LOCUS       NM_001108967            3926 bp    mRNA    linear   ROD 15-JUL-2024
DEFINITION  Rattus norvegicus neurotensin receptor 1 (Ntsr1), mRNA.
ACCESSION   NM_001108967 XM_001059204 XM_006235788 XM_345484
VERSION     NM_001108967.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3926)
  AUTHORS   Wei,Z.X., Cai,X.X., Fei,Y.D., Wang,Q., Hu,X.L., Li,C., Hou,J.W.,
            Yang,Y.L., Wang,Y.P. and Li,Y.G.
  TITLE     Ntsr1 contributes to pulmonary hypertension by enhancing
            endoplasmic reticulum stress via JAK2-STAT3-Thbs1 signaling
  JOURNAL   Transl Res 269, 64-75 (2024)
   PUBMED   38395391
  REMARK    GeneRIF: Ntsr1 contributes to pulmonary hypertension by enhancing
            endoplasmic reticulum stress via JAK2-STAT3-Thbs1 signaling.
REFERENCE   2  (bases 1 to 3926)
  AUTHORS   Budzinski,J., Maschauer,S., Kobayashi,H., Couvineau,P., Vogt,H.,
            Gmeiner,P., Roggenhofer,A., Prante,O., Bouvier,M. and Weikert,D.
  TITLE     Bivalent ligands promote endosomal trafficking of the dopamine D3
            receptor-neurotensin receptor 1 heterodimer
  JOURNAL   Commun Biol 4 (1), 1062 (2021)
   PUBMED   34508168
  REMARK    GeneRIF: Bivalent ligands promote endosomal trafficking of the
            dopamine D3 receptor-neurotensin receptor 1 heterodimer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3926)
  AUTHORS   Li,B., Chang,L.L. and Xi,K.
  TITLE     Neurotensin 1 receptor in the prelimbic cortex regulates
            anxiety-like behavior in rats
  JOURNAL   Prog Neuropsychopharmacol Biol Psychiatry 104, 110011 (2021)
   PUBMED   32561375
  REMARK    GeneRIF: Neurotensin 1 receptor in the prelimbic cortex regulates
            anxiety-like behavior in rats.
REFERENCE   4  (bases 1 to 3926)
  AUTHORS   Bumbak,F., Keen,A.C., Gunn,N.J., Gooley,P.R., Bathgate,R.A.D. and
            Scott,D.J.
  TITLE     Optimization and 13CH3 methionine labeling of a signaling competent
            neurotensin receptor 1 variant for NMR studies
  JOURNAL   Biochim Biophys Acta Biomembr 1860 (6), 1372-1383 (2018)
   PUBMED   29596791
  REMARK    GeneRIF: A thermostable variant termed enNTS1 exhibited the best
            combination of signaling capability and stability upon
            solubilization with detergents. Several well dispersed
            (13)CH3-methionine resonances were seen by solution NMR
            spectroscopy, many of which exhibited chemical shift changes upon
            the addition of the high affinity agonist peptide, NT8-13.
REFERENCE   5  (bases 1 to 3926)
  AUTHORS   Steele,F.F. 3rd, Whitehouse,S.C., Aday,J.S. and Prus,A.J.
  TITLE     Neurotensin NTS1 and NTS2 receptor agonists produce anxiolytic-like
            effects in the 22-kHz ultrasonic vocalization model in rats
  JOURNAL   Brain Res 1658, 31-35 (2017)
   PUBMED   28089664
  REMARK    GeneRIF: Study suggests that NTS1 and NTS2 neurotensin receptor
            mechanisms appear involved in fear conditioning processes and that
            agonists for neurotensin receptors may be pursued as novel
            anxiolytic drugs.
REFERENCE   6  (bases 1 to 3926)
  AUTHORS   Yamada,M., Cho,T., Coleman,N.J., Yamada,M. and Richelson,E.
