LOCUS       NM_001013925            2569 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus negative regulator of ubiquitin-like proteins 1
            (Nub1), mRNA.
ACCESSION   NM_001013925 XM_231280
VERSION     NM_001013925.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2569)
  AUTHORS   Richet,E., Pooler,A.M., Rodriguez,T., Novoselov,S.S., Schmidtke,G.,
            Groettrup,M., Hanger,D.P., Cheetham,M.E. and van der Spuy,J.
  TITLE     NUB1 modulation of GSK3beta reduces tau aggregation
  JOURNAL   Hum Mol Genet 21 (24), 5254-5267 (2012)
   PUBMED   22965877
  REMARK    GeneRIF: Data propose that NUB1, by regulating GSK3beta levels,
            modulates tau phosphorylation and aggregation, and is a key player
            in neurodegeneration associated with tau pathology.
REFERENCE   2  (bases 1 to 2569)
  AUTHORS   Schmidtke,G., Kalveram,B., Weber,E., Bochtler,P., Lukasiak,S.,
            Hipp,M.S. and Groettrup,M.
  TITLE     The UBA domains of NUB1L are required for binding but not for
            accelerated degradation of the ubiquitin-like modifier FAT10
  JOURNAL   J Biol Chem 281 (29), 20045-20054 (2006)
   PUBMED   16707496
REFERENCE   3  (bases 1 to 2569)
  AUTHORS   Parry,G. and Estelle,M.
  TITLE     Regulation of cullin-based ubiquitin ligases by the Nedd8/RUB
            ubiquitin-like proteins
  JOURNAL   Semin Cell Dev Biol 15 (2), 221-229 (2004)
   PUBMED   15209382
  REMARK    Review article
REFERENCE   4  (bases 1 to 2569)
  AUTHORS   Kito,K., Yeh,E.T. and Kamitani,T.
  TITLE     NUB1, a NEDD8-interacting protein, is induced by interferon and
            down-regulates the NEDD8 expression
  JOURNAL   J Biol Chem 276 (23), 20603-20609 (2001)
   PUBMED   11259415
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC083586.1.
            
            On Apr 20, 2005 this sequence version replaced XM_231280.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083586.1, SRR8487226.2420.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2569
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q11"
     gene            1..2569
                     /gene="Nub1"
                     /gene_synonym="BS4; NYREN18"
                     /note="negative regulator of ubiquitin-like proteins 1"
                     /db_xref="GeneID:296731"
                     /db_xref="RGD:1359489"
     exon            1..79
                     /gene="Nub1"
                     /gene_synonym="BS4; NYREN18"
                     /inference="alignment:Splign:2.1.0"
     exon            80..210
                     /gene="Nub1"
                     /gene_synonym="BS4; NYREN18"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..1935
                     /gene="Nub1"
                     /gene_synonym="BS4; NYREN18"
                     /note="NY-REN-18 antigen"
                     /codon_start=1
                     /product="NEDD8 ultimate buster 1"
                     /protein_id="NP_001013947.1"
                     /db_xref="GeneID:296731"
                     /db_xref="RGD:1359489"
                     /translation="MAQKKYLQAKLTQFLREDRIQLWKPPYTEENKEVGLALKDLAKR
                     YSERLECCENEVENIIEEIRCKAIERGTGNEHYRTTGIATIEVFLPPRLRKDKKSLLE
                     TRLHVTGRDLRSKIAETFGFQENYIKIVINKKQLQLGKSLEEQGVTHNVKAMVLELKQ
                     SEEDVRRNLQLEEEEQNEAEQKEKRIQRTKRGLEILAERAEMVVDPETMPYLDIANQT
                     GRSIRIPPSERKALMLAMGYHEKGRAFLKRKEYGIALPCLLDADRYFCECKELLDTVD
                     NYAVLQLDIVWCYFRLEQLECLDDAEKKLNLAQTCFTNCYGENHQRLVNIKGNCGKEK
                     VLFLRLYLLQGIRNYHSGNGEEAREYLNKARQLFKELYIDPSKVHNLLQLGFTAQEAR
                     LGLRACDGNVDHAATHISNRREELAQIRKEEKEKRKRRLESVNTLRGMGYSTQAAKQA
                     LHQARGNLDDALKILLSNPHMWWLQDSDSENNSRQASPSQESIDQLVYMGFDTVVAEA
                     ALRVFAGNVQLAAQTLAHHGGSLPPDLQFSGEDSSSTPSTSPSDSAGTSSASTDEDME
                     TEAVNEILEDIPEHEEDYLDSTLEDEEVIIAEYLSYVDRTSSATKDN"
     exon            211..378
                     /gene="Nub1"
                     /gene_synonym="BS4; NYREN18"
                     /inference="alignment:Splign:2.1.0"
     exon            379..437
                     /gene="Nub1"
                     /gene_synonym="BS4; NYREN18"
                     /inference="alignment:Splign:2.1.0"
     exon            438..508
                     /gene="Nub1"
                     /gene_synonym="BS4; NYREN18"
                     /inference="alignment:Splign:2.1.0"
     exon            509..691
                     /gene="Nub1"
                     /gene_synonym="BS4; NYREN18"
                     /inference="alignment:Splign:2.1.0"
     exon            692..783
                     /gene="Nub1"
