LOCUS       NM_001270655            2749 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Rattus norvegicus neurotrophic receptor tyrosine kinase 3 (Ntrk3),
            transcript variant 2, mRNA.
ACCESSION   NM_001270655
VERSION     NM_001270655.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2749)
  AUTHORS   Chen,Z., Huang,Z., Luo,Y., Zou,Q., Bai,L., Tang,G., Wang,X.,
            Cao,G., Huang,M., Xiang,J. and Yu,H.
  TITLE     Genome-wide analysis identifies critical DNA methylations within
            NTRKs genes in colorectal cancer
  JOURNAL   J Transl Med 19 (1), 73 (2021)
   PUBMED   33593392
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2749)
  AUTHORS   Tan,W., Dong,L., Shi,X., Tang,Q. and Jiang,D.
  TITLE     P75NTR Exacerbates SCI-induced Mitochondrial Damage and Neuronal
            Apoptosis Depending on NTRK3
  JOURNAL   Curr Neurovasc Res 18 (5), 552-564 (2021)
   PUBMED   34970951
  REMARK    GeneRIF: P75NTR Exacerbates SCI-induced Mitochondrial Damage and
            Neuronal Apoptosis Depending on NTRK3.
REFERENCE   3  (bases 1 to 2749)
  AUTHORS   Qiao,X., Yin,F., Ji,Y., Li,Y., Yan,P. and Lai,J.
  TITLE     5-Aza-2'-deoxycytidine in the medial prefrontal cortex regulates
            alcohol-related behavior and Ntf3-TrkC expression in rats
  JOURNAL   PLoS One 12 (6), e0179469 (2017)
   PUBMED   28614398
  REMARK    GeneRIF: Data show that 5-Aza-dc reversed the alcohol-induced
            downregulation of neurotrophin-3 (Ntf3), correspondingly the
            expression of its receptor-neurotrophic receptor tyrosine kinase 3
            (TrkC) was reduced.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2749)
  AUTHORS   Behrouz Sharif,S., Hashemzadeh,S., Mousavi Ardehaie,R.,
            Eftekharsadat,A., Ghojazadeh,M., Mehrtash,A.H., Estiar,M.A.,
            Teimoori-Toolabi,L. and Sakhinia,E.
  TITLE     Detection of aberrant methylated SEPT9 and NTRK3 genes in sporadic
            colorectal cancer patients as a potential diagnostic biomarker
  JOURNAL   Oncol Lett 12 (6), 5335-5343 (2016)
   PUBMED   28105243
REFERENCE   5  (bases 1 to 2749)
  AUTHORS   Dmitrieva,V.G., Stavchansky,V.V., Povarova,O.V., Skvortsova,V.I.,
            Limborska,S.A. and Dergunova,L.V.
  TITLE     [Effects of ischemia on the expression of neurotrophins and their
            receptors in rat brain structures outside the lesion site,
            including on the opposite hemisphere]
  JOURNAL   Mol Biol (Mosk) 50 (5), 775-784 (2016)
   PUBMED   27830679
  REMARK    GeneRIF: It has been shown that ischemia influenced the expression
            of neurotrophins (Bdnf, Ngf, Nt-3) and their receptors (TrkB, TrkA,
            TrkC, p75) in brain structures outside the lesion focus, including
            the contralateral hemisphere.
REFERENCE   6  (bases 1 to 2749)
  AUTHORS   Qian,X., Riccio,A., Zhang,Y. and Ginty,D.D.
  TITLE     Identification and characterization of novel substrates of Trk
            receptors in developing neurons
  JOURNAL   Neuron 21 (5), 1017-1029 (1998)
   PUBMED   9856458
REFERENCE   7  (bases 1 to 2749)
  AUTHORS   Fernyhough,P., Diemel,L.T. and Tomlinson,D.R.
