquitous
                     casein kinase 2; nuclear ubiquitous casein and
                     cyclin-dependent kinases substrate-like"
                     /codon_start=1
                     /product="nuclear ubiquitous casein and cyclin-dependent
                     kinase substrate 1"
                     /protein_id="NP_073636.1"
                     /db_xref="GeneID:64709"
                     /db_xref="RGD:620993"
                     /translation="MSRPVRNRKVVDYSQFQESDDADEDYGRDSGPPAKKIRSSPREA
                     KNKRRSGKNSQEDSEDSEEKDVKTKKDDSHSAEDSEDEKDDHKSVRQQRQAASKAASK
                     QREMLLEDVGSEEEPEEDDEAPFQEKDSGSDEDFLMEDDDDSDYGSSKKKNKKMVKKS
                     KPERKEKKMPKPRLKATVTPSPVKGKGKVGRPTASKTSKEKTPSPKEEDEEAESPPEK
                     KTSASPPLEKSGDEGSEDEAASGED"
     exon            193..242
                     /gene="Nucks1"
                     /gene_synonym="Nucks"
                     /inference="alignment:Splign:2.1.0"
     exon            243..348
                     /gene="Nucks1"
                     /gene_synonym="Nucks"
                     /inference="alignment:Splign:2.1.0"
     exon            349..404
                     /gene="Nucks1"
                     /gene_synonym="Nucks"
                     /inference="alignment:Splign:2.1.0"
     exon            405..557
                     /gene="Nucks1"
                     /gene_synonym="Nucks"
                     /inference="alignment:Splign:2.1.0"
     exon            558..707
                     /gene="Nucks1"
                     /gene_synonym="Nucks"
                     /inference="alignment:Splign:2.1.0"
     exon            708..1713
                     /gene="Nucks1"
                     /gene_synonym="Nucks"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggctcgtca gatccaggga cccgaaacaa gcagccgcgg actctgagaa gccagcagct
       61 ccgggcttgg cagcagcggc cccgccggcc ggagcggggg ggtggggcgc cgagtgcgcg
      121 gggagggggg tcctggtcct cgtctcctcg acttggtcgc gcctcgacaa cgaacatgtc
      181 tcggcctgtc agaaatagga aggtcgttga ttactcacag tttcaggagt cagatgatgc
      241 agacgaagat tatggaagag attcaggccc tcctgctaag aagattcggt catctccccg
      301 agaggctaaa aataagaggc gatctggcaa aaattcacaa gaagacagtg aagactcaga
      361 agaaaaagat gtgaagacca agaaggatga ttctcactca gcagaagaca gtgaggatga
      421 aaaagatgac cataaaagtg tacgccagca gcggcaggca gcatcaaaag cagcttctaa
      481 gcagagagag atgctcttgg aagatgtggg cagcgaggag gagccggaag aagatgatga
      541 ggcgccattc caggagaaag attctggcag cgacgaagat ttcctaatgg aggacgacga
      601 tgatagtgat tatggcagtt caaaaaagaa aaacaaaaag atggttaaga agtccaaacc
      661 tgagaggaaa gaaaagaaaa tgcccaaacc cagactaaag gctacagtga caccaagtcc
      721 agtgaaaggc aaggggaaag tgggtcgccc cacggcttca aagacatcaa aggaaaaaac
      781 tccttctccc aaagaagagg acgaggaagc agaaagccct ccagaaaaga agacatctgc
      841 aagcccccca ctcgagaagt ctggagatga agggtctgaa gatgaagcgg catctgggga
      901 agattaaaag tgatactggg gagaggtttt attaaaaaaa caaaacaaaa aaggaaacct
      961 atgtaggaca cggtttgggc tgtggcttga ctcatgggct ttcagtgcta tttcatttgt
     1021 ctagaataat gtttttctct ctaccatcta tctttctcaa aaccattgta tgctgatgtg
     1081 tttaagttgc cattttgtct cagtcttttc tctgccagcc cccccacccc cacgaaagcc
     1141 atgtcaatca atcactggat tgaccatttc atgtgttaat agcaggaagg aatgccacgg
     1201 ccgcacagca gtaagatttg aggtgggcgc tatggaagct gctttttgct agcaacttga
     1261 acaataatca aaaacaaaaa tctagaaagg ttttaattaa acagttgctt tttcttctcc
     1321 tgtacttttg acagaccagt tgtcatttaa catgagctta tatgtctaaa ctgtaaatgt
     1381 caaaaagaat catgactcta aatttgtccg gtgaggcagt tgggaggcga acatgaattc
     1441 tgggttgcta actcagtacg cagttactcc cgggtgtgga gggaggccgt cctggaactc
     1501 agtgtactcg ctgttctcag agactcgggt ccaccggttc tttcgtcttg ataatgggct
     1561 tctgtctttt cttactgggc caccagaatg agtcttaatt tcatatttca ttcatgtttt
     1621 cattgattca agtttttaaa gtacatcctg ttttctggta aagttttacc aatggtcaaa
     1681 aattaaaaag atttctttga atttcaatga caaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1741 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa
//
