LOCUS       NM_022695               1526 bp    mRNA    linear   ROD 04-OCT-2024
DEFINITION  Rattus norvegicus neurotensin receptor 2 (Ntsr2), mRNA.
ACCESSION   NM_022695
VERSION     NM_022695.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1526)
  AUTHORS   Pandey,S. and Barson,J.R.
  TITLE     Heightened Exploratory Behavior Following Chronic Excessive Ethanol
            Drinking: Mediation by Neurotensin Receptor Type 2 in the Anterior
            Paraventricular Thalamus
  JOURNAL   Alcohol Clin Exp Res 44 (9), 1747-1759 (2020)
   PUBMED   32623746
  REMARK    GeneRIF: Heightened Exploratory Behavior Following Chronic
            Excessive Ethanol Drinking: Mediation by Neurotensin Receptor Type
            2 in the Anterior Paraventricular Thalamus.
REFERENCE   2  (bases 1 to 1526)
  AUTHORS   Steele,F.F. 3rd, Whitehouse,S.C., Aday,J.S. and Prus,A.J.
  TITLE     Neurotensin NTS1 and NTS2 receptor agonists produce anxiolytic-like
            effects in the 22-kHz ultrasonic vocalization model in rats
  JOURNAL   Brain Res 1658, 31-35 (2017)
   PUBMED   28089664
  REMARK    GeneRIF: Study suggests that NTS1 and NTS2 neurotensin receptor
            mechanisms appear involved in fear conditioning processes and that
            agonists for neurotensin receptors may be pursued as novel
            anxiolytic drugs.
REFERENCE   3  (bases 1 to 1526)
  AUTHORS   Thomas,J.B., Giddings,A.M., Wiethe,R.W., Olepu,S., Warner,K.R.,
            Sarret,P., Gendron,L., Longpre,J.M., Zhang,Y., Runyon,S.P. and
            Gilmour,B.P.
  TITLE     Identification of
            N-[(5-{[(4-methylphenyl)sulfonyl]amino}-3-(trifluoroacetyl)-1H-
            indol-1-yl)acetyl]-l-leucine (NTRC-824), a neurotensin-like
            nonpeptide compound selective for the neurotensin receptor type 2
  JOURNAL   J Med Chem 57 (17), 7472-7477 (2014)
   PUBMED   25157640
REFERENCE   4  (bases 1 to 1526)
  AUTHORS   Buhler,A.V., Proudfit,H.K. and Gebhart,G.F.
  TITLE     Neurotensin-produced antinociception in the rostral ventromedial
            medulla is partially mediated by spinal cord norepinephrine
  JOURNAL   Pain 135 (3), 280-290 (2008)
   PUBMED   17664042
  REMARK    GeneRIF: These results also provide evidence that activation of
            NTR1 in the RVM produces antinociception through spinal release of
            norepinephrine (NE) and serotonin, and that activation of NTR2 in
            the RVM produces antinociception mediated by spinal release of NE.
REFERENCE   5  (bases 1 to 1526)
  AUTHORS   Perron,A., Sharif,N., Sarret,P., Stroh,T. and Beaudet,A.
  TITLE     NTS2 modulates the intracellular distribution and trafficking of
            NTS1 via heterodimerization
  JOURNAL   Biochem Biophys Res Commun 353 (3), 582-590 (2007)
   PUBMED   17188644
  REMARK    GeneRIF: NTS1/NTS2 heterodimerization affects the intracellular
            distribution and trafficking of NTS1 by making it more similar to
            that of NTS2 as witnessed in cells expressing NTS2 alone.
REFERENCE   6  (bases 1 to 1526)
  AUTHORS   Gendron,L., Perron,A., Payet,M.D., Gallo-Payet,N., Sarret,P. and
            Beaudet,A.
  TITLE     Low-affinity neurotensin receptor (NTS2) signaling:
            internalization-dependent activation of extracellular
            signal-regulated kinases 1/2
  JOURNAL   Mol Pharmacol 66 (6), 1421-1430 (2004)
   PUBMED   15361549
  REMARK    GeneRIF: NTS2 is a bona fide NT receptor and that activation of
            this receptor by NT or NT analogs results in an
            internalization-dependent activation of the ERK1/2 signaling
            cascade.
REFERENCE   7  (bases 1 to 1526)
  AUTHORS   Sarret,P., Perron,A., Stroh,T. and Beaudet,A.
  TITLE     Immunohistochemical distribution of NTS2 neurotensin receptors in
            the rat central nervous system
  JOURNAL   J Comp Neurol 461 (4), 520-538 (2003)
   PUBMED   12746866
  REMARK    GeneRIF: The distribution of NTS2-like immunoreactivity largely
            exceeded that of neurotensin terminal fields, and some of the
            highest concentrations of the receptor were found in areas devoid
            of neurotensinergic inputs.
REFERENCE   8  (bases 1 to 1526)
  AUTHORS   Sarret,P., Gendron,L., Kilian,P., Nguyen,H.M., Gallo-Payet,N.,
            Payet,M.D. and Beaudet,A.
  TITLE     Pharmacology and functional properties of NTS2 neurotensin
            receptors in cerebellar granule cells
  JOURNAL   J Biol Chem 277 (39), 36233-36243 (2002)
   PUBMED   12084713
  REMARK    GeneRIF: Expression and function of NTR2 receptors in rat
            cerebellar granule cells
REFERENCE   9  (bases 1 to 1526)
  AUTHORS   Mazella,J., Botto,J.M., Guillemare,E., Coppola,T., Sarret,P. and
            Vincent,J.P.