  TITLE     Target tissue production and axonal transport of neurotrophin-3 are
            reduced in streptozotocin-diabetic rats
  JOURNAL   Diabetologia 41 (3), 300-306 (1998)
   PUBMED   9541170
REFERENCE   8  (bases 1 to 2749)
  AUTHORS   Tsoulfas,P., Soppet,D., Escandon,E., Tessarollo,L.,
            Mendoza-Ramirez,J.L., Rosenthal,A., Nikolics,K. and Parada,L.F.
  TITLE     The rat trkC locus encodes multiple neurogenic receptors that
            exhibit differential response to neurotrophin-3 in PC12 cells
  JOURNAL   Neuron 10 (5), 975-990 (1993)
   PUBMED   8494648
REFERENCE   9  (bases 1 to 2749)
  AUTHORS   Valenzuela,D.M., Maisonpierre,P.C., Glass,D.J., Rojas,E., Nunez,L.,
            Kong,Y., Gies,D.R., Stitt,T.N., Ip,N.Y. and Yancopoulos,G.D.
  TITLE     Alternative forms of rat TrkC with different functional
            capabilities
  JOURNAL   Neuron 10 (5), 963-974 (1993)
   PUBMED   8494647
REFERENCE   10 (bases 1 to 2749)
  AUTHORS   Merlio,J.P., Ernfors,P., Jaber,M. and Persson,H.
  TITLE     Molecular cloning of rat trkC and distribution of cells expressing
            messenger RNAs for members of the trk family in the rat central
            nervous system
  JOURNAL   Neuroscience 51 (3), 513-532 (1992)
   PUBMED   1488112
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            L03813.1 and L14446.1.
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon compared to variant 1. The resulting isoform (2) has the same
            N- and C-termini but is shorter compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L14446.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5756307,
                                           SAMEA5760383 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-51                L03813.1           1-51
            52-2749             L14446.1           1-2698
FEATURES             Location/Qualifiers
     source          1..2749
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q31"
     gene            1..2749
                     /gene="Ntrk3"
                     /gene_synonym="trkC"
                     /note="neurotrophic receptor tyrosine kinase 3"
                     /db_xref="GeneID:29613"
                     /db_xref="RGD:3214"
     exon            1..299
                     /gene="Ntrk3"
                     /gene_synonym="trkC"
                     /inference="alignment:Splign:2.1.0"
     CDS             52..2571
                     /gene="Ntrk3"
                     /gene_synonym="trkC"
                     /EC_number="2.7.10.1"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; NT-3 growth factor receptor; trk-C; GP145-TrkC;
                     trkC tyrosine kinase; neurotrophic tyrosine kinase,
                     receptor, type 3; neural receptor protein-tyrosine kinase
                     (trkC)"
                     /codon_start=1
                     /product="NT-3 growth factor receptor isoform 2 precursor"
                     /protein_id="NP_001257584.1"
                     /db_xref="GeneID:29613"
                     /db_xref="RGD:3214"
                     /translation="MDVSLCPAKCSFWRIFLLGSVWLDYVGSVLACPANCVCSKTEIN
                     CRRPDDGNLFPLLEGQDSGNSNGNASINITDISRNITSIHIENWRGLHTLNAVDMELY
                     TGLQKLTIKNSGLRNIQPRAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELRLEQN
                     FFNCSCDIRWMQLWQEQGEARLDSQSLYCISADGSQLPLFRMNISQCDLPEISVSHVN
                     LTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSE
