LOCUS       NM_012731               4755 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Rattus norvegicus neurotrophic receptor tyrosine kinase 2 (Ntrk2),
            transcript variant 1, mRNA.
ACCESSION   NM_012731
VERSION     NM_012731.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4755)
  AUTHORS   Ahmadi,S., Majidi,M., Koraei,M. and Vasef,S.
  TITLE     The Inflammation/NF-kappaB and BDNF/TrkB/CREB Pathways in the
            Cerebellum Are Implicated in the Changes in Spatial Working Memory
            After Both Morphine Dependence and Withdrawal in Rat
  JOURNAL   Mol Neurobiol 61 (9), 6721-6733 (2024)
   PUBMED   38347284
  REMARK    GeneRIF: The Inflammation/NF-kappaB and BDNF/TrkB/CREB Pathways in
            the Cerebellum Are Implicated in the Changes in Spatial Working
            Memory After Both Morphine Dependence and Withdrawal in Rat.
REFERENCE   2  (bases 1 to 4755)
  AUTHORS   H,Z. R, H,J. S, R C,S. B, Kr,R., R,R.D. and M,E. B.
  TITLE     Physical Exercise Promotes Beneficial Changes on Neurotrophic
            Factors in Mesolimbic Brain Areas After AMPH Relapse: Involvement
            of the Endogenous Opioid System
  JOURNAL   Neurotox Res 41 (6), 741-751 (2023)
   PUBMED   37904065
REFERENCE   3  (bases 1 to 4755)
  AUTHORS   Andreska,T., Luningschror,P., Wolf,D., McFleder,R.L.,
            Ayon-Olivas,M., Rattka,M., Drechsler,C., Perschin,V., Blum,R.,
            Aufmkolk,S., Granado,N., Moratalla,R., Sauer,M., Monoranu,C.,
            Volkmann,J., Ip,C.W., Stigloher,C. and Sendtner,M.
  TITLE     DRD1 signaling modulates TrkB turnover and BDNF sensitivity in
            direct pathway striatal medium spiny neurons
  JOURNAL   Cell Rep 42 (6), 112575 (2023)
   PUBMED   37252844
  REMARK    GeneRIF: DRD1 signaling modulates TrkB turnover and BDNF
            sensitivity in direct pathway striatal medium spiny neurons.
REFERENCE   4  (bases 1 to 4755)
  AUTHORS   Serra,M.P., Sanna,F., Boi,M., Trucas,M., Fernandez-Teruel,A.,
            Corda,M.G., Giorgi,O. and Quartu,M.
  TITLE     Effects of Tail Pinch on BDNF and trkB Expression in the
            Hippocampus of Roman Low- (RLA) and High-Avoidance (RHA) Rats
  JOURNAL   Int J Mol Sci 24 (11), 9498 (2023)
   PUBMED   37298449
  REMARK    GeneRIF: Effects of Tail Pinch on BDNF and trkB Expression in the
            Hippocampus of Roman Low- (RLA) and High-Avoidance (RHA) Rats.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4755)
  AUTHORS   Yang,J., Wang,L., Huang,L., Che,X., Zhang,Z., Wang,C., Bai,L.,
            Liu,P., Zhao,Y., Hu,X., Shi,B., Shen,Y., Liang,X.J., Wu,C. and
            Xue,X.
  TITLE     Receptor-targeting nanomaterials alleviate binge drinking-induced
            neurodegeneration as artificial neurotrophins
  JOURNAL   Exploration (Beijing) 1 (1), 61-74 (2021)
   PUBMED   37366469
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4755)
  AUTHORS   Eide,F.F., Vining,E.R., Eide,B.L., Zang,K., Wang,X.Y. and
            Reichardt,L.F.
  TITLE     Naturally occurring truncated trkB receptors have dominant
            inhibitory effects on brain-derived neurotrophic factor signaling
  JOURNAL   J Neurosci 16 (10), 3123-3129 (1996)
   PUBMED   8627351
REFERENCE   7  (bases 1 to 4755)
  AUTHORS   Middlemas,D.S., Meisenhelder,J. and Hunter,T.
