LOCUS       NM_001007617            2900 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus NUAK family kinase 2 (Nuak2), mRNA.
ACCESSION   NM_001007617 XM_223108
VERSION     NM_001007617.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2900)
  AUTHORS   Humbert,N., Navaratnam,N., Augert,A., Da Costa,M., Martien,S.,
            Wang,J., Martinez,D., Abbadie,C., Carling,D., de Launoit,Y., Gil,J.
            and Bernard,D.
  TITLE     Regulation of ploidy and senescence by the AMPK-related kinase
            NUAK1
  JOURNAL   EMBO J 29 (2), 376-386 (2010)
   PUBMED   19927127
REFERENCE   2  (bases 1 to 2900)
  AUTHORS   Lefebvre,D.L. and Rosen,C.F.
  TITLE     Regulation of SNARK activity in response to cellular stresses
  JOURNAL   Biochim Biophys Acta 1724 (1-2), 71-85 (2005)
   PUBMED   15893879
  REMARK    GeneRIF: SNARK (SNF1/AMP-activated protein kinase) activity is
            regulated by a broad range of cellular stresses in a
            cell-type-specific manner.
REFERENCE   3  (bases 1 to 2900)
  AUTHORS   Legembre,P., Schickel,R., Barnhart,B.C. and Peter,M.E.
  TITLE     Identification of SNF1/AMP kinase-related kinase as an
            NF-kappaB-regulated anti-apoptotic kinase involved in CD95-induced
            motility and invasiveness
  JOURNAL   J Biol Chem 279 (45), 46742-46747 (2004)
   PUBMED   15345718
REFERENCE   4  (bases 1 to 2900)
  AUTHORS   Lizcano,J.M., Goransson,O., Toth,R., Deak,M., Morrice,N.A.,
            Boudeau,J., Hawley,S.A., Udd,L., Makela,T.P., Hardie,D.G. and
            Alessi,D.R.
  TITLE     LKB1 is a master kinase that activates 13 kinases of the AMPK
            subfamily, including MARK/PAR-1
  JOURNAL   EMBO J 23 (4), 833-843 (2004)
   PUBMED   14976552
REFERENCE   5  (bases 1 to 2900)
  AUTHORS   Suzuki,A., Kusakai,G., Kishimoto,A., Minegichi,Y., Ogura,T. and
            Esumi,H.
  TITLE     Induction of cell-cell detachment during glucose starvation through
            F-actin conversion by SNARK, the fourth member of the AMP-activated
            protein kinase catalytic subunit family
  JOURNAL   Biochem Biophys Res Commun 311 (1), 156-161 (2003)
   PUBMED   14575707
REFERENCE   6  (bases 1 to 2900)
  AUTHORS   Lefebvre,D.L., Bai,Y., Shahmolky,N., Sharma,M., Poon,R.,
            Drucker,D.J. and Rosen,C.F.
  TITLE     Identification and characterization of a novel
            sucrose-non-fermenting protein kinase/AMP-activated protein
            kinase-related protein kinase, SNARK
  JOURNAL   Biochem J 355 (Pt 2), 297-305 (2001)
   PUBMED   11284715
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC081899.1.