                     DNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLVEPEVRLEHCIEFVVRGNPTPTLH
                     WLYNGQPLRESKIIHMDYYQEGEVSEGCLLFNKPTHYNNGNYTLIAKNALGTANQTIN
                     GHFLKEPFPESTDFFDFESDASPTPPITVTHKPEEDTFGVSIAVGLAAFACVLLVVLF
                     IMINKYGRRSKFGMKGPVAVISGEEDSASPLHHINHGITTPSSLDAGPDTVVIGMTRI
                     PVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDK
                     MLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGD
                     LNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLAT
                     RNCLVGANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPE
                     SIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKE
                     VYDVMLGCWQREPQQRLNIKEIYKILHALGKATPIYLDILG"
     exon            300..374
                     /gene="Ntrk3"
                     /gene_synonym="trkC"
                     /inference="alignment:Splign:2.1.0"
     exon            375..446
                     /gene="Ntrk3"
                     /gene_synonym="trkC"
                     /inference="alignment:Splign:2.1.0"
     exon            447..515
                     /gene="Ntrk3"
                     /gene_synonym="trkC"
                     /inference="alignment:Splign:2.1.0"
     exon            516..673
                     /gene="Ntrk3"
                     /gene_synonym="trkC"
                     /inference="alignment:Splign:2.1.0"
     exon            674..816
                     /gene="Ntrk3"
                     /gene_synonym="trkC"
                     /inference="alignment:Splign:2.1.0"
     exon            817..958
                     /gene="Ntrk3"
                     /gene_synonym="trkC"
                     /inference="alignment:Splign:2.1.0"
     exon            959..1255
                     /gene="Ntrk3"
                     /gene_synonym="trkC"
                     /inference="alignment:Splign:2.1.0"
     exon            1256..1279
                     /gene="Ntrk3"
                     /gene_synonym="trkC"
                     /inference="alignment:Splign:2.1.0"
     exon            1280..1344
                     /gene="Ntrk3"
                     /gene_synonym="trkC"
                     /inference="alignment:Splign:2.1.0"
     exon            1345..1447
                     /gene="Ntrk3"
                     /gene_synonym="trkC"
                     /inference="alignment:Splign:2.1.0"
     exon            1448..1636
                     /gene="Ntrk3"
                     /gene_synonym="trkC"
                     /inference="alignment:Splign:2.1.0"
     exon            1637..1767
                     /gene="Ntrk3"
                     /gene_synonym="trkC"
                     /inference="alignment:Splign:2.1.0"
     exon            1768..1940
                     /gene="Ntrk3"
                     /gene_synonym="trkC"
                     /inference="alignment:Splign:2.1.0"
     exon            1941..2184
                     /gene="Ntrk3"
                     /gene_synonym="trkC"
                     /inference="alignment:Splign:2.1.0"
     exon            2185..2226
                     /gene="Ntrk3"
                     /gene_synonym="trkC"
                     /inference="alignment:Splign:2.1.0"
     exon            2227..2385
                     /gene="Ntrk3"
                     /gene_synonym="trkC"
                     /inference="alignment:Splign:2.1.0"
     exon            2386..2749
                     /gene="Ntrk3"