  TITLE     Identification of TrkB autophosphorylation sites and evidence that
            phospholipase C-gamma 1 is a substrate of the TrkB receptor
  JOURNAL   J Biol Chem 269 (7), 5458-5466 (1994)
   PUBMED   8106527
REFERENCE   8  (bases 1 to 4755)
  AUTHORS   Klein,R., Smeyne,R.J., Wurst,W., Long,L.K., Auerbach,B.A.,
            Joyner,A.L. and Barbacid,M.
  TITLE     Targeted disruption of the trkB neurotrophin receptor gene results
            in nervous system lesions and neonatal death
  JOURNAL   Cell 75 (1), 113-122 (1993)
   PUBMED   8402890
REFERENCE   9  (bases 1 to 4755)
  AUTHORS   Soppet,D., Escandon,E., Maragos,J., Middlemas,D.S., Reid,S.W.,
            Blair,J., Burton,L.E., Stanton,B.R., Kaplan,D.R., Hunter,T.,
            Nikolics,K. and Parada,L.F.
  TITLE     The neurotrophic factors brain-derived neurotrophic factor and
            neurotrophin-3 are ligands for the trkB tyrosine kinase receptor
  JOURNAL   Cell 65 (5), 895-903 (1991)
   PUBMED   1645620
REFERENCE   10 (bases 1 to 4755)
  AUTHORS   Middlemas,D.S., Lindberg,R.A. and Hunter,T.
  TITLE     trkB, a neural receptor protein-tyrosine kinase: evidence for a
            full-length and two truncated receptors
  JOURNAL   Mol Cell Biol 11 (1), 143-153 (1991)
   PUBMED   1846020
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000017.1.
            
            On Sep 24, 2021 this sequence version replaced NM_012731.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M55291.1, SRR26643298.68122.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760393,
                                           SAMN12840105 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-322               JAXUCZ010000017.1  5874307-5874628     c
            323-878             JAXUCZ010000017.1  5873378-5873933     c
            879-953             JAXUCZ010000017.1  5841956-5842030     c
            954-1025            JAXUCZ010000017.1  5841766-5841837     c
            1026-1094           JAXUCZ010000017.1  5837011-5837079     c
            1095-1249           JAXUCZ010000017.1  5833559-5833713     c
            1250-1386           JAXUCZ010000017.1  5819604-5819740     c
            1387-1519           JAXUCZ010000017.1  5818584-5818716     c
            1520-1825           JAXUCZ010000017.1  5817400-5817705     c
            1826-1861           JAXUCZ010000017.1  5807435-5807470     c
            1862-1959           JAXUCZ010000017.1  5805145-5805242     c
            1960-2059           JAXUCZ010000017.1  5800186-5800285     c
            2060-2248           JAXUCZ010000017.1  5699429-5699617     c
            2249-2379           JAXUCZ010000017.1  5642345-5642475     c
            2380-2552           JAXUCZ010000017.1  5628111-5628283     c
            2553-2787           JAXUCZ010000017.1  5622073-5622307     c
            2788-2946           JAXUCZ010000017.1  5568040-5568198     c
            2947-4755           JAXUCZ010000017.1  5564570-5566378     c
FEATURES             Location/Qualifiers
     source          1..4755
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p14"
     gene            1..4755
                     /gene="Ntrk2"
                     /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
                     /note="neurotrophic receptor tyrosine kinase 2"
                     /db_xref="GeneID:25054"
                     /db_xref="RGD:3213"
     exon            1..322
                     /gene="Ntrk2"
                     /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