            
            On Nov 29, 2004 this sequence version replaced XM_223108.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081899.1, SRR8487231.5064.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2900
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q13"
     gene            1..2900
                     /gene="Nuak2"
                     /gene_synonym="1200013b22rik; Snark; UV126"
                     /note="NUAK family kinase 2"
                     /db_xref="GeneID:289419"
                     /db_xref="RGD:1359167"
     exon            1..315
                     /gene="Nuak2"
                     /gene_synonym="1200013b22rik; Snark; UV126"
                     /inference="alignment:Splign:2.1.0"
     CDS             73..1965
                     /gene="Nuak2"
                     /gene_synonym="1200013b22rik; Snark; UV126"
                     /EC_number="2.7.11.1"
                     /note="SNF1/AMP kinase-related kinase; SNF1/AMP-activated
                     protein kinase; NUAK family, SNF1-like kinase, 2"
                     /codon_start=1
                     /product="NUAK family SNF1-like kinase 2"
                     /protein_id="NP_001007618.1"
                     /db_xref="GeneID:289419"
                     /db_xref="RGD:1359167"
                     /translation="MESVALHRRGNLAPSASALATESARPLADRLIKSPKPLMKKQAV
                     KRHHHKHNLRHRYEFLETLGKGTYGKVKKARESSGRLVAIKSIRKDKIKDEQDLLHIR
                     REIEIMSSLNHPHIIAIHEVFENSSKIVIVMEYASRGDLYDYISERPRLNERDARHFF
                     RQIVSALHYCHQNGIVHRDLKLENILLDASGNIKIADFGLSNLYHKGKFLQTFCGSPL
                     YASPEIVNGKPYVGPEVDSWSLGVLLYILVHGTMPFDGQDHKTLVKQISSGAYREPCK
                     PSDACGLIRWLLMVNPIRRATLEDVASHWWVNWGYSTRIGEQEALREGGHPSGDSGRA
                     SMADWLRRSSRPLLENGAKVCSFFKQHVPGGGSTGPGLERQHSLKKSRKENDMAQTLQ
                     NDPAEDTSSRPGKNSLKLPKGILKKKASPSSGEVQEGPQELRPVSNTPGQPVPAIPLL
                     PRKGILKKSRQRESGYYSSPEPSESGELLDAGDVFVSGDPMEQKSPQASGRLHRKGIL
                     KLNGKFSRTALEGTAPSTFGSLDQLASPHPTARASRPSGAVSEDSILSSESFDQLDLP
                     ERLPETPLRGCVSVDNLRRLEQPPSEGLKRWWQESLGDSCFSLTDCQEVTAAYRQALG
                     ICSKLS"
     exon            316..436
                     /gene="Nuak2"
                     /gene_synonym="1200013b22rik; Snark; UV126"
                     /inference="alignment:Splign:2.1.0"
     exon            437..588
                     /gene="Nuak2"
                     /gene_synonym="1200013b22rik; Snark; UV126"
                     /inference="alignment:Splign:2.1.0"
     exon            589..654
                     /gene="Nuak2"
                     /gene_synonym="1200013b22rik; Snark; UV126"
                     /inference="alignment:Splign:2.1.0"
     exon            655..774
                     /gene="Nuak2"
                     /gene_synonym="1200013b22rik; Snark; UV126"
                     /inference="alignment:Splign:2.1.0"
     exon            775..907
                     /gene="Nuak2"
                     /gene_synonym="1200013b22rik; Snark; UV126"
                     /inference="alignment:Splign:2.1.0"
     exon            908..2880
                     /gene="Nuak2"
                     /gene_synonym="1200013b22rik; Snark; UV126"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gacctctgag cctgcggctc tccgcgcgct gctgctgctg cccgaccccc tccgcctcgc
       61 cgtccccgca ccatggagtc ggtggcctta caccggcgcg ggaacctggc tccctcggcc
