LOCUS       NM_001102381             798 bp    mRNA    linear   ROD 21-JAN-2025
DEFINITION  Rattus norvegicus neurotensin (Nts), mRNA.
ACCESSION   NM_001102381 XM_001080677 XM_216884
VERSION     NM_001102381.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 798)
  AUTHORS   Liu,Y., Qu,H.Q., Chang,X., Qu,J., Mentch,F.D., Nguyen,K., Tian,L.,
            Glessner,J., Sleiman,P.M.A. and Hakonarson,H.
  TITLE     Mutation burden analysis of six common mental disorders in African
            Americans by whole genome sequencing
  JOURNAL   Hum Mol Genet 31 (22), 3769-3776 (2022)
   PUBMED   35642741
REFERENCE   2  (bases 1 to 798)
  AUTHORS   Mohamed,A.A., Abo-Elmatty,D.M., Ezzat,O., Mesbah,N.M., Ali,N.S.,
            Abd El Fatah,A.S., Alsayed,E., Hamada,M., Hassnine,A.A.,
            Abd-Elsalam,S., Abdelghani,A., Hassan,M.B. and Fattah,S.A.
  TITLE     Pro-Neurotensin as a Potential Novel Diagnostic Biomarker for
            Detection of Nonalcoholic Fatty Liver Disease
  JOURNAL   Diabetes Metab Syndr Obes 15, 1935-1943 (2022)
   PUBMED   35769889
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 798)
  AUTHORS   Al-Alem,L., Puttabyatappa,M., Shrestha,K., Choi,Y., Rosewell,K.,
            Brannstrom,M., Akin,J., Jo,M., Duffy,D.M. and Curry,T.E.
  TITLE     Neurotensin: a neuropeptide induced by hCG in the human and rat
            ovary during the periovulatory perioddagger
  JOURNAL   Biol Reprod 104 (6), 1337-1346 (2021)
   PUBMED   33682882
  REMARK    GeneRIF: Neurotensin: a neuropeptide induced by hCG in the human
            and rat ovary during the periovulatory perioddagger.
REFERENCE   4  (bases 1 to 798)
  AUTHORS   Saiyasit,N., Chunchai,T., Apaijai,N., Pratchayasakul,W.,
            Sripetchwandee,J., Chattipakorn,N. and Chattipakorn,S.C.
  TITLE     Chronic high-fat diet consumption induces an alteration in
            plasma/brain neurotensin signaling, metabolic disturbance, systemic
            inflammation/oxidative stress, brain apoptosis, and dendritic spine
            loss
  JOURNAL   Neuropeptides 82, 102047 (2020)
   PUBMED   32327191
  REMARK    GeneRIF: Chronic high-fat diet consumption induces an alteration in
            plasma/brain neurotensin signaling, metabolic disturbance, systemic
            inflammation/oxidative stress, brain apoptosis, and dendritic spine
            loss.
REFERENCE   5  (bases 1 to 798)
  AUTHORS   Pandey,S., Badve,P.S., Curtis,G.R., Leibowitz,S.F. and Barson,J.R.
  TITLE     Neurotensin in the posterior thalamic paraventricular nucleus:
            inhibitor of pharmacologically relevant ethanol drinking
  JOURNAL   Addict Biol 24 (1), 3-16 (2019)
   PUBMED   28877396
  REMARK    GeneRIF: Results provide strong evidence that low endogenous levels
            of NTS in the pPVT contribute to an increased propensity toward
            excessive ethanol drinking.
REFERENCE   6  (bases 1 to 798)
  AUTHORS   Watts,A.G. and Sanchez-Watts,G.
  TITLE     Region-specific regulation of neuropeptide mRNAs in rat limbic
            forebrain neurones by aldosterone and corticosterone
  JOURNAL   J Physiol 484 (Pt 3) (Pt 3), 721-736 (1995)
   PUBMED   7623287
REFERENCE   7  (bases 1 to 798)
  AUTHORS   Watts,A.G. and Sanchez-Watts,G.
  TITLE     Physiological regulation of peptide messenger RNA colocalization in
            rat hypothalamic paraventricular medial parvicellular neurons
  JOURNAL   J Comp Neurol 352 (4), 501-514 (1995)
   PUBMED   7721997
REFERENCE   8  (bases 1 to 798)
  AUTHORS   Yamada,M., Yamada,M. and Richelson,E.