                     /inference="alignment:Splign:2.1.0"
     exon            323..878
                     /gene="Ntrk2"
                     /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
                     /inference="alignment:Splign:2.1.0"
     CDS             667..3132
                     /gene="Ntrk2"
                     /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
                     /EC_number="2.7.10.1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; BDNF/NT-3 growth factors receptor;
                     GP145-TrkB/GP95-TrkB; trkB tyrosine kinase; neural
                     receptor protein-tyrosine kinase (trkB); neurotrophic
                     tyrosine receptor kinase type 2; neurotrophic tyrosine
                     kinase, receptor, type 2"
                     /codon_start=1
                     /product="BDNF/NT-3 growth factors receptor isoform 1
                     precursor"
                     /protein_id="NP_036863.1"
                     /db_xref="GeneID:25054"
                     /db_xref="RGD:3213"
                     /translation="MSPWPRWHGPAMARLWGLCLLVLGFWRASLACPMSCKCSTTRIW
                     CTEPSPGIVAFPRLEPNSIDPENITEILIANQKRLEIINEDDVEAYVGLKNLTIVDSG
                     LKFVAYKAFLKNGNLRHINFTRNKLTSLSRRHFRHLDLSDLILTGNPFTCSCDIMWLK
                     TLQETKSSPDTQDLYCLNESSKNTPLANLQIPNCGLPSARLAAPNLTVEEGKSVTISC
                     SVGGDPLPTLYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQ
                     DSVNLTVHFAPTITFLESPTSDHHWCIPFTVRGNPKPALQWFYNGAILNESKYICTKI
                     HVTNHTEYHGCLQLDNPTHMNNGDYTLMAKNEYGKDERQISAHFMGRPGVDYETNPNY
                     PEVLYEDWTTPTDIGDTTNKSNEIPSTDVADQTNREHLSVYAVVVIASVVGFCLLVML
                     LLLKLARHSKFGMKGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIP
                     VIENPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKI
                     LVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDL
                     NKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCL
                     VGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGV
                     VLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHTRKN
                     IKNIHTLLQNLAKASPVYLDILG"
     exon            879..953
                     /gene="Ntrk2"
                     /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1025
                     /gene="Ntrk2"
                     /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1094
                     /gene="Ntrk2"
                     /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1249
                     /gene="Ntrk2"
                     /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..1386
                     /gene="Ntrk2"
                     /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1387..1519
                     /gene="Ntrk2"
                     /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1520..1825
                     /gene="Ntrk2"
                     /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1826..1861
                     /gene="Ntrk2"
                     /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1862..1959
                     /gene="Ntrk2"
                     /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1960..2059
                     /gene="Ntrk2"
                     /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
                     /inference="alignment:Splign:2.1.0"
     exon            2060..2248
                     /gene="Ntrk2"