  TITLE     Regulation of daily rhythm of body temperature by neurotensin
            receptor in rats
  JOURNAL   Res Commun Mol Pathol Pharmacol 87 (3), 323-332 (1995)
   PUBMED   7620825
REFERENCE   7  (bases 1 to 3926)
  AUTHORS   Yamada,M., Yamada,M. and Richelson,E.
  TITLE     Heterogeneity of melanized neurons expressing neurotensin receptor
            messenger RNA in the substantia nigra and the nucleus paranigralis
            of control and Parkinson's disease brain
  JOURNAL   Neuroscience 64 (2), 405-417 (1995)
   PUBMED   7700529
REFERENCE   8  (bases 1 to 3926)
  AUTHORS   Evers,B.M., Rajaraman,S., Chung,D.H., Townsend,C.M. Jr., Wang,X.,
            Graves,K. and Thompson,J.C.
  TITLE     Developmental expression of the neurotensin gene in the rat liver
  JOURNAL   Ann Surg 218 (2), 183-188 (1993)
   PUBMED   8342998
REFERENCE   9  (bases 1 to 3926)
  AUTHORS   Vita,N., Laurent,P., Lefort,S., Chalon,P., Dumont,X., Kaghad,M.,
            Gully,D., Le Fur,G., Ferrara,P. and Caput,D.
  TITLE     Cloning and expression of a complementary DNA encoding a high
            affinity human neurotensin receptor
  JOURNAL   FEBS Lett 317 (1-2), 139-142 (1993)
   PUBMED   8381365
REFERENCE   10 (bases 1 to 3926)
  AUTHORS   Tanaka,K., Masu,M. and Nakanishi,S.
  TITLE     Structure and functional expression of the cloned rat neurotensin
            receptor
  JOURNAL   Neuron 4 (6), 847-854 (1990)
   PUBMED   1694443
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On or before Jun 3, 2021 this sequence version replaced
            XM_006235788.1, NM_001108967.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.20745.1,
                                           SRR26360194.2205623.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMN06621351
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1181              JAXUCZ010000003.1  187983778-187984958
            1182-1395           JAXUCZ010000003.1  188028276-188028489
            1396-1486           JAXUCZ010000003.1  188030372-188030462
            1487-3926           JAXUCZ010000003.1  188031495-188033934
FEATURES             Location/Qualifiers
     source          1..3926
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q43"
     gene            1..3926
                     /gene="Ntsr1"
                     /gene_synonym="Ntsr"
                     /note="neurotensin receptor 1"
                     /db_xref="GeneID:366274"
                     /db_xref="RGD:1306076"
     exon            1..1181
                     /gene="Ntsr1"
                     /gene_synonym="Ntsr"
                     /inference="alignment:Splign:2.1.0"
     CDS             465..1739
                     /gene="Ntsr1"
                     /gene_synonym="Ntsr"
                     /note="NTRH; NT-R-1; high-affinity
                     levocabastine-insensitive neurotensin receptor; NTR1"
                     /codon_start=1
                     /product="neurotensin receptor type 1"
                     /protein_id="NP_001102437.1"
                     /db_xref="GeneID:366274"