  TITLE     Heterogeneity of melanized neurons expressing neurotensin receptor
            messenger RNA in the substantia nigra and the nucleus paranigralis
            of control and Parkinson's disease brain
  JOURNAL   Neuroscience 64 (2), 405-417 (1995)
   PUBMED   7700529
REFERENCE   9  (bases 1 to 798)
  AUTHORS   Bullock,B.P., McNeil,G.P. and Dobner,P.R.
  TITLE     Synergistic induction of neurotensin gene transcription in PC12
            cells parallels changes in AP-1 activity
  JOURNAL   Brain Res Mol Brain Res 27 (2), 232-242 (1994)
   PUBMED   7898306
REFERENCE   10 (bases 1 to 798)
  AUTHORS   Kislauskis,E., Bullock,B., McNeil,S. and Dobner,P.R.
  TITLE     The rat gene encoding neurotensin and neuromedin N. Structure,
            tissue-specific expression, and evolution of exon sequences
  JOURNAL   J Biol Chem 263 (10), 4963-4968 (1988)
   PUBMED   2832414
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473960.2.
            
            On or before Aug 22, 2007 this sequence version replaced
            XM_216884.4, XM_001080677.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ214250.1, FM072651.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760396
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..798
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q21"
     gene            1..798
                     /gene="Nts"
                     /note="neurotensin"
                     /db_xref="GeneID:299757"
                     /db_xref="RGD:621612"
     exon            1..150
                     /gene="Nts"
                     /inference="alignment:Splign:2.1.0"
     CDS             81..590
                     /gene="Nts"
                     /note="neurotensin/neuromedin N"
                     /codon_start=1
                     /product="neurotensin/neuromedin N precursor"
                     /protein_id="NP_001095851.1"
                     /db_xref="GeneID:299757"
                     /db_xref="RGD:621612"
                     /translation="MIGMNLQLVCLTLLAFSSWSLCSDSEEDVRVLEADLLTNMHASK
                     VSKGSPPSWKMTLLNVCSLINNLNSAAEEAGEMRDDDLVAKRKLPLVLDDFSLEALLT
                     VFQLQKICRSRAFQHWEIIQEDILDHGNEKTEKEEVIKRKIPYILKRQLYENKPRRPY
                     ILKRASYYY"
     exon            151..212
                     /gene="Nts"
                     /inference="alignment:Splign:2.1.0"
     exon            213..437
                     /gene="Nts"
                     /inference="alignment:Splign:2.1.0"
     exon            438..798
                     /gene="Nts"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccagctgaa ggcaagagga agcaccaaga gagctccttc cgtgtctgtg tggacctgct
       61 tgtcagaagg ctgagacaag atgataggaa tgaaccttca gctggtgtgc ctgactctcc
      121 tggctttcag ctcctggagt ctgtgctcag attcagaaga agatgtgaga gtcctggagg
      181 cagatctcct gacaaatatg catgcatcga aggtcagcaa aggaagtcct ccctcttgga
      241 aaatgacctt gctcaacgtt tgcagcctga tcaataacct gaacagcgca gcggaggaag
      301 cgggagaaat gcgtgatgac gaccttgttg cgaaaaggaa acttcccctt gtcctggatg
      361 actttagctt ggaagcgctg ctgaccgtat tccaactcca gaagatctgc cgcagccggg
      421 cctttcaaca ctgggagata attcaggagg atatcctcga tcatggcaat gagaaaactg
      481 agaaggaaga agtgataaag agaaaaatcc cttatattct gaaacggcag ctctatgaga
      541 ataaacccag aaggccctac atactcaaga gggcctccta ctactactga gaagttaatt
      601 cttgacatgt gattctcatc ctttacctgt tatctggata cacatgatgc ttatctagat
      661 atataattat atgtgtgtat gaatgtatgc cagaacttga ttattttacc ttttccacaa
      721 ttgtgctttc ttggatggga ttttcctgca ttcttgcaaa ctggacgcaa tgttttcaaa
      781 taaaggtaga tctcgagc
//
