LOCUS       NP_001257584             839 aa            linear   ROD 03-JUN-2024
DEFINITION  NT-3 growth factor receptor isoform 2 precursor [Rattus
            norvegicus].
ACCESSION   NP_001257584
VERSION     NP_001257584.1
DBSOURCE    REFSEQ: accession NM_001270655.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 839)
  AUTHORS   Chen,Z., Huang,Z., Luo,Y., Zou,Q., Bai,L., Tang,G., Wang,X.,
            Cao,G., Huang,M., Xiang,J. and Yu,H.
  TITLE     Genome-wide analysis identifies critical DNA methylations within
            NTRKs genes in colorectal cancer
  JOURNAL   J Transl Med 19 (1), 73 (2021)
   PUBMED   33593392
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 839)
  AUTHORS   Tan,W., Dong,L., Shi,X., Tang,Q. and Jiang,D.
  TITLE     P75NTR Exacerbates SCI-induced Mitochondrial Damage and Neuronal
            Apoptosis Depending on NTRK3
  JOURNAL   Curr Neurovasc Res 18 (5), 552-564 (2021)
   PUBMED   34970951
  REMARK    GeneRIF: P75NTR Exacerbates SCI-induced Mitochondrial Damage and
            Neuronal Apoptosis Depending on NTRK3.
REFERENCE   3  (residues 1 to 839)
  AUTHORS   Qiao,X., Yin,F., Ji,Y., Li,Y., Yan,P. and Lai,J.
  TITLE     5-Aza-2'-deoxycytidine in the medial prefrontal cortex regulates
            alcohol-related behavior and Ntf3-TrkC expression in rats
  JOURNAL   PLoS One 12 (6), e0179469 (2017)
   PUBMED   28614398
  REMARK    GeneRIF: Data show that 5-Aza-dc reversed the alcohol-induced
            downregulation of neurotrophin-3 (Ntf3), correspondingly the
            expression of its receptor-neurotrophic receptor tyrosine kinase 3
            (TrkC) was reduced.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 839)
  AUTHORS   Behrouz Sharif,S., Hashemzadeh,S., Mousavi Ardehaie,R.,
            Eftekharsadat,A., Ghojazadeh,M., Mehrtash,A.H., Estiar,M.A.,
            Teimoori-Toolabi,L. and Sakhinia,E.
  TITLE     Detection of aberrant methylated SEPT9 and NTRK3 genes in sporadic
            colorectal cancer patients as a potential diagnostic biomarker
  JOURNAL   Oncol Lett 12 (6), 5335-5343 (2016)
   PUBMED   28105243
REFERENCE   5  (residues 1 to 839)
  AUTHORS   Dmitrieva,V.G., Stavchansky,V.V., Povarova,O.V., Skvortsova,V.I.,
            Limborska,S.A. and Dergunova,L.V.
  TITLE     [Effects of ischemia on the expression of neurotrophins and their
            receptors in rat brain structures outside the lesion site,
            including on the opposite hemisphere]
  JOURNAL   Mol Biol (Mosk) 50 (5), 775-784 (2016)
   PUBMED   27830679
  REMARK    GeneRIF: It has been shown that ischemia influenced the expression
            of neurotrophins (Bdnf, Ngf, Nt-3) and their receptors (TrkB, TrkA,
            TrkC, p75) in brain structures outside the lesion focus, including
            the contralateral hemisphere.
REFERENCE   6  (residues 1 to 839)
  AUTHORS   Qian,X., Riccio,A., Zhang,Y. and Ginty,D.D.
  TITLE     Identification and characterization of novel substrates of Trk
            receptors in developing neurons
  JOURNAL   Neuron 21 (5), 1017-1029 (1998)
   PUBMED   9856458
REFERENCE   7  (residues 1 to 839)
  AUTHORS   Fernyhough,P., Diemel,L.T. and Tomlinson,D.R.
  TITLE     Target tissue production and axonal transport of neurotrophin-3 are
            reduced in streptozotocin-diabetic rats
  JOURNAL   Diabetologia 41 (3), 300-306 (1998)
   PUBMED   9541170
REFERENCE   8  (residues 1 to 839)
  AUTHORS   Tsoulfas,P., Soppet,D., Escandon,E., Tessarollo,L.,
            Mendoza-Ramirez,J.L., Rosenthal,A., Nikolics,K. and Parada,L.F.
  TITLE     The rat trkC locus encodes multiple neurogenic receptors that
            exhibit differential response to neurotrophin-3 in PC12 cells
  JOURNAL   Neuron 10 (5), 975-990 (1993)
   PUBMED   8494648
REFERENCE   9  (residues 1 to 839)
  AUTHORS   Valenzuela,D.M., Maisonpierre,P.C., Glass,D.J., Rojas,E., Nunez,L.,
            Kong,Y., Gies,D.R., Stitt,T.N., Ip,N.Y. and Yancopoulos,G.D.
  TITLE     Alternative forms of rat TrkC with different functional
            capabilities
  JOURNAL   Neuron 10 (5), 963-974 (1993)
   PUBMED   8494647
REFERENCE   10 (residues 1 to 839)
  AUTHORS   Merlio,J.P., Ernfors,P., Jaber,M. and Persson,H.