                     /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
                     /inference="alignment:Splign:2.1.0"
     exon            2249..2379
                     /gene="Ntrk2"
                     /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
                     /inference="alignment:Splign:2.1.0"
     exon            2380..2552
                     /gene="Ntrk2"
                     /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
                     /inference="alignment:Splign:2.1.0"
     exon            2553..2787
                     /gene="Ntrk2"
                     /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
                     /inference="alignment:Splign:2.1.0"
     exon            2788..2946
                     /gene="Ntrk2"
                     /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
                     /inference="alignment:Splign:2.1.0"
     exon            2947..4755
                     /gene="Ntrk2"
                     /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgcgtgtgc gtgcgtgcgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt
       61 gtgtgtgagc gtgtgtgttt ttggatttca tactaatttt ctggagtttc tgcccctgct
      121 ctgcgtcagc cctcacgtca cttcgccagc agtagcagag gcggcggcgg ccgccggtta
      181 gagcccagtc gctgcttcag ctgctgttgc tgcttctgcg gcgctctgct ccctgcgctg
      241 gctacgggag gccgggggag ccgcgccgac agtcctctgt ggccagggcc ggcactgtcc
      301 tgctaccgca gttgctcccc agccctgagg tgcgcaccga tatcgatatc cgtgccggtt
      361 tagcggttct gcgacccaaa gagtccaggg agagccaccg agtggcgcct ggcgtatagg
      421 accatgcagc cgccttgtgg cttggagcag cggcccgtga tgttccagcc actgtgaacc
      481 atttggtcag cgccaacctg ctcagcccca gcaccgacag gctcagcctc tggtacgctc
      541 ctctcggcgg gaggccatca gcaccaagca gcaagagggc tcagggaagg cctcccccct
      601 ccggcggggg acgcctggct cagcgtaggg acacgcactc tgactgactg gcactggcag
      661 ctcgggatgt cgccctggcc gaggtggcat ggacccgcca tggcgcggct ctggggctta
      721 tgcttgctgg tcttgggctt ctggagggct tctcttgcct gccccatgtc ctgcaaatgc
      781 agcaccacta ggatttggtg taccgagcct tctcctggca tcgtggcatt tccgaggttg
      841 gaacctaaca gcattgaccc agagaacatc accgaaattc tcattgcaaa ccagaaaagg
      901 ttagaaatca tcaatgaaga tgatgtcgaa gcttacgtgg ggctgaaaaa ccttacaatt
      961 gtggattccg gcttaaagtt tgtggcttac aaggcgtttc tgaagaacgg caacctgcgg
     1021 cacatcaatt tcactcgaaa caagctgacg agtttgtcca ggagacattt ccgccacctt
     1081 gacttgtctg acctgatcct gacgggtaat ccgttcacgt gttcctgtga catcatgtgg
     1141 ctcaagactc tccaggagac gaaatccagc cccgacactc aggatttgta ttgcctcaat
     1201 gagagcagca agaatacccc tctggcgaac ctgcagattc ccaattgtgg tctgccgtct
     1261 gcacgtctgg ccgctcctaa cctcacggtg gaggaaggga agtctgtgac catttcctgc
     1321 agcgtcgggg gtgacccgct ccccaccttg tactgggacg ttgggaattt ggtttccaaa
     1381 cacatgaatg aaacaagcca cacacagggc tccttaagga taacaaacat ttcatcggat
     1441 gacagtggga aacaaatctc ttgtgtggca gaaaacctcg ttggagaaga tcaagactct
     1501 gtgaacctca ctgtgcattt tgcaccaacc atcacatttc tcgaatctcc aacctcagac
     1561 caccactggt gcatcccatt cactgtgaga ggcaacccca agccagcact tcagtggttc
     1621 tacaacggag ccatactgaa tgaatccaag tacatctgta ccaaaataca cgtcaccaat
     1681 cacacggagt accacggctg cctccagctg gataacccca ctcatatgaa taatggagac
     1741 tacaccctaa tggccaagaa tgaatatggg aaggacgaga gacagatttc tgctcacttc
     1801 atgggccggc ctggagttga ctatgagaca aacccaaatt accctgaagt cctctatgaa
     1861 gactggacca cgccaactga catcggggat actacaaaca aaagtaatga gatcccctcc
     1921 acggatgttg ctgaccaaac caatcgggag catctctcgg tctatgccgt ggtggtgatt