                     /db_xref="RGD:1306076"
                     /translation="MHLNSSVPQGTPGEPDAQPFSGPQSEMEATFLALSLSNGSGNTS
                     ESDTAGPNSDLDVNTDIYSKVLVTAIYLALFVVGTVGNSVTAFTLARKKSLQSLQSTV
                     HYHLGSLALSDLLILLLAMPVELYNFIWVHHPWAFGDAGCRGYYFLRDACTYATALNV
                     ASLSVERYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAIPMLFTMGLQNRSGDGT
                     HPGGLVCTPIVDTATVKVVIQVNTFMSFLFPMLVISILNTVIANKLTVMVHQAAEQGR
                     VCTVGTHNGLEHSTFNMTIEPGRVQALRHGVLVLRAVVIAFVVCWLPYHVRRLMFCYI
                     SDEQWTTFLFDFYHYFYMLTNALFYVSSAINPILYNLVSANFRQVFLSTLACLCPGWR
                     HRRKKRPTFSRKPNSMSSNHAFSTSATRETLY"
     exon            1182..1395
                     /gene="Ntsr1"
                     /gene_synonym="Ntsr"
                     /inference="alignment:Splign:2.1.0"
     exon            1396..1486
                     /gene="Ntsr1"
                     /gene_synonym="Ntsr"
                     /inference="alignment:Splign:2.1.0"
     exon            1487..3926
                     /gene="Ntsr1"
                     /gene_synonym="Ntsr"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caagcagaag agggagaacg agggtgagca cactgggtag ccgtgtgtgc gctccgctct
       61 gcgccacagg ctcccccaac gaagccacaa gccagcaggg tcgcggtcct gaggacatta
      121 ctaccaccca ggagtgcaga gaaccaacca cagaatctgg aggtccgtag cagcccggat
      181 ctaggcaggc taggggctag ggggtcgggg ggtggggtgc cgaggaagag cgaaaccgga
      241 acgcagatcc cagactctgg aggagaaaga agagtggatc cctgagccgg caagtcgtga
      301 gccccagagc taccaggcag gatcccctgg ataacgcgct tagccgctgg acggcacgcc
      361 ccccttagct tctgcaccct ctcctctggg cgcctcctca tctgcccctg gagggacttt
      421 cacctgcaaa ggtgcaggac aaagcagcat acccggcacc caccatgcac ctcaacagct
      481 ccgtgccgca gggcacccct ggtgaacccg atgcccagcc cttttcggga ccacagtccg
      541 aaatggaagc gacgttcctg gcgctcagtt tgagcaatgg ttctggcaat acctcggaat
      601 ccgacacggc agggcccaac agcgacctgg acgtgaacac tgacatttat tccaaggtgc
      661 tggtgactgc tatatacctg gcactcttcg tggtgggcac tgtgggcaac tccgtgacag
      721 ccttcactct agcgcggaag aagtcactgc agagcctgca gagcactgtg cattaccacc
      781 tgggcagcct ggcactgtct gacctgctta tccttctgct ggccatgccc gtggagctat
      841 acaacttcat ctgggtacac catccctggg cctttgggga cgctggctgc cgtggctact
      901 atttcctgcg tgatgcctgc acctatgcca cagccctcaa tgtagccagc ctgagtgtgg
      961 agcgctactt ggccatctgc catcccttca aggccaagac cctcatgtcc cgcagccgca
     1021 ccaagaaatt catcagtgcc atatggctag cttcggcgct gctggctata cccatgcttt
     1081 tcaccatggg cctgcagaac cgcagtggtg acggcacgca ccctggcggc ctggtgtgca
     1141 cacccattgt ggacacagcc actgtcaagg tcgtcatcca ggttaacacc ttcatgtcct
     1201 tcctgtttcc catgttggtc atctccatcc taaacaccgt gattgccaac aaactgacag
     1261 tcatggtgca ccaggccgcc gagcagggcc gagtgtgcac cgtgggcaca cacaacggtt
     1321 tagagcacag cacgttcaac atgaccatcg agccgggtcg tgtccaggcc ctgcgccacg
     1381 gagtcctcgt cttacgtgct gtggtcattg cctttgtggt ctgctggctg ccctaccacg
     1441 tgcgacgcct gatgttctgc tatatctcgg atgaacagtg gactacgttc ctcttcgatt