      121 tccgccctgg ccacggagag cgcccggccg ctggcggacc ggctcatcaa gtcgcccaaa
      181 cctctgatga agaagcaggc ggtgaagcgg caccatcaca aacacaacct gaggcaccgc
      241 tacgagttcc tggagaccct gggcaagggc acctacggga aggtgaagaa agcacgagag
      301 agctcgggac gcctggtggc catcaagtct atcaggaagg acaaaatcaa agatgagcag
      361 gatctgttgc acataaggag ggagatcgag atcatgtctt cactcaacca cccccacatc
      421 attgccatcc atgaagtgtt tgagaacagc agcaagattg tgattgtcat ggagtacgcc
      481 agccgaggcg atctgtacga ttacatcagt gagcggccac ggctgaatga gcgggacgcc
      541 aggcatttct tccgacagat cgtgtccgcc ctgcactact gccaccagaa cgggattgtt
      601 caccgggacc tcaagctgga gaacatcctt ctagatgcca gtggcaacat caagattgct
      661 gattttggcc tctccaacct gtatcacaaa ggcaagttcc tccagacgtt ctgtgggagc
      721 cctctctatg cctcacctga gatcgtcaac gggaagccct atgtgggccc agaggtggac
      781 agctggtctc tgggcgttct tctgtacatc ctggtgcatg gcaccatgcc ctttgacggg
      841 caggatcata aaaccctggt gaaacaaatc agtagcgggg cttaccgaga gccgtgcaaa
      901 ccgtctgatg cctgtggcct gatccggtgg ctgttaatgg tgaatcccat ccgtcgggcc
      961 actctggagg atgtagccag tcattggtgg gtcaactggg gttacagcac ccgaattggg
     1021 gaacaggaag ctctgcgaga gggtgggcac cctagcggtg actctggccg ggcctctatg
     1081 gcggactggt tacgtcgctc ctcccgcccc ctcctggaga atggagccaa agtgtgtagc
     1141 ttcttcaagc agcatgtgcc gggaggtgga agcacgggac cggggctgga gcggcaacat
     1201 tctcttaaga agtcccgcaa ggagaatgac atggctcaga ctctgcagaa tgacccagct
     1261 gaagatactt cctctcgccc tggcaagaac agcctcaagc ttccgaaagg tatcctcaag
     1321 aaaaaggcct ctccctcatc gggggaggta caggagggcc ctcaggaact cagaccagtg
     1381 tccaataccc cagggcagcc tgtccctgct atacccctgc tcccaaggaa gggcattctt
     1441 aagaagtctc ggcagcgtga atctggttac tactcctctc cagagcccag tgagtctggg
     1501 gaactcttag acgcaggtga tgtgtttgtg agtggggacc ccatggagca gaagtctcca
     1561 caagcttcag ggcgcctcca tcgcaagggc atcctcaaac tcaatggcaa gttttcccgc
     1621 acagccttag aaggcactgc ccctagcacc tttggctccc tagaccaact ggcctcccct
     1681 catcctacag cccgggccag ccgtccctcg ggagctgtga gtgaggacag catcctgtcc
     1741 tccgagtcct ttgaccaatt ggacttgccc gagcggcttc ccgaaacccc actgaggggc
     1801 tgtgtgtctg tggacaacct gaggaggctt gagcagcctc cctcagaagg cctaaaacga
     1861 tggtggcagg aatccttggg ggatagctgc ttttctctga cagactgcca agaggtgaca
     1921 gcagcctaca gacaagccct aggaatctgc tcgaagctca gctgaggagg agaggcagtg
     1981 ccccagtgat ggggtagact ctgagagggg tttgcagagg aaccctgggt aggattcccc
     2041 aggggagtag agtacatcaa gaactctctc tctgtcttca gcctgattga acctggaggc
     2101 tgagagaaat agcagagata tggaaaggac tgacctacag agtcctgact gccagaatgt
     2161 tcaagcgggg ccacagagac ctgaaagtgc ctacctcctt tatgctgagt gctacccatg
     2221 gcatctcccc cctgctctct gccagtgtca gggtgtaccc acataagttc ctgttcgcat
     2281 cgaccaccag ggttagaacc ctgacatccc tggaagtaat gtggagcaac ctcgcttatt
     2341 taaagaggaa acagcctctg gtttccatct ctgctgctgt gcatctcaaa gacctagaaa
     2401 gactcaactg ctgtttcact tcatctcaag gggacctcag agacctgagc cttgaagctg
     2461 ttcctgataa ccagactatg atggatatgt ctgtttctca ggccagcagg acccagaatg
     2521 tgctgactta tttatttttg tgattctcac ttctggtttc tgtttcgttt tttctgttgt
     2581 tggttttgtt gttgtcgttt gtttcttgtt ttttgtttgt ttgtttgttt tttaaagtga
     2641 attttgctgc tttcggtaat gtgaatgctg tgttctgggg aaagccactg tgtcattgaa
     2701 gtgtgtgtac agagaagtat ttggcagtga ttccttctaa tggggggtgg ctttttcaga
     2761 tgtatgtctt gagcactgtc tggattgggt ctcctgtccc ctcacaccag aggctgtcca
     2821 ccctccctca tctgtggcca aaaaaaacct cattaaaacc agcaacggca actggaaaaa
     2881 aaaaaaaaaa aaaaaaaaaa
//
