LOCUS       NM_001106774            2864 bp    mRNA    linear   ROD 28-DEC-2023
DEFINITION  Rattus norvegicus NUAK family kinase 1 (Nuak1), mRNA.
ACCESSION   NM_001106774 XM_001079579 XM_234998
VERSION     NM_001106774.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2864)
  AUTHORS   Mudunuru J, Ren C, Taft DR and Maniar M.
  TITLE     Effect of Gender on the Pharmacokinetics of ON 123300, A Dual
            Inhibitor of ARK5 and CDK4/6 for the Treatment of Cancer, in Rats
  JOURNAL   Eur J Drug Metab Pharmacokinet 44 (4), 531-538 (2019)
   PUBMED   30701428
  REMARK    GeneRIF: A small molecule dual inhibitor of the c-MYC activated
            kinases ARK5 and CDK4/6, is being developed.
REFERENCE   2  (bases 1 to 2864)
  AUTHORS   Esteve-Puig R, Gil R, Gonzalez-Sanchez E, Bech-Serra JJ, Grueso J,
            Hernandez-Losa J, Moline T, Canals F, Ferrer B, Cortes J, Bastian
            B, Ramon Y Cajal S, Martin-Caballero J, Flores JM, Vivancos A,
            Garcia-Patos V and Recio JA.
  TITLE     A mouse model uncovers LKB1 as an UVB-induced DNA damage sensor
            mediating CDKN1A (p21WAF1/CIP1) degradation
  JOURNAL   PLoS Genet 10 (10), e1004721 (2014)
   PUBMED   25329316
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2864)
  AUTHORS   Maekawa R, Sato S, Yamagata Y, Asada H, Tamura I, Lee L, Okada M,
            Tamura H, Takaki E, Nakai A and Sugino N.
  TITLE     Genome-wide DNA methylation analysis reveals a potential mechanism
            for the pathogenesis and development of uterine leiomyomas
  JOURNAL   PLoS One 8 (6), e66632 (2013)
   PUBMED   23818951
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2864)
  AUTHORS   Hou X, Liu JE, Liu W, Liu CY, Liu ZY and Sun ZY.
  TITLE     A new role of NUAK1: directly phosphorylating p53 and regulating
            cell proliferation
  JOURNAL   Oncogene 30 (26), 2933-2942 (2011)
   PUBMED   21317932
REFERENCE   5  (bases 1 to 2864)
  AUTHORS   Zagorska A, Deak M, Campbell DG, Banerjee S, Hirano M, Aizawa S,
            Prescott AR and Alessi DR.
  TITLE     New roles for the LKB1-NUAK pathway in controlling myosin
            phosphatase complexes and cell adhesion
  JOURNAL   Sci Signal 3 (115), ra25 (2010)
   PUBMED   20354225
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2864)
  AUTHORS   Humbert N, Navaratnam N, Augert A, Da Costa M, Martien S, Wang J,
            Martinez D, Abbadie C, Carling D, de Launoit Y, Gil J and Bernard
            D.
  TITLE     Regulation of ploidy and senescence by the AMPK-related kinase
            NUAK1
  JOURNAL   EMBO J 29 (2), 376-386 (2010)
   PUBMED   19927127
REFERENCE   7  (bases 1 to 2864)
  AUTHORS   Al-Hakim AK, Zagorska A, Chapman L, Deak M, Peggie M and Alessi DR.