  TITLE     Molecular cloning of rat trkC and distribution of cells expressing
            messenger RNAs for members of the trk family in the rat central
            nervous system
  JOURNAL   Neuroscience 51 (3), 513-532 (1992)
   PUBMED   1488112
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            L03813.1 and L14446.1.
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon compared to variant 1. The resulting isoform (2) has the same
            N- and C-termini but is shorter compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L14446.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5756307,
                                           SAMEA5760383 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..839
                     /organism="Rattus norvegicus"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q31"
     Protein         1..839
                     /product="NT-3 growth factor receptor isoform 2 precursor"
                     /EC_number="2.7.10.1"
                     /note="NT-3 growth factor receptor; trk-C; GP145-TrkC;
                     trkC tyrosine kinase; neurotrophic tyrosine kinase,
                     receptor, type 3; neural receptor protein-tyrosine kinase
                     (trkC)"
                     /calculated_mol_wt=90928
     sig_peptide     1..31
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=3477
     Region          103..160
                     /region_name="LRR_8"
                     /note="Leucine rich repeat; pfam13855"
                     /db_xref="CDD:404697"
     Region          105..128
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          129..151
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          152..164
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          163..208
                     /region_name="LRRCT_2"
                     /note="Leucine rich repeat C-terminal motif; pfam16920"
                     /db_xref="CDD:465313"
     Region          214..299
                     /region_name="ig"
                     /note="Immunoglobulin domain; pfam00047"
                     /db_xref="CDD:395002"
     Region          227..231
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          240..244
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          266..270
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          281..286
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          294..297
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          304..396
                     /region_name="IgI_TrKABC_d5"
                     /note="Fifth domain (immunoglobulin-like) of Trk receptors
                     TrkA, TrkB, and TrkC; member of the I-set of Ig
                     superfamily (IgSF) domains; cd04971"
                     /db_xref="CDD:409360"
     Region          305..311
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409360"
     Region          313..316
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409360"
     Region          319..327
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409360"
     Site            328
                     /site_type="other"
                     /note="interdomain interface [polypeptide binding]"
                     /db_xref="CDD:409360"
     Region          330..337
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409360"
     Region          340..343
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409360"
     Region          348..354
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409360"
     Site            order(353,366..367,370)
                     /site_type="other"
                     /note="receptor binding site [polypeptide binding]"
                     /db_xref="CDD:409360"
     Region          358..366
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409360"
     Region          374..382
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409360"
     Region          385..393
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409360"
     Region          532..832
                     /region_name="PTKc_TrkC"
                     /note="Catalytic domain of the Protein Tyrosine Kinase,
                     Tropomyosin Related Kinase C; cd05094"
                     /db_xref="CDD:270676"
     Site            order(544..548,552,570,572,617..620,623..624,679,683..684,
                     686,697,729..733,742,776)
                     /site_type="active"
                     /db_xref="CDD:270676"
     Site            order(544..545,547..548,552,570,572,617..620,623..624,
                     683..684,686,697)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270676"
     Site            order(679,683,729..733,742,776)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270676"
     Site            order(696..711,726..735)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270676"
     CDS             1..839
                     /gene="Ntrk3"
                     /gene_synonym="trkC"
                     /coded_by="NM_001270655.1:52..2571"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2"
                     /db_xref="GeneID:29613"
                     /db_xref="RGD:3214"
ORIGIN      
        1 mdvslcpakc sfwrifllgs vwldyvgsvl acpancvcsk teincrrpdd gnlfpllegq
       61 dsgnsngnas initdisrni tsihienwrg lhtlnavdme lytglqklti knsglrniqp
      121 rafaknphlr yinlssnrlt tlswqlfqtl slrelrleqn ffncscdirw mqlwqeqgea
      181 rldsqslyci sadgsqlplf rmnisqcdlp eisvshvnlt vregdnavit cngsgsplpd
      241 vdwivtglqs inthqtnlnw tnvhainltl vnvtsedngf tltciaenvv gmsnasvalt
      301 vyypprvvsl vepevrlehc iefvvrgnpt ptlhwlyngq plreskiihm dyyqegevse
      361 gcllfnkpth ynngnytlia knalgtanqt inghflkepf pestdffdfe sdasptppit
      421 vthkpeedtf gvsiavglaa facvllvvlf iminkygrrs kfgmkgpvav isgeedsasp
      481 lhhinhgitt pssldagpdt vvigmtripv ienpqyfrqg hnchkpdtyv qhikrrdivl
      541 krelgegafg kvflaecynl sptkdkmlva vkalkdptla arkdfqreae lltnlqhehi
      601 vkfygvcgdg dplimvfeym khgdlnkflr ahgpdamilv dgqprqakge lglsqmlhia
      661 sqiasgmvyl asqhfvhrdl atrnclvgan llvkigdfgm srdvystdyy rlfnpsgndf
      721 ciwcevgght mlpirwmppe simyrkftte sdvwsfgvil weiftygkqp wfqlsntevi
      781 ecitqgrvle rprvcpkevy dvmlgcwqre pqqrlnikei ykilhalgka tpiyldilg
//