     1501 tctaccacta tttctacatg ctaaccaacg ctctcttcta cgtcagctcc gccatcaatc
     1561 ccatcctcta caacctggtc tccgccaact tccgccaggt ctttctgtcc acgctggcct
     1621 gcctttgtcc tgggtggcgc caccgccgaa agaagaggcc aacgttctcc aggaagccca
     1681 acagcatgtc cagcaaccat gccttttcca ccagcgccac ccgggagacc ctgtactagg
     1741 aggccctgaa gaggttgaga ggaggcctca gcctacgcac agggcccacc ccccaccccc
     1801 accccaggct tccaagggtt aagtagtggt ccatccaagc cgtgcaggtg aggctggggc
     1861 accctcagtg gtagcttctt tcttcccagt ttctccttct ttccttcttc cagtccctgc
     1921 tcctcagtcc tttattcttg ctccttgcct tctcttacct ccaccttaaa aaccagaaca
     1981 gaggcagttt ctctccaggc cctgcaaaag gcctttaaca agaagaaatt agcactcagc
     2041 agggacagtc tcctttgttc ccagactaat ggatgtttta gaaggaagaa atgaaagcac
     2101 cgtgttgggc cggggctctg gacggatgta ctgttgtaat cataacagca ccttgtaact
     2161 gcactggcta ggagagacag tgactgaagt tggacttggc ctcagaggca caggcttcct
     2221 ctcagctccc ttatgcagct gtccctgccc tggtccagca gacaccatga ctctctctga
     2281 gcctcatgtc cagacccttc cttagcaggc tggcacactg cctctcccag ggtggtccag
     2341 agaagccccc aaaattctct ttaaggccca ggggccacag ctgaaagctg agggaatcta
     2401 tgccacgccc ggacagctat ggcccactca atagaccccc aaaccccaca tgctcaggaa
     2461 ggacaaaagg gctggcccgg aaccacccag gacaaacttc aagtggcttt gccgggatac
     2521 ctgcactggg tccttgacct cttggatctg cagaaggatg gccttcccct gtccaggtgg
     2581 ctttgctggg gacacgcata gttctgtgtc tcgtatacag ctatatagac taaggtctgg
     2641 cagctgctgg cttcgggctg ggattcctga gaagaggtac tgagccaggt cctcagcaag
     2701 atgccagcgt ctgagactat aggtgagggg aggccaagca ccccagcatc cagctggcca
     2761 gcagccccgg gcagaggcat tcgtcagttt gttaccagcc gccaatcagc tgccctggcc
     2821 caggttgtag gcgcctggaa aagcaggcac ccttcatctc tgggagctgt ctccaaacaa
     2881 gacagaacca tccagcctcc agccaaaaaa ggctggctga gctcttggag acagtcccag
     2941 gatgccatgg accagcagag tagaagtagc agcagggtca agttcagcct tttgcaaaag
     3001 agcctttgcc ctgttgtctg gaagagaagt gattggatgg acgctgctct gtgagaaacg
     3061 tattgccgtg ggacatggga ggttcagtca tggcccaggg ctaacctctg ccctcttgaa
     3121 ctacaaaaca atgggttgaa agtcagggta tctgtggtta cccagagata tgaggagggc
     3181 gttgaacccc acaaaaacgc cgctggtagt aacgtgaccc ctcaagtcat caagggcagg
     3241 acctgggtga atcagggtca aggccaacac caggaagatg tgatcacccc agagggaggt
     3301 ttctccttcc aagaactgtc cgcatgggaa cccctcccaa ccctgtggag ccaccttgcc
     3361 cagtgagtgg gttacaggcc agtgatgagg atttcgacgt agactcaagc tgagcagccc
     3421 agccccagga tactaccctg ggtttctaga ccttgggcaa gccattcttc tgagcctctg
     3481 tttcctcatc tcaactgact ggggctgtct tgaaggactc ggcctggagt aagcagaagg
     3541 gagacacctg gggctgggta gagccaattc cctattacag gattcctcgg aaatgctgtg
     3601 gcctcattct aggggtggtc caggctgtca ccagaagtct ctgctgtagt ccgtagcatc
     3661 ttgtctgtat gcttgatgta gttagggacg tatatccatg caccgccaga tgcacctgtg
     3721 accctggctg ggtatcctgt gctctgggcc aacagaagat gtaaatagct ctggaggctg
     3781 tcctgagtgt cctggctaga gcccagtcat aatgtagaaa caggtcacgt gtcccaaacc
     3841 tctgtcagaa tgccacccac ccacccacca cacttcaata gaagaacacc ctcctcatat
     3901 ctcaataaaa ataaaggaag ctgtgt
//