  TITLE     Structure, functional expression, and cerebral localization of the
            levocabastine-sensitive neurotensin/neuromedin N receptor from
            mouse brain
  JOURNAL   J Neurosci 16 (18), 5613-5620 (1996)
   PUBMED   8795617
REFERENCE   10 (bases 1 to 1526)
  AUTHORS   Chalon,P., Vita,N., Kaghad,M., Guillemot,M., Bonnin,J., Delpech,B.,
            Le Fur,G., Ferrara,P. and Caput,D.
  TITLE     Molecular cloning of a levocabastine-sensitive neurotensin binding
            site
  JOURNAL   FEBS Lett 386 (2-3), 91-94 (1996)
   PUBMED   8647296
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from X97121.1.
            
            On Aug 31, 2012 this sequence version replaced NM_022695.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X97121.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760384, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1526              X97121.1           3-1528
FEATURES             Location/Qualifiers
     source          1..1526
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q16"
     gene            1..1526
                     /gene="Ntsr2"
                     /note="neurotensin receptor 2"
                     /db_xref="GeneID:64636"
                     /db_xref="RGD:70962"
     exon            1..662
                     /gene="Ntsr2"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..1289
                     /gene="Ntsr2"
                     /note="high-affinity levocabastine-sensitive neurotensin
                     receptor; NT-R-2; NTR2 receptor"
                     /codon_start=1
                     /product="neurotensin receptor type 2"
                     /protein_id="NP_073186.1"
                     /db_xref="GeneID:64636"
                     /db_xref="RGD:70962"
                     /translation="METSSPWPPRPSPSAGLSLEARLGVDTRLWAKVLFTALYSLIFA
                     FGTAGNALSVHVVLKARAGRPGRLRYHVLSLALSALLLLLVSMPMELYNFVWSHYPWV
                     FGDLGCRGYYFVRELCAYATVLSVASLSAERCLAVCQPLRARRLLTPRRTRRLLSLVW
                     VASLGLALPMAVIMGQKHEVESADGEPEPASRVCTVLVSRATLQVFIQVNVLVSFALP
                     LALTAFLNGITVNHLMALYSQVPSASAQVSSIPSRLELLSEEGLLGFITWRKTLSLGV
                     QASLVRHKDASQIRSLQHSAQVLRAIVAVYVICWLPYHARRLMYCYIPDDGWTNELYD
                     FYHYFYMVTNTLFYVSSAVTPILYNAVSSSFRKLFLESLGSLCGEQHSLVPLPQEAPE
                     STTSTYSFRLWGSPRNPSLGEIQV"
     exon            663..936
                     /gene="Ntsr2"
                     /inference="alignment:Splign:2.1.0"
     exon            937..1027
                     /gene="Ntsr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1526
                     /gene="Ntsr2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtgagaggg agggagctca ggccaccacg agacagagat ggagaccagc agtccgtggc
       61 ctccgaggcc cagccccagc gcagggctga gcctggaggc gcggctgggc gtggacactc
      121 gcctctgggc caaggtgctg ttcaccgcgc tctactcgct catcttcgca tttggcacag
      181 cgggcaatgc gctgtccgtg cacgtggtgc tgaaggcgcg ggccggtcgc cccgggcgcc
      241 tgcgctacca cgtgctcagc ctggcgctct cagccctgct gctactgctg gtcagcatgc
      301 ccatggagct ctacaacttc gtgtggtccc actacccatg ggtcttcggc gatctgggct
      361 gccgtggcta ttacttcgtg cgcgagctgt gcgcctacgc cacagtgctg agcgttgcca
      421 gcctaagcgc agagcgctgc ctggccgtgt gccagccgct gcgcgcccgc cgccttctca
      481 ccccgcgccg cacccgccgc ctgctgtcac tggtctgggt cgcctctctg ggccttgccc
      541 tgcccatggc ggttatcatg ggacagaagc acgaagtgga aagcgcggac ggggagcctg
      601 agcctgcctc gcgtgtgtgc acggtgctgg tgagccgcgc cacacttcag gtcttcatcc
      661 aggtgaatgt gctggtgtcc ttcgctctcc ccttggcact cactgctttc ctgaatggca
      721 tcactgtcaa ccacctgatg gccctctact cccaggtacc atcagcttct gcccaagtca
      781 gctccatccc cagccgcctg gagctcctga gtgaggaagg cctcctgggc ttcatcacgt
      841 ggagaaagac tctctccctg ggggtccaag ccagcctggt gagacacaag gatgccagcc
      901 agatccgcag cctccagcac agcgcccagg ttctcagagc catcgtggct gtgtatgtca
      961 tctgctggct gccgtaccat gcccgccgac tcatgtactg ctacatcccc gatgatggat
     1021 ggactaatga gctctatgat ttctatcact atttctacat ggtgaccaac acgctcttct
     1081 atgtcagctc agcagtgacc ccaatcctct acaacgccgt gtcttcctcc ttcagaaagc
     1141 tcttcctgga atccctcggc tccctgtgtg gtgaacagca ctccttggtg cccttacccc
     1201 aagaagcccc agagtcaacc actagtacgt acagtttccg gctttgggga tccccaagaa
     1261 accccagcct gggagaaata caagtatgaa gagaacaaac aatggctgct tgggacatgc
     1321 ccgtcagaca agccatgcca tcactaacag tccaggtgga cctactgacc cagtgcatac
     1381 tgcaggcaaa ccacataaca cctactgccc tcagcttccc acagagaaca acagagttga
     1441 agaataggaa ccgtggccta gtgatgaagg tgcccagtgc caggcctggt acatagtcac
     1501 tactcaataa attttaaccc ggtgct
//