                     /gene_synonym="trkC"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acccccctct cctctcctcc tcctcctctt ttttagaagc agcgatcgga gatggatgtc
       61 tctctttgcc cagccaagtg tagtttctgg cggattttct tgctgggaag cgtctggctg
      121 gactatgtgg gctccgtgct ggcttgccct gcaaattgtg tctgcagcaa gactgagatc
      181 aattgccggc ggccggacga tgggaacctc tttcccctcc tggaagggca ggattcaggg
      241 aacagcaatg ggaacgccag catcaacatc acggacatct caaggaatat cacttccata
      301 cacatagaga actggcgggg cctgcacaca ctcaatgctg tggatatgga gctctacacg
      361 ggactccaga agctgaccat caagaattct ggactccgga atattcagcc cagagccttt
      421 gctaagaatc cccacttgcg ttatataaac ttgtcaagta accggctcac cacactctcc
      481 tggcagctct tccagacgct gagtcttcgg gaattgagac tggagcagaa cttcttcaac
      541 tgcagctgtg acatccgctg gatgcagctg tggcaggaac agggggaggc acggctggac
      601 agccagagcc tctactgcat cagtgctgat ggctcccaac tccccctctt ccgcatgaac
      661 atcagtcagt gtgatctccc tgagatcagt gtgagtcacg tgaacctgac tgtccgagaa
      721 ggagacaatg ctgtaatcac ttgtaatggc tctggctctc ctttgcctga tgtggactgg
      781 atagtcaccg gactgcagtc catcaatact catcagacca atctgaactg gaccaatgta
      841 catgccatca acttgaccct ggtgaatgtg acgagcgaag acaatggttt caccctgacg
      901 tgcattgcag agaacgtggt gggcatgagc aatgccagcg ttgctctcac tgtctactac
      961 cctccacgtg tggtgagctt ggtggagcct gaggtacgcc tggaacattg cattgagttt
     1021 gtggtgcgtg gcaacccgac acccacgctg cattggctgt acaatggaca gccactgagg
     1081 gaatccaaga tcattcatat ggactactac caggagggtg aagtctcaga gggctgcctg
     1141 ctcttcaaca agcccaccca ctacaacaat ggcaactaca ccctcattgc taagaatgcc
     1201 ctgggcacag ccaaccagac catcaacggc cacttcctta aggagccctt tccagagagc
     1261 acagatttct ttgactttga gtctgatgcg agccctacac ctcctatcac tgtgacccac
     1321 aaaccagagg aagacacttt tggggtgtcc atagcagttg gacttgctgc ttttgcctgc
     1381 gtccttctgg tggtcctctt tatcatgatc aacaagtacg gtcgacggtc caaatttgga
     1441 atgaagggtc ctgtggctgt tatcagtggg gaggaggact cagccagccc actgcaccat
     1501 atcaaccatg gcatcactac accttcatcg ctggatgctg ggccggatac agtggtcatt
     1561 ggcatgactc gaattccagt cattgagaac ccccaatatt tccgtcaggg acacaattgc
     1621 cacaagccag acacatatgt tcaacacatc aagaggagag acatcgtgtt gaagagagaa
     1681 ctgggtgagg gagcctttgg aaaggtcttc ctggctgagt gctacaatct aagccccacc
     1741 aaagacaaga tgcttgtggc agtgaaggcc ctgaaggatc ccaccttggc tgccaggaag
     1801 gatttccaga gggaggccga gctgctcact aacctgcagc atgagcatat tgtcaaattc
     1861 tatggggtct gtggtgatgg ggatccactc atcatggtct ttgaatacat gaagcatgga
     1921 gacctgaaca agttcctcag ggcccatggg ccagatgcga tgatccttgt ggatggacag
     1981 ccacgccagg ccaaggggga gctaggactc tcccagatgc tccacatcgc cagtcagata
     2041 gcctccggca tggtgtactt ggcctcccag cactttgtgc accgggacct ggccaccagg
     2101 aactgcctag ttggagccaa ccttctagtg aagattggag attttggcat gtccagggac
     2161 gtctacagta ctgattacta caggctcttt aatccatctg gaaatgattt ttgtatatgg
     2221 tgtgaggtgg gaggacacac catgctcccc atccgctgga tgccacctga aagcatcatg
     2281 taccggaagt ttaccacaga gagtgatgtg tggagctttg gggttattct ttgggagatc
     2341 tttacctatg ggaagcaacc atggttccag ctctctaaca cagaggtcat tgaatgcatc
     2401 acccaaggcc gtgtcttgga gagaccccga gtctgcccaa aagaagtata tgatgtcatg
     2461 ctggggtgct ggcagaggga accacaacag cgactgaata ttaaggagat ctacaaaatc
     2521 ctccatgctt tggggaaggc caccccaatc tacctggaca ttcttggcta gtggtgactg
     2581 gtggccaagc gtttatactc tgttgcctcc tctctccctg cctcatctcc tctttttcct
     2641 cacctcaact cctttcgtcc atctttgacc gaaacgaaca tcttcatata aactcaagtg
     2701 cctgctacac atacaacact gaatttaaac aaaacaaaac aaaacaaaa
//