                     /gene_synonym="BS4; NYREN18"
                     /inference="alignment:Splign:2.1.0"
     exon            784..890
                     /gene="Nub1"
                     /gene_synonym="BS4; NYREN18"
                     /inference="alignment:Splign:2.1.0"
     exon            891..1074
                     /gene="Nub1"
                     /gene_synonym="BS4; NYREN18"
                     /inference="alignment:Splign:2.1.0"
     exon            1075..1182
                     /gene="Nub1"
                     /gene_synonym="BS4; NYREN18"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1335
                     /gene="Nub1"
                     /gene_synonym="BS4; NYREN18"
                     /inference="alignment:Splign:2.1.0"
     exon            1336..1482
                     /gene="Nub1"
                     /gene_synonym="BS4; NYREN18"
                     /inference="alignment:Splign:2.1.0"
     exon            1483..1578
                     /gene="Nub1"
                     /gene_synonym="BS4; NYREN18"
                     /inference="alignment:Splign:2.1.0"
     exon            1579..1756
                     /gene="Nub1"
                     /gene_synonym="BS4; NYREN18"
                     /inference="alignment:Splign:2.1.0"
     exon            1757..2543
                     /gene="Nub1"
                     /gene_synonym="BS4; NYREN18"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cacccggaat gaaaacaaac ggcggcctct gccgcatccg ggcatttggc tggtctcggc
       61 tggctcggtg gtggcgcagt tttactttca aggatggcgc agaagaaata tcttcaagca
      121 aaactgaccc agtttctaag ggaagacaga attcaacttt ggaaacctcc atatactgaa
      181 gaaaataaag aagttggttt ggccttaaag gaccttgcta agaggtactc cgagcggcta
      241 gagtgctgtg aaaatgaagt ggaaaacata atagaggaaa tccgatgcaa agcgattgag
      301 cgcggcactg ggaatgagca ctaccgcaca actgggattg ctacgattga ggtgttcctg
      361 cctccgaggc tccggaaaga taagaaaagc ttgttggaga cccgcttgca tgtcactggt
      421 agagacctga ggagtaaaat agctgaaacc tttggatttc aagaaaatta catcaagatc
      481 gtaataaata agaaacagct tcaactaggg aaaagccttg aagagcaagg agtcactcac
      541 aatgtgaagg ccatggtgtt ggagctgaaa cagtctgaag aggatgtgag gagaaacctg
      601 cagctggagg aggaggaaca gaacgaggct gagcagaagg agaaacgcat tcagaggacc
      661 aaaaggggac tggagatcct ggccgagaga gctgagatgg tggtagaccc ggaaacgatg
      721 ccttacttag acattgcgaa ccagactggc aggtcaatca gaattccccc ttcagaaaga
      781 aaagccctaa tgttagccat ggggtaccat gagaagggca gggctttcct gaaaagaaaa
      841 gagtatggga tagccttgcc atgccttctg gacgccgaca gatacttctg tgagtgcaaa
      901 gagctgctgg acactgtgga caactatgca gtcctccagc tggacatcgt gtggtgctac
      961 ttccgcctgg aacagctgga gtgccttgat gatgcagaga aaaagctgaa cttggcccag
     1021 acgtgcttta caaactgtta cggggagaat caccagagac tggtcaacat aaaagggaac
     1081 tgtgggaaag agaaggtgtt gtttttaaga ctctacttgc ttcagggaat ccgaaactat
     1141 cacagtggaa atggagagga ggctcgggaa tatctcaaca aggcacgtca gctctttaaa
     1201 gagctgtaca tcgacccatc gaaagttcac aacttgttac agttggggtt cactgcccag
     1261 gaagcacggc tgggcctgcg ggcctgtgat gggaacgtgg accacgcagc cactcacatt
     1321 tccaaccgca gagaggaact ggcccagata cggaaggaag agaaggagaa gaggaaacgc
     1381 cgtctggaaa gtgtcaacac tttgagagga atgggctact ccacacaagc tgccaaacaa
     1441 gcccttcacc aggccagagg caacctggac gatgccctga agattctcct cagcaacccc
     1501 cacatgtggt ggttacagga ttcagactct gagaacaaca gccggcaagc aagcccttcc
     1561 caagaaagca tcgaccagct ggtgtacatg ggcttcgaca cagtggtggc cgaagctgcg
     1621 ctgagggtgt ttgcaggcaa tgtccagctg gcagctcaga ccctggcaca ccatggagga
     1681 agcctccctc ctgacctaca gttctcagga gaggactcct cctccacccc atccacatcc
     1741 ccgtctgact ccgcagggac ctctagtgcc tccacggatg aggacatgga gacagaggcc
     1801 gtgaacgaaa tcctggagga cattccggag cacgaggaag actacctgga ctccacactg
     1861 gaggacgaag aagtcatcat cgctgagtac ctgtcctacg tggacaggac cagttctgcc
     1921 acaaaggaca actgagcgga gggacagaag ggctacgctt ctgctataaa ttctggcgtt
     1981 gtgaatggtt gaatgctttg cgttcctctt gcttttcaac gattttgctc taagtaggct
     2041 tcctcctcag gtccagggac ccagcgcagc agagacttgt cagtcagagg acagtctagg
     2101 agaaggaatt ctccagccca gctctgctgc cccctcctct tctaggtctg cacccctgac
     2161 ggccactctg ctggctttcc atccagtccc ggagggcctg ggactaactc tgtctcctgt
     2221 cttctcctca gctagtcctc ctgtgcactc ttcccactgt ccgctgctga aactgctctc
     2281 ctctgctgtg cgagcttccc tcggccctcg ctgctctgcc tcaccccttg agtctccaag
     2341 tgctgtcgag cacagcagca aggtaccagc cgtcactatg cagatggtgc agatacctta
     2401 atctagaaat gtcagtgttt tgtgctctca gatcagtaaa atctgtactt aaaattcaag
     2461 gttgcaaaat cagagtttat atggattcta aattcctcat acaaaatgaa aaatctttta
     2521 ttaaatggaa gttttaaatg ctaaaaaaaa aaaaaaaaaa aaaaaaaaa
//