     1981 gcctctgtgg taggattctg cctgctggtg atgctgcttc tgctcaagtt ggcgagacat
     2041 tccaagtttg gcatgaaagg cccagcttcc gtcatcagca acgacgatga ctctgccagc
     2101 cctctccacc acatctccaa cgggagcaac actccgtctt cttcggaggg cgggcccgat
     2161 gctgtcatca ttgggatgac caagatccct gtcattgaaa acccccagta cttcggtatc
     2221 accaacagcc agctcaagcc ggacacattt gttcagcaca tcaagagaca caacatcgtt
     2281 ctgaagaggg agcttggaga aggagccttt gggaaagttt tcctagcgga gtgctataac
     2341 ctctgccccg agcaggataa gatcctggtg gccgtgaaga cgctgaagga cgccagcgac
     2401 aatgctcgca aggactttca tcgcgaagcc gagctgctga ccaacctcca gcacgagcac
     2461 attgtcaagt tctacggtgt ctgtgtggag ggcgacccac tcatcatggt ctttgagtac
     2521 atgaagcacg gggacctcaa caagttcctt agggcacacg ggccagatgc agtgctgatg
     2581 gcagagggta acccgcccac cgagctgacg cagtcgcaga tgctgcacat cgctcagcaa
     2641 atcgcagcag gcatggtcta cctggcatcc caacacttcg tgcaccgaga cctggccacc
     2701 cggaactgct tggtaggaga gaacctgctg gtgaaaattg gggacttcgg gatgtcccgg
     2761 gatgtataca gcaccgacta ctaccgggtt ggtggccaca caatgttgcc catccgatgg
     2821 atgcctccag agagcatcat gtacaggaaa ttcaccaccg agagtgacgt ctggagcctg
     2881 ggagttgtgt tgtgggagat cttcacctac ggcaagcagc cctggtatca gctatcaaac
     2941 aacgaggtga tagaatgcat cacccagggc agagtccttc agcggcctcg cacgtgtccc
     3001 caggaggtgt acgagctgat gctgggatgc tggcagcggg aaccacacac aaggaagaac
     3061 atcaagaaca tccacacact ccttcagaac ttggcgaagg cgtcgcccgt ctacctggac
     3121 atcctaggct agactccctc ttctcccaga cggcccttcc caaggcaccc ctcagacctc
     3181 ttaactgccg ctgatgtcac caccttgctg tccttcgctc tgacagtgtt aacaagacaa
     3241 ggagcggctc tccggggtga ggcagtgcgc acttccccat ccacagacag tatcgactcg
     3301 cttctggctt tgtcgctttc tctccctttg gtttgtttct ttcttttgcc cattctccat
     3361 ttatttattt atttatttat ttatttattt atttatttat ctatctatct atctatctat
     3421 ctatctattt atttatttat tggtcttcac tgcttcatgg tcctcggcct ctctccttga
     3481 ccgatctggc ttctgtactc ctattcactg tacatagaca aaggccttaa caaacctgat
     3541 ttgttatatc agcagacact ccagtttgcc caccacaact aacaatgcct tgttgtattc
     3601 ctgcctttga tgtggatgaa aaaaagggaa aaaaaaataa tcaaacatct gacttaaacc
     3661 gtcacttccg atgtacagac acggggcgtt tctatggatt cacttctatc tatctattta
     3721 tttatttatc tatttattta tttctcttct ttgttgtttt ccggtggttt tagcctgtgt
     3781 atgagaaggg aaagtcatgt acagtctggg aaaactttat ctgtgggaaa tggaaaccag
     3841 aaagggaaag aagctttacc ataaagcaca gcaggagtga gacacagaaa agccattgga
     3901 tcagccagag tccgtcctgc ataggaaaac ccagcagcca tcaggctgga ggatcatgtt
     3961 cggcactgac ccccgaggac ctttctgagg aggacacaga atgttaaact ctgcatcatg
     4021 gacacagttt ccgatcacag atactggcct tcaatggaaa aaaaaaaaaa cccagatagt
     4081 tcttgtgaga cctggacagc acgtccaaca tccagacatt gtggtcgggc acagtgacag
     4141 agttgatgca tttctcacgg gttattctac agagcttttg tcaagtccaa tggaaggagg
     4201 tagattcttg ttcagatatg atttcgggaa aaaccgagtc cttgacaaag acaggagaca
     4261 ccctcagttg ggaggcaagt ttctcttacc ttggactttc tcacacagca attctcaccc
     4321 ccaccccctc cactctcacc tgtcttgtaa ctgtgcaaac aaaagtgtgc atggtctttg
     4381 tcagttgata cctttgtgca cctctgtgca gaaactgctg tctgtcccgg ctgtggtacc
     4441 cgatcagtgg ggtagatcca cgaaaggtct cattttaggc cgctttggga aggtaaccag
     4501 atcggtagct ggaagcactc tccagtaggt ggcgaagggt gagtgggtct gctgaagcct
     4561 gcatatcttc acccacctca aacccaccgg gctgcacagg ggacaggcac aggccacccc
     4621 tgagggacag ggaagctctc ttgggatacc acctgagttt acattcagtg tgctcaggtc
     4681 aagtctctcg ctcggggctc tgtttcgggg agaatggttt cattccaacg cactcattat
     4741 caggattctg ttttc
//