  TITLE     Control of AMPK-related kinases by USP9X and atypical
            Lys(29)/Lys(33)-linked polyubiquitin chains
  JOURNAL   Biochem J 411 (2), 249-260 (2008)
   PUBMED   18254724
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473960.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001079579.1, XM_234998.4.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132291,
                              SAMD00132294 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2864
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q13"
     gene            1..2864
                     /gene="Nuak1"
                     /gene_synonym="RGD1309956"
                     /note="NUAK family kinase 1"
                     /db_xref="GeneID:299694"
                     /db_xref="RGD:1309956"
     exon            1..396
                     /gene="Nuak1"
                     /gene_synonym="RGD1309956"
                     /inference="alignment:Splign:2.1.0"
     CDS             154..2139
                     /gene="Nuak1"
                     /gene_synonym="RGD1309956"
                     /EC_number="2.7.11.1"
                     /note="AMPK-related protein kinase 5; NUAK family,
                     SNF1-like kinase, 1"
                     /codon_start=1
                     /product="NUAK family SNF1-like kinase 1"
                     /protein_id="NP_001100244.1"
                     /db_xref="GeneID:299694"
                     /db_xref="RGD:1309956"
                     /translation="MEGAAVSAAGDGPAVETGLPGSPREVVAGATAAPVEPRKPHGVK
                     RHHHKHNLKHRYELQETLGKGTYGKVKRATERFSGRVVAIKSIRKDKIKDELDMVHIR
                     REIEIMSSLNHPHIISIYEVFENKDKIVIIMEYASKGELYDYISERRRLSERETRHFF
                     RQIVSAVHYCHKNGVVHRDLKLENILLDDNCNIKIADFGLSNLYQKDKFLQTFCGSPL
                     YASPEIVNGRPYRGPEVDSWALGVLLYTLIYGTMPFDGFDHKNLIRQISSGEYREPTQ
                     PSDARGLIRWMLMVNPDRRATIEDIANHWWVNWGYKSSVCDCDALPDSESPLLARIID
                     WHHRSTGLQAEADAKMKAKPGASEVVLERQRSLKKSKKENDFPQSGQDSLPESPSKLS
                     SKRPKGILKKRSNSEHRSHSTGFIEGIVGPALPSPFKMEQDLCRTAIPLPGSPEAQGS
                     SGKLSLKQSATMPKKGILKKTQQRESGYYSSPERSESSELLDSNNVIISSGLSSPPPD
                     PARGTSHSLSCRRKGILKHSSRYSDGATDPALTGPEIPTLESLSPPGVPSDGISRSYS
                     RPSSIISDDSVLSSDSFDLLDLQENRPARQRIRSCVSAENFLQLQDFETPHNRPRPQY
                     LKRYRNRLADSSFSLLADMDDVTQVYKKALEICSKLN"
     exon            397..517
                     /gene="Nuak1"
                     /gene_synonym="RGD1309956"
                     /inference="alignment:Splign:2.1.0"
     exon            518..669
                     /gene="Nuak1"
                     /gene_synonym="RGD1309956"
                     /inference="alignment:Splign:2.1.0"
     exon            670..735
                     /gene="Nuak1"
                     /gene_synonym="RGD1309956"
                     /inference="alignment:Splign:2.1.0"
     exon            736..855
                     /gene="Nuak1"
                     /gene_synonym="RGD1309956"
                     /inference="alignment:Splign:2.1.0"
     exon            856..988
                     /gene="Nuak1"
                     /gene_synonym="RGD1309956"
                     /inference="alignment:Splign:2.1.0"
     exon            989..2864
                     /gene="Nuak1"
                     /gene_synonym="RGD1309956"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgccccggcg gcagccagag ccaggtcggg tcgtctcagc aatgctgctg cgggggcgac
       61 cttgaacgca ccccggtttc cctcggcagg gaccaccccg agcccccgtg ccgggtccag
      121 ccctctccag ctcggcttgc ctggcgcttg gtcatggaag gggcggcagt gtccgcggca
      181 ggggatggcc ctgctgtgga gacgggtttg cccggctctc cgcgggaggt agtggccggg
      241 gcgactgctg ctccagtgga acccaggaag ccgcacgggg tgaagcgaca tcaccacaaa
      301 cacaacttga agcatcgcta tgagctgcaa gagaccctgg gcaaaggtac ctacggcaaa
      361 gtcaagagag ccacggagag gttttcaggc cgagtggttg ctataaaatc catccgtaag
      421 gacaaaatca aggatgagct agacatggtt cacatcagac gagagattga gattatgtca
      481 tccctcaacc atcctcatat catcagtatt tatgaagtgt ttgagaacaa agataagatt
      541 gtgatcatca tggaatatgc cagcaaagga gagctgtatg actacatcag tgagcggaga
      601 cgcctcagcg agagggagac caggcacttc ttccggcaga tcgtgtctgc cgtgcattac
      661 tgtcacaaga atggcgtggt ccatcgggac ttgaagctgg agaacatact gcttgatgac
      721 aactgtaata ttaagatcgc tgactttggg ctttccaacc tgtaccagaa ggacaagttc
      781 ttgcaaacat tttgtgggag cccactctat gcatcacccg agattgtcaa tggcaggcct
      841 taccgggggc cagaggtgga cagctgggcc ctgggcgtct tgctttacac tctcatttat
      901 ggaacaatgc ccttcgatgg ctttgatcac aaaaacctca tccgacagat cagcagtgga
      961 gagtaccggg agcccacaca accctcagat gctcggggac tcatccggtg gatgctgatg
     1021 gtgaatcctg accgccgggc caccatcgag gacatcgcca accactggtg ggtgaactgg
     1081 ggctacaaga gcagcgtctg tgactgcgat gcccttcccg actccgagtc tccgctcttg
     1141 gctcggatca ttgattggca tcaccgctcc accgggctgc aggctgaggc tgacgccaag
     1201 atgaaggcca agcccggggc ctcggaggtt gtgttggagc ggcaacggtc actgaagaag
     1261 tccaagaaag agaacgactt tccccagtct ggccaggact cattgcctga aagcccatcc
     1321 aagctgagtt ccaagaggcc caagggcatc ctgaagaagc ggagcaacag tgaacatcgc
     1381 tcccacagca ctggcttcat cgaaggcatc gtgggccccg ccttaccatc ccctttcaaa
     1441 atggagcaag acttgtgccg gactgccatc cccctccccg gctcccccga ggcgcaggga
     1501 agctcaggga agctcagcct caaacagtct gccaccatgc ccaagaaagg catcttgaaa
     1561 aagacccagc agagagaatc tggttactac tcgtccccag agcgcagcga gtcctcagag
     1621 ctgctggaca gtaacaatgt gatcatcagc agtggcctct cctcccctcc cccagaccca
     1681 gccaggggaa cgtcccacag cctgtcctgc cggaggaagg gcatcttgaa acacagcagc
     1741 aggtactcgg atggtgccac agaccctgcc ctcaccggcc ccgaaatacc cacactggaa
     1801 tccttgtcgc ctcccggtgt cccctccgat ggcatctctc ggagctacag tcgcccgtcc
     1861 agtatcatca gtgacgacag cgtcctgtcc agcgactctt tcgacttgtt agatctccag
     1921 gagaatcggc cggcccgcca gcgcatccgc agctgcgtct ctgcggaaaa cttcctccag
     1981 cttcaggact ttgagactcc ccacaaccgg ccccggcccc agtacctgaa gcggtaccgg
     2041 aaccggctgg cagacagtag cttctccctt cttgctgata tggacgacgt gactcaggtg
     2101 tataagaagg ctctggagat ctgcagcaag ctcaactagc cctccgaggc tgggctgggt
     2161 gggtgggaga gcccaaggga cgaggggaac agaactcagc ctgcaggctg gttacctctt
     2221 tgctggtcat ggcaaccgac tgggaaaaga ctagtaacgt ctggcccccg gccagctttc
     2281 gcagccttga gtcagcacct aaaggggacg gaaactgttc tttaccagtt ctgccagccg
     2341 ccagtcagaa catgggtcct aactggcatt cccatatggc atctcacagg gaaggtggtt
     2401 gttggccagc ctgaaacggg aaggggcatt atgggtaagg ggggcgggtt tcctagaagt
     2461 catctaggtg tttctggagg agggcaagaa agactgagac catctgcctt gggtgaatag
     2521 gttagcgagc ctggtctggc tatgtagggg ctagcaagat gccagcgacc tgagtgtgaa
     2581 ttggggatca actggtaatg tccgcactgc ggtctgaatt tagtggacca ggcacaccag
     2641 ggagcagtga tcgagtacca gtaactgcca ggggatcagg aatgggggca acagcatgac
     2701 ctgccattgc taggacctgg gacttaggtg aaagcaccct gtttaaaaga aaaaaggcta
     2761 actctttcct ggcacagcat gacatgttaa tttgctcctg gactttgagt agaaagcaaa
     2821 tgcattgaac tctgataggg gaatagtctg gtggcggtta actt
//
